Author results

1YBX
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CONSERVED HYPOTHETICAL PROTEIN CTH-383 FROM CLOSTRIDIUM THERMOCELLUM
Descriptor:Conserved hypothetical protein, UNKNOWN ATOM OR ION
Authors:Tempel, W., Chang, J., Zhao, M., Habel, J., Kataeva, I., Xu, H., Chen, L., Lee, D., Nguyen, J., Chang, S.-H., Horanyi, P., Florence, Q., Zhou, W., Lin, D., Zhang, H., Ljundahl, L., Liu, Z.-J., Rose, J., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2004-12-21
Release date:2005-02-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Conserved hypothetical protein Cth-383 from Clostridium thermocellum
To be published
5UPD
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METHYLTRANSFERASE DOMAIN OF HUMAN WOLF-HIRSCHHORN SYNDROME CANDIDATE 1-LIKE PROTEIN 1 (WHSC1L1)
Descriptor:Histone-lysine N-methyltransferase NSD3, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION, ...
Authors:Tempel, W., Yu, W., Dong, A., Cerovina, T., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2017-02-02
Release date:2017-02-15
Last modified:2017-03-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)
To Be Published
5W1Y
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SETD8 IN COMPLEX WITH A COVALENT INHIBITOR
Descriptor:N-lysine methyltransferase KMT5A, 2-(4-methylpiperazin-1-yl)-3-(phenylsulfanyl)naphthalene-1,4-dione, UNKNOWN ATOM OR ION
Authors:Tempel, W., Yu, W., Li, Y., Blum, G., Luo, M., Pittella-Silva, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2017-06-05
Release date:2017-06-21
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:SETD8 in complex with a covalent inhibitor
to be published
1HQL
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THE XENOGRAFT ANTIGEN IN COMPLEX WITH THE B4 ISOLECTIN OF GRIFFONIA SIMPLICIFOLIA LECTIN-1
Descriptor:LECTIN, ALPHA D-GALACTOSE, METHYL-BETA-GALACTOSE, ...
Authors:Tempel, W., Lipscomb, L.A., Rose, J.P., Woods, R.J.
Deposit date:2000-12-18
Release date:2002-01-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The xenograft antigen bound to Griffonia simplicifolia lectin 1-B(4). X-ray crystal structure of the complex and molecular dynamics characterization of the binding site.
J.Biol.Chem., 277, 2002
1NXC
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STRUCTURE OF MOUSE GOLGI ALPHA-1,2-MANNOSIDASE IA REVEALS THE MOLECULAR BASIS FOR SUBSTRATE SPECIFICITY AMONG CLASS I ENZYMES (FAMILY 47 GLYCOSIDASES)
Descriptor:Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Tempel, W., Liu, Z.-J., Karaveg, K., Rose, J., Moremen, K.W., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2003-02-10
Release date:2004-05-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases
J.Biol.Chem., 279, 2004
1UPS
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GLCNAC[ALPHA]1-4GAL RELEASING ENDO-[BETA]-GALACTOSIDASE FROM CLOSTRIDIUM PERFRINGENS
Descriptor:GLCNAC-ALPHA-1,4-GAL-RELEASING ENDO-BETA-GALACTOSIDASE, CALCIUM ION
Authors:Tempel, W., Liu, Z.-J., Horanyi, P.S., Deng, L., Lee, D., Newton, M.G., Rose, J.P., Ashida, H., Li, S.-C., Li, Y.-T., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2003-10-10
Release date:2004-11-25
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Three-dimensional structure of GlcNAcalpha1-4Gal releasing endo-beta-galactosidase from Clostridium perfringens.
Proteins, 59, 2005
1XK8
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DIVALENT CATION TOLERANT PROTEIN CUTA FROM HOMO SAPIENS O60888
Descriptor:Divalent cation tolerant protein CUTA, SODIUM ION
Authors:Tempel, W., Chen, L., Liu, Z.-J., Lee, D., Shah, A., Dailey, T.A., Mayer, M.R., Arendall III, W.B., Rose, J.P., Dailey, H.A., Richardson, J.S., Richardson, D.C., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2004-09-27
Release date:2004-10-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Divalent cation tolerant protein CUTA from Homo sapiens O60888
To be published
2PXX
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HUMAN PUTATIVE METHYLTRANSFERASE MGC2408
Descriptor:Uncharacterized protein MGC2408, UNKNOWN ATOM OR ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Tempel, W., Wu, H., Dombrovsky, L., Zeng, H., Zhu, H., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
Deposit date:2007-05-14
Release date:2007-05-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene.
Proteins, 74, 2009
3KUP
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CRYSTAL STRUCTURE OF THE CBX3 CHROMO SHADOW DOMAIN
Descriptor:Chromobox protein homolog 3, UNKNOWN ATOM OR ION
Authors:Tempel, W., Li, Z., Li, Y., Kozieradzki, I., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Ouyang, H., Structural Genomics Consortium (SGC)
Deposit date:2009-11-27
Release date:2009-12-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal Structure of the CBX3 Chromo Shadow Domain
to be published
3RPX
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CRYSTAL STRUCTURE OF COMPLEMENT COMPONENT 1, Q SUBCOMPONENT BINDING PROTEIN, C1QBP
Descriptor:Complement component 1 Q subcomponent-binding protein, UNKNOWN ATOM OR ION
Authors:Tempel, W., Tong, Y., Crombet, L., Shen, Y., Guan, X., Nedyalkova, L., Walker, J.R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-04-27
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of complement component 1, q subcomponent binding protein, C1QBP
to be published
4L1M
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STRUCTURE OF THE FIRST RCC1-LIKE DOMAIN OF HERC2
Descriptor:E3 ubiquitin-protein ligase HERC2, SULFATE ION, UNKNOWN ATOM OR ION
Authors:Tempel, W., Khan, M.B., Dong, A., Hu, J., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2013-06-03
Release date:2013-07-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the first RCC1-like domain of HERC2
TO BE PUBLISHED
4PWY
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CRYSTAL STRUCTURE OF A CALMODULIN-LYSINE N-METHYLTRANSFERASE FRAGMENT
Descriptor:Calmodulin-lysine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL, ...
Authors:Tempel, W., Hong, B.S., Walker, J.R., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2014-03-21
Release date:2014-04-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a Calmodulin-lysine N-methyltransferase fragment
TO BE PUBLISHED
4QPN
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CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKE PROTEIN 21B
Descriptor:Protein-lysine methyltransferase METTL21B, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Tempel, W., Hong, B.S., Seitova, A., He, H., Li, Y., Graslund, S., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
Deposit date:2014-06-24
Release date:2014-07-09
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal Structure of Human Methyltransferase-Like Protein 21B
TO BE PUBLISHED
5C8H
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CRYSTAL STRUCTURE OF ORC2 C-TERMINAL DOMAIN
Descriptor:Origin recognition complex subunit 2, UNKNOWN ATOM OR ION
Authors:Tempel, W., Xu, C., Dong, A., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2015-06-25
Release date:2015-07-08
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of ORC2 C-terminal domain
To Be Published
5KCH
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SETDB1 IN COMPLEX WITH AN EARLY STAGE, LOW AFFINITY FRAGMENT CANDIDATE MODELLED AT REDUCED OCCUPANCY INTO WEAK ELECTRON DENSITY
Descriptor:Histone-lysine N-methyltransferase SETDB1, UNKNOWN ATOM OR ION, DIMETHYL SULFOXIDE, ...
Authors:Tempel, W., Harding, R.J., Mader, P., Dobrovetsky, E., Walker, J.R., Brown, P.J., Schapira, M., Collins, P., Pearce, N., Brandao-Neto, J., Douangamath, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Santhakumar, V., Structural Genomics Consortium (SGC)
Deposit date:2016-06-06
Release date:2016-07-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy
To Be Published
5KCO
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SETDB1 IN COMPLEX WITH AN EARLY STAGE, LOW AFFINITY FRAGMENT CANDIDATE MODELLED AT REDUCED OCCUPANCY
Descriptor:Histone-lysine N-methyltransferase SETDB1, SULFATE ION, ~{N}-(4-chlorophenyl)methanesulfonamide, ...
Authors:Tempel, W., Harding, R.J., Mader, P., Dobrovetsky, E., Walker, J.R., Brown, P.J., Schapira, M., Collins, P., Pearce, N., Brandao-Neto, J., Douangamath, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Santhakumar, V., Structural Genomics Consortium (SGC)
Deposit date:2016-06-06
Release date:2016-07-27
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy
To Be Published
6EDF
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FRAGMENT OF A TYROSINE-PROTEIN KINASE
Descriptor:FYN, GLYCEROL, UNKNOWN ATOM OR ION
Authors:Tempel, W., Huang, H., Sochirca, I., Liu, K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Sidhu, S.S., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-08-09
Release date:2018-08-29
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Fragment of a tyrosine-protein kinase
To be Published
6MEW
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RFXANK ANKYRIN REPEATS IN COMPLEX WITH A RFX7 PEPTIDE
Descriptor:DNA-binding protein RFXANK, RFX7 peptide, UNKNOWN ATOM OR ION
Authors:Tempel, W., Xu, C., Dong, A., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-09-07
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:RFXANK ankyrin repeats in complex with a RFX7 peptide
to be published
6N8U
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DRAFT MODEL OF SCHISTOSOMA JAPONICUM GLUTATHIONE S-TRANSFERASE EXPRESSION TAG
Descriptor:Glutathione S-transferase class-mu 26 kDa isozyme
Authors:Tempel, W., Dong, C.
Deposit date:2018-11-30
Release date:2019-01-16
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:DRAFT model of Schistosoma japonicum Glutathione S-transferase expression tag
To Be Published
6P9G
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STRUCTURE OF USP5 ZINC-FINGER UBIQUITIN BINDING DOMAIN CO-CRYSTALLIZED WITH 2-(4-OXOQUINAZOLIN-3(4H)-YL)PROPANOIC ACID
Descriptor:Ubiquitin carboxyl-terminal hydrolase 5, ZINC ION, (2R)-2-(4-oxoquinazolin-3(4H)-yl)propanoic acid, ...
Authors:Tempel, W., Mann, M.K., Harding, R.J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Schapira, M., Structural Genomics Consortium (SGC)
Deposit date:2019-06-10
Release date:2019-09-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 2-(4-oxoquinazolin-3(4H)-yl)propanoic acid
To Be Published
2AYV
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CRYSTAL STRUCTURE OF A PUTATIVE UBIQUITIN-CONJUGATING ENZYME E2 FROM TOXOPLASMA GONDII
Descriptor:ubiquitin-conjugating enzyme E2, UNKNOWN ATOM OR ION
Authors:Tempel, W., Dong, A., Zhao, Y., Lew, J., Alam, Z., Melone, M., Wasney, G., Kozieradzki, I., Vedadi, M., Arrowsmith, C., Sundstrom, M., Weigelt, J., Edwards, A., Bochkarev, A., Hui, R., Amani, M., Structural Genomics Consortium (SGC)
Deposit date:2005-09-08
Release date:2005-09-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
3IUF
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CRYSTAL STRUCTURE OF THE C2H2-TYPE ZINC FINGER DOMAIN OF HUMAN UBI-D4
Descriptor:Zinc finger protein ubi-d4, ZINC ION
Authors:Tempel, W., Xu, C., Bian, C., Adams-Cioaba, M., Eryilmaz, J., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2009-08-31
Release date:2009-11-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Cys2His2-type zinc finger domain of human DPF2.
Biochem.Biophys.Res.Commun., 413, 2011
3L42
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PWWP DOMAIN OF HUMAN BROMODOMAIN AND PHD FINGER CONTAINING PROTEIN 1
Descriptor:Peregrin, UNKNOWN ATOM OR ION
Authors:Tempel, W., Zeng, H., Ni, S., Amaya, M.F., Dong, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Wu, H., Structural Genomics Consortium (SGC)
Deposit date:2009-12-18
Release date:2010-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural and Histone Binding Ability Characterizations of Human PWWP Domains.
Plos One, 6, 2011
4O61
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STRUCTURE OF HUMAN ALKBH5 CRYSTALLIZED IN THE PRESENCE OF CITRATE
Descriptor:RNA demethylase ALKBH5, GLYCEROL, CITRIC ACID, ...
Authors:Tempel, W., Chao, X., Liu, K., Dong, A., Cerovina, T., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2013-12-20
Release date:2014-02-26
Last modified:2015-07-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
J.Biol.Chem., 289, 2014
4OCT
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CRYSTAL STRUCTURE OF HUMAN ALKBH5 CRYSTALLIZED IN THE PRESENCE OF MN^{2+} AND 2-OXOGLUTARATE
Descriptor:RNA demethylase ALKBH5, MANGANESE (II) ION, 2-OXOGLUTARIC ACID, ...
Authors:Tempel, W., Chao, X., Liu, K., Dong, A., Cerovina, T., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2014-01-09
Release date:2014-04-16
Last modified:2014-12-24
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
J.Biol.Chem., 289, 2014