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6QOZ
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BU of 6qoz by Molmil
CryoEM reconstruction of Cowpea Mosaic Virus (CPMV) bound to an Affimer reagent
Descriptor: Affimer binding protein, Cowpea mosaic virus large subunit, RNA2 polyprotein
Authors:Hesketh, E.L, Tiede, C, Adamson, H, Adams, T.L, Byrne, M.J, Meshcheriakova, Y, Lomonossoff, G.P, Kruse, I, McPherson, M.J, Tomlinson, D.C, Ranson, N.A.
Deposit date:2019-02-13
Release date:2019-12-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Affimer reagents as tools in diagnosing plant virus diseases.
Sci Rep, 9, 2019
5A0O
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BU of 5a0o by Molmil
adhiron raised against p300
Descriptor: ADHIRON
Authors:Kyle, H.F, Wickson, K.F, Stott, J, Burslem, G.M, Breeze, A.L, Tiede, C, Tomlinson, D.C, Warriner, S.L, Nelson, A, Wilson, A.J, Edwards, T.A.
Deposit date:2015-04-21
Release date:2015-07-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Exploration of the Hif-1Alpha.P300 Interface Using Peptide and Adhiron Phage Display Technologies
Mol.Biosyst., 11, 2015
6YR8
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BU of 6yr8 by Molmil
Affimer K6 - KRAS protein complex
Descriptor: Affimer K6, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C.
Deposit date:2020-04-19
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
Nat Commun, 12, 2021
6YXW
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BU of 6yxw by Molmil
Affimer K3 - KRAS protein complex
Descriptor: Affimer K3, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C.
Deposit date:2020-05-04
Release date:2020-07-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
Nat Commun, 12, 2021
6HJL
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BU of 6hjl by Molmil
Affimer:BclxL
Descriptor: Affimer ADB13, Bcl-2-like protein 1
Authors:Miles, J.A, Trinh, C.H, Tomlinson, D.C, Wilson, A.J, Edwards, T.A.
Deposit date:2018-09-04
Release date:2020-03-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
Biorxiv, 2020
5ML9
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BU of 5ml9 by Molmil
Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer F4, a specific binding protein which blocks IgG binding to the receptor.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Affimer F4 with specificity for Fc gamma receptor IIIa, CHLORIDE ION, ...
Authors:Robinson, J.I, Tomlinson, D.C, Baxter, E.W, Owen, R.L, Thomsen, M, Win, S.J, Nettleship, J.E, Tiede, C, Foster, R.J, Waterhouse, M.P, Harris, S.A, Owens, R.J, Fishwick, C.W.G, Goldman, A, McPherson, M.J, Morgan, A.W.
Deposit date:2016-12-06
Release date:2017-12-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5MN2
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BU of 5mn2 by Molmil
Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer G3, a specific binding protein which blocks IgG binding to the receptor.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Affimer G3, DI(HYDROXYETHYL)ETHER, ...
Authors:Robinson, J.I, Owen, R.L, Tomlinson, D.C, Baxter, E.W, Nettleship, J.E, Waterhouse, M.P, Harris, S.A, Owens, R.J, McPherson, M.J, Morgan, A.W, Tiede, C, Goldman, A, Thomsen, M.
Deposit date:2016-12-12
Release date:2017-12-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Affimer proteins inhibit immune complex binding to Fc gamma RIIIa with high specificity through competitive and allosteric modes of action.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
7NY8
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BU of 7ny8 by Molmil
Affimer K69 - KRAS protein complex
Descriptor: Affimer K69, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Turner, A.L, Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C.
Deposit date:2021-03-21
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site.
Nat Commun, 12, 2021
8C12
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BU of 8c12 by Molmil
Identification of an intermediate activation state of PAK5 reveals a novel mechanism of kinase inhibition.
Descriptor: PAK5-Af17, Serine/threonine-protein kinase PAK 5
Authors:Martin, H.L, Turner, A.L, Trinh, C.H, Bayliss, R.W, Tomlinson, D.C.
Deposit date:2022-12-19
Release date:2023-10-25
Method:X-RAY DIFFRACTION (1.549 Å)
Cite:Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition.
Cell Rep, 42, 2023
5EQL
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BU of 5eql by Molmil
Isoform-specific inhibition of SUMO-dependent protein-protein interactions
Descriptor: SUMO-Affirmer-S2D5, Small ubiquitin-related modifier 2
Authors:Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A.
Deposit date:2015-11-13
Release date:2016-11-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Sci Signal, 10, 2017
5ELJ
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BU of 5elj by Molmil
Isoform-specific inhibition of SUMO-dependent protein-protein interactions
Descriptor: SUMO-Affirmer-S2D5, Small ubiquitin-related modifier 1
Authors:Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A.
Deposit date:2015-11-04
Release date:2016-11-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.983 Å)
Cite:Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Sci Signal, 10, 2017
5ELU
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BU of 5elu by Molmil
Isoform-specific inhibition of SUMO-dependent protein-protein interactions
Descriptor: SULFATE ION, SUMO-Affirmer-S2B3, Small ubiquitin-related modifier 2
Authors:Hughes, D.J, Tiede, C, Hall, N, Tang, A.A.S, Trinh, C.H, Zajac, K, Mandal, U, Howell, G, Edwards, T.A, McPherson, M.J, Tomlinson, D.C, Whitehouse, A.
Deposit date:2015-11-05
Release date:2016-11-16
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Sci Signal, 10, 2017
6ST2
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BU of 6st2 by Molmil
Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
Descriptor: Affimer AF6, Bcl-2-like protein 1, SULFATE ION
Authors:Hobor, F, Miles, J.A, Trinh, C.H, Taylor, J, Tiede, C, Rowell, P.R, Jackson, B, Nadat, F, Kyle, H.F, Wicky, B.I.M, Clarke, J, Tomlinson, D.C, Wilson, A.J, Edwards, T.A.
Deposit date:2019-09-09
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Selective Affimers Recognise the BCL-2 Family Proteins BCL-x L and MCL-1 through Noncanonical Structural Motifs*.
Chembiochem, 22, 2021
6STJ
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BU of 6stj by Molmil
Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
Descriptor: Cystatin domain-containing protein, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Hobor, F, Miles, J.A, Trinh, C.H, Taylor, J, Tiede, C, Rowell, P.R, Jackson, B, Nadat, F, Kyle, H.F, Wicky, B.I.M, Clarke, J, Tomlinson, D.C, Wilson, A.J, Edwards, T.A.
Deposit date:2019-09-10
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Selective Affimers Recognise the BCL-2 Family Proteins BCL-x L and MCL-1 through Noncanonical Structural Motifs*.
Chembiochem, 22, 2021
6Z0O
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BU of 6z0o by Molmil
Structure of Affimer-NP bound to Crimean-Congo Haemorrhagic Fever Virus Nucleocapsid Protein
Descriptor: Affimer-NP, Nucleocapsid
Authors:Alvarez-Rodriguez, B, Tiede, C, Trinh, C, Tomlinson, D, Edwards, T.A, Barr, J.N.
Deposit date:2020-05-10
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5974 Å)
Cite:Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests.
Plos Negl Trop Dis, 14, 2020
4N6U
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BU of 4n6u by Molmil
Adhiron: a stable and versatile peptide display scaffold - truncated adhiron
Descriptor: Adhiron
Authors:Mcpherson, M, Tomlinson, D, Owen, R.L, Nettleship, J.E, Owens, R.J.
Deposit date:2013-10-14
Release date:2014-04-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications.
Protein Eng.Des.Sel., 27, 2014
4N6T
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BU of 4n6t by Molmil
Adhiron: a stable and versatile peptide display scaffold - full length adhiron
Descriptor: Adhiron
Authors:Mcpherson, M, Tomlinson, D, Owen, R.L, Nettleship, J.E, Owens, R.J.
Deposit date:2013-10-14
Release date:2014-04-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications.
Protein Eng.Des.Sel., 27, 2014

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