Author results

1RD4
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AN ALLOSTERIC INHIBITOR OF LFA-1 BOUND TO ITS I-DOMAIN
Descriptor:Integrin alpha-L, 1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHENYL}PYRIDIN-2-YL)PIPERAZINE
Authors:Crump, M.P., Ceska, T.A., Spyracopoulos, L., Henry, A., Archibald, S.C., Alexander, R., Taylor, R.J., Findlow, S.C., O'Connell, J., Robinson, M.K., Shock, A.
Deposit date:2003-11-05
Release date:2004-03-30
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry
Biochemistry, 43, 2004
2K8P
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CHARACTERISATION OF THE STRUCTURAL FEATURES AND INTERACTIONS OF SCLEROSTIN: MOLECULAR INSIGHT INTO A KEY REGULATOR OF WNT-MEDIATED BONE FORMATION
Descriptor:Sclerostin
Authors:Veverka, V., Henry, A.J., Slocombe, P.M., Ventom, A., Mulloy, B., Muskett, F.W., Muzylak, M., Greenslade, K., Moore, A., Zhang, L., Gong, J., Qian, X., Paszty, C., Taylor, R.J., Robinson, M.K., Carr, M.D.
Deposit date:2008-09-18
Release date:2009-02-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation
J.Biol.Chem., 284, 2009
2KH2
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SOLUTION STRUCTURE OF A SCFV-IL-1B COMPLEX
Descriptor:Interleukin-1 beta, scFv
Authors:Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D.
Deposit date:2009-03-23
Release date:2009-09-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development.
J.Biol.Chem., 284, 2009
2L3Y
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SOLUTION STRUCTURE OF MOUSE IL-6
Descriptor:Interleukin-6
Authors:Veverka, V., Redpath, N.T., Carrington, B., Muskett, F.W., Taylor, R.J., Henry, A.J., Carr, M.D.
Deposit date:2010-09-25
Release date:2011-09-28
Last modified:2013-01-02
Method:SOLUTION NMR
Cite:Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
2NPU
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THE SOLUTION STRUCTURE OF THE RAPAMYCIN-BINDING DOMAIN OF MTOR (FRB)
Descriptor:FKBP12-rapamycin complex-associated protein
Authors:Veverka, V., Crabbe, T., Bird, I., Lennie, G., Muskett, F.W., Taylor, R.J., Carr, M.D.
Deposit date:2006-10-30
Release date:2007-09-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
Oncogene, 27, 2008
5O57
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SOLUTION STRUCTURE OF THE N-TERMINAL REGION OF DKK4
Descriptor:Dickkopf-related protein 4
Authors:Waters, L.C., Patel, S., Barkell, A.M., Muskett, F.W., Robinson, M.K., Holdsworth, G., Carr, M.D.
Deposit date:2017-06-01
Release date:2018-06-13
Last modified:2018-08-15
Method:SOLUTION NMR
Cite:Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
J. Biol. Chem., 293, 2018
6MIT
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LPTBFGC FROM ENTEROBACTER CLOACAE
Descriptor:Lipopolysaccharide export system ATP-binding protein, Lipopolysaccharide export system protein LptC, LPS export ABC transporter permease LptF, ...
Authors:Owens, T.W., Kahne, D., Kruse, A.C.
Deposit date:2018-09-20
Release date:2019-03-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of unidirectional export of lipopolysaccharide to the cell surface.
Nature, 567, 2019
6MJP
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LPTB(E163Q)FGC FROM VIBRIO CHOLERAE
Descriptor:ABC transporter ATP-binding protein, Lipopolysaccharide export system protein LptC, FIG000988: Predicted permease, ...
Authors:Owens, T.W., Kahne, D., Kruse, A.C.
Deposit date:2018-09-21
Release date:2019-03-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of unidirectional export of lipopolysaccharide to the cell surface.
Nature, 567, 2019