Author results

3ZMS
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LSD1-COREST IN COMPLEX WITH INSM1 PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, INSULINOMA-ASSOCIATED PROTEIN 1, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMT
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LSD1-COREST IN COMPLEX WITH PRSFLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMU
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LSD1-COREST IN COMPLEX WITH PKSFLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PKSFLV PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMV
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LSD1-COREST IN COMPLEX WITH PLSFLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PKSFLV PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-12
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZMZ
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LSD1-COREST IN COMPLEX WITH PRSFAV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-13
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZN0
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LSD1-COREST IN COMPLEX WITH PRSFAA PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-13
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
3ZN1
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LSD1-COREST IN COMPLEX WITH PRLYLV PEPTIDE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, PEPTIDE, ...
著者Tortorici, M., Borrello, M.T., Tardugno, M., Chiarelli, L.R., Pilotto, S., Ciossani, G., Vellore, N.A., Cowan, J., O'Connell, M., Mai, A., Baron, R., Ganesan, A., Mattevi, A.
登録日2013-02-13
公開日2013-06-12
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.
Acs Chem.Biol., 8, 2013
4UV8
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LSD1(KDM1A)-COREST IN COMPLEX WITH 1-BENZYL-TRANYLCYPROMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [[(2R,3S,4S)-5-[(4aS,10aS)-4a-[(1S)-3-azanylidene-1,4-diphenyl-butyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-5,10a-dihydro-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentoxy]-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UV9
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LSD1(KDM1A)-COREST IN COMPLEX WITH 1-ETHYL-TRANYLCYPROMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS,10aS)-4a-[(1S,3E)-3-imino-1-phenylpentyl]-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UVA
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LSD1(KDM1A)-COREST IN COMPLEX WITH 1-METHYL-TRANYLCYPROMINE (1R,2S)
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS)-4a-[(1S,3E)-3-imino-1-phenylbutyl]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UVB
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LSD1(KDM1A)-COREST IN COMPLEX WITH 1-METHYL-TRANYLCYPROMINE (1S,2R)
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,7aS)-1-amino-1,10,11-trimethyl-4,6-dioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4UVC
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LSD1(KDM1A)-COREST IN COMPLEX WITH 1-PHENYL-TRANYLCYPROMINE
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-[(1S)-1-azanyl-1,3-diphenyl-propyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-4aH-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate
著者Vianello, P., Botrugno, O., Cappa, A., Ciossani, G., Dessanti, P., Mai, A., Mattevi, A., Meroni, G., Minucci, S., Thaler, F., Tortorici, M., Trifiro, P., Valente, S., Villa, M., Varasi, M., Mercurio, C.
登録日2014-08-05
公開日2014-09-10
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A.
Eur.J.Med.Chem., 86C, 2014
4A79
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CRYSTAL STRUCTURE OF HUMAN MONOAMINE OXIDASE B (MAO B) IN COMPLEX WITH PIOGLITAZONE
分子名称:AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
著者Binda, C., Aldeco, M., Geldenhuys, W.J., Tortorici, M., Mattevi, A., Edmondson, D.E.
登録日2011-11-11
公開日2012-04-25
最終更新日2012-05-30
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Molecular Insights Into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs
Acs Med. Chem. Lett., 3, 2012
4A7A
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CRYSTAL STRUCTURE OF HUMAN MONOAMINE OXIDASE B (MAO B) IN COMPLEX WITH ROSIGLITAZONE
分子名称:AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (R)-ROSIGLITAZONE
著者Binda, C., Aldeco, M., Geldenhuys, W.J., Tortorici, M., Mattevi, A., Edmondson, D.E.
登録日2011-11-11
公開日2012-04-25
最終更新日2012-07-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular Insights Into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs
Acs Med. Chem. Lett., 3, 2012
2Y48
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH A N-TERMINAL SNAIL PEPTIDE
分子名称:LYSINE-SPECIFIC DEMETHYLASE 1A, REST COREPRESSOR 1, ZINC FINGER PROTEIN SNAI1, ...
著者Baron, R., Binda, C., Tortorici, M., McCammon, J.A., Mattevi, A.
登録日2011-01-05
公開日2011-02-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase Lsd1-Corest Complex.
Structure, 19, 2011
4BAY
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PHOSPHOMIMETIC MUTANT OF LSD1-8A SPLICING VARIANT IN COMPLEX WITH COREST
分子名称:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE
著者Toffolo, E., Paganini, L., Rusconi, F., Tortorici, M., Pilotto, S., Verpelli, C., Tedeschi, G., Maffioli, E., Sala, C., Mattevi, A., Battaglioli, E.
登録日2012-09-17
公開日2013-11-27
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Phosphorylation of Neuronal Lysine-Specific Demethylase 1Lsd1/Kdm1A Impairs Transcriptional Repression by Regulating Interaction with Corest and Histone Deacetylases Hdac1/2.
J.Neurochem., 128, 2014
5MWJ
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STRUCTURE ENABLED DISCOVERY OF A STAPLED PEPTIDE INHIBITOR TO TARGET THE ONCOGENIC TRANSCRIPTIONAL REPRESSOR TLE1
分子名称:Transducin-like enhancer protein 1, DIMETHYL SULFOXIDE, pepide inhibtor
著者McGrath, S., Tortorici, M., Vidler, L., Drouin, L., Westwood, I., Gimeson, P., Van Montfort, R., Hoelder, S.
登録日2017-01-18
公開日2017-04-05
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1.
Chemistry, 23, 2017
2WB8
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CRYSTAL STRUCTURE OF HASPIN KINASE
分子名称:SERINE/THREONINE-PROTEIN KINASE HASPIN
著者Villa, F., Tortorci, M., Forneris, F., Mattevi, A., Musacchio, A.
登録日2009-02-23
公開日2009-11-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal Structure of the Catalytic Domain of Haspin, an Atypical Kinase Implicated in Chromatin Organization.
Proc.Natl.Acad.Sci.USA, 106, 2009
5LSS
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
著者Tisi, D., Pathuri, P.
登録日2016-09-05
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSU
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase NSD2, ZINC ION, S-ADENOSYLMETHIONINE
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-05
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSX
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, [(2~{R},5~{S})-1-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]-5-azaniumyl-6-oxidanyl-6-oxidanylidene-hexan-2-yl]-(phenylmethyl)azanium
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-05
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSY
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-05
公開日2016-10-12
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LSZ
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-05
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LT6
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-06
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
5LT7
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STRUCTURE OF THE EPIGENETIC ONCOGENE MMSET AND INHIBITION BY N-ALKYL SINEFUNGIN DERIVATIVES
分子名称:Histone-lysine N-methyltransferase SETD2, ZINC ION, THIOCYANATE ION, ...
著者Tisi, D., Pathuri, P., Heightman, T.
登録日2016-09-06
公開日2016-10-05
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
ACS Chem. Biol., 11, 2016
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