Author results

2JPH
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NMR SOLUTION STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF HUMAN PLEXIN-B1
分子名称:Plexin-B1
著者Tong, Y., Buck, M.
登録日2007-05-11
公開日2008-03-18
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Insights into Oncogenic Mutations of Plexin-B1 Based on the Solution Structure of the Rho GTPase Binding Domain
Structure, 16, 2008
3GBJ
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CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF KINESIN KIF13B BOUND WITH ADP
分子名称:KIF13B protein, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Tong, Y., Shen, L., Shen, Y., Tempel, W., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2009-02-19
公開日2009-03-03
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Crystal structure of the motor domain of kinesin KIF13B bound with ADP
To be Published
3NF1
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CRYSTAL STRUCTURE OF THE TPR DOMAIN OF KINESIN LIGHT CHAIN 1
分子名称:Kinesin light chain 1
著者Tong, Y., Tempel, W., Shen, L., Shen, Y., Nedyalkova, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2010-06-09
公開日2011-05-25
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the TPR domain of kinesin light chain 1
to be published
1NI1
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IMIDAZOLE AND CYANOPHENYL FARNESYL TRANSFERASE INHIBITORS
分子名称:Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
著者Tong, Y., Lin, N.H., Wang, L., Hasvold, L., Wang, W., Leonard, N., Li, T., Li, Q., Cohen, J., Gu, W.Z., Zhang, H., Stoll, V., Bauch, J., Marsh, K., Rosenberg, S.H., Sham, H.L.
登録日2002-12-20
公開日2004-04-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Bioorg.Med.Chem.Lett., 13, 2003
2IQJ
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CRYSTAL STRUCTURE OF THE GAP DOMAIN OF SMAP1L (LOC64744) STROMAL MEMBRANE-ASSOCIATED PROTEIN 1-LIKE
分子名称:Stromal membrane-associated protein 1-like, ZINC ION, BETA-MERCAPTOETHANOL, ...
著者Tong, Y., Dimov, S., Shen, L., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2006-10-13
公開日2006-10-24
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the GAP domain of SMAP1L (LOC64744) stromal membrane-associated protein 1-like
To be Published
2OLM
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ARFGAP DOMAIN OF HIV-1 REV BINDING PROTEIN
分子名称:Nucleoporin-like protein RIP, ZINC ION, SULFATE ION, ...
著者Tong, Y., Tempel, W., Shen, L., Dimov, S., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2007-01-19
公開日2007-01-30
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献ArfGap domain of HIV-1 Rev binding protein
To be Published
2P57
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GAP DOMAIN OF ZNF289, AN ID1-REGULATED ZINC FINGER PROTEIN
分子名称:GTPase-activating protein ZNF289, ZINC ION, UNKNOWN ATOM OR ION
著者Tong, Y., Dimov, S., Shen, L., Zhu, H., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2007-03-14
公開日2007-03-27
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献GAP domain of ZNF289, an ID1-regulated zinc finger protein
To be Published
2QFZ
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CRYSTAL STRUCTURE OF HUMAN TBC1 DOMAIN FAMILY MEMBER 22A
分子名称:TBC1 domain family member 22A, UNKNOWN ATOM OR ION
著者Tong, Y., Tempel, W., Dimov, S., Dong, A., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2007-06-28
公開日2007-07-10
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of human TBC1 domain family member 22A.
To be Published
2QQ8
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CRYSTAL STRUCTURE OF THE PUTATIVE RABGAP DOMAIN OF HUMAN TBC1 DOMAIN FAMILY MEMBER 14
分子名称:TBC1 domain family member 14, UNKNOWN ATOM OR ION
著者Tong, Y., Tempel, W., Dimov, S., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2007-07-26
公開日2007-08-07
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14.
To be Published
2R2O
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CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF HUMAN PLEXIN B1
分子名称:Plexin-B1, UNKNOWN ATOM OR ION
著者Tong, Y., Tempel, W., Shen, L., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2007-08-27
公開日2007-09-04
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.
J.Biol.Chem., 282, 2007
2REX
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CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PLXNB1 BOUND WITH RND1 GTPASE
分子名称:Plexin-B1, Rho-related GTP-binding protein Rho6, UNKNOWN ATOM OR ION, ...
著者Tong, Y., Tempel, W., Shen, L., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2007-09-27
公開日2007-11-20
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the effector domain of PLXNB1 bound with Rnd1 GTPase.
To be Published
3GFT
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HUMAN K-RAS (Q61H) IN COMPLEX WITH A GTP ANALOGUE
分子名称:GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
著者Tong, Y., Tempel, W., Shen, L., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2009-02-27
公開日2009-03-10
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Human K-Ras in complex with a GTP analogue
To be Published
3H6N
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CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE DOMAIN OF PLEXIN D1
分子名称:Plexin-D1, ARSENIC, UNKNOWN ATOM OR ION
著者Tong, Y., Nedyalkova, L., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Buck, M., Park, H., Structural Genomics Consortium (SGC)
登録日2009-04-23
公開日2009-05-19
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.004 Å)
主引用文献Crystal Structure of the ubiquitin-like domain of plexin D1
To be Published
3HM6
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CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF HUMAN PLEXIN B1
分子名称:Plexin-B1, Unknown peptide, UNKNOWN ATOM OR ION
著者Tong, Y., He, H., Shen, L., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2009-05-28
公開日2009-06-09
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.402 Å)
主引用文献Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
J.Biol.Chem., 284, 2009
3KFV
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CRYSTAL STRUCTURE OF THE SH3-KINASE FRAGMENT OF TIGHT JUNCTION PROTEIN 3 (TJP3) IN APO-FORM
分子名称:Tight junction protein ZO-3, UNKNOWN ATOM OR ION
著者Tong, Y., Nedyalkova, L., Tempel, W., Zhong, N., Guan, X., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2009-10-28
公開日2009-11-03
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form
to be published
4IQ6
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GSK-3BETA WITH INHIBITOR 6-CHLORO-N-CYCLOHEXYL-4-(1H-PYRROLO[2,3-B]PYRIDIN-3-YL)PYRIDIN-2-AMINE
分子名称:Glycogen synthase kinase-3 beta, 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine
著者Tong, Y., Stewart, K.D., Florjancic, A.S., Harlan, J.E., Merta, P.J., Przytulinska, M., Soni, N., Swinger, K.S., Zhu, H., Johnson, E.F., Shoemaker, A.R., Penning, T.D.
登録日2013-01-10
公開日2013-04-24
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (3.12 Å)
主引用文献Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195.
ACS Med Chem Lett, 4, 2013
6D0S
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RABGAP DOMAIN OF HUMAN TBC1D22B
分子名称:TBC1 domain family member 22B, SULFATE ION, UNKNOWN ATOM OR ION
著者Tong, Y., Tempel, W., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Park, H., Structural Genomics Consortium (SGC)
登録日2018-04-10
公開日2018-06-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献RabGAP domain of human TBC1D22B
To be Published
3CPF
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CRYSTAL STRUCTURE OF HUMAN EUKARYOTIC TRANSLATION INITIATION FACTOR EIF5A
分子名称:Eukaryotic translation initiation factor 5A-1, UNKNOWN ATOM OR ION
著者Nedyalkova, L., Tong, Y., Tempel, W., Hong, B., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2008-03-31
公開日2008-04-15
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2.
Proteins, 75, 2009
3EO3
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CRYSTAL STRUCTURE OF THE N-ACETYLMANNOSAMINE KINASE DOMAIN OF HUMAN GNE PROTEIN
分子名称:Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, ZINC ION, UNKNOWN ATOM OR ION
著者Nedyalkova, L., Tong, Y., Rabeh, W.M., Hong, B., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2008-09-26
公開日2008-10-07
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Crystal structure of the N-acetylmannosamine kinase domain of GNE.
Plos One, 4, 2009
3FEH
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CRYSTAL STRUCTURE OF FULL LENGTH CENTAURIN ALPHA-1
分子名称:Centaurin-alpha-1, ZINC ION, UNKNOWN ATOM OR ION
著者Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2008-11-29
公開日2008-12-23
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin {alpha}1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3FM8
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CRYSTAL STRUCTURE OF FULL LENGTH CENTAURIN ALPHA-1 BOUND WITH THE FHA DOMAIN OF KIF13B (CAPRI TARGET)
分子名称:Kinesin-like protein KIF13B, Centaurin-alpha-1, UNKNOWN ATOM OR ION, ...
著者Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2008-12-19
公開日2009-08-25
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LJU
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CRYSTAL STRUCTURE OF FULL LENGTH CENTAURIN ALPHA-1 BOUND WITH THE HEAD GROUP OF PIP3
分子名称:Arf-GAP with dual PH domain-containing protein 1, ZINC ION, (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane-1,2-diyl dioctanoate
著者Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2010-01-26
公開日2010-11-24
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.702 Å)
主引用文献Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3GF9
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CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 RHOGEF DOMAIN
分子名称:Intersectin 2, UNKNOWN ATOM OR ION
著者Shen, Y., Tong, Y., Tempel, W., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2009-02-26
公開日2009-03-10
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of human Intersectin 2 RhoGEF domain
To be Published
3JZY
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CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 C2 DOMAIN
分子名称:Intersectin 2, UNKNOWN ATOM OR ION
著者Shen, Y., Tempel, W., Tong, Y., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2009-09-24
公開日2009-10-06
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Crystal structure of human Intersectin 2 C2 domain
To be Published
3PFN
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CRYSTAL STRUCTURE OF HUMAN NAD KINASE
分子名称:NAD kinase, UNKNOWN ATOM OR ION
著者Wang, H., Tempel, W., Wernimont, A.K., Tong, Y., Guan, X., Shen, Y., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
登録日2010-10-28
公開日2010-11-10
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structure of human NAD kinase
to be published