Author results

1YBX
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CONSERVED HYPOTHETICAL PROTEIN CTH-383 FROM CLOSTRIDIUM THERMOCELLUM
分子名称:Conserved hypothetical protein, UNKNOWN ATOM OR ION
著者Tempel, W., Chang, J., Zhao, M., Habel, J., Kataeva, I., Xu, H., Chen, L., Lee, D., Nguyen, J., Chang, S.-H., Horanyi, P., Florence, Q., Zhou, W., Lin, D., Zhang, H., Ljundahl, L., Liu, Z.-J., Rose, J., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
登録日2004-12-21
公開日2005-02-01
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Conserved hypothetical protein Cth-383 from Clostridium thermocellum
To be published
5UPD
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METHYLTRANSFERASE DOMAIN OF HUMAN WOLF-HIRSCHHORN SYNDROME CANDIDATE 1-LIKE PROTEIN 1 (WHSC1L1)
分子名称:Histone-lysine N-methyltransferase NSD3, S-ADENOSYLMETHIONINE, UNKNOWN ATOM OR ION, ...
著者Tempel, W., Yu, W., Dong, A., Cerovina, T., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
登録日2017-02-02
公開日2017-02-15
最終更新日2017-03-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)
To Be Published
5W1Y
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SETD8 IN COMPLEX WITH A COVALENT INHIBITOR
分子名称:N-lysine methyltransferase KMT5A, 2-(4-methylpiperazin-1-yl)-3-(phenylsulfanyl)naphthalene-1,4-dione, UNKNOWN ATOM OR ION
著者Tempel, W., Yu, W., Li, Y., Blum, G., Luo, M., Pittella-Silva, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
登録日2017-06-05
公開日2017-06-21
最終更新日2017-07-12
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献SETD8 in complex with a covalent inhibitor
to be published
1HQL
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THE XENOGRAFT ANTIGEN IN COMPLEX WITH THE B4 ISOLECTIN OF GRIFFONIA SIMPLICIFOLIA LECTIN-1
分子名称:LECTIN, ALPHA D-GALACTOSE, METHYL-BETA-GALACTOSE, ...
著者Tempel, W., Lipscomb, L.A., Rose, J.P., Woods, R.J.
登録日2000-12-18
公開日2002-01-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The xenograft antigen bound to Griffonia simplicifolia lectin 1-B(4). X-ray crystal structure of the complex and molecular dynamics characterization of the binding site.
J.Biol.Chem., 277, 2002
1NXC
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STRUCTURE OF MOUSE GOLGI ALPHA-1,2-MANNOSIDASE IA REVEALS THE MOLECULAR BASIS FOR SUBSTRATE SPECIFICITY AMONG CLASS I ENZYMES (FAMILY 47 GLYCOSIDASES)
分子名称:Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Tempel, W., Liu, Z.-J., Karaveg, K., Rose, J., Moremen, K.W., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
登録日2003-02-10
公開日2004-05-04
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases
J.Biol.Chem., 279, 2004
1UPS
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GLCNAC[ALPHA]1-4GAL RELEASING ENDO-[BETA]-GALACTOSIDASE FROM CLOSTRIDIUM PERFRINGENS
分子名称:GLCNAC-ALPHA-1,4-GAL-RELEASING ENDO-BETA-GALACTOSIDASE, CALCIUM ION
著者Tempel, W., Liu, Z.-J., Horanyi, P.S., Deng, L., Lee, D., Newton, M.G., Rose, J.P., Ashida, H., Li, S.-C., Li, Y.-T., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
登録日2003-10-10
公開日2004-11-25
最終更新日2019-08-21
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Three-dimensional structure of GlcNAcalpha1-4Gal releasing endo-beta-galactosidase from Clostridium perfringens.
Proteins, 59, 2005
1XK8
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DIVALENT CATION TOLERANT PROTEIN CUTA FROM HOMO SAPIENS O60888
分子名称:Divalent cation tolerant protein CUTA, SODIUM ION
著者Tempel, W., Chen, L., Liu, Z.-J., Lee, D., Shah, A., Dailey, T.A., Mayer, M.R., Arendall III, W.B., Rose, J.P., Dailey, H.A., Richardson, J.S., Richardson, D.C., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
登録日2004-09-27
公開日2004-10-19
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Divalent cation tolerant protein CUTA from Homo sapiens O60888
To be published
2PXX
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HUMAN PUTATIVE METHYLTRANSFERASE MGC2408
分子名称:Uncharacterized protein MGC2408, UNKNOWN ATOM OR ION, S-ADENOSYL-L-HOMOCYSTEINE
著者Tempel, W., Wu, H., Dombrovsky, L., Zeng, H., Zhu, H., Loppnau, P., Weigelt, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Plotnikov, A.N., Structural Genomics Consortium (SGC)
登録日2007-05-14
公開日2007-05-22
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene.
Proteins, 74, 2009
3KUP
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CRYSTAL STRUCTURE OF THE CBX3 CHROMO SHADOW DOMAIN
分子名称:Chromobox protein homolog 3, UNKNOWN ATOM OR ION
著者Tempel, W., Li, Z., Li, Y., Kozieradzki, I., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Ouyang, H., Structural Genomics Consortium (SGC)
登録日2009-11-27
公開日2009-12-08
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Crystal Structure of the CBX3 Chromo Shadow Domain
to be published
3RPX
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CRYSTAL STRUCTURE OF COMPLEMENT COMPONENT 1, Q SUBCOMPONENT BINDING PROTEIN, C1QBP
分子名称:Complement component 1 Q subcomponent-binding protein, UNKNOWN ATOM OR ION
著者Tempel, W., Tong, Y., Crombet, L., Shen, Y., Guan, X., Nedyalkova, L., Walker, J.R., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Genomics Consortium (SGC)
登録日2011-04-27
公開日2011-05-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal structure of complement component 1, q subcomponent binding protein, C1QBP
to be published
4L1M
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STRUCTURE OF THE FIRST RCC1-LIKE DOMAIN OF HERC2
分子名称:E3 ubiquitin-protein ligase HERC2, SULFATE ION, UNKNOWN ATOM OR ION
著者Tempel, W., Khan, M.B., Dong, A., Hu, J., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
登録日2013-06-03
公開日2013-07-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of the first RCC1-like domain of HERC2
TO BE PUBLISHED
4PWY
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CRYSTAL STRUCTURE OF A CALMODULIN-LYSINE N-METHYLTRANSFERASE FRAGMENT
分子名称:Calmodulin-lysine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL, ...
著者Tempel, W., Hong, B.S., Walker, J.R., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
登録日2014-03-21
公開日2014-04-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a Calmodulin-lysine N-methyltransferase fragment
TO BE PUBLISHED
4QPN
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CRYSTAL STRUCTURE OF HUMAN METHYLTRANSFERASE-LIKE PROTEIN 21B
分子名称:Protein-lysine methyltransferase METTL21B, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
著者Tempel, W., Hong, B.S., Seitova, A., He, H., Li, Y., Graslund, S., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
登録日2014-06-24
公開日2014-07-09
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Crystal Structure of Human Methyltransferase-Like Protein 21B
TO BE PUBLISHED
5C8H
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CRYSTAL STRUCTURE OF ORC2 C-TERMINAL DOMAIN
分子名称:Origin recognition complex subunit 2, UNKNOWN ATOM OR ION
著者Tempel, W., Xu, C., Dong, A., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2015-06-25
公開日2015-07-08
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Crystal structure of ORC2 C-terminal domain
To Be Published
5KCH
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SETDB1 IN COMPLEX WITH AN EARLY STAGE, LOW AFFINITY FRAGMENT CANDIDATE MODELLED AT REDUCED OCCUPANCY INTO WEAK ELECTRON DENSITY
分子名称:Histone-lysine N-methyltransferase SETDB1, UNKNOWN ATOM OR ION, DIMETHYL SULFOXIDE, ...
著者Tempel, W., Harding, R.J., Mader, P., Dobrovetsky, E., Walker, J.R., Brown, P.J., Schapira, M., Collins, P., Pearce, N., Brandao-Neto, J., Douangamath, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Santhakumar, V., Structural Genomics Consortium (SGC)
登録日2016-06-06
公開日2016-07-27
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy
To Be Published
5KCO
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SETDB1 IN COMPLEX WITH AN EARLY STAGE, LOW AFFINITY FRAGMENT CANDIDATE MODELLED AT REDUCED OCCUPANCY
分子名称:Histone-lysine N-methyltransferase SETDB1, SULFATE ION, ~{N}-(4-chlorophenyl)methanesulfonamide, ...
著者Tempel, W., Harding, R.J., Mader, P., Dobrovetsky, E., Walker, J.R., Brown, P.J., Schapira, M., Collins, P., Pearce, N., Brandao-Neto, J., Douangamath, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Santhakumar, V., Structural Genomics Consortium (SGC)
登録日2016-06-06
公開日2016-07-27
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy
To Be Published
6EDF
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FRAGMENT OF A TYROSINE-PROTEIN KINASE
分子名称:FYN, GLYCEROL, UNKNOWN ATOM OR ION
著者Tempel, W., Huang, H., Sochirca, I., Liu, K., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Sidhu, S.S., Min, J., Structural Genomics Consortium (SGC)
登録日2018-08-09
公開日2018-08-29
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Fragment of a tyrosine-protein kinase
To be Published
6MEW
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RFXANK ANKYRIN REPEATS IN COMPLEX WITH A RFX7 PEPTIDE
分子名称:DNA-binding protein RFXANK, RFX7 peptide, UNKNOWN ATOM OR ION
著者Tempel, W., Xu, C., Dong, A., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2018-09-07
公開日2018-10-03
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献RFXANK ankyrin repeats in complex with a RFX7 peptide
to be published
6N8U
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DRAFT MODEL OF SCHISTOSOMA JAPONICUM GLUTATHIONE S-TRANSFERASE EXPRESSION TAG
分子名称:Glutathione S-transferase class-mu 26 kDa isozyme
著者Tempel, W., Dong, C.
登録日2018-11-30
公開日2019-01-16
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献DRAFT model of Schistosoma japonicum Glutathione S-transferase expression tag
To Be Published
6P9G
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STRUCTURE OF USP5 ZINC-FINGER UBIQUITIN BINDING DOMAIN CO-CRYSTALLIZED WITH 2-(4-OXOQUINAZOLIN-3(4H)-YL)PROPANOIC ACID
分子名称:Ubiquitin carboxyl-terminal hydrolase 5, ZINC ION, (2R)-2-(4-oxoquinazolin-3(4H)-yl)propanoic acid, ...
著者Tempel, W., Mann, M.K., Harding, R.J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Schapira, M., Structural Genomics Consortium (SGC)
登録日2019-06-10
公開日2019-09-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 2-(4-oxoquinazolin-3(4H)-yl)propanoic acid
To Be Published
2AYV
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CRYSTAL STRUCTURE OF A PUTATIVE UBIQUITIN-CONJUGATING ENZYME E2 FROM TOXOPLASMA GONDII
分子名称:ubiquitin-conjugating enzyme E2, UNKNOWN ATOM OR ION
著者Tempel, W., Dong, A., Zhao, Y., Lew, J., Alam, Z., Melone, M., Wasney, G., Kozieradzki, I., Vedadi, M., Arrowsmith, C., Sundstrom, M., Weigelt, J., Edwards, A., Bochkarev, A., Hui, R., Amani, M., Structural Genomics Consortium (SGC)
登録日2005-09-08
公開日2005-09-20
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
3IUF
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CRYSTAL STRUCTURE OF THE C2H2-TYPE ZINC FINGER DOMAIN OF HUMAN UBI-D4
分子名称:Zinc finger protein ubi-d4, ZINC ION
著者Tempel, W., Xu, C., Bian, C., Adams-Cioaba, M., Eryilmaz, J., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Structural Genomics Consortium (SGC)
登録日2009-08-31
公開日2009-11-03
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of the Cys2His2-type zinc finger domain of human DPF2.
Biochem.Biophys.Res.Commun., 413, 2011
3L42
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PWWP DOMAIN OF HUMAN BROMODOMAIN AND PHD FINGER CONTAINING PROTEIN 1
分子名称:Peregrin, UNKNOWN ATOM OR ION
著者Tempel, W., Zeng, H., Ni, S., Amaya, M.F., Dong, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Wu, H., Structural Genomics Consortium (SGC)
登録日2009-12-18
公開日2010-01-12
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structural and Histone Binding Ability Characterizations of Human PWWP Domains.
Plos One, 6, 2011
4O61
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STRUCTURE OF HUMAN ALKBH5 CRYSTALLIZED IN THE PRESENCE OF CITRATE
分子名称:RNA demethylase ALKBH5, GLYCEROL, CITRIC ACID, ...
著者Tempel, W., Chao, X., Liu, K., Dong, A., Cerovina, T., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2013-12-20
公開日2014-02-26
最終更新日2015-07-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
J.Biol.Chem., 289, 2014
4OCT
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CRYSTAL STRUCTURE OF HUMAN ALKBH5 CRYSTALLIZED IN THE PRESENCE OF MN^{2+} AND 2-OXOGLUTARATE
分子名称:RNA demethylase ALKBH5, MANGANESE (II) ION, 2-OXOGLUTARIC ACID, ...
著者Tempel, W., Chao, X., Liu, K., Dong, A., Cerovina, T., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-01-09
公開日2014-04-16
最終更新日2014-12-24
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
J.Biol.Chem., 289, 2014