Author results

5WT9
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COMPLEX STRUCTURE OF PD-1 AND NIVOLUMAB-FAB
Descriptor:Heavy Chain of Nivolumab, Light Chain of Nivolumab, Programmed cell death protein 1, ...
Authors:Tan, S., Zhang, H., Chai, Y., Song, H., Tong, Z., Wang, Q., Qi, J., Wong, G., Zhu, X., Liu, W.J., Gao, S., Wang, Z., Shi, Y., Yang, F., Gao, G.F., Yan, J.
Deposit date:2016-12-10
Release date:2017-02-15
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:An unexpected N-terminal loop in PD-1 dominates binding by nivolumab.
Nat Commun, 8, 2017
2FLR
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NOVEL 5-AZAINDOLE FACTOR VIIA INHIBITORS
Descriptor:Coagulation factor VII, Tissue factor, [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA
Authors:Riggs, J.R., Hu, H., Kolesnikov, A., Tong, Z., Leahy, E.M., Wesson, K.E., Shrader, W.D., Vijaykumar, D., Wahl, T.A., Sprengeler, P.A., Green, M.J., Yu, C., Katz, B.A., Young, W.B.
Deposit date:2006-01-06
Release date:2007-01-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Novel 5-azaindole factor VIIa inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
5GZN
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STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN
Descriptor:Genome polyprotein, Antibody Heavy chain, Antibody light chain
Authors:Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.
Deposit date:2016-09-29
Release date:2016-12-28
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
5GZO
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STRUCTURE OF NEUTRALIZING ANTIBODY BOUND TO ZIKA ENVELOPE PROTEIN
Descriptor:Genome polyprotein, Antibody heavy chain, Antibody light chain
Authors:Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.
Deposit date:2016-09-29
Release date:2017-01-18
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.755 Å)
Cite:Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
5XJ3
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COMPLEX STRUCTURE OF IPILIMUMAB-SCFV AND CTLA-4
Descriptor:ipilimumab-VH, ipilimumab-VL, Cytotoxic T-lymphocyte protein 4
Authors:He, M., Chai, Y., Qi, J., Tong, Z., Tan, S., Gao, G.F.
Deposit date:2017-04-29
Release date:2018-04-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies
Oncotarget, 8, 2017
6IEA
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STRUCTURE OF RVFV GN AND HUMAN MONOCLONAL ANTIBODY R13
Descriptor:NSmGnGc, R13 L chain, R13 H chain, ...
Authors:Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F.
Deposit date:2018-09-13
Release date:2019-04-10
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.
Nat Microbiol, 4, 2019
6IEB
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STRUCTURE OF RVFV GN AND HUMAN MONOCLONAL ANTIBODY R15
Descriptor:R15 H chain, R15 L chain, NSmGnGc
Authors:Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F.
Deposit date:2018-09-13
Release date:2019-04-10
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.409 Å)
Cite:Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.
Nat Microbiol, 4, 2019
6IEC
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STRUCTURE OF RVFV GN AND HUMAN MONOCLONAL ANTIBODY R17
Descriptor:NSmGnGc, R17 H chain, R17 L chain
Authors:Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F.
Deposit date:2018-09-13
Release date:2019-04-10
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.
Nat Microbiol, 4, 2019
6IEK
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STRUCTURE OF RVFV GN AND HUMAN MONOCLONAL ANTIBODY R12
Descriptor:NSmGnGc, Heavy chain of Fab R12, Light chain of Fab R12
Authors:Wang, Q.H., Wu, Y., Gao, F., Qi, J.X., Gao, G.F.
Deposit date:2018-09-14
Release date:2019-04-10
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus.
Nat Microbiol, 4, 2019
6A3V
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COMPLEX STRUCTURE OF HUMAN 4-1BB AND 4-1BBL
Descriptor:Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, N-ACETYL-D-GLUCOSAMINE
Authors:Li, Y., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F.
Deposit date:2018-06-17
Release date:2018-10-10
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (3.391 Å)
Cite:Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
6A3W
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COMPLEX STRUCTURE OF 4-1BB AND UTOMILUMAB
Descriptor:utomilumab VH, utomilumab VL, Tumor necrosis factor receptor superfamily member 9, ...
Authors:Li, Y., Tan, S., Zhang, C., Chai, Y., Qi, J., Tien, P., Gao, S., Gao, G.F.
Deposit date:2018-06-17
Release date:2018-10-10
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
4PL0
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CRYSTAL STRUCTURE OF THE ANTIBACTERIAL PEPTIDE ABC TRANSPORTER MCJD IN AN OUTWARD OCCLUDED STATE
Descriptor:Microcin-J25 export ATP-binding/permease protein McjD, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Choudhury, H.G., Beis, K.
Deposit date:2014-05-15
Release date:2014-06-18
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state.
Proc.Natl.Acad.Sci.USA, 111, 2014
5GZR
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ZIKA VIRUS E PROTEIN COMPLEXED WITH A NEUTRALIZING ANTIBODY Z23-FAB
Descriptor:structural protein E, strutural protein M, Z23 Fab heavy chain, ...
Authors:Gao, G.G., Shi, Y., Peng, R., Liu, S.
Deposit date:2016-10-01
Release date:2016-11-30
Last modified:2016-12-28
Method:ELECTRON MICROSCOPY (9.4 Å)
Cite:Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8, 2016
1FW1
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GLUTATHIONE TRANSFERASE ZETA/MALEYLACETOACETATE ISOMERASE
Descriptor:GLUTATHIONE TRANSFERASE ZETA, SULFATE ION, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ...
Authors:Polekhina, G., Board, P.G., Blackburn, A.C., Parker, M.W.
Deposit date:2000-09-20
Release date:2001-09-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity.
Biochemistry, 40, 2001
5EG1
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ANTIBACTERIAL PEPTIDE ABC TRANSPORTER MCJD WITH A RESOLVED LIPID
Descriptor:Microcin-J25 export ATP-binding/permease protein McjD, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Choudhury, H.G., Beis, K.
Deposit date:2015-10-26
Release date:2016-08-31
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Structural and Functional Basis for Lipid Synergy on the Activity of the Antibacterial Peptide ABC Transporter McjD.
J.Biol.Chem., 291, 2016
5OFP
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STRUCTURE OF THE ANTIBACTERIAL PEPTIDE ABC TRANSPORTER MCJD IN AN APO INWARD OCCLUDED CONFORMATION
Descriptor:Microcin-J25 export ATP-binding/permease protein McjD
Authors:Beis, K., Choudhury, H.G.
Deposit date:2017-07-11
Release date:2017-09-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (4.71 Å)
Cite:Structural basis for antibacterial peptide self-immunity by the bacterial ABC transporter McjD.
EMBO J., 36, 2017
5OFR
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STRUCTURE OF THE ANTIBACTERIAL PEPTIDE ABC TRANSPORTER MCJD IN A HIGH ENERGY OUTWARD OCCLUDED INTERMEDIATE STATE
Descriptor:Microcin-J25 export ATP-binding/permease protein McjD, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Beis, K., Bountra, K.
Deposit date:2017-07-11
Release date:2017-09-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis for antibacterial peptide self-immunity by the bacterial ABC transporter McjD.
EMBO J., 36, 2017