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3KU4
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
Descriptor:Uridine phosphorylase, SULFATE ION
Authors:Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
Deposit date:2009-11-26
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3KUK
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
Descriptor:Uridine phosphorylase, SULFATE ION, 2'-DEOXYURIDINE
Authors:Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
Deposit date:2009-11-27
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.783 Å)
Cite:Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3KVR
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
Descriptor:Uridine phosphorylase, 5-FLUOROURACIL, SULFATE ION, ...
Authors:Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
Deposit date:2009-11-30
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3KVV
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
Descriptor:Uridine phosphorylase, 5-FLUOROURACIL, SULFATE ION, ...
Authors:Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
Deposit date:2009-11-30
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3KVY
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TRAPPING OF AN OXOCARBENIUM ION INTERMEDIATE IN UP CRYSTALS
Descriptor:Uridine Phosphorylase, SULFATE ION, URACIL, ...
Authors:Paul, D., O'Leary, S., Rajashankar, K., Bu, W., Toms, A., Settembre, E., Sanders, J., Begley, T.P., Ealick, S.E.
Deposit date:2009-11-30
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Glycal formation in crystals of uridine phosphorylase.
Biochemistry, 49, 2010
3O4X
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CRYSTAL STRUCTURE OF COMPLEX BETWEEN AMINO AND CARBOXY TERMINAL FRAGMENTS OF MDIA1
Descriptor:Protein diaphanous homolog 1
Authors:Eck, M.J., Nezami, A., Toms, A.V.
Deposit date:2010-07-27
Release date:2010-10-13
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins.
Plos One, 5, 2010
3R7G
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CRYSTAL STRUCTURE OF SPIRE KIND DOMAIN IN COMPLEX WITH THE TAIL OF FMN2
Descriptor:Protein spire homolog 1, Formin-2
Authors:Kreutz, B., Vizcarra, C.L., Rodal, A.A., Toms, A.V., Lu, J., Quinlan, M.E., Eck, M.J.
Deposit date:2011-03-22
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the Spire KIND domain and insights into its interaction with Fmn-family formins
Proc.Natl.Acad.Sci.USA, 2011
3RBW
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CRYSTAL STRUCTURE OF SPIRE KIND DOMAIN
Descriptor:Protein spire homolog 1
Authors:Vizcarra, C.L., Kreutz, B., Rodal, A.A., Toms, A.V., Lu, J., Zheng, W., Quinlan, M.E., Eck, M.J.
Deposit date:2011-03-30
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the Spire KIND domain and insights into its interaction with Fmn-family formins
Proc.Natl.Acad.Sci.USA, 2011
6MX8
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CRYSTAL STRUCTURE OF ANAPLASTIC LYMPHOMA KINASE (ALK) BOUND BY BRIGATINIB
Descriptor:ALK tyrosine kinase receptor, 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine
Authors:Dougan, D.R., Zhou, T.
Deposit date:2018-10-30
Release date:2018-12-12
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.
J. Med. Chem., 59, 2016