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5COM
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CRYSTAL STRUCTURE OF UNCHARACTERIZED PROTEIN Q187F5 FROM CLOSTRIDIUM DIFFICILE 630
Descriptor:Putative conjugative transposon protein Tn1549-like, CTn5-Orf2, D(-)-TARTARIC ACID, ...
Authors:Taylor, J.D., Taylor, G., Matthews, S.J.
Deposit date:2015-07-20
Release date:2016-02-03
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.
J.Mol.Biol., 428, 2016
5CIV
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SIBLING LETHAL FACTOR PRECURSOR - DFSB
Descriptor:Sibling bacteriocin
Authors:Taylor, J.D., Matthews, S.J.
Deposit date:2015-07-13
Release date:2016-02-03
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.384 Å)
Cite:Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.
J.Mol.Biol., 428, 2016
5COF
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CRYSTAL STRUCTURE OF UNCHARACTERISED PROTEIN Q1R1X2 FROM ESCHERICHIA COLI UTI89
Descriptor:Uncharacterized protein, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ...
Authors:Taylor, J.D., Hare, S., Matthews, S.J.
Deposit date:2015-07-20
Release date:2016-02-03
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.
J.Mol.Biol., 428, 2016
5COG
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CRYSTAL STRUCTURE OF YEAST IRC4
Descriptor:IRC4, PHOSPHATE ION, CHLORIDE ION, ...
Authors:Taylor, J.D., Matthews, S.J.
Deposit date:2015-07-20
Release date:2016-02-03
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.613 Å)
Cite:Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.
J.Mol.Biol., 428, 2016
5CQV
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CRYSTAL STRUCTURE OF UNCHARACTERIZED PROTEIN Q8DWV2 FROM STREPTOCOCCUS AGALACTIAE
Descriptor:Uncharacterized protein, (4S)-2-METHYL-2,4-PENTANEDIOL, (4R)-2-METHYLPENTANE-2,4-DIOL
Authors:Taylor, J.D., Hare, S., Matthews, S.J.
Deposit date:2015-07-22
Release date:2016-02-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.
J.Mol.Biol., 428, 2016
2JYQ
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NMR STRUCTURE OF THE APO V-SRC SH2 DOMAIN
Descriptor:Tyrosine-protein kinase transforming protein Src
Authors:Taylor, J.D., Ababou, A., Williams, M.A., Ladbury, J.E.
Deposit date:2007-12-17
Release date:2008-06-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: Implications for drug design
Proteins, 73, 2008
2Y2T
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E. COLI CSGC IN REDUCED FORM
Descriptor:CURLI PRODUCTION PROTEIN CSGC
Authors:Taylor, J.D., Salgado, P.S., Cota, E., Matthews, S.J.
Deposit date:2010-12-16
Release date:2011-09-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Atomic Resolution Insights Into Curli Fiber Biogenesis.
Structure, 19, 2011
2Y2Y
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OXIDISED FORM OF E. COLI CSGC
Descriptor:CURLI PRODUCTION PROTEIN CSGC, ACETATE ION
Authors:Taylor, J.D., Salgado, P.S., Constable, S.C., Cota, E., Mathews, S.J.
Deposit date:2010-12-16
Release date:2011-09-21
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Atomic Resolution Insights Into Curli Fiber Biogenesis.
Structure, 19, 2011
2N59
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SOLUTION STRUCTURE OF R. PALUSTRIS CSGH
Descriptor:Putative uncharacterized protein CsgH
Authors:Hawthorne, W.J., Taylor, J.D., Escalera-Maurer, A., Lambert, S., Koch, M., Scull, N., Sefer, L., Xu, Y., Matthews, S.J.
Deposit date:2015-07-13
Release date:2016-05-11
Method:SOLUTION NMR
Cite:Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones.
Sci Rep, 6, 2016
2XSK
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E. COLI CURLI PROTEIN CSGC - SECYS
Descriptor:CSGC, ACETATE ION
Authors:Salgado, P.S., Taylor, J.D., Cota, E., Matthews, S.J.
Deposit date:2010-09-29
Release date:2010-12-29
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Extending the Usability of the Phasing Power of Diselenide Bonds: Secys Sad Phasing of Csgc Using a Non-Auxotrophic Strain.
Acta Crystallogr.,Sect.D, 67, 2011
5KH2
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CRYSTAL STRUCTURE OF STEPTOCOCCUS PNEUMONIAE UNDECAPRENYL PYROPHOSPHATE SYNTHASE (UPPS)
Descriptor:Isoprenyl transferase
Authors:Concha, N.O.
Deposit date:2016-06-14
Release date:2016-07-20
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase.
J.Med.Chem., 59, 2016
5KH4
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CRYSTAL STRUCTURE OF STEPTOCOCCUS PNEUMONIAE UNDECAPRENYL PYROPHOSPHATE SYNTHASE (UPPS) WITH FARNESYL DIPHOSPHATE
Descriptor:Isoprenyl transferase, FARNESYL DIPHOSPHATE
Authors:Concha, N.O.
Deposit date:2016-06-14
Release date:2016-07-20
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase.
J.Med.Chem., 59, 2016
5KH5
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CRYSTAL STRUCTURE OF STEPTOCOCCUS PNEUMONIAE UNDECAPRENYL PYROPHOSPHATE SYNTHASE (UPPS) IN COMPLEX WITH ~{N}-(3-AZANYL-3-OXIDANYLIDENE-PROPYL)-5-(1-BENZOTHIOPHEN-5-YL)-1-(PHENYLMETHYL)-~{N}-[(4-PROPAN-2-YLOXYPHENYL)METHYL]PYRAZOLE-4-CARBOXAMIDE
Descriptor:Isoprenyl transferase, ~{N}-(3-azanyl-3-oxidanylidene-propyl)-5-(1-benzothiophen-5-yl)-1-(phenylmethyl)-~{N}-[(4-propan-2-yloxyphenyl)methyl]pyrazole-4-carboxamide
Authors:Concha, N.O.
Deposit date:2016-06-14
Release date:2016-07-20
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase.
J.Med.Chem., 59, 2016
2KUB
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SOLUTION STRUCTURE OF THE ALPHA SUBDOMAIN OF THE MAJOR NON-REPEAT UNIT OF FAP1 FIMBRIAE OF STREPTOCOCCUS PARASANGUIS
Descriptor:Fimbriae-associated protein Fap1
Authors:Ramboarina, S., Garnett, J.A., Bodey, A., Simpson, P., Bardiaux, B., Nilges, M., Matthews, S.
Deposit date:2010-02-17
Release date:2010-07-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into serine-rich fimbriae from gram-positive bacteria.
J.Biol.Chem., 2010
2X12
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PH-INDUCED MODULATION OF STREPTOCOCCUS PARASANGUINIS ADHESION BY FAP1 FIMBRIAE
Descriptor:FIMBRIAE-ASSOCIATED PROTEIN FAP1
Authors:Ramboarina, S., Murray, J.W., Garnett, J., Matthews, S.
Deposit date:2009-12-21
Release date:2010-07-07
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Insights Into Serine-Rich Fimbriae from Gram-Positive Bacteria.
J.Biol.Chem., 285, 2010
2Y7L
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STRUCTURE OF N-TERMINAL DOMAIN OF CANDIDA ALBICANS ALS9-2 IN COMPLEX WITH HUMAN FIBRINOGEN GAMMA PEPTIDE
Descriptor:AGGLUTININ-LIKE ALS9 PROTEIN, FIBRINOGEN GAMMA CHAIN, ISOFORM CRA_A
Authors:Salgado, P.S., Cota, E.
Deposit date:2011-01-31
Release date:2011-10-05
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural Basis for the Broad Specificity to Host- Cell Ligands by the Pathogenic Fungus Candida Albicans.
Proc.Natl.Acad.Sci.USA, 108, 2011
2Y7M
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STRUCTURE OF N-TERMINAL DOMAIN OF CANDIDA ALBICANS ALS9-2 (PT DERIVATIVE)
Descriptor:AGGLUTININ-LIKE ALS9 PROTEIN
Authors:Salgado, P.S., Cota, E.
Deposit date:2011-01-31
Release date:2011-10-05
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans.
Proc. Natl. Acad. Sci. U.S.A., 108, 2011
2Y7N
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STRUCTURE OF N-TERMINAL DOMAIN OF CANDIDA ALBICANS ALS9-2 - APO FORM
Descriptor:AGGLUTININ-LIKE ALS9 PROTEIN
Authors:Salgado, P.S., Cota, E.
Deposit date:2011-01-31
Release date:2011-10-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for the Broad Specificity to Host- Cell Ligands by the Pathogenic Fungus Candida Albicans.
Proc.Natl.Acad.Sci.USA, 108, 2011
2Y7O
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STRUCTURE OF N-TERMINAL DOMAIN OF CANDIDA ALBICANS ALS9-2 - G299W MUTANT
Descriptor:AGGLUTININ-LIKE ALS9 PROTEIN
Authors:Salgado, P.S., Burchell, L., Cota, E.
Deposit date:2011-01-31
Release date:2011-10-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for the Broad Specificity to Host- Cell Ligands by the Pathogenic Fungus Candida Albicans.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YLH
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STRUCTURE OF N-TERMINAL DOMAIN OF CANDIDA ALBICANS ALS9-2 G299W MUTANT
Descriptor:AGGLUTININ-LIKE PROTEIN
Authors:Salgado, P.S., Burchell, L., Cota, E.
Deposit date:2011-06-02
Release date:2011-10-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for the Broad Specificity to Host- Cell Ligands by the Pathogenic Fungus Candida Albicans.
Proc.Natl.Acad.Sci.USA, 108, 2011
4G31
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CRYSTAL STRUCTURE OF GSK6414 BOUND TO PERK (R587-R1092, DELETE A660-T867) AT 2.28 A RESOLUTION
Descriptor:Eukaryotic translation initiation factor 2-alpha kinase 3, GLYCEROL, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone
Authors:Gampe, R.T., Axten, J.M.
Deposit date:2012-07-13
Release date:2012-08-08
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK).
J.Med.Chem., 55, 2012
4G34
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CRYSTAL STRUCTURE OF GSK6924 BOUND TO PERK (R587-R1092, DELETE A660-T867) AT 2.70 A RESOLUTION
Descriptor:Eukaryotic translation initiation factor 2-alpha kinase 3, 1-[5-(4-aminothieno[3,2-c]pyridin-3-yl)-2,3-dihydro-1H-indol-1-yl]-2-phenylethanone
Authors:Gampe, R.T., Axten, J.M.
Deposit date:2012-07-13
Release date:2012-08-08
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK).
J.Med.Chem., 55, 2012
4Z0V
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THE STRUCTURE OF HUMAN PDE12 RESIDUES 161-609
Descriptor:2',5'-phosphodiesterase 12, MAGNESIUM ION, GLYCEROL
Authors:Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.
Deposit date:2015-03-26
Release date:2015-06-17
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015
4Z2A
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CRYSTAL STRUCTURE OF UNGLYCOSYLATED APO HUMAN FURIN @1.89A
Descriptor:Furin, CALCIUM ION, PHOSPHATE ION, ...
Authors:Gampe, R.T., Pearce, K., Reid, R.
Deposit date:2015-03-29
Release date:2016-05-04
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:BacMam production and crystal structure of nonglycosylated apo human furin at 1.89A resolution
Acta Crystallogr.,Sect.F, 2019
4Z2B
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THE STRUCTURE OF HUMAN PDE12 RESIDUES 161-609 IN COMPLEX WITH GSK3036342A
Descriptor:2',5'-phosphodiesterase 12, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Nolte, R.T., Wisely, B., Wang, L., Wood, E.R.
Deposit date:2015-03-29
Release date:2015-06-17
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.
J.Biol.Chem., 290, 2015