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2VJ8
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COMPLEX OF HUMAN LEUKOTRIENE A4 HYDROLASE WITH A HYDROXAMIC ACID INHIBITOR
Descriptor:LTA4H PROTEIN, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Thunnissen, M.M.G.M., Andersson, B., Wong, C.-H., Samuelsson, B., Haeggstrom, J.Z.
Deposit date:2007-12-07
Release date:2008-01-15
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Leukotriene A4 Hydrolase in Complex with Captopril and Two Competitive Tight-Binding Inhibitors
Faseb J., 16, 2002
3CHO
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CRYSTAL STRUCTURE OF LEUKOTRIENE A4 HYDROLASE IN COMPLEX WITH 2-AMINO-N-[4-(PHENYLMETHOXY)PHENYL]-ACETAMIDE
Descriptor:Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Thunnissen, M.M.G.M., Adler, M., Whitlow, M.
Deposit date:2008-03-10
Release date:2008-04-22
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
3CHP
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CRYSTAL STRUCTURE OF LEUKOTRIENE A4 HYDROLASE IN COMPLEX WITH (3S)-3-AMINO-4-OXO-4-[(4-PHENYLMETHOXYPHENYL)AMINO]BUTANOIC ACID
Descriptor:Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Thunnissen, M.M.G.M., Adler, M., Whitlow, M.
Deposit date:2008-03-10
Release date:2008-04-22
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
3CHQ
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CRYSTAL STRUCTURE OF LEUKOTRIENE A4 HYDROLASE IN COMPLEX WITH N5-[4-(PHENYLMETHOXY)PHENYL]-L-GLUTAMINE
Descriptor:Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Thunnissen, M.M.G.M., Adler, M., Whitlow, M.
Deposit date:2008-03-10
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
3CHR
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CRYSTAL STRUCTURE OF LEUKOTRIENE A4 HYDROLASE IN COMPLEX WITH 4-AMINO-N-[4-(PHENYLMETHOXY)PHENYL]-BUTANAMIDE
Descriptor:Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Thunnissen, M.M.G.M., Adler, M., Whitlow, M.
Deposit date:2008-03-10
Release date:2008-04-22
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
3CHS
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CRYSTAL STRUCTURE OF LEUKOTRIENE A4 HYDROLASE IN COMPLEX WITH (2S)-2-AMINO-5-[[4-[(2S)-2-HYDROXY-2-PHENYL-ETHOXY]PHENYL]AMINO]-5-OXO-PENTANOIC ACID
Descriptor:Leukotriene A-4 hydrolase, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Thunnissen, M.M.G.M., Adler, M., Whitlow, M.
Deposit date:2008-03-10
Release date:2008-04-22
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Bioorg.Med.Chem., 16, 2008
1GW6
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STRUCTURE OF LEUKOTRIENE A4 HYDROLASE D375N MUTANT
Descriptor:LEUKOTRIENE A-4 HYDROLASE, 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, ...
Authors:Rudberg, P.C., Tholander, F., Thunnissen, M.M.G.M., Samuelsson, B., Haeggstrom, J.Z.
Deposit date:2002-03-07
Release date:2003-03-06
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Leukotriene A4 Hydrolase: Selective Abrogation of Leukotriene B4 Formation by Mutation of Aspartic Acid 375
Proc.Natl.Acad.Sci.USA, 99, 2002
5P2P
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X-RAY STRUCTURE OF PHOSPHOLIPASE A2 COMPLEXED WITH A SUBSTRATE-DERIVED INHIBITOR
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION, PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER
Authors:Dijkstra, B.W., Thunnissen, M.M.G.M., Kalk, K.H., Drenth, J.
Deposit date:1990-09-01
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structure of phospholipase A2 complexed with a substrate-derived inhibitor.
Nature, 347, 1990
1H19
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STRUCTURE OF [E271Q]LEUKOTRIENE A4 HYDROLASE
Descriptor:LEUKOTRIENE A-4 HYDROLASE, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Rudberg, P.C., Tholander, F., Thunnissen, M.M.G.M., Haeggstrom, J.Z.
Deposit date:2002-07-04
Release date:2002-08-08
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Leukotriene A4 Hydrolase/Aminopeptidase, Glutamate 271 is a Catalyticresidue with Specific Roles in Two Distinct Enzyme Mechanisms
J.Biol.Chem., 277, 2002
1SQM
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STRUCTURE OF [R563A] LEUKOTRIENE A4 HYDROLASE
Descriptor:LEUKOTRIENE A-4 HYDROLASE, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Tholander, F.O.T., Rudberg, P.C., Thunnissen, M.M.G.M., Haeggstrom, J.Z.
Deposit date:2004-03-19
Release date:2004-08-03
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates
J.Biol.Chem., 279, 2004
2XPY
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STRUCTURE OF NATIVE LEUKOTRIENE A4 HYDROLASE FROM SACCHAROMYCES CEREVISIAE
Descriptor:LEUKOTRIENE A-4 HYDROLASE, GLYCEROL, ZINC ION, ...
Authors:Helgstrand, C., Hasan, M., Usyal, H., Haeggstrom, J.Z., Thunnissen, M.M.G.M.
Deposit date:2010-08-31
Release date:2010-12-29
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding.
J.Mol.Biol., 406, 2011
2XPZ
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STRUCTURE OF NATIVE YEAST LTA4 HYDROLASE
Descriptor:LEUKOTRIENE A-4 HYDROLASE, (R,R)-2,3-BUTANEDIOL, ZINC ION, ...
Authors:Helgstrand, C., Hasan, M., Usyal, H., Haeggstrom, J.Z., Thunnissen, M.M.G.M.
Deposit date:2010-08-31
Release date:2010-12-29
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding.
J.Mol.Biol., 406, 2011
2XQ0
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STRUCTURE OF YEAST LTA4 HYDROLASE IN COMPLEX WITH BESTATIN
Descriptor:LEUKOTRIENE A-4 HYDROLASE, 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ZINC ION, ...
Authors:Helgstrand, C., Hasan, M., Usyal, H., Haeggstrom, J.Z., Thunnissen, M.M.G.M.
Deposit date:2010-08-31
Release date:2010-12-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.955 Å)
Cite:A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit Upon Inhibitor Binding.
J.Mol.Biol., 406, 2011
1HS6
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STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN.
Descriptor:LEUKOTRIENE A-4 HYDROLASE, ZINC ION, YTTERBIUM (III) ION, ...
Authors:Thunnissen, M.M.G.M., Nordlund, P.N., Haeggstrom, J.Z.
Deposit date:2000-12-24
Release date:2001-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.
Nat.Struct.Biol., 8, 2001
2ACY
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ACYL-PHOSPHATASE (COMMON TYPE) FROM BOVINE TESTIS
Descriptor:ACYLPHOSPHATASE, SULFATE ION, CHLORIDE ION
Authors:Thunnissen, M.M.G.M., Nordlund, P.
Deposit date:1996-11-08
Release date:1997-11-12
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of common type acylphosphatase from bovine testis.
Structure, 5, 1997
1IIB
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CRYSTAL STRUCTURE OF IIBCELLOBIOSE FROM ESCHERICHIA COLI
Descriptor:ENZYME IIB OF THE CELLOBIOSE-SPECIFIC PHOSPHOTRANSFERASE SYSTEM
Authors:Van Montfort, R.L.M., Pijning, T., Kalk, K.H., Reizer, J., Saier, M.H., Thunnissen, M.M.G.M., Robillard, G.T., Dijkstra, B.W.
Deposit date:1996-12-23
Release date:1997-12-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of an energy-coupling protein from bacteria, IIBcellobiose, reveals similarity to eukaryotic protein tyrosine phosphatases.
Structure, 5, 1997
2PHI
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A LARGE CONFORMATIONAL CHANGE IS FOUND IN THE CRYSTAL STRUCTURE OF THE PORCINE PANCREATIC PHOSPHOLIPASE A2 POINT MUTANT F63V
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Dijkstra, B.W., Thunnissen, M.M.G.M., Kalk, K.H., Drenth, J.
Deposit date:1993-04-08
Release date:1993-07-15
Last modified:2012-01-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a porcine pancreatic phospholipase A2 mutant. A large conformational change caused by the F63V point mutation.
J.Mol.Biol., 232, 1993
2W60
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ANTI CITRULLINATED COLLAGEN TYPE 2 ANTIBODY ACC4
Descriptor:ANTI-CITRULLINATED COLLAGEN TYPE II FAB ACC4, NITRATE ION
Authors:Uysal, H., Bockermann, R., Nandakumar, K.S., Sehnert, B., Bajtner, E., Engstrom, A., Serre, G., Burkhardt, H., Thunnissen, M.M.G.M., Holmdahl, R.
Deposit date:2008-12-16
Release date:2009-02-24
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
J. Exp. Med., 206, 2009
2W65
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ANTI CITRULLINATED COLLAGEN TYPE 2 ANTIBODY ACC4 IN COMPLEX WITH A CITRULLINATED PEPTIDE
Descriptor:ANTI-CITRULLINATED COLLAGEN TYPE II FAB ACC4, COLLAGEN DERIVED PEPTIDE PCII-CIT1, SULFATE ION
Authors:Uysal, H., Bockermann, R., Nandakumar, K.S., Sehnert, B., Bajtner, E., Engstrom, A., Serre, G., Burkhardt, H., Thunnissen, M.M.G.M., Holmdahl, R.
Deposit date:2008-12-17
Release date:2009-02-24
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
J. Exp. Med., 206, 2009
3P2P
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ENHANCED ACTIVITY AND ALTERED SPECIFICITY OF PHOSPHOLIPASE A2 BY DELETION OF A SURFACE LOOP
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Dijkstra, B.W., Thunnissen, M.M.G.M., Kalk, K.H., Drenth, J.
Deposit date:1989-11-29
Release date:1990-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop.
Science, 244, 1989
3ZH5
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THE STRUCTURE OF HAEMOPHILUS INFLUENZAE PROTEIN E
Descriptor:PROTEIN E, 1,2-ETHANEDIOL, GLYCEROL
Authors:Singh, B., Al-Jubair, T., Riesbeck, K., Thunnissen, M.M.G.M.
Deposit date:2012-12-20
Release date:2013-03-20
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:The Unique Structure of Haemophilus Influenzae Protein E Reveals Multiple Binding Sites for Host Factors.
Infect.Immun., 81, 2013
3ZH6
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THE STRUCTURE OF HAEMOPHILUS INFLUENZAE SE_MET FORM OF PROTEIN E
Descriptor:PROTEIN E
Authors:Singh, B., Al-Jubair, T., Riesbeck, K., Thunnissen, M.M.G.M.
Deposit date:2012-12-20
Release date:2013-03-20
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:The Unique Structure of Haemophilus Influenzae Protein E Reveals Multiple Binding Sites for Host Factors.
Infect.Immun., 81, 2013
3ZH7
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THE STRUCTURE OF CRYSTAL FORM II OF HAEMOPHILUS INFLUENZAE PROTEIN E
Descriptor:PROTEIN E, 1,2-ETHANEDIOL
Authors:Singh, B., Al-Jubair, T., Riesbeck, K., Thunnissen, M.M.G.M.
Deposit date:2012-12-20
Release date:2013-04-17
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:The Unique Structure of Haemophilus Influenzae Protein E Reveals Multiple Binding Sites for Host Factors.
Infect.Immun., 81, 2013
4BWE
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CRYSTAL STRUCTURE OF C-TERMINALLY TRUNCATED GLYPICAN-1 AFTER CONTROLLED DEHYDRATION TO 86 PERCENT RELATIVE HUMIDITY
Descriptor:Glypican-1, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION
Authors:Awad, W., Svensson Birkedal, G., Thunnissen, M.M.G.M., Mani, K., Logan, D.T.
Deposit date:2013-07-01
Release date:2013-12-18
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Improvements in the order, isotropy and electron density of glypican-1 crystals by controlled dehydration.
Acta Crystallogr. D Biol. Crystallogr., 69, 2013