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5OCE
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BU of 5oce by Molmil
THE MOLECULAR MECHANISM OF SUBSTRATE RECOGNITION AND CATALYSIS OF THE MEMBRANE ACYLTRANSFERASE PatA -- Complex of PatA with palmitate, mannose, and palmitoyl-6-mannose
Descriptor: PALMITIC ACID, Phosphatidylinositol mannoside acyltransferase, [(2~{R},3~{S},4~{S},5~{S},6~{S})-3,4,5,6-tetrakis(oxidanyl)oxan-2-yl]methyl hexadecanoate, ...
Authors:Albesa-Jove, D, Tersa, M, Guerin, M.E.
Deposit date:2017-06-30
Release date:2017-12-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:The Molecular Mechanism of Substrate Recognition and Catalysis of the Membrane Acyltransferase PatA from Mycobacteria.
ACS Chem. Biol., 13, 2018
4ZIL
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BU of 4zil by Molmil
Crystal structure of Rv2466c and oxidoreductase from Mycobacterium tuberculosis in its reduced state
Descriptor: DSBA oxidoreductase, MAGNESIUM ION
Authors:Albesa-Jove, D, Urresti, S, Comino, N, Tersa, M, Guerin, M.E.
Deposit date:2015-04-28
Release date:2015-11-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.507 Å)
Cite:The Redox State Regulates the Conformation of Rv2466c to Activate the Antitubercular Prodrug TP053.
J.Biol.Chem., 290, 2015
7OPP
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BU of 7opp by Molmil
Crystal structure of the Rab27a fusion with Slp2a-RBDa1 effector for SF4 pocket drug targeting
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Synaptotagmin-like protein 2,Ras-related protein Rab-27A
Authors:Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E.
Deposit date:2021-06-01
Release date:2022-04-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Rsc Med Chem, 13, 2022
7OPR
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BU of 7opr by Molmil
Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CB1 in C123
Descriptor: GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E.
Deposit date:2021-06-01
Release date:2022-04-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Rsc Med Chem, 13, 2022
7OPQ
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BU of 7opq by Molmil
Rab27a fusion with Slp2a-RBDa1 effector covalent adduct with CA1 in C188
Descriptor: 1-[(2~{S})-2-(4-methoxyphenyl)pyrrolidin-1-yl]propan-1-one, GLYCEROL, MAGNESIUM ION, ...
Authors:Jamshidiha, M, Tersa, M, Lanyon-Hogg, T, Perez-Dorado, I, Sutherell, C.L, De Vita, E, Morgan, R.M.L, Tate, E.W, Cota, E.
Deposit date:2021-06-01
Release date:2022-04-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Rsc Med Chem, 13, 2022
5F31
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BU of 5f31 by Molmil
Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with palmitate - P 42 21 2 space group
Descriptor: ETHANOL, PALMITIC ACID, Phosphatidylinositol mannoside acyltransferase, ...
Authors:Albesa-Jove, D, Svetlikova, Z, Carreras-Gonzalez, A, Tersa, M, Sancho-Vaello, E, Cifuente, J.O, Mikusova, K, Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F2Z
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BU of 5f2z by Molmil
Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with palmitate - P21 space group
Descriptor: PALMITIC ACID, Phosphatidylinositol mannoside acyltransferase
Authors:Albesa-Jove, D, Svetlikova, Z, Carreras-Gonzalez, A, Tersa, M, Sancho-Vaello, E, Cifuente, J.O, Mikusova, K, Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F2T
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BU of 5f2t by Molmil
Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with palmitate - C 2 space group
Descriptor: MAGNESIUM ION, PALMITIC ACID, Phosphatidylinositol mannoside acyltransferase
Authors:Albesa-Jove, D, Svetlikova, Z, Carreras-Gonzalez, A, Tersa, M, Sancho-Vaello, E, Cifuente, J.O, Mikusova, K, Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
5F34
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BU of 5f34 by Molmil
Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with S-hexadecyl Coenzyme A - P21 space group
Descriptor: Phosphatidylinositol mannoside acyltransferase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{S})-4-[[3-(2-hexadecylsulfanylethylamino)-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate
Authors:Albesa-Jove, D, Svetlikova, Z, Carreras-Gonzalez, A, Tersa, M, Sancho-Vaello, E, Cifuente, J.O, Mikusova, K, Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.281 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
4NXI
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BU of 4nxi by Molmil
Rv2466c Mediates the Activation of TP053 To Kill Replicating and Non-replicating Mycobacterium tuberculosis
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, Uncharacterized protein
Authors:Albesa-Jove, D, Urresti, S, Comino, N, Guerin, M.E.
Deposit date:2013-12-09
Release date:2014-10-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.
Acs Chem.Biol., 9, 2014
7OJT
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BU of 7ojt by Molmil
Crystal structure of unliganded PatA, a membrane associated acyltransferase from Mycobacterium smegmatis
Descriptor: GLYCEROL, Phosphatidylinositol mannoside acyltransferase
Authors:Anso, I, Wang, L, Marina, A, Paez-Perez, E.D, Perrone, S, Lowary, T.L, Trastoy, B, Guerin, M.E.
Deposit date:2021-05-17
Release date:2021-10-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.67 Å)
Cite:Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA.
Sci Adv, 7, 2021

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