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4P5W
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STRUCTURE OF THE N- AND C-TERMINAL DOMAIN FUSION OF THE HUMAN MITOCHONDRIAL ASPARTATE/GLUTAMATE CARRIER CITRIN IN THE CALCIUM-BOUND STATE
Descriptor:Calcium-binding mitochondrial carrier protein Aralar2,Calcium-binding mitochondrial carrier protein Aralar2, CALCIUM ION
Authors:Thangaratnarajah, C., Ruprecht, J.J., Kunji, E.R.S.
Deposit date:2014-03-20
Release date:2014-11-26
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.
Nat Commun, 5, 2014
4P5X
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STRUCTURE OF THE N-TERMINAL DOMAIN OF THE HUMAN MITOCHONDRIAL ASPARTATE/GLUTAMATE CARRIER ARALAR IN THE CALCIUM-BOUND STATE
Descriptor:Calcium-binding mitochondrial carrier protein Aralar1, CALCIUM ION
Authors:Thangaratnarajah, C., Ruprecht, J.J., Kunji, E.R.S.
Deposit date:2014-03-20
Release date:2014-11-26
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.261 Å)
Cite:Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.
Nat Commun, 5, 2014
4P60
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STRUCTURE OF THE N-TERMINAL DOMAIN OF THE HUMAN MITOCHONDRIAL ASPARTATE/GLUTAMATE CARRIER ARALAR IN THE APO STATE
Descriptor:Calcium-binding mitochondrial carrier protein Aralar1, SODIUM ION
Authors:Thangaratnarajah, C., Ruprecht, J.J., Kunji, E.R.S.
Deposit date:2014-03-20
Release date:2014-11-26
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.
Nat Commun, 5, 2014
3MTL
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CRYSTAL STRUCTURE OF THE PCTAIRE1 KINASE IN COMPLEX WITH INDIRUBIN E804
Descriptor:Cell division protein kinase 16, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
Authors:Krojer, T., Sharpe, T.D., Roos, A., Savitsky, P., Amos, A., Ayinampudi, V., Berridge, G., Fedorov, O., Keates, T., Phillips, C., Burgess-Brown, N., Zhang, Y., Pike, A.C.W., Muniz, J., Vollmar, M., Thangaratnarajah, C., Rellos, P., Ugochukwu, E., Filippakopoulos, P., Yue, W., Das, S., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
to be published
3PRY
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CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN HSP90-BETA REFINED AT 2.3 A RESOLUTION
Descriptor:Heat shock protein HSP 90-beta, SULFATE ION, GLYCEROL, ...
Authors:Chaikuad, A., Pilka, E., Sharpe, T.D., Cooper, C.D.O., Phillips, C., Berridge, G., Ayinampudi, V., Fedorov, O., Keates, T., Thangaratnarajah, C., Zimmermann, T., Vollmar, M., Yue, W.W., Che, K.H., Krojer, T., Muniz, J.R.C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-11-30
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
To be Published
4AGU
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CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN
Descriptor:CYCLIN-DEPENDENT KINASE-LIKE 1, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
Authors:Canning, P., Sharpe, T.D., Allerston, C., Savitsky, P., Pike, A.C.W., Muniz, J.R.C., Chaikuad, A., Kuo, K., Burgess-Brown, N., Ayinampudi, V., Zhang, Y., Thangaratnarajah, C., Ugochukwu, E., Vollmar, M., Krojer, T., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Knapp, S., Bullock, A.
Deposit date:2012-01-31
Release date:2012-02-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Human Cdkl1 Kinase Domain
To be Published
3II7
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CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL7
Descriptor:Kelch-like protein 7, 1,2-ETHANEDIOL
Authors:Chaikuad, A., Thangaratnarajah, C., Cooper, C.D.O., Ugochukwu, E., Muniz, J.R.C., Krojer, T., Sethi, R., Pike, A.C.W., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2009-07-31
Release date:2009-08-25
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
J.Biol.Chem., 288, 2013
3G2F
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE II (BMPR2) AT 2.35 A RESOLUTION
Descriptor:Bone morphogenetic protein receptor type-2, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Chaikuad, A., Thangaratnarajah, C., Roos, A.K., Filippakopoulos, P., Salah, E., Phillips, C., Keates, T., Fedorov, O., Chalk, R., Petrie, K., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2009-01-31
Release date:2009-02-17
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the BMPR2 kinase domain
To be Published
4ASC
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CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KBTBD5
Descriptor:KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 5, 1,2-ETHANEDIOL
Authors:Canning, P., Ayinampudi, V., Krojer, T., Strain-Damerell, C., Raynor, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N., Structural Genomics Consortium (SGC)
Deposit date:2012-04-30
Release date:2012-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
2VPJ
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CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL12
Descriptor:KELCH-LIKE PROTEIN 12, ACETATE ION
Authors:Keates, T., Pike, A.C.W., Bullock, A.N., Salah, E., Filippakopoulos, P., Roos, A.K., von Delft, F., Savitsky, P., Weigelt, J., Edwards, A., Arrowsmith, C.H., Bountra, C., Knapp, S.
Deposit date:2008-02-29
Release date:2008-03-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
2XN4
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CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL2 (MAYVEN)
Descriptor:KELCH-LIKE PROTEIN 2, SODIUM ION, SULFATE ION, ...
Authors:Canning, P., Hozjan, V., Cooper, C.D.O., Ayinampudi, V., Vollmar, M., Pike, A.C.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.
Deposit date:2010-07-30
Release date:2010-08-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
4ABN
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CRYSTAL STRUCTURE OF FULL LENGTH MOUSE STRAP (TTC5)
Descriptor:TETRATRICOPEPTIDE REPEAT PROTEIN 5, 1,2-ETHANEDIOL
Authors:Pike, A.C.W., Bullock, A.N., Kleinekofort, W., Zimmermann, T., Burgess-Brown, N., Sharpe, T.D., Thangaratnarajah, C., Keates, T., Ugochukwu, E., Bunkoczi, G., Uppenberg, J., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., La Thangue, N.B., Knapp, S.
Deposit date:2011-12-09
Release date:2012-01-25
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The P53 Cofactor Strap Exhibits an Unexpected Tpr Motif and Oligonucleotide-Binding (Ob)-Fold Structure.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AP2
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CRYSTAL STRUCTURE OF THE HUMAN KLHL11-CUL3 COMPLEX AT 2.8A RESOLUTION
Descriptor:KELCH-LIKE PROTEIN 11, CULLIN-3, 1,2-ETHANEDIOL, ...
Authors:Canning, P., Cooper, C.D.O., Krojer, T., Filippakopoulos, P., Ayinampudi, V., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.N., Structural Genomics Consortium (SGC)
Deposit date:2012-03-30
Release date:2012-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
4APF
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CRYSTAL STRUCTURE OF THE HUMAN KLHL11-CUL3 COMPLEX AT 3.1A RESOLUTION
Descriptor:KELCH-LIKE PROTEIN 11, CULLIN 3
Authors:Canning, P., Cooper, C.D.O., Krojer, T., Vollmar, M., Ugochukwu, E., Muniz, J.R.C., Ayinampudi, V., Savitsky, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.N., Structural Genomics Consortium (SGC)
Deposit date:2012-04-02
Release date:2012-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013