Author results

1ZXF
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SOLUTION STRUCTURE OF A SELF-SACRIFICING RESISTANCE PROTEIN, CALC FROM MICROMONOSPORA ECHINOSPORA
Descriptor:CalC
Authors:Singh, S., Hager, M.H., Zhang, C., Griffith, B.R., Lee, M.S., Hallenga, K., Markley, J.L., Thorson, J.S., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2005-06-08
Release date:2005-12-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insight into the self-sacrifice mechanism of enediyne resistance.
Acs Chem.Biol., 1, 2006
1IIM
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THYMIDYLYLTRANSFERASE COMPLEXED WITH TTP
Descriptor:glucose-1-phosphate thymidylyltransferase, THYMIDINE-5'-TRIPHOSPHATE
Authors:Barton, W.A., Lesniak, J., Biggins, J.B., Jeffrey, P.D., Jiang, J., Rajashankar, K.R., Thorson, J.S., Nikolov, D.B.
Deposit date:2001-04-23
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization.
Nat.Struct.Biol., 8, 2001
1IIN
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THYMIDYLYLTRANSFERASE COMPLEXED WITH UDP-GLUCOSE
Descriptor:glucose-1-phosphate thymidylyltransferase, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Barton, W.A., Lesniak, J., Biggins, J.B., Jeffrey, P.D., Jiang, J., Rajashankar, K.R., Thorson, J.S., Nikolov, D.B.
Deposit date:2001-04-23
Release date:2001-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization.
Nat.Struct.Biol., 8, 2001
1MP4
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W224H VARIANT OF S. ENTERICA RMLA
Descriptor:W224H Variant of S. Enterica RmlA Bound to UDP-Glucose, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Barton, W.A., Biggins, J.B., Jiang, J., Thorson, J.S., Nikolov, D.B.
Deposit date:2002-09-11
Release date:2002-10-09
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering
Proc.Natl.Acad.Sci.USA, 99, 2002
1MP5
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Y177F VARIANT OF S. ENTERICA RMLA
Descriptor:Y177F VARIANT OF S. ENTERICA RmlA BOUND TO UDP-GLUCOSE, URIDINE-5'-DIPHOSPHATE-GLUCOSE
Authors:Barton, W.A., Biggins, J.B., Jiang, J., Thorson, J.S., Nikolov, D.B.
Deposit date:2002-09-11
Release date:2002-10-09
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering
Proc.Natl.Acad.Sci.USA, 99, 2002
2GKD
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STRUCTURAL INSIGHT INTO SELF-SACRIFICE MECHANISM OF ENEDIYNE RESISTANCE
Descriptor:5'-D(*GP*CP*AP*TP*AP*TP*GP*AP*TP*AP*G)-3', 5'-D(*CP*TP*AP*TP*CP*AP*TP*AP*TP*GP*C)-3', CalC
Authors:Singh, S., Thorson, J.S.
Deposit date:2006-04-01
Release date:2006-08-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insight into the self-sacrifice mechanism of enediyne resistance.
Acs Chem.Biol., 1, 2006
2L65
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HADDOCK CALCULATED MODEL OF THE COMPLEX OF THE RESISTANCE PROTEIN CALC AND CALICHEAMICIN-GAMMA
Descriptor:CalC, 4,6-DIDEOXY-4-AMINO-BETA-D-GLUCOPYRANOSIDE, 2,6-DIDEOXY-4-THIO-BETA-D-ALLOSEPYRANOSIDE, ...
Authors:Singh, S., Markley, J.L., Thorson, J.S., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2010-11-15
Release date:2011-03-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insight into the self-sacrifice mechanism of enediyne resistance.
Acs Chem.Biol., 1, 2006
2LUZ
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SOLUTION NMR STRUCTURE OF CALU16 FROM MICROMONOSPORA ECHINOSPORA, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET MIR12
Descriptor:CalU16
Authors:Ramelot, T.A., Yang, Y., Lee, H., Pederson, K., Lee, D., Kohan, E., Janjua, H., Xiao, R., Acton, T.B., Everett, J.K., Wrobel, R.L., Bingman, C.A., Singh, S., Thorson, J.S., Prestegard, J.H., Montelione, G.T., Phillips Jr., G.N., Kennedy, M.A., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Northeast Structural Genomics Consortium (NESG)
Deposit date:2012-06-22
Release date:2012-10-03
Last modified:2014-11-12
Method:SOLUTION NMR
Cite:Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19.
Acs Chem.Biol., 9, 2014
3BUJ
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CRYSTAL STRUCTURE OF CALO2
Descriptor:CalO2, PROTOPORPHYRIN IX CONTAINING FE
Authors:McCoy, J.G., Johnson, H.D., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N.
Deposit date:2008-01-02
Release date:2008-04-29
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structural characterization of CalO2: a putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway.
Proteins, 74, 2009
3BUS
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CRYSTAL STRUCTURE OF REBM
Descriptor:Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:McCoy, J.G., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N.
Deposit date:2008-01-03
Release date:2008-03-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM.
J.Biol.Chem., 283, 2008
3GWZ
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STRUCTURE OF THE MITOMYCIN 7-O-METHYLTRANSFERASE MMCR
Descriptor:MmcR, CALCIUM ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Singh, S., Chang, A., Bingman, C.A., Phillips Jr., G.N., Thorson, J.S.
Deposit date:2009-04-01
Release date:2010-04-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Structural characterization of the mitomycin 7-O-methyltransferase.
Proteins, 79, 2011
3GXO
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STRUCTURE OF THE MITOMYCIN 7-O-METHYLTRANSFERASE MMCR WITH BOUND MITOMYCIN A
Descriptor:MmcR, S-ADENOSYL-L-HOMOCYSTEINE, [(1aS,8S,8aR,8bS)-6,8a-dimethoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate, ...
Authors:Singh, S., Chang, A., Bingman, C.A., Phillips Jr., G.N., Thorson, J.S.
Deposit date:2009-04-02
Release date:2010-04-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural characterization of the mitomycin 7-O-methyltransferase.
Proteins, 79, 2011
3IA7
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CRYSTAL STRUCTURE OF CALG4, THE CALICHEAMICIN GLYCOSYLTRANSFERASE
Descriptor:CalG4, CALCIUM ION, CHLORIDE ION
Authors:Chang, A., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N.
Deposit date:2009-07-13
Release date:2010-06-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.
Proc.Natl.Acad.Sci.USA, 108, 2011
3IAA
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CRYSTAL STRUCTURE OF CALG2, CALICHEAMICIN GLYCOSYLTRANSFERASE, TDP BOUND FORM
Descriptor:CalG2, THYMIDINE-5'-DIPHOSPHATE
Authors:Chang, A., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N.
Deposit date:2009-07-13
Release date:2010-06-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.505 Å)
Cite:Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.
Proc.Natl.Acad.Sci.USA, 108, 2011
3LST
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CRYSTAL STRUCTURE OF CALO1, METHYLTRANSFERASE IN CALICHEAMICIN BIOSYNTHESIS, SAH BOUND FORM
Descriptor:CalO1 Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 1,2-ETHANEDIOL
Authors:Chang, A., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2010-02-12
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway.
Acta Crystallogr.,Sect.D, 67, 2011
3OTG
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CRYSTAL STRUCTURE OF CALG1, CALICHEAMICIN GLYCOSTYLTRANSFERASE, TDP BOUND FORM
Descriptor:CalG1, THYMIDINE-5'-DIPHOSPHATE, CHLORIDE ION
Authors:Chang, A., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Center for Eukaryotic Structural Genomics (CESG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2010-09-11
Release date:2010-12-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.
Proc.Natl.Acad.Sci.USA, 108, 2011
3OTH
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CRYSTAL STRUCTURE OF CALG1, CALICHEAMICIN GLYCOSTYLTRANSFERASE, TDP AND CALICHEAMICIN ALPHA3I BOUND FORM
Descriptor:CalG1, THYMIDINE-5'-DIPHOSPHATE, Calicheamicin alpha3I
Authors:Chang, A., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Center for Eukaryotic Structural Genomics (CESG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2010-09-11
Release date:2010-12-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.
Proc.Natl.Acad.Sci.USA, 108, 2011
3OTI
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CRYSTAL STRUCTURE OF CALG3, CALICHEAMICIN GLYCOSTYLTRANSFERASE, TDP AND CALICHEAMICIN T0 BOUND FORM
Descriptor:CalG3, THYMIDINE-5'-DIPHOSPHATE, Calicheamicin T0, ...
Authors:Chang, A., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Center for Eukaryotic Structural Genomics (CESG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2010-09-11
Release date:2010-12-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.597 Å)
Cite:Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PKP
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Q83S VARIANT OF S. ENTERICA RMLA WITH DATP
Descriptor:Glucose-1-phosphate thymidylyltransferase, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Chang, A., Moretti, R., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2010-11-11
Release date:2011-01-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution.
J.Biol.Chem., 286, 2011
3PKQ
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Q83D VARIANT OF S. ENTERICA RMLA WITH DGTP
Descriptor:Glucose-1-phosphate thymidylyltransferase, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Chang, A., Moretti, R., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2010-11-11
Release date:2011-01-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution.
J.Biol.Chem., 286, 2011
3RSC
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CRYSTAL STRUCTURE OF CALG2, CALICHEAMICIN GLYCOSYLTRANSFERASE, TDP AND CALICHEAMICIN T0 BOUND FORM
Descriptor:CalG2, THYMIDINE-5'-DIPHOSPHATE, Calicheamicin T0, ...
Authors:Chang, A., Helmich, K.E., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Center for Eukaryotic Structural Genomics (CESG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2011-05-02
Release date:2011-08-10
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity.
Proc.Natl.Acad.Sci.USA, 108, 2011
3TOS
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CRYSTAL STRUCTURE OF CALS11, CALICHEAMICIN METHYLTRANSFERASE
Descriptor:CalS11, S-ADENOSYL-L-HOMOCYSTEINE, GLUTAMIC ACID, ...
Authors:Chang, A., Aceti, D.J., Beebe, E.T., Makino, S.-I., Wrobel, R.L., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Center for Eukaryotic Structural Genomics (CESG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2011-09-06
Release date:2011-10-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal Structure of CalS11, Calicheamicin methyltransferase
To be Published
4FZR
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CRYSTAL STRUCTURE OF SSFS6, STREPTOMYCES SP. SF2575 GLYCOSYLTRANSFERASE
Descriptor:SsfS6
Authors:Wang, F., Zhou, M., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2012-07-07
Release date:2012-07-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.397 Å)
Cite:Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis.
Proteins, 81, 2013
4G2T
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CRYSTAL STRUCTURE OF STREPTOMYCES SP. SF2575 GLYCOSYLTRANSFERASE SSFS6, COMPLEXED WITH THYMIDINE DIPHOSPHATE
Descriptor:SsfS6, THYMIDINE-5'-DIPHOSPHATE
Authors:Wang, F., Zhou, M., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2012-07-12
Release date:2012-07-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Crystal structure of SsfS6, the putative C-glycosyltransferase involved in SF2575 biosynthesis.
Proteins, 81, 2013
4HPV
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE FROM SULFOLOBUS SOLFATARICUS
Descriptor:S-adenosylmethionine synthase
Authors:Wang, F., Hurley, K.A., Helmich, K.E., Singh, S., Bingman, C.A., Thorson, J.S., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2012-10-24
Release date:2012-11-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.214 Å)
Cite:Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus.
Febs J., 281, 2014
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