Author results

3J2T
  • Download 3j2t
  • View 3j2t
Molmil generated image of 3j2t
AN IMPROVED MODEL OF THE HUMAN APOPTOSOME
Descriptor:Apoptotic protease-activating factor 1, Cytochrome c, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Yuan, S., Topf, M., Akey, C.W.
Deposit date:2012-12-23
Release date:2013-04-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:Changes in apaf-1 conformation that drive apoptosome assembly.
Biochemistry, 52, 2013
4BIP
  • Download 4bip
  • View 4bip
Molmil generated image of 4bip
HOMOLOGY MODEL OF COXSACKIEVIRUS A7 (CAV7) FULL CAPSID PROTEINS.
Descriptor:VP1, VP2, VP3
Authors:Seitsonen, J.J.T., Shakeel, S., Susi, P., Pandurangan, A.P., Sinkovits, R.S., Hyvonen, H., Laurinmaki, P., Yla-Pelto, J., Topf, M., Hyypia, T., Butcher, S.J.
Deposit date:2013-04-12
Release date:2013-10-02
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (8.23 Å)
Cite:Combined Approaches to Flexible Fitting and Assessment in Virus Capsids Undergoing Conformational Change.
J.Struct.Biol., 185, 2014
4BIQ
  • Download 4biq
  • View 4biq
Molmil generated image of 4biq
HOMOLOGY MODEL OF COXSACKIEVIRUS A7 (CAV7) EMPTY CAPSID PROTEINS.
Descriptor:VP1, VP2, VP3
Authors:Seitsonen, J.J.T., Shakeel, S., Susi, P., Pandurangan, A.P., Sinkovits, R.S., Hyvonen, H., Laurinmaki, P., Yla-Pelto, J., Topf, M., Hyypia, T., Butcher, S.J.
Deposit date:2013-04-12
Release date:2013-10-02
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (6.09 Å)
Cite:Combined Approaches to Flexible Fitting and Assessment in Virus Capsids Undergoing Conformational Change.
J.Struct.Biol., 185, 2014
2X7N
  • Download 2x7n
  • View 2x7n
Molmil generated image of 2x7n
MECHANISM OF EIF6S ANTI-ASSOCIATION ACTIVITY
Descriptor:SARCIN-RICIN LOOP, EUKARYOTIC TRANSLATION INITIATION FACTOR 6, 60S RIBOSOMAL PROTEIN L23, ...
Authors:Gartmann, M., Blau, M., Armache, J.-P., Mielke, T., Topf, M., Beckmann, R.
Deposit date:2010-03-02
Release date:2010-03-31
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (11.8 Å)
Cite:Mechanism of Eif6-Mediated Inhibition of Ribosomal Subunit Joining.
J.Biol.Chem., 285, 2010
3B5U
  • Download 3b5u
  • View 3b5u
Molmil generated image of 3b5u
ACTIN FILAMENT MODEL FROM EXTENDED FORM OF ACROMSOMAL BUNDLE IN THE LIMULUS SPERM
Descriptor:Actin, alpha skeletal muscle
Authors:Cong, Y., Topf, M., Sali, A., Matsudaira, P., Dougherty, M., Chiu, W., Schmid, M.F.
Deposit date:2007-10-26
Release date:2008-04-15
Last modified:2018-07-18
Method:ELECTRON CRYSTALLOGRAPHY (9.5 Å)
Cite:Crystallographic conformers of actin in a biologically active bundle of filaments
J.Mol.Biol., 375, 2008
3B63
  • Download 3b63
  • View 3b63
Molmil generated image of 3b63
ACTIN FILAMENT MODEL IN THE EXTENDED FORM OF ACROMSOMAL BUNDLE IN THE LIMULUS SPERM
Descriptor:Actin
Authors:Cong, Y., Topf, M., Sali, A., Matsudaira, P., Dougherty, M., Chiu, W., Schmid, M.F.
Deposit date:2007-10-26
Release date:2008-11-18
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:Crystallographic conformers of actin in a biologically active bundle of filaments.
J.Mol.Biol., 375, 2008
5M50
  • Download 5m50
  • View 5m50
Molmil generated image of 5m50
MECHANISM OF MICROTUBULE MINUS-END RECOGNITION AND PROTECTION BY CAMSAP PROTEINS
Descriptor:Tubulin alpha chain, Tubulin beta-2B chain, Calmodulin-regulated spectrin-associated protein 3, ...
Authors:Akhmanova, A., Moores, C.A., Baldus, M., Steinmetz, M.O., Topf, M., Roberts, A.J., Grant, B.J., Scarabelli, G., Joseph, A.-P., van Hooff, J.J.E., Houben, K., Hua, S., Luo, Y., Stangier, M.M., Jiang, K., Atherton, J.
Deposit date:2016-10-20
Release date:2017-10-04
Last modified:2017-11-15
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.
Nat. Struct. Mol. Biol., 24, 2017
5M54
  • Download 5m54
  • View 5m54
Molmil generated image of 5m54
MECHANISM OF MICROTUBULE MINUS-END RECOGNITION AND PROTECTION BY CAMSAP PROTEINS
Descriptor:Calmodulin-regulated spectrin-associated protein 1, Tubulin alpha chain, Tubulin beta-2B chain, ...
Authors:Akhmanova, A., Moores, C.A., Baldus, M., Steinmetz, M.O., Topf, M., Roberts, A.J., Grant, B.J., Scarabelli, G., Joseph, A.-J., van Hooff, J.J.E., Houben, K., Hua, S., Luo, Y., Stangier, M.M., Jiang, K., Atherton, J.
Deposit date:2016-10-20
Release date:2017-10-04
Last modified:2017-11-15
Method:ELECTRON MICROSCOPY (8 Å)
Cite:A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.
Nat. Struct. Mol. Biol., 24, 2017
5M5C
  • Download 5m5c
  • View 5m5c
Molmil generated image of 5m5c
MECHANISM OF MICROTUBULE MINUS-END RECOGNITION AND PROTECTION BY CAMSAP PROTEINS
Descriptor:Calmodulin-regulated spectrin-associated protein 1, Tubulin alpha chain, Tubulin beta-2B chain, ...
Authors:Akhmanova, A., Moores, C.A., Baldus, M., Steinmetz, M.O., Topf, M., Roberts, A.J., Grant, B.J., Scarabelli, G., Joseph, A.-P., van Hooff, J.J.E., Houben, K., Hua, S., Luo, Y., Stangier, M.M., Jiang, K., Atherton, J.
Deposit date:2016-10-21
Release date:2017-10-04
Last modified:2017-11-15
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.
Nat. Struct. Mol. Biol., 24, 2017
5OFO
  • Download 5ofo
  • View 5ofo
Molmil generated image of 5ofo
CRYO EM STRUCTURE OF THE E. COLI DISAGGREGASE CLPB (BAP FORM, DWB MUTANT), IN THE ATPGAMMAS STATE, BOUND TO THE MODEL SUBSTRATE CASEIN
Descriptor:Chaperone protein ClpB,ATP-dependent Clp protease ATP-binding subunit ClpA,Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Deville, C., Carroni, M., Franke, K.B., Topf, M., Bukau, B., Mogk, A., Saibil, H.R.
Deposit date:2017-07-11
Release date:2017-08-16
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.
Sci Adv, 3, 2017
5OG1
  • Download 5og1
  • View 5og1
Molmil generated image of 5og1
CRYO EM STRUCTURE OF THE E. COLI DISAGGREGASE CLPB (BAP FORM, DWB MUTANT), IN THE ATPGAMMAS STATE
Descriptor:Chaperone protein ClpB,ATP-dependent Clp protease ATP-binding subunit ClpA,Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Deville, C., Carroni, M., Franke, K.B., Topf, M., Bukau, B., Mogk, A., Saibil, H.R.
Deposit date:2017-07-11
Release date:2017-08-16
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.
Sci Adv, 3, 2017
6H03
  • Download 6h03
  • View 6h03
Molmil generated image of 6h03
OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Descriptor:Complement C5,Complement C5, Complement component C8 beta chain, Complement component C7, ...
Authors:Menny, A., Serna, M., Boyd, C.M., Gardner, S., Joseph, A.P., Topf, M., Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
6H04
  • Download 6h04
  • View 6h04
Molmil generated image of 6h04
CLOSED CONFORMATION OF THE MEMBRANE ATTACK COMPLEX
Descriptor:Complement component C9, Complement C5,Complement C5, Complement component C8 beta chain, ...
Authors:Menny, A., Serna, M., Boyd, C.M., Gardner, S., Joseph, A.P., Topf, M., Bubeck, D.
Deposit date:2018-07-06
Release date:2018-12-19
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nat Commun, 9, 2018
1NX4
  • Download 1nx4
  • View 1nx4
Molmil generated image of 1nx4
THE CRYSTAL STRUCTURE OF CARBAPENEM SYNTHASE (CARC)
Descriptor:Carbapenem synthase, FE (III) ION, 2-OXOGLUTARIC ACID
Authors:Clifton, I.J., Doan, L.X., Sleeman, M.C., Topf, M., Suzuki, H., Wilmouth, R.C., Schofield, C.J.
Deposit date:2003-02-08
Release date:2003-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of carbapenem synthase (CarC).
J.Biol.Chem., 278, 2003
1NX8
  • Download 1nx8
  • View 1nx8
Molmil generated image of 1nx8
STRUCTURE OF CARBAPENEM SYNTHASE (CARC) COMPLEXED WITH N-ACETYL PROLINE
Descriptor:Carbapenem synthase, FE (III) ION, 2-OXOGLUTARIC ACID, ...
Authors:Clifton, I.J., Doan, L.X., Sleeman, M.C., Topf, M., Suzuki, H., Wilmouth, R.C., Schofield, C.J.
Deposit date:2003-02-10
Release date:2003-06-17
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of carbapenem synthase (CarC).
J.Biol.Chem., 278, 2003
3DEG
  • Download 3deg
  • View 3deg
Molmil generated image of 3deg
COMPLEX OF ELONGATING ESCHERICHIA COLI 70S RIBOSOME AND EF4(LEPA)-GMPPNP
Descriptor:A/L-tRNA, P-tRNA, 30S RNA helix 8, ...
Authors:Connell, S.R., Topf, M., Qin, Y., Wilson, D.N., Mielke, T., Fucini, P., Nierhaus, K.H., Spahn, C.M.T.
Deposit date:2008-06-10
Release date:2008-08-19
Last modified:2014-04-16
Method:ELECTRON MICROSCOPY (10.9 Å)
Cite:A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
Nat.Struct.Mol.Biol., 15, 2008
4AAQ
  • Download 4aaq
  • View 4aaq
Molmil generated image of 4aaq
ATP-TRIGGERED MOLECULAR MECHANICS OF THE CHAPERONIN GROEL
Descriptor:60 KDA CHAPERONIN, ADENOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ...
Authors:Clare, D.K., Vasishtan, D., Stagg, S., Quispe, J., Farr, G.W., Topf, M., Horwich, A.L., Saibil, H.R.
Deposit date:2011-12-05
Release date:2012-12-12
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (8 Å)
Cite:ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the Groel Chaperonin.
Cell(Cambridge,Mass.), 149, 2012
4AAR
  • Download 4aar
  • View 4aar
Molmil generated image of 4aar
ATP-TRIGGERED MOLECULAR MECHANICS OF THE CHAPERONIN GROEL
Descriptor:60 KDA CHAPERONIN, ADENOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, ...
Authors:Clare, D.K., Vasishtan, D., Stagg, S., Quispe, J., Farr, G.W., Topf, M., Horwich, A.L., Saibil, H.R.
Deposit date:2011-12-05
Release date:2012-12-12
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (8 Å)
Cite:ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the Groel Chaperonin.
Cell(Cambridge,Mass.), 149, 2012
4AAS
  • Download 4aas
  • View 4aas
Molmil generated image of 4aas
ATP-TRIGGERED MOLECULAR MECHANICS OF THE CHAPERONIN GROEL
Descriptor:60 KDA CHAPERONIN, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Clare, D.K., Vasishtan, D., Stagg, S., Quispe, J., Farr, G.W., Topf, M., Horwich, A.L., Saibil, H.R.
Deposit date:2011-12-05
Release date:2012-12-12
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (8.5 Å)
Cite:ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the Groel Chaperonin.
Cell(Cambridge,Mass.), 149, 2012
4AAU
  • Download 4aau
  • View 4aau
Molmil generated image of 4aau
ATP-TRIGGERED MOLECULAR MECHANICS OF THE CHAPERONIN GROEL
Descriptor:60 KDA CHAPERONIN, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Clare, D.K., Vasishtan, D., Stagg, S., Quispe, J., Farr, G.W., Topf, M., Horwich, A.L., Saibil, H.R.
Deposit date:2011-12-05
Release date:2012-12-12
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (8.5 Å)
Cite:ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the Groel Chaperonin.
Cell(Cambridge,Mass.), 149, 2012
4AB2
  • Download 4ab2
  • View 4ab2
Molmil generated image of 4ab2
ATP-TRIGGERED MOLECULAR MECHANICS OF THE CHAPERONIN GROEL
Descriptor:60 KDA CHAPERONIN, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Clare, D.K., Vasishtan, D., Stagg, S., Quispe, J., Farr, G.W., Topf, M., Horwich, A.L., Saibil, H.R.
Deposit date:2011-12-06
Release date:2012-12-12
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (8.5 Å)
Cite:ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the Groel Chaperonin.
Cell(Cambridge,Mass.), 149, 2012
4AB3
  • Download 4ab3
  • View 4ab3
Molmil generated image of 4ab3
ATP-TRIGGERED MOLECULAR MECHANICS OF THE CHAPERONIN GROEL
Descriptor:60 KDA CHAPERONIN, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Clare, D.K., Vasishtan, D., Stagg, S., Quispe, J., Farr, G.W., Topf, M., Horwich, A.L., Saibil, H.R.
Deposit date:2011-12-06
Release date:2012-12-12
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (8.5 Å)
Cite:ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the Groel Chaperonin.
Cell(Cambridge,Mass.), 149, 2012
4BOM
  • Download 4bom
  • View 4bom
Molmil generated image of 4bom
STRUCTURE OF HERPESVIRUS FUSION GLYCOPROTEIN B-BILAYER COMPLEX REVEALING THE PROTEIN-MEMBRANE AND LATERAL PROTEIN-PROTEIN INTERACTION
Descriptor:ENVELOPE GLYCOPROTEIN B
Authors:Maurer, U.E., Zeev-Ben-Mordehai, Z., Pandurangan, A.P., Cairns, T.M., Hannah, B.P., Whitbeck, J.C., Eisenberg, R.J., Cohen, G.H., Topf, M., Huiskonen, J.T., Grunewald, K.
Deposit date:2013-05-21
Release date:2013-07-31
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (27 Å)
Cite:The structure of herpesvirus fusion glycoprotein B-bilayer complex reveals the protein-membrane and lateral protein-protein interaction.
Structure, 21, 2013
4L0J
  • Download 4l0j
  • View 4l0j
Molmil generated image of 4l0j
STRUCTURE OF A TRANSLOCATION SIGNAL DOMAIN MEDIATING CONJUGATIVE TRANSFER BY TYPE IV SECRETION SYSTEMS
Descriptor:DNA helicase I, SULFATE ION, MAGNESIUM ION
Authors:Redzej, A., Ilangovan, A., Lang, S., Gruber, C.J., Topf, M., Zangger, K., Zechner, E.L., Waksman, G.
Deposit date:2013-05-31
Release date:2013-06-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems.
Mol.Microbiol., 89, 2013
4UXO
  • Download 4uxo
  • View 4uxo
Molmil generated image of 4uxo
CONSERVED MECHANISMS OF MICROTUBULE-STIMULATED ADP RELEASE, ATP BINDING, AND FORCE GENERATION IN TRANSPORT KINESINS
Descriptor:TUBULIN ALPHA-1B CHAIN, TUBULIN BETA-2B CHAIN, KINESIN-3 MOTOR DOMAIN, ...
Authors:Atherton, J., Farabella, I., Yu, I.M., Rosenfeld, S.S., Houdusse, A., Topf, M., Moores, C.
Deposit date:2014-08-27
Release date:2014-09-24
Last modified:2018-04-04
Method:ELECTRON MICROSCOPY (6.3 Å)
Cite:Conserved Mechanisms of Microtubule-Stimulated Adp Release, ATP Binding, and Force Generation in Transport Kinesins.
Elife, 3, 2014
<12>