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6Q8Y
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BU of 6q8y by Molmil
Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Tesina, P, Heckel, E, Cheng, J, Buschauer, R, Kater, L, Berninghausen, O, Becker, T, Beckmann, R.
Deposit date:2018-12-16
Release date:2019-03-13
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of the 80S ribosome-Xrn1 nuclease complex.
Nat.Struct.Mol.Biol., 26, 2019
2N3A
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BU of 2n3a by Molmil
Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404)
Descriptor: PC4 and SFRS1-interacting protein, Pogo transposable element with ZNF domain
Authors:Tesina, P, Cermakova, K, Horejsi, M, Prochazkova, K, Fabry, M, Sharma, S, Christ, F, Demeulemeester, J, Debyser, Z, De Rijck, J, Veverka, V, Rezacova, P.
Deposit date:2015-05-26
Release date:2015-08-19
Method:SOLUTION NMR
Cite:Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.
Nat Commun, 6, 2015
8AGU
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BU of 8agu by Molmil
Yeast RQC complex in state E
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Tesina, P, Buschauer, R, Beckmann, R.
Deposit date:2022-07-20
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
8AGX
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BU of 8agx by Molmil
Yeast RQC complex in state with the RING domain of Ltn1 in the IN position
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Tesina, P, Buschauer, R, Beckmann, R.
Deposit date:2022-07-20
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
8AGV
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BU of 8agv by Molmil
Yeast RQC complex in state H
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Tesina, P, Buschauer, R, Beckmann, R.
Deposit date:2022-07-20
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
8AGT
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BU of 8agt by Molmil
Yeast RQC complex in state F
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Tesina, P, Buschauer, R, Beckmann, R.
Deposit date:2022-07-20
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
8AGW
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BU of 8agw by Molmil
Yeast RQC complex in state D
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Tesina, P, Buschauer, R, Beckmann, R.
Deposit date:2022-07-20
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
8AAF
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BU of 8aaf by Molmil
Yeast RQC complex in state G
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Tesina, P, Buschauer, R, Beckmann, R.
Deposit date:2022-07-01
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
8AGZ
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BU of 8agz by Molmil
Yeast RQC complex in state with the RING domain of Ltn1 in the OUT position
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Tesina, P, Buschauer, R, Beckmann, R.
Deposit date:2022-07-20
Release date:2023-03-08
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control.
Mol.Cell, 83, 2023
6T7I
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BU of 6t7i by Molmil
Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination.
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Tesina, P, Buschauer, R, Cheng, J, Berninghausen, O, Becker, R, Beckmann, R.
Deposit date:2019-10-22
Release date:2019-12-25
Last modified:2020-02-12
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.
Embo J., 39, 2020
6T4Q
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BU of 6t4q by Molmil
Structure of yeast 80S ribosome stalled on the CGA-CCG inhibitory codon combination.
Descriptor: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ...
Authors:Tesina, P, Buschauer, R, Cheng, J, Berninghausen, O, Becker, R, Beckmann, R.
Deposit date:2019-10-14
Release date:2019-12-25
Last modified:2020-02-12
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.
Embo J., 39, 2020
6T83
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BU of 6t83 by Molmil
Structure of yeast disome (di-ribosome) stalled on poly(A) tract.
Descriptor: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ...
Authors:Tesina, P, Buschauer, R, Cheng, J, Berninghausen, O, Becker, R, Beckmann, R.
Deposit date:2019-10-24
Release date:2019-12-25
Last modified:2020-02-12
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.
Embo J., 39, 2020
6T7T
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BU of 6t7t by Molmil
Structure of yeast 80S ribosome stalled on poly(A) tract.
Descriptor: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ...
Authors:Tesina, P, Buschauer, R, Cheng, J, Berninghausen, O, Becker, R, Beckmann, R.
Deposit date:2019-10-23
Release date:2019-12-25
Last modified:2020-02-19
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.
Embo J., 39, 2020
6I7O
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BU of 6i7o by Molmil
The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Tesina, P, Cheng, J, Becker, T, Beckmann, R.
Deposit date:2018-11-16
Release date:2019-01-16
Last modified:2019-03-13
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways.
EMBO J., 38, 2019
6SNT
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BU of 6snt by Molmil
Yeast 80S ribosome stalled on SDD1 mRNA.
Descriptor: 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, 40S ribosomal protein S10-A, ...
Authors:Tesina, P, Buschauer, R, Cheng, J, Becker, T, Beckmann, R.
Deposit date:2019-08-27
Release date:2020-03-04
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1.
Nat.Struct.Mol.Biol., 27, 2020
6SV4
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BU of 6sv4 by Molmil
The cryo-EM structure of SDD1-stalled collided trisome.
Descriptor: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ...
Authors:Tesina, P, Buschauer, R, Cheng, J, Becker, T, Beckmann, R.
Deposit date:2019-09-17
Release date:2020-03-04
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:RQT complex dissociates ribosomes collided on endogenous RQC substrate SDD1.
Nat.Struct.Mol.Biol., 27, 2020
7AXZ
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BU of 7axz by Molmil
Ku70/80 complex apo form
Descriptor: X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6
Authors:Hnizda, A, Tesina, P, Novak, P, Blundell, T.L.
Deposit date:2020-11-10
Release date:2021-02-10
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:SAP domain forms a flexible part of DNA aperture in Ku70/80.
Febs J., 288, 2021
7QVP
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BU of 7qvp by Molmil
Human collided disome (di-ribosome) stalled on XBP1 mRNA
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Denk, T.G, Tesina, P, Beckmann, R.
Deposit date:2022-01-22
Release date:2022-10-12
Last modified:2022-11-23
Method:ELECTRON MICROSCOPY (3 Å)
Cite:A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.
Nat Commun, 13, 2022
2MSR
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BU of 2msr by Molmil
Solution structure of LEDGF/p75 IBD in complex with MLL1 peptide (140-160)
Descriptor: Histone-lysine N-methyltransferase 2A, PC4 and SFRS1-interacting protein
Authors:Cermakova, K, Tesina, P, Demeulemeester, J, El Ashkar, S, Mereau, H, Schwaller, J, Rezacova, P, Veverka, V, De Rijck, J.
Deposit date:2014-08-05
Release date:2014-08-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Validation and Structural Characterization of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia.
Cancer Res., 74, 2014
6TB3
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BU of 6tb3 by Molmil
yeast 80S ribosome in complex with the Not5 subunit of the CCR4-NOT complex
Descriptor: 25S rRNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Buschauer, R, Cheng, J, Berninghausen, O, Tesina, P, Becker, T, Beckmann, R.
Deposit date:2019-10-31
Release date:2020-04-22
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Science, 368, 2020
6TNU
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BU of 6tnu by Molmil
Yeast 80S ribosome in complex with eIF5A and decoding A-site and P-site tRNAs.
Descriptor: 18S rRNA, 25S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
Authors:Buschauer, R, Cheng, J, Berninghausen, O, Tesina, P, Becker, T, Beckmann, R.
Deposit date:2019-12-10
Release date:2020-04-22
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Science, 368, 2020
5YI9
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BU of 5yi9 by Molmil
Solution structure of the LEDGF/p75 IBD - JPO2 (aa 56-91) complex
Descriptor: PC4 and SFRS1-interacting protein,Cell division cycle-associated 7-like protein
Authors:Veverka, V.
Deposit date:2017-10-03
Release date:2018-08-15
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EMO
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BU of 6emo by Molmil
Solution structure of the LEDGF/p75 IBD - JPO2 (aa 1-32) complex
Descriptor: PC4 and SFRS1-interacting protein,LEDGF/p75 IBD-JPO2 M1
Authors:Veverka, V.
Deposit date:2017-10-03
Release date:2018-07-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EMR
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BU of 6emr by Molmil
Solution structure of the LEDGF/p75 IBD - IWS1 (aa 446-548) complex
Descriptor: PC4 and SFRS1-interacting protein,Protein IWS1 homolog
Authors:Veverka, V.
Deposit date:2017-10-03
Release date:2018-07-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6EMQ
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BU of 6emq by Molmil
Solution structure of the LEDGF/p75 IBD - MLL1 (aa 111-160) complex
Descriptor: PC4 and SFRS1-interacting protein,Histone-lysine N-methyltransferase 2A
Authors:Veverka, V.
Deposit date:2017-10-03
Release date:2018-08-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018

 

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