Author results

2JPH
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NMR SOLUTION STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF HUMAN PLEXIN-B1
Descriptor:Plexin-B1
Authors:Tong, Y., Buck, M.
Deposit date:2007-05-11
Release date:2008-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Insights into Oncogenic Mutations of Plexin-B1 Based on the Solution Structure of the Rho GTPase Binding Domain
Structure, 16, 2008
3GBJ
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CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF KINESIN KIF13B BOUND WITH ADP
Descriptor:KIF13B protein, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Tong, Y., Shen, L., Shen, Y., Tempel, W., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-02-19
Release date:2009-03-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Crystal structure of the motor domain of kinesin KIF13B bound with ADP
To be Published
3NF1
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CRYSTAL STRUCTURE OF THE TPR DOMAIN OF KINESIN LIGHT CHAIN 1
Descriptor:Kinesin light chain 1
Authors:Tong, Y., Tempel, W., Shen, L., Shen, Y., Nedyalkova, L., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-06-09
Release date:2011-05-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the TPR domain of kinesin light chain 1
to be published
1NI1
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IMIDAZOLE AND CYANOPHENYL FARNESYL TRANSFERASE INHIBITORS
Descriptor:Protein farnesyltransferase alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
Authors:Tong, Y., Lin, N.H., Wang, L., Hasvold, L., Wang, W., Leonard, N., Li, T., Li, Q., Cohen, J., Gu, W.Z., Zhang, H., Stoll, V., Bauch, J., Marsh, K., Rosenberg, S.H., Sham, H.L.
Deposit date:2002-12-20
Release date:2004-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Bioorg.Med.Chem.Lett., 13, 2003
2IQJ
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CRYSTAL STRUCTURE OF THE GAP DOMAIN OF SMAP1L (LOC64744) STROMAL MEMBRANE-ASSOCIATED PROTEIN 1-LIKE
Descriptor:Stromal membrane-associated protein 1-like, ZINC ION, BETA-MERCAPTOETHANOL, ...
Authors:Tong, Y., Dimov, S., Shen, L., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2006-10-13
Release date:2006-10-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the GAP domain of SMAP1L (LOC64744) stromal membrane-associated protein 1-like
To be Published
2OLM
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ARFGAP DOMAIN OF HIV-1 REV BINDING PROTEIN
Descriptor:Nucleoporin-like protein RIP, ZINC ION, SULFATE ION, ...
Authors:Tong, Y., Tempel, W., Shen, L., Dimov, S., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-01-19
Release date:2007-01-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:ArfGap domain of HIV-1 Rev binding protein
To be Published
2P57
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GAP DOMAIN OF ZNF289, AN ID1-REGULATED ZINC FINGER PROTEIN
Descriptor:GTPase-activating protein ZNF289, ZINC ION, UNKNOWN ATOM OR ION
Authors:Tong, Y., Dimov, S., Shen, L., Zhu, H., Tempel, W., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-03-14
Release date:2007-03-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:GAP domain of ZNF289, an ID1-regulated zinc finger protein
To be Published
2QFZ
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CRYSTAL STRUCTURE OF HUMAN TBC1 DOMAIN FAMILY MEMBER 22A
Descriptor:TBC1 domain family member 22A, UNKNOWN ATOM OR ION
Authors:Tong, Y., Tempel, W., Dimov, S., Dong, A., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human TBC1 domain family member 22A.
To be Published
2QQ8
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CRYSTAL STRUCTURE OF THE PUTATIVE RABGAP DOMAIN OF HUMAN TBC1 DOMAIN FAMILY MEMBER 14
Descriptor:TBC1 domain family member 14, UNKNOWN ATOM OR ION
Authors:Tong, Y., Tempel, W., Dimov, S., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-07-26
Release date:2007-08-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14.
To be Published
2R2O
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CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF HUMAN PLEXIN B1
Descriptor:Plexin-B1, UNKNOWN ATOM OR ION
Authors:Tong, Y., Tempel, W., Shen, L., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-08-27
Release date:2007-09-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.
J.Biol.Chem., 282, 2007
2REX
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CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PLXNB1 BOUND WITH RND1 GTPASE
Descriptor:Plexin-B1, Rho-related GTP-binding protein Rho6, UNKNOWN ATOM OR ION, ...
Authors:Tong, Y., Tempel, W., Shen, L., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2007-09-27
Release date:2007-11-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the effector domain of PLXNB1 bound with Rnd1 GTPase.
To be Published
3GFT
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HUMAN K-RAS (Q61H) IN COMPLEX WITH A GTP ANALOGUE
Descriptor:GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Tong, Y., Tempel, W., Shen, L., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-02-27
Release date:2009-03-10
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Human K-Ras in complex with a GTP analogue
To be Published
3H6N
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CRYSTAL STRUCTURE OF THE UBIQUITIN-LIKE DOMAIN OF PLEXIN D1
Descriptor:Plexin-D1, ARSENIC, UNKNOWN ATOM OR ION
Authors:Tong, Y., Nedyalkova, L., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Buck, M., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-04-23
Release date:2009-05-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Crystal Structure of the ubiquitin-like domain of plexin D1
To be Published
3HM6
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CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF HUMAN PLEXIN B1
Descriptor:Plexin-B1, Unknown peptide, UNKNOWN ATOM OR ION
Authors:Tong, Y., He, H., Shen, L., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-05-28
Release date:2009-06-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
J.Biol.Chem., 284, 2009
3KFV
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CRYSTAL STRUCTURE OF THE SH3-KINASE FRAGMENT OF TIGHT JUNCTION PROTEIN 3 (TJP3) IN APO-FORM
Descriptor:Tight junction protein ZO-3, UNKNOWN ATOM OR ION
Authors:Tong, Y., Nedyalkova, L., Tempel, W., Zhong, N., Guan, X., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-10-28
Release date:2009-11-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form
to be published
4IQ6
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GSK-3BETA WITH INHIBITOR 6-CHLORO-N-CYCLOHEXYL-4-(1H-PYRROLO[2,3-B]PYRIDIN-3-YL)PYRIDIN-2-AMINE
Descriptor:Glycogen synthase kinase-3 beta, 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine
Authors:Tong, Y., Stewart, K.D., Florjancic, A.S., Harlan, J.E., Merta, P.J., Przytulinska, M., Soni, N., Swinger, K.S., Zhu, H., Johnson, E.F., Shoemaker, A.R., Penning, T.D.
Deposit date:2013-01-10
Release date:2013-04-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195.
ACS Med Chem Lett, 4, 2013
6D0S
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RABGAP DOMAIN OF HUMAN TBC1D22B
Descriptor:TBC1 domain family member 22B, SULFATE ION, UNKNOWN ATOM OR ION
Authors:Tong, Y., Tempel, W., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2018-04-10
Release date:2018-06-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:RabGAP domain of human TBC1D22B
To be Published
3CPF
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CRYSTAL STRUCTURE OF HUMAN EUKARYOTIC TRANSLATION INITIATION FACTOR EIF5A
Descriptor:Eukaryotic translation initiation factor 5A-1, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L., Tong, Y., Tempel, W., Hong, B., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-03-31
Release date:2008-04-15
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2.
Proteins, 75, 2009
3EO3
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CRYSTAL STRUCTURE OF THE N-ACETYLMANNOSAMINE KINASE DOMAIN OF HUMAN GNE PROTEIN
Descriptor:Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, ZINC ION, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L., Tong, Y., Rabeh, W.M., Hong, B., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-09-26
Release date:2008-10-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Crystal structure of the N-acetylmannosamine kinase domain of GNE.
Plos One, 4, 2009
3FEH
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CRYSTAL STRUCTURE OF FULL LENGTH CENTAURIN ALPHA-1
Descriptor:Centaurin-alpha-1, ZINC ION, UNKNOWN ATOM OR ION
Authors:Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-11-29
Release date:2008-12-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin {alpha}1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3FM8
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CRYSTAL STRUCTURE OF FULL LENGTH CENTAURIN ALPHA-1 BOUND WITH THE FHA DOMAIN OF KIF13B (CAPRI TARGET)
Descriptor:Kinesin-like protein KIF13B, Centaurin-alpha-1, UNKNOWN ATOM OR ION, ...
Authors:Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2008-12-19
Release date:2009-08-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3LJU
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CRYSTAL STRUCTURE OF FULL LENGTH CENTAURIN ALPHA-1 BOUND WITH THE HEAD GROUP OF PIP3
Descriptor:Arf-GAP with dual PH domain-containing protein 1, ZINC ION, (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane-1,2-diyl dioctanoate
Authors:Shen, L., Tong, Y., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-01-26
Release date:2010-11-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3GF9
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CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 RHOGEF DOMAIN
Descriptor:Intersectin 2, UNKNOWN ATOM OR ION
Authors:Shen, Y., Tong, Y., Tempel, W., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-02-26
Release date:2009-03-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human Intersectin 2 RhoGEF domain
To be Published
3JZY
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CRYSTAL STRUCTURE OF HUMAN INTERSECTIN 2 C2 DOMAIN
Descriptor:Intersectin 2, UNKNOWN ATOM OR ION
Authors:Shen, Y., Tempel, W., Tong, Y., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2009-09-24
Release date:2009-10-06
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal structure of human Intersectin 2 C2 domain
To be Published
3PFN
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CRYSTAL STRUCTURE OF HUMAN NAD KINASE
Descriptor:NAD kinase, UNKNOWN ATOM OR ION
Authors:Wang, H., Tempel, W., Wernimont, A.K., Tong, Y., Guan, X., Shen, Y., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2010-10-28
Release date:2010-11-10
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of human NAD kinase
to be published