Author results

1K9O
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CRYSTAL STRUCTURE OF MICHAELIS SERPIN-TRYPSIN COMPLEX
Descriptor:ALASERPIN, TRYPSIN II ANIONIC
Authors:Ye, S., Cech, A.L., Belmares, R., Bergstrom, R.C., Tong, Y., Corey, D.R., Kanost, M.R., Goldsmith, E.J.
Deposit date:2001-10-29
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of a Michaelis serpin-protease complex.
Nat.Struct.Biol., 8, 2001
1M60
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SOLUTION STRUCTURE OF ZINC-SUBSTITUTED CYTOCHROME C
Descriptor:Zinc-substituted cytochrome c, ZINC SUBSTITUTED HEME C
Authors:Qian, C., Yao, Y., Tong, Y., Wang, J., Tang, W.
Deposit date:2002-07-11
Release date:2002-08-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural analysis of zinc-substituted cytochrome c.
J.Biol.Inorg.Chem., 8, 2003
1NI1
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IMIDAZOLE AND CYANOPHENYL FARNESYL TRANSFERASE INHIBITORS
Descriptor:Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
Authors:Tong, Y., Lin, N.H., Wang, L., Hasvold, L., Wang, W., Leonard, N., Li, T., Li, Q., Cohen, J., Gu, W.Z., Zhang, H., Stoll, V., Bauch, J., Marsh, K., Rosenberg, S.H., Sham, H.L.
Deposit date:2002-12-20
Release date:2004-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Bioorg.Med.Chem.Lett., 13, 2003
1NMI
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SOLUTION STRUCTURE OF THE IMIDAZOLE COMPLEX OF ISO-1 CYTOCHROME C
Descriptor:Cytochrome c, iso-1, IMIDAZOLE, ...
Authors:Yao, Y., Tong, Y., Liu, G., Wang, J., Zheng, J., Tang, W.
Deposit date:2003-01-10
Release date:2003-02-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the imidazole complex of iso-1 cytochrome c
To be Published
1Y9X
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SOLUTION STRUCTURE OF ARCHAEON DNA-BINDING PROTEIN SSH10B
Descriptor:DNA/RNA-binding protein Alba 1
Authors:Cui, Q., Tong, Y., Wang, J.
Deposit date:2004-12-16
Release date:2005-06-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A stabilizing alpha/beta-hydrophobic core greatly contributes to hyperthermostability of archaeal [P62A]Ssh10b.
Biochemistry, 47, 2008
2E9N
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STRUCTURE OF H-CHK1 COMPLEXED WITH A767085
Descriptor:Serine/threonine-protein kinase Chk1, 3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL)-1,4-DIHYDROINDENO[1,2-C]PYRAZOLE-6-CARBOXAMIDE
Authors:Park, C.
Deposit date:2007-01-26
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Bioorg.Med.Chem., 15, 2007
2E9O
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STRUCTURE OF H-CHK1 COMPLEXED WITH AA582939
Descriptor:Serine/threonine-protein kinase Chk1, 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID
Authors:Park, C.
Deposit date:2007-01-26
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.
Bioorg.Med.Chem., 15, 2007
2E9P
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STRUCTURE OF H-CHK1 COMPLEXED WITH A771129
Descriptor:Serine/threonine-protein kinase Chk1, 1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA
Authors:Park, C.
Deposit date:2007-01-26
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Based Design, Synthesis and Biological Evaluation of Potent and Selective Macrocyclic Chk1 Inhibitors
To be Published
2E9U
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STRUCTURE OF H-CHK1 COMPLEXED WITH A780125
Descriptor:Serine/threonine-protein kinase Chk1, 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE
Authors:Park, C.
Deposit date:2007-01-27
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Design, Synthesis and Biological Evaluation of Potent Selective Macrocyclic Chk1 Inhibitors
To be Published
2E9V
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STRUCTURE OF H-CHK1 COMPLEXED WITH A859017
Descriptor:Serine/threonine-protein kinase Chk1, 18-CHLORO-2-OXO-17-[(PYRIDIN-4-YLMETHYL)AMINO]-2,3,11,12,13,14-HEXAHYDRO-1H,10H-4,8-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECINE-7-CARBONITRILE
Authors:Park, C.
Deposit date:2007-01-27
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Design, Synthesis and Biological Evaluation of Potent Selective Macrocyclic Chk1 Inhibitors
To be Published
2IQJ
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CRYSTAL STRUCTURE OF THE GAP DOMAIN OF SMAP1L (LOC64744) STROMAL MEMBRANE-ASSOCIATED PROTEIN 1-LIKE
Descriptor:Stromal membrane-associated protein 1-like, ZINC ION, BETA-MERCAPTOETHANOL, ...
Authors:Tong, Y., Dimov, S., Shen, L., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-10-13
Release date:2006-10-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the GAP domain of SMAP1L (LOC64744) stromal membrane-associated protein 1-like
To be Published
2JPH
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NMR SOLUTION STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF HUMAN PLEXIN-B1
Descriptor:Plexin-B1
Authors:Tong, Y., Buck, M.
Deposit date:2007-05-11
Release date:2008-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Insights into Oncogenic Mutations of Plexin-B1 Based on the Solution Structure of the Rho GTPase Binding Domain
Structure, 16, 2008
2OLM
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ARFGAP DOMAIN OF HIV-1 REV BINDING PROTEIN
Descriptor:Nucleoporin-like protein RIP, ZINC ION, SULFATE ION, ...
Authors:Tong, Y., Tempel, W., Shen, L., Dimov, S., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-01-19
Release date:2007-01-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:ArfGap domain of HIV-1 Rev binding protein
To be Published
2P57
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GAP DOMAIN OF ZNF289, AN ID1-REGULATED ZINC FINGER PROTEIN
Descriptor:GTPase-activating protein ZNF289, ZINC ION, UNKNOWN ATOM OR ION
Authors:Tong, Y., Dimov, S., Shen, L., Zhu, H., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-03-14
Release date:2007-03-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:GAP domain of ZNF289, an ID1-regulated zinc finger protein
To be Published
2PQE
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SOLUTION STRUCTURE OF PROLINE-FREE MUTANT OF STAPHYLOCOCCAL NUCLEASE
Descriptor:Thermonuclease
Authors:Shan, L., Tong, Y., Xie, T., Wang, M., Wang, J.
Deposit date:2007-05-01
Release date:2007-06-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Restricted backbone conformational and motional flexibilities of loops containing peptidyl-proline bonds dominate the enzyme activity of staphylococcal nuclease.
Biochemistry, 46, 2007
2PZ9
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CRYSTAL STRUCTURE OF PUTATIVE TRANSCRIPTIONAL REGULATOR SCO4942 FROM STREPTOMYCES COELICOLOR
Descriptor:Putative regulatory protein, SULFATE ION
Authors:Filippova, E.V., Chruszcz, M., Xu, X., Zheng, H., Cymborowski, M., Savchenko, A., Edwards, A., Joachimiak, A., Minor, W., Midwest Center for Structural Genomics (MCSG)
Deposit date:2007-05-17
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:In situ proteolysis for protein crystallization and structure determination.
Nat.Methods, 4, 2007
2QFZ
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CRYSTAL STRUCTURE OF HUMAN TBC1 DOMAIN FAMILY MEMBER 22A
Descriptor:TBC1 domain family member 22A, UNKNOWN ATOM OR ION
Authors:Tong, Y., Tempel, W., Dimov, S., Dong, A., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human TBC1 domain family member 22A.
To be Published
2QQ8
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CRYSTAL STRUCTURE OF THE PUTATIVE RABGAP DOMAIN OF HUMAN TBC1 DOMAIN FAMILY MEMBER 14
Descriptor:TBC1 domain family member 14, UNKNOWN ATOM OR ION
Authors:Tong, Y., Tempel, W., Dimov, S., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-07-26
Release date:2007-08-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14.
To be Published
2R2O
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CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF HUMAN PLEXIN B1
Descriptor:Plexin-B1, UNKNOWN ATOM OR ION
Authors:Tong, Y., Tempel, W., Shen, L., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-08-27
Release date:2007-09-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.
J.Biol.Chem., 282, 2007
2R79
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CRYSTAL STRUCTURE OF A PERIPLASMIC HEME BINDING PROTEIN FROM PSEUDOMONAS AERUGINOSA
Descriptor:Periplasmic binding protein, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Ho, W.W., Li, H., Poulos, T.L.
Deposit date:2007-09-07
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Holo- and apo-bound structures of bacterial periplasmic heme-binding proteins.
J.Biol.Chem., 282, 2007
2R7A
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CRYSTAL STRUCTURE OF A PERIPLASMIC HEME BINDING PROTEIN FROM SHIGELLA DYSENTERIAE
Descriptor:Bacterial heme binding protein, PROTOPORPHYRIN IX CONTAINING FE
Authors:Ho, W.W., Li, H., Poulos, T.L.
Deposit date:2007-09-07
Release date:2007-10-09
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Holo- and apo-bound structures of bacterial periplasmic heme-binding proteins.
J.Biol.Chem., 282, 2007
2REX
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CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PLXNB1 BOUND WITH RND1 GTPASE
Descriptor:Plexin-B1, Rho-related GTP-binding protein Rho6, UNKNOWN ATOM OR ION, ...
Authors:Tong, Y., Tempel, W., Shen, L., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-09-27
Release date:2007-11-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the effector domain of PLXNB1 bound with Rnd1 GTPase.
To be Published
2RG7
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APO- CRYSTAL STRUCTURE OF A PERIPLASMIC HEME BINDING PROTEIN FROM SHIGELLA DYSENTERIAE
Descriptor:Periplasmic HEME binding protein
Authors:Ho, W.W., Li, H.
Deposit date:2007-10-02
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Holo- and apo-bound structures of bacterial periplasmic heme-binding proteins.
J.Biol.Chem., 282, 2007
3C5C
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CRYSTAL STRUCTURE OF HUMAN RAS-LIKE, FAMILY 12 PROTEIN IN COMPLEX WITH GDP
Descriptor:RAS-like protein 12, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Shen, L., Tong, Y., Tempel, W., Loppnau, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-01-31
Release date:2008-02-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of human Ras-like, family 12 protein in complex with GDP.
To be Published
3C5H
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CRYSTAL STRUCTURE OF THE RAS HOMOLOG DOMAIN OF HUMAN GRLF1 (P190RHOGAP)
Descriptor:Glucocorticoid receptor DNA-binding factor 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-01-31
Release date:2008-02-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP).
To be Published