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The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody
Descriptor:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, SNS-101 Fab heavy chain, ...
Authors:	van der Horst, E.H, Mukherjee, A, Thisted, T.
Deposit date:	2023-06-29
Release date:	2024-03-20
Method:	X-RAY DIFFRACTION (2.593 Å)
Cite:	The pH-selective anti-VISTA antibody SNS-101 displays a favorable pharmacokinetic and safety profile and promotes anti-tumoral M1 macrophage polarization in PD-1 refractory settings To Be Published

Novel non-antibody protein scaffold targeting CD40L
Descriptor:	CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:	Oganesyan, V, Baca, M, Thisted, T, Grinberg, L, Wu, H, Dall'Acqua, W.F.
Deposit date:	2017-11-30
Release date:	2018-12-05
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.82 Å)
Cite:	A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity. Sci Transl Med, 11, 2019