1YBX | | CONSERVED HYPOTHETICAL PROTEIN CTH-383 FROM CLOSTRIDIUM THERMOCELLUM | | Descriptor: | Conserved hypothetical protein, UNKNOWN ATOM OR ION | | Authors: | Tempel, W., Chang, J., Zhao, M., Habel, J., Kataeva, I., Xu, H., Chen, L., Lee, D., Nguyen, J., Chang, S.-H., Horanyi, P., Florence, Q., Zhou, W., Lin, D., Zhang, H., Ljundahl, L., Liu, Z.-J., Rose, J., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2004-12-21 | | Release date: | 2005-02-01 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Conserved hypothetical protein Cth-383 from Clostridium thermocellum
To be published
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5UPD | | METHYLTRANSFERASE DOMAIN OF HUMAN WOLF-HIRSCHHORN SYNDROME CANDIDATE 1-LIKE PROTEIN 1 (WHSC1L1) | | Descriptor: | Histone-lysine N-methyltransferase NSD3, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION, ... | | Authors: | Tempel, W., Yu, W., Dong, A., Cerovina, T., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2017-02-02 | | Release date: | 2017-02-15 | | Last modified: | 2017-03-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)
To Be Published
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5W1Y | | SETD8 IN COMPLEX WITH A COVALENT INHIBITOR | | Descriptor: | N-lysine methyltransferase KMT5A, 2-(4-methylpiperazin-1-yl)-3-(phenylsulfanyl)naphthalene-1,4-dione, UNKNOWN ATOM OR ION | | Authors: | Tempel, W., Yu, W., Li, Y., Blum, G., Luo, M., Pittella-Silva, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC) | | Deposit date: | 2017-06-05 | | Release date: | 2017-06-21 | | Last modified: | 2017-07-12 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | SETD8 in complex with a covalent inhibitor
to be published
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1HQL | | THE XENOGRAFT ANTIGEN IN COMPLEX WITH THE B4 ISOLECTIN OF GRIFFONIA SIMPLICIFOLIA LECTIN-1 | | Descriptor: | LECTIN, ALPHA D-GALACTOSE, METHYL-BETA-GALACTOSE, ... | | Authors: | Tempel, W., Lipscomb, L.A., Rose, J.P., Woods, R.J. | | Deposit date: | 2000-12-18 | | Release date: | 2002-01-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The xenograft antigen bound to Griffonia simplicifolia lectin 1-B(4). X-ray crystal structure of the complex and molecular dynamics characterization of the binding site.
J.Biol.Chem., 277, 2002
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1NXC | | STRUCTURE OF MOUSE GOLGI ALPHA-1,2-MANNOSIDASE IA REVEALS THE MOLECULAR BASIS FOR SUBSTRATE SPECIFICITY AMONG CLASS I ENZYMES (FAMILY 47 GLYCOSIDASES) | | Descriptor: | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ... | | Authors: | Tempel, W., Liu, Z.-J., Karaveg, K., Rose, J., Moremen, K.W., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2003-02-10 | | Release date: | 2004-05-04 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases
J.Biol.Chem., 279, 2004
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1UPS | | GLCNAC[ALPHA]1-4GAL RELEASING ENDO-[BETA]-GALACTOSIDASE FROM CLOSTRIDIUM PERFRINGENS | | Descriptor: | GLCNAC-ALPHA-1,4-GAL-RELEASING ENDO-BETA-GALACTOSIDASE, CALCIUM ION | | Authors: | Tempel, W., Liu, Z.-J., Horanyi, P.S., Deng, L., Lee, D., Newton, M.G., Rose, J.P., Ashida, H., Li, S.-C., Li, Y.-T., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2003-10-10 | | Release date: | 2004-11-25 | | Last modified: | 2019-08-21 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Three-dimensional structure of GlcNAcalpha1-4Gal releasing endo-beta-galactosidase from Clostridium perfringens.
Proteins, 59, 2005
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1XK8 | | DIVALENT CATION TOLERANT PROTEIN CUTA FROM HOMO SAPIENS O60888 | | Descriptor: | Divalent cation tolerant protein CUTA, SODIUM ION | | Authors: | Tempel, W., Chen, L., Liu, Z.-J., Lee, D., Shah, A., Dailey, T.A., Mayer, M.R., Arendall III, W.B., Rose, J.P., Dailey, H.A., Richardson, J.S., Richardson, D.C., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2004-09-27 | | Release date: | 2004-10-19 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Divalent cation tolerant protein CUTA from Homo sapiens O60888
To be published
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2PXX | | HUMAN PUTATIVE METHYLTRANSFERASE MGC2408 | | Descriptor: | Uncharacterized protein MGC2408, UNKNOWN ATOM OR ION, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Tempel, W., Wu, H., Dombrovsky, L., Zeng, H., Zhu, H., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-05-14 | | Release date: | 2007-05-22 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene.
Proteins, 74, 2009
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3KUP | | CRYSTAL STRUCTURE OF THE CBX3 CHROMO SHADOW DOMAIN | | Descriptor: | Chromobox protein homolog 3, UNKNOWN ATOM OR ION | | Authors: | Tempel, W., Li, Z., Li, Y., Kozieradzki, I., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Ouyang, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2009-11-27 | | Release date: | 2009-12-08 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Crystal Structure of the CBX3 Chromo Shadow Domain
to be published
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3RPX | | CRYSTAL STRUCTURE OF COMPLEMENT COMPONENT 1, Q SUBCOMPONENT BINDING PROTEIN, C1QBP | | Descriptor: | Complement component 1 Q subcomponent-binding protein, UNKNOWN ATOM OR ION | | Authors: | Tempel, W., Tong, Y., Crombet, L., Shen, Y., Guan, X., Nedyalkova, L., Walker, J.R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2011-04-27 | | Release date: | 2011-05-11 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Crystal structure of complement component 1, q subcomponent binding protein, C1QBP
to be published
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4L1M | | STRUCTURE OF THE FIRST RCC1-LIKE DOMAIN OF HERC2 | | Descriptor: | E3 ubiquitin-protein ligase HERC2, SULFATE ION, UNKNOWN ATOM OR ION | | Authors: | Tempel, W., Khan, M.B., Dong, A., Hu, J., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC) | | Deposit date: | 2013-06-03 | | Release date: | 2013-07-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of the first RCC1-like domain of HERC2
TO BE PUBLISHED
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4PWY | | CRYSTAL STRUCTURE OF A CALMODULIN-LYSINE N-METHYLTRANSFERASE FRAGMENT | | Descriptor: | Calmodulin-lysine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL, ... | | Authors: | Tempel, W., Hong, B.S., Walker, J.R., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC) | | Deposit date: | 2014-03-21 | | Release date: | 2014-04-16 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of a Calmodulin-lysine N-methyltransferase fragment
TO BE PUBLISHED
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4QPN | | CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKE PROTEIN 21B | | Descriptor: | Protein-lysine methyltransferase METTL21B, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... | | Authors: | Tempel, W., Hong, B.S., Seitova, A., He, H., Li, Y., Graslund, S., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC) | | Deposit date: | 2014-06-24 | | Release date: | 2014-07-09 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Crystal Structure of Human Methyltransferase-Like Protein 21B
TO BE PUBLISHED
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5C8H | | CRYSTAL STRUCTURE OF ORC2 C-TERMINAL DOMAIN | | Descriptor: | Origin recognition complex subunit 2, UNKNOWN ATOM OR ION | | Authors: | Tempel, W., Xu, C., Dong, A., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2015-06-25 | | Release date: | 2015-07-08 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Crystal structure of ORC2 C-terminal domain
To Be Published
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5KCH | | SETDB1 IN COMPLEX WITH AN EARLY STAGE, LOW AFFINITY FRAGMENT CANDIDATE MODELLED AT REDUCED OCCUPANCY INTO WEAK ELECTRON DENSITY | | Descriptor: | Histone-lysine N-methyltransferase SETDB1, UNKNOWN ATOM OR ION, DIMETHYL SULFOXIDE, ... | | Authors: | Tempel, W., Harding, R.J., Mader, P., Dobrovetsky, E., Walker, J.R., Brown, P.J., Schapira, M., Collins, P., Pearce, N., Brandao-Neto, J., Douangamath, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Santhakumar, V., Structural Genomics Consortium (SGC) | | Deposit date: | 2016-06-06 | | Release date: | 2016-07-27 | | Last modified: | 2019-02-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy
To Be Published
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5KCO | | SETDB1 IN COMPLEX WITH AN EARLY STAGE, LOW AFFINITY FRAGMENT CANDIDATE MODELLED AT REDUCED OCCUPANCY | | Descriptor: | Histone-lysine N-methyltransferase SETDB1, SULFATE ION, ~{N}-(4-chlorophenyl)methanesulfonamide, ... | | Authors: | Tempel, W., Harding, R.J., Mader, P., Dobrovetsky, E., Walker, J.R., Brown, P.J., Schapira, M., Collins, P., Pearce, N., Brandao-Neto, J., Douangamath, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Santhakumar, V., Structural Genomics Consortium (SGC) | | Deposit date: | 2016-06-06 | | Release date: | 2016-07-27 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy
To Be Published
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6EDF | | FRAGMENT OF A TYROSINE-PROTEIN KINASE | | Descriptor: | FYN, GLYCEROL, UNKNOWN ATOM OR ION | | Authors: | Tempel, W., Huang, H., Sochirca, I., Liu, K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Sidhu, S.S., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2018-08-09 | | Release date: | 2018-08-29 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Fragment of a tyrosine-protein kinase
To be Published
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6MEW | | RFXANK ANKYRIN REPEATS IN COMPLEX WITH A RFX7 PEPTIDE | | Descriptor: | DNA-binding protein RFXANK, RFX7 peptide, UNKNOWN ATOM OR ION | | Authors: | Tempel, W., Xu, C., Dong, A., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2018-09-07 | | Release date: | 2018-10-03 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | RFXANK ankyrin repeats in complex with a RFX7 peptide
to be published
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6N8U | |
6P9G | | STRUCTURE OF USP5 ZINC-FINGER UBIQUITIN BINDING DOMAIN CO-CRYSTALLIZED WITH 2-(4-OXOQUINAZOLIN-3(4H)-YL)PROPANOIC ACID | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 5, ZINC ION, (2R)-2-(4-oxoquinazolin-3(4H)-yl)propanoic acid, ... | | Authors: | Tempel, W., Mann, M.K., Harding, R.J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Schapira, M., Structural Genomics Consortium (SGC) | | Deposit date: | 2019-06-10 | | Release date: | 2019-09-18 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 2-(4-oxoquinazolin-3(4H)-yl)propanoic acid
To Be Published
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2AYV | | CRYSTAL STRUCTURE OF A PUTATIVE UBIQUITIN-CONJUGATING ENZYME E2 FROM TOXOPLASMA GONDII | | Descriptor: | ubiquitin-conjugating enzyme E2, UNKNOWN ATOM OR ION | | Authors: | Tempel, W., Dong, A., Zhao, Y., Lew, J., Alam, Z., Melone, M., Wasney, G., Kozieradzki, I., Vedadi, M., Arrowsmith, C., Sundstrom, M., Weigelt, J., Edwards, A., Bochkarev, A., Hui, R., Amani, M., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-09-08 | | Release date: | 2005-09-20 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.001 Å) | | Cite: | Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
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3IUF | | CRYSTAL STRUCTURE OF THE C2H2-TYPE ZINC FINGER DOMAIN OF HUMAN UBI-D4 | | Descriptor: | Zinc finger protein ubi-d4, ZINC ION | | Authors: | Tempel, W., Xu, C., Bian, C., Adams-Cioaba, M., Eryilmaz, J., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2009-08-31 | | Release date: | 2009-11-03 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the Cys2His2-type zinc finger domain of human DPF2.
Biochem.Biophys.Res.Commun., 413, 2011
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3L42 | | PWWP DOMAIN OF HUMAN BROMODOMAIN AND PHD FINGER CONTAINING PROTEIN 1 | | Descriptor: | Peregrin, UNKNOWN ATOM OR ION | | Authors: | Tempel, W., Zeng, H., Ni, S., Amaya, M.F., Dong, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Wu, H., Structural Genomics Consortium (SGC) | | Deposit date: | 2009-12-18 | | Release date: | 2010-01-12 | | Last modified: | 2017-11-01 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structural and Histone Binding Ability Characterizations of Human PWWP Domains.
Plos One, 6, 2011
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4O61 | | STRUCTURE OF HUMAN ALKBH5 CRYSTALLIZED IN THE PRESENCE OF CITRATE | | Descriptor: | RNA demethylase ALKBH5, GLYCEROL, CITRIC ACID, ... | | Authors: | Tempel, W., Chao, X., Liu, K., Dong, A., Cerovina, T., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2013-12-20 | | Release date: | 2014-02-26 | | Last modified: | 2015-07-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
J.Biol.Chem., 289, 2014
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4OCT | | CRYSTAL STRUCTURE OF HUMAN ALKBH5 CRYSTALLIZED IN THE PRESENCE OF MN^{2+} AND 2-OXOGLUTARATE | | Descriptor: | RNA demethylase ALKBH5, MANGANESE (II) ION, 2-OXOGLUTARIC ACID, ... | | Authors: | Tempel, W., Chao, X., Liu, K., Dong, A., Cerovina, T., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC) | | Deposit date: | 2014-01-09 | | Release date: | 2014-04-16 | | Last modified: | 2014-12-24 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
J.Biol.Chem., 289, 2014
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