Author results

1AO5
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MOUSE GLANDULAR KALLIKREIN-13 (PRORENIN CONVERTING ENZYME)
Descriptor:GLANDULAR KALLIKREIN-13, N-ACETYL-D-GLUCOSAMINE
Authors:Timm, D.E.
Deposit date:1997-07-16
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of the mouse glandular kallikrein-13 (prorenin converting enzyme)
Protein Sci., 6, 1997
1I04
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CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN-I FROM MOUSE LIVER
Descriptor:MAJOR URINARY PROTEIN I
Authors:Timm, D.E., Baker, L.J., Mueller, H., Zidek, L., Novotny, M.V.
Deposit date:2001-01-28
Release date:2001-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of pheromone binding to mouse major urinary protein (MUP-I)
Protein Sci., 10, 2001
1I05
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CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH HYDROXY-METHYL-HEPTANONE
Descriptor:MAJOR URINARY PROTEIN I, CADMIUM ION, 6-HYDROXY-6-METHYL-HEPTAN-3-ONE
Authors:Timm, D.E., Baker, L.J., Mueller, H., Zidek, L., Novotny, M.V.
Deposit date:2001-01-28
Release date:2001-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis of Pheromone Binding to Mouse Major Urinary Protein (MUP-I)
Protein Sci., 10, 2001
1I06
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CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH SEC-BUTYL-THIAZOLINE
Descriptor:MAJOR URINARY PROTEIN I, CADMIUM ION, 2-(SEC-BUTYL)THIAZOLE
Authors:Timm, D.E., Baker, L.J., Mueller, H., Zidek, L., Novotny, M.V.
Deposit date:2001-01-28
Release date:2001-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis of Pheromone Binding to Mouse Major Urinary Protein (MUP-I)
Protein Sci., 10, 2001
1IG3
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MOUSE THIAMIN PYROPHOSPHOKINASE COMPLEXED WITH THIAMIN
Descriptor:thiamin pyrophosphokinase, SULFATE ION, 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM
Authors:Timm, D.E., Liu, J., Baker, L.-J., Harris, R.A.
Deposit date:2001-04-16
Release date:2001-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of thiamin pyrophosphokinase.
J.Mol.Biol., 310, 2001
1QCN
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CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE
Descriptor:FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, ACETATE ION, ...
Authors:Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J.
Deposit date:1999-05-14
Release date:2000-06-07
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
1QCO
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CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE COMPLEXED WITH FUMARATE AND ACETOACETATE
Descriptor:FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, NICKEL (II) ION, ...
Authors:Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J.
Deposit date:1999-05-17
Release date:2000-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
1QQJ
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CRYSTAL STRUCTURE OF MOUSE FUMARYLACETOACETATE HYDROLASE REFINED AT 1.55 ANGSTROM RESOLUTION
Descriptor:FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, ACETATE ION, ...
Authors:Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J.
Deposit date:1999-06-07
Release date:2000-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
3RN8
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CRYSTAL STRUCTURE OF IGLUR2 LIGAND BINDING DOMAIN AND SYMMETRICAL CARBOXYL CONTAINING POTENTIATOR
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, 3,3'-benzene-1,4-diylbis(4-cyano-5-ethylthiophene-2-carboxylic acid), ...
Authors:Timm, D.E.
Deposit date:2011-04-22
Release date:2011-05-25
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
Mol.Pharmacol., 80, 2011
3RNN
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CRYSTAL STRUCTURE OF IGLUR2 LIGAND BINDING DOMAIN WITH SYMMETRIC SULFONAMIDE CONTAINING POTENTIATOR
Descriptor:Glutamate receptor 2, N,N'-(benzene-1,4-diyldiethane-2,1-diyl)dipropane-2-sulfonamide, GLUTAMIC ACID, ...
Authors:Timm, D.E.
Deposit date:2011-04-22
Release date:2011-05-25
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
Mol.Pharmacol., 80, 2011
4X7I
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CRYSTAL STRUCTURE OF BACE WITH AMINO THIAZINE INHIBITOR LY2886721
Descriptor:Beta-secretase 1, N-{3-[(4aS,7aS)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide, GLYCEROL
Authors:Timm, D.E.
Deposit date:2014-12-09
Release date:2014-12-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A beta Pharmacodynamic Responses in Mice, Dogs, and Humans.
J.Neurosci., 35, 2015
1EY2
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HUMAN HOMOGENTISATE DIOXYGENASE WITH FE(II)
Descriptor:HOMOGENTISATE 1,2-DIOXYGENASE, FE (II) ION
Authors:Timm, D.E., Titus, G.P., Penalva, M.A., Mueller, H.A., de Cordoba, S.M.
Deposit date:2000-05-05
Release date:2000-11-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human homogentisate dioxygenase.
Nat.Struct.Biol., 7, 2000
1EYB
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CRYSTAL STRUCTURE OF APO HUMAN HOMOGENTISATE DIOXYGENASE
Descriptor:HOMOGENTISATE 1,2-DIOXYGENASE
Authors:Timm, D.E., Titus, G.P., Penalva, M.A., Mueller, H.A., de Cordoba, S.M.
Deposit date:2000-05-05
Release date:2000-11-05
Last modified:2015-06-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human homogentisate dioxygenase.
Nat.Struct.Biol., 7, 2000
2OGZ
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CRYSTAL STRUCTURE OF DPP-IV COMPLEXED WITH LILLY ARYL KETONE INHIBITOR
Descriptor:Dipeptidyl peptidase, 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE
Authors:Timm, D.E.
Deposit date:2007-01-09
Release date:2007-03-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site.
Bioorg.Med.Chem.Lett., 17, 2007
4YBI
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CRYSTAL STRUCTURE OF BACE WITH AMINO THIAZINE INHIBITOR LY2811376
Descriptor:Beta-secretase 1, (4S)-4-[2,4-difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine, GLYCEROL
Authors:Timm, D.E.
Deposit date:2015-02-18
Release date:2015-04-01
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor.
J.Neurosci., 31, 2011
4ZSM
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BACE CRYSTAL STRUCTURE WITH BICYCLIC AMINOTHIAZINE FRAGMENT
Descriptor:Beta-secretase 1, (4aS,8aR)-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-2-amine, GLYCEROL
Authors:Timm, D.E.
Deposit date:2015-05-13
Release date:2015-06-10
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Bioorg.Med.Chem., 23, 2015
4ZSP
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BACE CRYSTAL STRUCTURE WITH BICYCLIC AMINOTHIAZINE INHIBITOR
Descriptor:Beta-secretase 1, N-[(4aS,6S,8aR)-2-amino-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-6-yl]-3-chlorobenzamide, GLYCEROL
Authors:Timm, D.E.
Deposit date:2015-05-13
Release date:2015-06-10
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Bioorg.Med.Chem., 23, 2015
4ZSQ
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BACE CRYSTAL STRUCTURE WITH TRICYCLIC AMINOTHIAZINE INHIBITOR
Descriptor:Beta-secretase 1, N-[(4S,4aS,6S,8aR)-10-aminohexahydro-3H-4,8a-(epithiomethenoazeno)isochromen-6(1H)-yl]-3-chlorobenzamide, GLYCEROL
Authors:Timm, D.E.
Deposit date:2015-05-13
Release date:2015-06-10
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Bioorg.Med.Chem., 23, 2015
4ZSR
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BACE CRYSTAL STRUCTURE WITH TRICYCLIC AMINOTHIAZINE INHIBITOR
Descriptor:Beta-secretase 1, N-[(4aS,6S,8aR)-2-amino-5,6,7,8-tetrahydro-4a,8a-(methanooxymethano)-3,1-benzothiazin-6(4H)-yl]-3-chlorobenzamide
Authors:Timm, D.E.
Deposit date:2015-05-13
Release date:2015-06-10
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Bioorg.Med.Chem., 23, 2015
1EQZ
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X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION
Descriptor:146 NUCLEOTIDES LONG DNA, PROTEIN (HISTONE H2A), PROTEIN (HISTONE H2B), ...
Authors:Hanson, B.L., Harp, J.M., Timm, D.E., Bunick, G.J.
Deposit date:2000-04-06
Release date:2000-04-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Asymmetries in the nucleosome core particle at 2.5 A resolution.
Acta Crystallogr.,Sect.D, 56, 2000
1HYO
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CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE COMPLEXED WITH 4-(HYDROXYMETHYLPHOSPHINOYL)-3-OXO-BUTANOIC ACID
Descriptor:FUMARYLACETOACETATE HYDROLASE, MAGNESIUM ION, CALCIUM ION, ...
Authors:Bateman, R.L., Bhanumoorthy, P., Witte, J.F., McClard, R.W., Grompe, M., Timm, D.E.
Deposit date:2001-01-21
Release date:2001-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitor.
J.Biol.Chem., 276, 2001
1IG0
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CRYSTAL STRUCTURE OF YEAST THIAMIN PYROPHOSPHOKINASE
Descriptor:Thiamin pyrophosphokinase, 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM
Authors:Baker, L.-J., Dorocke, J.A., Harris, R.A., Timm, D.E.
Deposit date:2001-04-16
Release date:2001-06-20
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of yeast thiamin pyrophosphokinase.
Structure, 9, 2001
2F17
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MOUSE THIAMIN PYROPHOSPHOKINASE IN A TERNARY COMPLEX WITH PYRITHIAMIN PYROPHOSPHATE AND AMP AT 2.5 ANGSTROM
Descriptor:Thiamin pyrophosphokinase 1, MAGNESIUM ION, SULFATE ION, ...
Authors:Liu, J.Y., Timm, D.E., Hurley, T.D.
Deposit date:2005-11-14
Release date:2005-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pyrithiamine as a substrate for thiamine pyrophosphokinase
J.Biol.Chem., 281, 2006
2HZY
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MOUSE FUMARYLACETOACETATE HYDROLASE COMPLEXES WITH A TRANSITION-STATE MIMIC OF THE COMPLETE SUBSTRATE
Descriptor:Fumarylacetoacetase, SODIUM ION, MANGANESE (II) ION, ...
Authors:Hurley, T.D., Timm, D.E.
Deposit date:2006-08-09
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.
Biochem.J., 402, 2007
2DYN
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DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)
Descriptor:DYNAMIN
Authors:Timm, D.E.
Deposit date:1997-07-21
Release date:1997-11-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the pleckstrin homology domain from dynamin.
Nat.Struct.Biol., 1, 1994
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