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1QF0
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THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYL-3-PHENYLPROPANOYL)-PHE-TYR. PARAMETERS FOR ZN-BIDENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE
分子名称:PROTEIN (THERMOLYSIN), ZINC ION, CALCIUM ION, ...
著者Gaucher, J.-F., Selkti, M., Tiraboschi, G., Prange, T., Roques, B.P., Tomas, A., Fournie-Zaluski, M.C.
登録日1999-04-06
公開日1999-12-29
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
1QF1
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THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYLHEPTANOYL)-PHE-ALA. PARAMETERS FOR ZN-BIDENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE
分子名称:PROTEIN (THERMOLYSIN), ZINC ION, CALCIUM ION, ...
著者Gaucher, J.-F., Selkti, M., Tiraboschi, G., Prange, T., Roques, B.P., Tomas, A., Fournie-Zaluski, M.C.
登録日1999-04-06
公開日1999-12-29
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
1QF2
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THERMOLYSIN (E.C.3.4.24.27) COMPLEXED WITH (2-SULPHANYL-3-PHENYLPROPANOYL)-GLY-(5-PHENYLPROLINE). PARAMETERS FOR ZN-MONODENTATION OF MERCAPTOACYLDIPEPTIDES IN METALLOENDOPEPTIDASE
分子名称:PROTEIN (THERMOLYSIN), ZINC ION, CALCIUM ION, ...
著者Gaucher, J.-F., Selkti, M., Tiraboschi, G., Prange, T., Roques, B.P., Tomas, A., Fournie-Zaluski, M.C.
登録日1999-04-06
公開日1999-12-29
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry, 38, 1999
3LAU
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CRYSTAL STRUCTURE OF AURORA2 KINASE IN COMPLEX WITH A GSK3BETA INHIBITOR
分子名称:Serine/threonine-protein kinase 6, N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]butanamide
著者Maignan, S., Guilloteau, J.P., Pouzieux, S.
登録日2010-01-07
公開日2010-03-02
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Bioorg.Med.Chem.Lett., 20, 2010
3LFN
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CRYSTAL STRUCTURE OF CDK2 WITH SAR57, AN AMINOINDAZOLE TYPE INHIBITOR
分子名称:Cell division protein kinase 2, N-[6-(4-hydroxyphenyl)-5-phenyl-1H-indazol-3-yl]butanamide
著者Dreyer, M.K., Wendt, K.U., Schimanski-Breves, S., Loenze, P.
登録日2010-01-18
公開日2010-03-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Bioorg.Med.Chem.Lett., 20, 2010
3LFQ
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CRYSTAL STRUCTURE OF CDK2 WITH SAR60, AN AMINOINDAZOLE TYPE INHIBITOR
分子名称:Cell division protein kinase 2, N-(6,7-difluoro-5-phenyl-1H-indazol-3-yl)butanamide
著者Dreyer, M.K., Wendt, K.U., Schimanski-Breves, S., Loenze, P.
登録日2010-01-18
公開日2010-03-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Bioorg.Med.Chem.Lett., 20, 2010
3LFS
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CRYSTAL STRUCTURE OF CDK2 WITH SAR37, AN AMINOINDAZOLE TYPE INHIBITOR
分子名称:Cell division protein kinase 2, N-(6-chloro-5-phenyl-1H-indazol-3-yl)butanamide
著者Dreyer, M.K., Wendt, K.U., Schimanski-Breves, S., Loenze, P.
登録日2010-01-18
公開日2010-03-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.
Bioorg.Med.Chem.Lett., 20, 2010
1OS0
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THERMOLYSIN WITH AN ALPHA-AMINO PHOSPHINIC INHIBITOR
分子名称:Thermolysin, ZINC ION, CALCIUM ION, ...
著者Selkti, M., Tomas, A., Prange, T.
登録日2003-03-18
公開日2003-03-25
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Interactions of a new alpha-aminophosphinic derivative inside the active site of TLN (thermolysin): a model for zinc-metalloendopeptidase inhibition.
Acta Crystallogr.,Sect.D, 59, 2003