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3MOS
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THE STRUCTURE OF HUMAN TRANSKETOLASE
Descriptor:Transketolase, THIAMINE DIPHOSPHATE, CALCIUM ION, ...
Authors:Parthier, C., Tittmann, K.
Deposit date:2010-04-23
Release date:2010-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The crystal structure of human transketolase and new insights into its mode of action.
J.Biol.Chem., 285, 2010
4JQ9
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DIHYDROLIPOYL DEHYDROGENASE OF ESCHERICHIA COLI PYRUVATE DEHYDROGENASE COMPLEX
Descriptor:Dihydrolipoyl dehydrogenase, SULFATE ION, GLYCEROL, ...
Authors:Tietzel, M., Neumann, P., Meyer, D., Ficner, R., Tittmann, K.
Deposit date:2013-03-20
Release date:2014-04-02
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Dihydrolipoyl dehydrogenase of Escherichia coli pyruvate dehydrogenase complex
TO BE PUBLISHED
6QL5
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STRUCTURE OF FATTY ACID SYNTHASE COMPLEX WITH BOUND GAMMA SUBUNIT FROM SACCHAROMYCES CEREVISIAE AT 2.8 ANGSTROM
Descriptor:Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Translation machinery-associated protein 17, ...
Authors:Singh, K., Graf, B., Linden, A., Sautner, V., Urlaub, H., Tittmann, K., Stark, H., Chari, A.
Deposit date:2019-01-31
Release date:2020-03-18
Last modified:2020-04-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
6QL6
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STRUCTURE OF FATTY ACID SYNTHASE COMPLEX FROM SACCHAROMYCES CEREVISIAE AT 2.9 ANGSTROM
Descriptor:Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, [(3~{R})-4-azanyl-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] dihydrogen phosphate, ...
Authors:Singh, K., Graf, B., Linden, A., Sautner, V., Urlaub, H., Tittmann, K., Stark, H., Chari, A.
Deposit date:2019-01-31
Release date:2020-03-18
Last modified:2020-04-08
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
6QL7
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STRUCTURE OF FATTY ACID SYNTHASE COMPLEX WITH BOUND GAMMA SUBUNIT FROM SACCHAROMYCES CEREVISIAE AT 4.6 ANGSTROM
Descriptor:Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Translation machinery-associated protein 17
Authors:Singh, K., Graf, B., Linden, A., Sautner, V., Urlaub, H., Tittmann, K., Stark, H., Chari, A.
Deposit date:2019-01-31
Release date:2020-03-18
Last modified:2020-04-08
Method:X-RAY DIFFRACTION (4.6 Å)
Cite:Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
6QL9
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STRUCTURE OF FATTY ACID SYNTHASE COMPLEX FROM SACCHAROMYCES CEREVISIAE AT 2.9 ANGSTROM
Descriptor:Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, 4'-PHOSPHOPANTETHEINE, ...
Authors:Singh, K., Graf, B., Linden, A., Sautner, V., Urlaub, H., Tittmann, K., Stark, H., Chari, A.
Deposit date:2019-01-31
Release date:2020-03-18
Last modified:2020-04-08
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase.
Cell, 180, 2020
2EZ4
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PYRUVATE OXIDASE VARIANT F479W
Descriptor:Pyruvate oxidase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.
Deposit date:2005-11-10
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
Nat.Chem.Biol., 2, 2006
2EZ8
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PYRUVATE OXIDASE VARIANT F479W IN COMPLEX WITH REACTION INTERMEDIATE 2-LACTYL-THIAMIN DIPHOSPHATE
Descriptor:Pyruvate oxidase, MAGNESIUM ION, SODIUM ION, ...
Authors:Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.
Deposit date:2005-11-10
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.963 Å)
Cite:The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
Nat.Chem.Biol., 2, 2006
2EZ9
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PYRUVATE OXIDASE VARIANT F479W IN COMPLEX WITH REACTION INTERMEDIATE ANALOGUE 2-PHOSPHONOLACTYL-THIAMIN DIPHOSPHATE
Descriptor:Pyruvate oxidase, MAGNESIUM ION, SODIUM ION, ...
Authors:Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.
Deposit date:2005-11-10
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
Nat.Chem.Biol., 2, 2006
2EZT
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PYRUVATE OXIDASE VARIANT F479W IN COMPLEX WITH REACTION INTERMEDIATE 2-HYDROXYETHYL-THIAMIN DIPHOSPHATE
Descriptor:Pyruvate oxidase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.
Deposit date:2005-11-10
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
Nat.Chem.Biol., 2, 2006
2EZU
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PYRUVATE OXIDASE VARIANT F479W IN COMPLEX WITH REACTION INTERMEDIATE 2-ACETYL-THIAMIN DIPHOSPHATE
Descriptor:Pyruvate oxidase, MAGNESIUM ION, SODIUM ION, ...
Authors:Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.
Deposit date:2005-11-10
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
Nat.Chem.Biol., 2, 2006
2R5N
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CRYSTAL STRUCTURE OF TRANSKETOLASE FROM ESCHERICHIA COLI IN NONCOVALENT COMPLEX WITH ACCEPTOR ALDOSE RIBOSE 5-PHOSPHATE
Descriptor:Transketolase 1, RIBOSE-5-PHOSPHATE, CALCIUM ION, ...
Authors:Parthier, C., Asztalos, P., Wille, G., Tittmann, K.
Deposit date:2007-09-04
Release date:2007-11-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Strain and Near Attack Conformers in Enzymic Thiamin Catalysis: X-ray Crystallographic Snapshots of Bacterial Transketolase in Covalent Complex with Donor Ketoses Xylulose 5-phosphate and Fructose 6-phosphate, and in Noncovalent Complex with Acceptor Aldose Ribose 5-phosphate.
Biochemistry, 46, 2007
2R8O
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TRANSKETOLASE FROM E. COLI IN COMPLEX WITH SUBSTRATE D-XYLULOSE-5-PHOSPHATE
Descriptor:Transketolase 1, CALCIUM ION, 2-C-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium-2-yl}-5-O-phosphono-D-xylitol, ...
Authors:Wille, G., Asztalos, P., Weiss, M.S., Tittmann, K.
Deposit date:2007-09-11
Release date:2007-12-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate.
Biochemistry, 46, 2007
2R8P
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TRANSKETOLASE FROM E. COLI IN COMPLEX WITH SUBSTRATE D-FRUCTOSE-6-PHOSPHATE
Descriptor:Transketolase 1, CALCIUM ION, 2-C-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium-2-yl}-6-O-phosphono-D-glucitol, ...
Authors:Wille, G., Asztalos, P., Weiss, M.S., Tittmann, K.
Deposit date:2007-09-11
Release date:2007-12-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate.
Biochemistry, 46, 2007
3EY9
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STRUCTURAL BASIS FOR MEMBRANE BINDING AND CATALYTIC ACTIVATION OF THE PERIPHERAL MEMBRANE ENZYME PYRUVATE OXIDASE FROM ESCHERICHIA COLI
Descriptor:Pyruvate dehydrogenase [cytochrome], THIAMIN DIPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Neumann, P., Weidner, A., Pech, A., Stubbs, M.T., Tittmann, K.
Deposit date:2008-10-20
Release date:2008-11-04
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli.
Proc.Natl.Acad.Sci.USA, 105, 2008
3EYA
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STRUCTURAL BASIS FOR MEMBRANE BINDING AND CATALYTIC ACTIVATION OF THE PERIPHERAL MEMBRANE ENZYME PYRUVATE OXIDASE FROM ESCHERICHIA COLI
Descriptor:Pyruvate dehydrogenase [cytochrome], THIAMIN DIPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Neumann, P., Weidner, A., Pech, A., Stubbs, M.T., Tittmann, K.
Deposit date:2008-10-20
Release date:2008-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli.
Proc.Natl.Acad.Sci.USA, 105, 2008
3FZN
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INTERMEDIATE ANALOGUE IN BENZOYLFORMATE DECARBOXYLASE
Descriptor:Benzoylformate decarboxylase, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(S)-hydroxy[(R)-hydroxy(methoxy)phosphoryl]phenylmethyl}-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, MAGNESIUM ION, ...
Authors:Bruning, M., Berheide, M., Meyer, D., Golbik, R., Bartunik, H., Liese, A., Tittmann, K.
Deposit date:2009-01-26
Release date:2009-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structural and kinetic studies on native intermediates and an intermediate analogue in benzoylformate decarboxylase reveal a least motion mechanism with an unprecedented short-lived predecarboxylation intermediate.
Biochemistry, 48, 2009
3OE1
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PYRUVATE DECARBOXYLASE VARIANT GLU473ASP FROM Z. MOBILIS IN COMPLEX WITH REACTION INTERMEDIATE 2-LACTYL-THDP
Descriptor:Pyruvate decarboxylase, MAGNESIUM ION, 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-(1-CARBOXY-1-HYDROXYETHYL)-5-(2-{[HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, ...
Authors:Meyer, D., Neumann, P., Parthier, C., Tittmann, K.
Deposit date:2010-08-12
Release date:2010-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.985 Å)
Cite:Double duty for a conserved glutamate in pyruvate decarboxylase: evidence of the participation in stereoelectronically controlled decarboxylation and in protonation of the nascent carbanion/enamine intermediate .
Biochemistry, 49, 2010
3S0C
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TRANSALDOLASE WT OF THERMOPLASMA ACIDOPHILUM
Descriptor:Probable transaldolase, GLYCEROL
Authors:Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.
Deposit date:2011-05-13
Release date:2011-08-24
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism.
Nat.Chem.Biol., 7, 2011
3S1U
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TRANSALDOLASE FROM THERMOPLASMA ACIDOPHILUM IN COMPLEX WITH D-ERYTHROSE 4-PHOSPHATE
Descriptor:Probable transaldolase, ERYTHOSE-4-PHOSPHATE, CHLORIDE ION
Authors:Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.
Deposit date:2011-05-16
Release date:2011-08-24
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism.
Nat.Chem.Biol., 7, 2011
3S1V
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TRANSALDOLASE FROM THERMOPLASMA ACIDOPHILUM IN COMPLEX WITH D-FRUCTOSE 6-PHOSPHATE SCHIFF-BASE INTERMEDIATE
Descriptor:Probable transaldolase, GLYCEROL, FRUCTOSE -6-PHOSPHATE
Authors:Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.
Deposit date:2011-05-16
Release date:2011-08-24
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism.
Nat.Chem.Biol., 7, 2011
3S1W
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TRANSALDOLASE VARIANT LYS86ALA FROM THERMOPLASMA ACIDOPHILUM IN COMPLEX WITH GLYCEROL AND CITRATE
Descriptor:Probable transaldolase, GLYCEROL, CITRATE ANION
Authors:Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.
Deposit date:2011-05-16
Release date:2011-08-24
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism.
Nat.Chem.Biol., 7, 2011
3S1X
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TRANSALDOLASE FROM THERMOPLASMA ACIDOPHILUM IN COMPLEX WITH D-SEDOHEPTULOSE 7-PHOSPHATE SCHIFF-BASE INTERMEDIATE
Descriptor:Probable transaldolase, D-ALTRO-HEPT-2-ULOSE 7-PHOSPHATE
Authors:Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.
Deposit date:2011-05-16
Release date:2011-08-24
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism.
Nat.Chem.Biol., 7, 2011
4FEE
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HIGH-RESOLUTION STRUCTURE OF PYRUVATE OXIDASE IN COMPLEX WITH REACTION INTERMEDIATE 2-HYDROXYETHYL-THIAMIN DIPHOSPHATE CARBANION-ENAMINE, CRYSTAL B
Descriptor:Pyruvate oxidase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Meyer, D., Neumann, P., Koers, E., Sjuts, H., Luedtke, S., Sheldrick, G.M., Ficner, R., Tittmann, K.
Deposit date:2012-05-30
Release date:2012-06-20
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FEG
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HIGH-RESOLUTION STRUCTURE OF PYRUVATE OXIDASE IN COMPLEX WITH REACTION INTERMEDIATE 2-HYDROXYETHYL-THIAMIN DIPHOSPHATE CARBANION-ENAMINE, CRYSTAL A
Descriptor:Pyruvate oxidase, PYRUVIC ACID, PHOSPHATE ION, ...
Authors:Meyer, D., Neumann, P., Koers, E., Sjuts, H., Luedtke, S., Sheldrick, G.M., Ficner, R., Tittmann, K.
Deposit date:2012-05-30
Release date:2012-06-20
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin.
Proc.Natl.Acad.Sci.USA, 109, 2012
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