2KH2
 
 | | Solution structure of a scFv-IL-1B complex | | Descriptor: | Interleukin-1 beta, scFv | | Authors: | Wilkinson, I.C, Hall, C.J, Veverka, V, Muskett, F.W, Stephens, P.E, Taylor, R.J, Henry, A.J, Carr, M.D. | | Deposit date: | 2009-03-23 | | Release date: | 2009-09-08 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development.
J.Biol.Chem., 284, 2009
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2K8P
 | | Characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation | | Descriptor: | Sclerostin | | Authors: | Veverka, V, Henry, A.J, Slocombe, P.M, Ventom, A, Mulloy, B, Muskett, F.W, Muzylak, M, Greenslade, K, Moore, A, Zhang, L, Gong, J, Qian, X, Paszty, C, Taylor, R.J, Robinson, M.K, Carr, M.D. | | Deposit date: | 2008-09-18 | | Release date: | 2009-02-17 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation
J.Biol.Chem., 284, 2009
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2L3Y
 | | Solution structure of mouse IL-6 | | Descriptor: | Interleukin-6 | | Authors: | Veverka, V, Redpath, N.T, Carrington, B, Muskett, F.W, Taylor, R.J, Henry, A.J, Carr, M.D. | | Deposit date: | 2010-09-25 | | Release date: | 2011-09-28 | | Last modified: | 2013-01-02 | | Method: | SOLUTION NMR | | Cite: | Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
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2NPU
 | | The solution structure of the rapamycin-binding domain of mTOR (FRB) | | Descriptor: | FKBP12-rapamycin complex-associated protein | | Authors: | Veverka, V, Crabbe, T, Bird, I, Lennie, G, Muskett, F.W, Taylor, R.J, Carr, M.D. | | Deposit date: | 2006-10-30 | | Release date: | 2007-09-18 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27, 2008
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1RD4
 | | An allosteric inhibitor of LFA-1 bound to its I-domain | | Descriptor: | 1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHENYL}PYRIDIN-2-YL)PIPERAZINE, Integrin alpha-L | | Authors: | Crump, M.P, Ceska, T.A, Spyracopoulos, L, Henry, A, Archibald, S.C, Alexander, R, Taylor, R.J, Findlow, S.C, O'Connell, J, Robinson, M.K, Shock, A. | | Deposit date: | 2003-11-05 | | Release date: | 2004-03-30 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry
Biochemistry, 43, 2004
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5O57
 | | Solution Structure of the N-terminal Region of Dkk4 | | Descriptor: | Dickkopf-related protein 4 | | Authors: | Waters, L.C, Patel, S, Barkell, A.M, Muskett, F.W, Robinson, M.K, Holdsworth, G, Carr, M.D. | | Deposit date: | 2017-06-01 | | Release date: | 2018-06-13 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
J. Biol. Chem., 293, 2018
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6MJP
 | | LptB(E163Q)FGC from Vibrio cholerae | | Descriptor: | 2-(2-ETHOXYETHOXY)ETHANOL, 6-cyclohexylhexyl beta-D-glucopyranoside, ABC transporter ATP-binding protein, ... | | Authors: | Owens, T.W, Kahne, D, Kruse, A.C. | | Deposit date: | 2018-09-21 | | Release date: | 2019-03-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structural basis of unidirectional export of lipopolysaccharide to the cell surface.
Nature, 567, 2019
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6MIT
 | | LptBFGC from Enterobacter cloacae | | Descriptor: | CHLORIDE ION, LPS export ABC transporter permease LptF, Lipopolysaccharide export system ATP-binding protein, ... | | Authors: | Owens, T.W, Kahne, D, Kruse, A.C. | | Deposit date: | 2018-09-20 | | Release date: | 2019-03-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural basis of unidirectional export of lipopolysaccharide to the cell surface.
Nature, 567, 2019
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7PQP
 | | tau-microtubule structural ensemble based on CryoEM data | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Isoform Tau-F of Microtubule-associated protein tau, ... | | Authors: | Brotzakis, Z.F, Vendruscolo, M. | | Deposit date: | 2021-09-18 | | Release date: | 2021-12-15 | | Last modified: | 2022-01-12 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms.
Acs Cent.Sci., 7, 2021
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7PQC
 | | tau-microtubule structural ensemble based on CryoEM data | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Isoform Tau-F of Microtubule-associated protein tau, ... | | Authors: | Brotzakis, Z.F, Vendruscolo, M. | | Deposit date: | 2021-09-16 | | Release date: | 2021-12-15 | | Last modified: | 2022-01-12 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms.
Acs Cent.Sci., 7, 2021
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6Z3X
 | | Crystal structure of the designed antibody DesAb-anti-HSA-P1 | | Descriptor: | CACODYLATE ION, DesAb-anti-HSA-P1, IMIDAZOLE, ... | | Authors: | Costanzi, E, Sormanni, P, Ricagno, S. | | Deposit date: | 2020-05-22 | | Release date: | 2021-03-31 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Fragment-based computational design of antibodies targeting structured epitopes.
Sci Adv, 8, 2022
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7OUB
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8CDG
 | | Crystal structure of human IL-17A cytokine in complex with macrocycle | | Descriptor: | (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid, Interleukin-17A | | Authors: | Schulze, M.-S. | | Deposit date: | 2023-01-30 | | Release date: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.
Chem Sci, 14, 2023
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