Author results

1DWN
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STRUCTURE OF BACTERIOPHAGE PP7 FROM PSEUDOMONAS AERUGINOSA AT 3.7 A RESOLUTION
Descriptor:PHAGE COAT PROTEIN
Authors:Tars, K., Fridborg, K., Bundule, M., Liljas, L.
Deposit date:1999-12-09
Release date:2000-02-07
Last modified:2012-01-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure Determination of Phage Pp7 from Pseudomonas Aeruginosa: From Poor Data to a Good Map
Acta Crystallogr.,Sect.D, 56, 2000
1GAV
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BACTERIOPHAGE GA PROTEIN CAPSID
Descriptor:BACTERIOPHAGE GA PROTEIN CAPSID
Authors:Tars, K., Bundule, M., Liljas, L.
Deposit date:1997-01-28
Release date:1997-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The crystal structure of bacteriophage GA and a comparison of bacteriophages belonging to the major groups of Escherichia coli leviviruses.
J.Mol.Biol., 271, 1997
1NG0
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THE THREE-DIMENSIONAL STRUCTURE OF COCKSFOOT MOTTLE VIRUS AT 2.7A RESOLUTION
Descriptor:coat protein, CALCIUM ION
Authors:Tars, K., Zeltins, A., Liljas, L.
Deposit date:2002-12-16
Release date:2003-02-04
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The three-dimensional structure of cocksfoot mottle virus at 2.7 A resolution.
Virology, 310, 2003
2C3N
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HUMAN GLUTATHIONE-S-TRANSFERASE T1-1, APO FORM
Descriptor:GLUTATHIONE S-TRANSFERASE THETA 1, IODIDE ION
Authors:Tars, K., Larsson, A.-K., Shokeer, A., Olin, B., Mannervik, B., Kleywegt, G.J.
Deposit date:2005-10-11
Release date:2005-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis of the Suppressed Catalytic Activity of Wild-Type Human Glutathione Transferase T1-1 Compared to its W234R Mutant.
J.Mol.Biol., 355, 2006
2C3Q
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HUMAN GLUTATHIONE-S-TRANSFERASE T1-1 W234R MUTANT, COMPLEX WITH S- HEXYLGLUTATHIONE
Descriptor:GLUTATHIONE S-TRANSFERASE THETA 1, S-HEXYLGLUTATHIONE, IODIDE ION
Authors:Tars, K., Larsson, A.-K., Shokeer, A., Olin, B., Mannervik, B., Kleywegt, G.J.
Deposit date:2005-10-11
Release date:2005-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis of the Suppressed Catalytic Activity of Wild-Type Human Glutathione Transferase T1-1 Compared to its W234R Mutant.
J.Mol.Biol., 355, 2006
2C3T
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HUMAN GLUTATHIONE-S-TRANSFERASE T1-1, W234R MUTANT, APO FORM
Descriptor:GLUTATHIONE S-TRANSFERASE THETA 1
Authors:Tars, K., Larsson, A.-K., Shokeer, A., Olin, B., Mannervik, B., Kleywegt, G.J.
Deposit date:2005-10-12
Release date:2005-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of the Suppressed Catalytic Activity of Wild-Type Human Glutathione Transferase T1-1 Compared to its W234R Mutant.
J.Mol.Biol., 355, 2006
2VCT
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GLUTATHIONE TRANSFERASE A2-2 IN COMPLEX WITH DELTA-4-ANDOSTRENE-3-17- DIONE
Descriptor:GLUTATHIONE S-TRANSFERASE A2, 4-ANDROSTENE-3-17-DIONE
Authors:Tars, K., Olin, B., Mannervik, B.
Deposit date:2007-09-27
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Featuring of Steroid Isomerase Activity in Alpha Class Glutathione Transferases.
J.Mol.Biol., 397, 2010
2VCV
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GLUTATHIONE TRANSFERASE A3-3 IN COMPLEX WITH GLUTATHIONE AND DELTA-4- ANDROSTENE-3-17-DIONE
Descriptor:GLUTATHIONE S-TRANSFERASE A3, GLUTATHIONE, 4-ANDROSTENE-3-17-DIONE
Authors:Tars, K., Olin, B., Mannervik, B.
Deposit date:2007-09-27
Release date:2008-10-28
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Featuring of Steroid Isomerase Activity in Alpha Class Glutathione Transferases.
J.Mol.Biol., 397, 2010
2WJU
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GLUTATHIONE TRANSFERASE A2-2 IN COMPLEX WITH GLUTATHIONE
Descriptor:GLUTATHIONE-S-TRANSFERASE A2-2, GLUTATHIONE
Authors:Tars, K., Olin, B., Mannervik, B.
Deposit date:2009-05-29
Release date:2009-06-09
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Featuring of Steroid Isomerase Activity in Alpha Class Glutathione Transferases.
J.Mol.Biol., 397, 2010
2YK1
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STRUCTURE OF HUMAN ANTI-NICOTINE FAB FRAGMENT IN COMPLEX WITH NICOTINE
Descriptor:FAB FRAGMENT, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Tars, K., Kotelovica, S., Lipowsky, G., Bauer, M., Beerli, R., Bachmann, M., Maurer, P.
Deposit date:2011-05-25
Release date:2011-11-16
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Different Binding Modes of Free and Carrier-Protein-Coupled Nicotine in a Human Monoclonal Antibody.
J.Mol.Biol., 415, 2012
2YKL
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STRUCTURE OF HUMAN ANTI-NICOTINE FAB FRAGMENT IN COMPLEX WITH NICOTINE-11-YL-METHYL-(4-ETHYLAMINO-4-OXO)-BUTANOATE
Descriptor:FAB FRAGMENT, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Tars, K., Kotelovica, S., Lipowsky, G., Bauer, M., Beerli, R., Bachmann, M., Maurer, P.
Deposit date:2011-05-27
Release date:2011-11-16
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Different Binding Modes of Free and Carrier-Protein-Coupled Nicotine in a Human Monoclonal Antibody.
J.Mol.Biol., 415, 2012
4BCW
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CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH (E)-2-(5-BROMO-2- HYDROXYPHENYL)ETHENESULFONIC ACID
Descriptor:CARBONIC ANHYDRASE 2, ZINC ION, (E)-2-(5-BROMO-2-HYDROXYPHENYL)ETHENESULFONIC ACID
Authors:Tars, K., Leitans, J., Kazaks, A.
Deposit date:2012-10-03
Release date:2013-02-06
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Sulfocoumarins (1,2-Benzoxathiine-2,2-Dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases.
J.Med.Chem., 56, 2013
4BG1
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THREE DIMENSIONAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE HYDROXYLASE IN COMPLEX WITH 1-(3-CARBOXYPROPYL)-1-METHYLPYRROLIDIN-1-IUM CHLORIDE
Descriptor:GAMMA-BUTYROBETAINE DIOXYGENASE, N-OXALYLGLYCINE, 1-(3-carboxypropyl)-1-methylpyrrolidin-1-ium, ...
Authors:Tars, K., Leitans, J., Kazaks, A.
Deposit date:2013-03-22
Release date:2014-03-12
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase.
J.Med.Chem., 57, 2014
4BGK
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THREE DIMENSIONAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE HYDROXYLASE IN COMPLEX WITH (3-(TRIMETHYLAMMONIO)PROPYL)PHOSPHINATE
Descriptor:GAMMA-BUTYROBETAINE DIOXYGENASE, N-OXALYLGLYCINE, trimethyl(3-oxidanylphosphonoylpropyl)azanium, ...
Authors:Tars, K., Leitans, J., Kazaks, A.
Deposit date:2013-03-27
Release date:2014-03-12
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase.
J.Med.Chem., 57, 2014
4BGM
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THREE DIMENSIONAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE HYDROXYLASE IN COMPLEX WITH 3-CARBOXY-N-(2-FLUOROETHYL)-N,N-DIMETHYLPROPAN-1- AMINIUM CHLORIDE
Descriptor:GAMMA-BUTYROBETAINE DIOXYGENASE, N-OXALYLGLYCINE, 3-Carboxy-N-(2-fluoroethyl)-N,N-dimethylpropan-1-aminium, ...
Authors:Tars, K., Leitans, J., Kazaks, A.
Deposit date:2013-03-27
Release date:2014-03-12
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase.
J.Med.Chem., 57, 2014
4BHF
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THREE DIMENSIONAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE HYDROXYLASE IN COMPLEX WITH 4-(TRIMETHYLAMMONIO)PENTANOATE
Descriptor:GAMMA-BUTYROBETAINE DIOXYGENASE, N-OXALYLGLYCINE, 4-(Trimethylammonio)pentanoic acid, ...
Authors:Tars, K., Leitans, J., Kazaks, A.
Deposit date:2013-04-02
Release date:2014-03-12
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase.
J.Med.Chem., 57, 2014
4BHG
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THREE DIMENSIONAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE HYDROXYLASE IN COMPLEX WITH 3-(1-ETHYL-1,1-DIMETHYLHYDRAZIN-1-IUM-2-YL)PROPANOATE
Descriptor:GAMMA-BUTYROBETAINE DIOXYGENASE, N-OXALYLGLYCINE, 3-(1-Ethyl-1,1-dimethylhydrazin-1-ium-2-yl)propanoic acid, ...
Authors:Tars, K., Leitans, J., Kazaks, A.
Deposit date:2013-04-02
Release date:2014-04-16
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Three Dimensional Structure of Human Gamma-Butyrobetaine Hydroxylase in Complex with 3-(1-Ethyl-1,1-Dimethylhydrazin-1-Ium-2-Yl)Propanoate
To be Published
4BHI
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THREE DIMENSIONAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE HYDROXYLASE IN COMPLEX WITH 3-(1,1,1,2-TETRAMETHYLHYDRAZIN-1-IUM-2-YL)PROPANOATE
Descriptor:GAMMA-BUTYROBETAINE DIOXYGENASE, N-OXALYLGLYCINE, 3-(1,1,1,2-TETRAMETHYLHYDRAZIN-1-IUM-2-YL)PROPANOATE, ...
Authors:Tars, K., Leitans, J., Kazaks, A.
Deposit date:2013-04-03
Release date:2014-03-12
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase.
J.Med.Chem., 57, 2014
4C5W
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THREE DIMENSIONAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE HYDROXYLASE IN COMPLEX WITH 4-(ETHYLDIMETHYLAMMONIO)BUTANOATE
Descriptor:GAMMA-BUTYROBETAINE DIOXYGENASE, N-OXALYLGLYCINE, ethyl-dimethyl-(4-oxidanyl-4-oxidanylidene-butyl)azanium, ...
Authors:Tars, K., Leitans, J., Kazaks, A.
Deposit date:2013-09-16
Release date:2014-03-12
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase.
J.Med.Chem., 57, 2014
4CKU
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THREE DIMENSIONAL STRUCTURE OF PLASMEPSIN II IN COMPLEX WITH HYDROXYETHYLAMINE-BASED INHIBITOR
Descriptor:PLASMEPSIN-2, 5-[1,1-bis(oxidanylidene)-1,2-thiazinan-2-yl]-N3-[(2S,3R)-4-[2-(3-methoxyphenyl)propan-2-ylamino]-3-oxidanyl-1-phenyl-butan-2-yl]-N1,N1-dipropyl-benzene-1,3-dicarboxamide
Authors:Tars, K., Leitans, J., Jaudzems, K.
Deposit date:2014-01-08
Release date:2014-06-18
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit.
Acs Med.Chem.Lett., 5, 2014
2C4J
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HUMAN GLUTATHIONE-S-TRANSFERASE M2-2 T210S MUTANT IN COMPLEX WITH GLUTATHIONE-STYRENE OXIDE CONJUGATE
Descriptor:GLUTATHIONE S-TRANSFERASE MU 2, L-GAMMA-GLUTAMYL-S-[(2S)-2-HYDROXY-2-PHENYLETHYL]-L-CYSTEINYLGLYCINE
Authors:Tars, K., Andersson, M., Ivarsson, Y., Olin, B., Mannervik, B.
Deposit date:2005-10-20
Release date:2005-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Alternative Mutations of a Positively Selected Residue Elicit Gain or Loss of Functionalities in Enzyme Evolution.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J9H
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE-S-TRANSFERASE P1-1 CYS-FREE MUTANT IN COMPLEX WITH S-HEXYLGLUTATHIONE AT 2.4 A RESOLUTION
Descriptor:GLUTATHIONE S-TRANSFERASE P, S-HEXYLGLUTATHIONE
Authors:Tars, K., Hegazy, U.M., Hellman, U., Mannervik, B.
Deposit date:2006-11-08
Release date:2006-11-14
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Modulating Catalytic Activity by Unnatural Amino Acid Residues in a Gsh-Binding Loop of Gst P1-1.
J.Mol.Biol., 376, 2008
3N6W
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CRYSTAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE HYDROXYLASE
Descriptor:Gamma-butyrobetaine dioxygenase, ZINC ION, SULFATE ION
Authors:Rumnieks, J., Zeltins, A., Leonchiks, A., Kazaks, A., Kotelovica, S., Tars, K.
Deposit date:2010-05-26
Release date:2010-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human gamma-butyrobetaine hydroxylase.
Biochem.Biophys.Res.Commun., 398, 2010
4BF1
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THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 5-(1-NAPHTHALEN-1-YL-1,2,3-TRIAZOL-4-YL)THIOPHENE-2-SULFONAMIDE
Descriptor:CARBONIC ANHYDRASE 2, ZINC ION, 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide, ...
Authors:Tars, K., Leitans, J., Zalubovskis, R.
Deposit date:2013-03-13
Release date:2014-01-22
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:5-Substituted-(1,2,3-Triazol-4-Yl)Thiophene-2-Sulfonamides Strongly Inhibit Human Carbonic Anhydrases I, II, Ix and Xii: Solution and X-Ray Crystallographic Studies.
Bioorg.Med.Chem., 21, 2013
4BF6
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THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 5-(1-(3-CYANOPHENYL)-1H-1,2,3-TRIAZOL-4-YL)THIOPHENE-2- SULFONAMIDE
Descriptor:CARBONIC ANHYDRASE 2, ZINC ION, 5-[1-(3-cyanophenyl)-1,2,3-triazol-4-yl]thiophene-2-sulfonamide, ...
Authors:Tars, K., Leitans, J., Zalubovskis, R.
Deposit date:2013-03-15
Release date:2014-01-22
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:5-Substituted-(1,2,3-Triazol-4-Yl)Thiophene-2-Sulfonamides Strongly Inhibit Human Carbonic Anhydrases I, II, Ix and Xii: Solution and X-Ray Crystallographic Studies.
Bioorg.Med.Chem., 21, 2013