4R07
| Crystal structure of human TLR8 in complex with ORN06 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-[(R)-{[(2R,3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-hydroxy-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]uridine 5'-(dihydrogen phosphate), ... | Authors: | Tanji, H, Ohto, U, Shibata, T, Taoka, M, Yamauchi, Y, Isobe, T, Miyake, K, Shimizu, T. | Deposit date: | 2014-07-30 | Release date: | 2015-01-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Toll-like receptor 8 senses degradation products of single-stranded RNA Nat.Struct.Mol.Biol., 22, 2015
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6AZ3
| Cryo-EM structure of of the large subunit of Leishmania ribosome bound to paromomycin | Descriptor: | 60S ribosomal protein L10, putative, 60S ribosomal protein L11 (L5, ... | Authors: | Shalev-Benami, M, Zhang, Y, Rozenberg, H, Nobe, Y, Taoka, M, Matzov, D, Zimmerman, E, Bashan, A, Isobe, T, Jaffe, C.L, Yonath, A, Skiniotis, G. | Deposit date: | 2017-09-09 | Release date: | 2017-12-06 | Last modified: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin. Nat Commun, 8, 2017
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6ZJ3
| Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis | Descriptor: | 18S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Matzov, D, Halfon, H, Zimmerman, E, Rozenberg, H, Bashan, A, Gray, M.W, Yonath, A.E, Shalev-Benami, M. | Deposit date: | 2020-06-27 | Release date: | 2020-10-07 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.15 Å) | Cite: | Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis. Nucleic Acids Res., 48, 2020
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6IF5
| Crystal structure of monkey TLR7 in complex with 2',3'-cGMP (Guanosine 2',3'-cyclic phosphate) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-PHOSPHATE-2',3'-CYCLIC PHOSPHATE, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2018-09-18 | Release date: | 2019-01-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands. Cell Rep, 25, 2018
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6SKF
| Cryo-EM Structure of T. kodakarensis 70S ribosome | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M. | Deposit date: | 2019-08-15 | Release date: | 2020-07-29 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature, 583, 2020
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6SKG
| Cryo-EM Structure of T. kodakarensis 70S ribosome in TkNat10 deleted strain | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M. | Deposit date: | 2019-08-15 | Release date: | 2020-07-29 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature, 583, 2020
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6TH6
| Cryo-EM Structure of T. kodakarensis 70S ribosome | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M. | Deposit date: | 2019-11-18 | Release date: | 2020-07-29 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature, 583, 2020
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5GMF
| Crystal structure of monkey TLR7 in complex with guanosine and polyU | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2016-07-14 | Release date: | 2016-11-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA Immunity, 45, 2016
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5GMG
| Crystal structure of monkey TLR7 in complex with loxoribine and polyU | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7-prop-2-enyl-1~{H}-purine-6,8-dione, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2016-07-14 | Release date: | 2016-11-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA Immunity, 45, 2016
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5GMH
| Crystal structure of monkey TLR7 in complex with R848 | Descriptor: | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2016-07-14 | Release date: | 2016-11-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA Immunity, 45, 2016
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4R08
| Crystal structure of human TLR8 in complex with ssRNA40 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-[(R)-{[(2R,3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-hydroxy-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]uridine 5'-(dihydrogen phosphate), ... | Authors: | Tanji, H, Ohto, U, Shimizu, T. | Deposit date: | 2014-07-30 | Release date: | 2015-01-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat.Struct.Mol.Biol., 22, 2015
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4R0A
| Crystal structure of human TLR8 in complex with uridine mononucleoside | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | Authors: | Tanji, H, Ohto, U, Shimizu, T. | Deposit date: | 2014-07-30 | Release date: | 2015-01-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat.Struct.Mol.Biol., 22, 2015
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4R09
| Crystal structure of human TLR8 in complex with ORN06S | Descriptor: | 1-[(2R,3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-sulfidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4(1H,3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Tanji, H, Ohto, U, Shimizu, T. | Deposit date: | 2014-07-30 | Release date: | 2015-01-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat.Struct.Mol.Biol., 22, 2015
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2NSQ
| Crystal structure of the C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase NEDD4-like protein, GLYCEROL | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-06 | Release date: | 2006-12-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein To be Published
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8OVE
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8OVA
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7QI5
| Human mitochondrial ribosome in complex with mRNA, A/A-, P/P- and E/E-tRNAs at 2.63 A resolution | Descriptor: | 1,4-DIAMINOBUTANE, 12S mitochondrial rRNA, 16S mitochondrial rRNA, ... | Authors: | Singh, V, Itoh, Y, Amunts, A. | Deposit date: | 2021-12-14 | Release date: | 2023-07-05 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications. Biorxiv, 2023
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7QIZ
| Specific features and methylation sites of a plant 80S ribosome | Descriptor: | 1,4-DIAMINOBUTANE, 18S, 25S rRNA, ... | Authors: | Cottilli, P, Itoh, Y, Amunts, A. | Deposit date: | 2021-12-16 | Release date: | 2022-08-03 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.38 Å) | Cite: | Cryo-EM structure and rRNA modification sites of a plant ribosome. Plant Commun., 3, 2022
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7QIX
| Specific features and methylation sites of a plant ribosome. 40S body ribosomal subunit. | Descriptor: | 18S rRNA body, 30S ribosomal protein S15, chloroplastic, ... | Authors: | Cottilli, P, Itoh, Y, Amunts, A. | Deposit date: | 2021-12-16 | Release date: | 2022-06-15 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.53 Å) | Cite: | Cryo-EM structure and rRNA modification sites of a plant ribosome. Plant Commun., 3, 2022
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7QIY
| Specific features and methylation sites of a plant ribosome. 40S head ribosomal subunit. | Descriptor: | 1,4-DIAMINOBUTANE, 18S rRNA head, 40S head ribosomal protein eS19, ... | Authors: | Cottilli, P, Itoh, Y, Amunts, A. | Deposit date: | 2021-12-16 | Release date: | 2022-06-15 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Cryo-EM structure and rRNA modification sites of a plant ribosome. Plant Commun., 3, 2022
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7QIW
| Specific features and methylation sites of a plant ribosome. 60S ribosomal subunit. | Descriptor: | 25S rRNA, 5.8S rRNA, 50S ribosomal protein L22, ... | Authors: | Cottilli, P, Itoh, Y, Amunts, A. | Deposit date: | 2021-12-16 | Release date: | 2022-07-13 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.35 Å) | Cite: | Cryo-EM structure and rRNA modification sites of a plant ribosome. Plant Commun., 3, 2022
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7QI4
| Human mitochondrial ribosome at 2.2 A resolution (bound to partly built tRNAs and mRNA) | Descriptor: | 1,4-DIAMINOBUTANE, 12S mitochondrial rRNA, 16S mitochondrial rRNA, ... | Authors: | Singh, V, Itoh, Y, Amunts, A. | Deposit date: | 2021-12-14 | Release date: | 2022-07-13 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.21 Å) | Cite: | Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications. Biorxiv, 2023
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7QI6
| Human mitochondrial ribosome in complex with mRNA, A/P- and P/E-tRNAs at 2.98 A resolution | Descriptor: | 1,4-DIAMINOBUTANE, 12S mitochondrial rRNA, 16S mitochondrial rRNA, ... | Authors: | Singh, V, Itoh, Y, Amunts, A. | Deposit date: | 2021-12-14 | Release date: | 2023-05-17 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications. Biorxiv, 2023
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6AZ1
| Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin | Descriptor: | E-site tRNA, LACK1, MAGNESIUM ION, ... | Authors: | Shalev-Benami, M, Zhang, Y, Rozenberg, H, Matzov, D, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G. | Deposit date: | 2017-09-09 | Release date: | 2017-12-06 | Last modified: | 2019-07-03 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin. Nat Commun, 8, 2017
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5ZSH
| Crystal structure of monkey TLR7 in complex with CL075 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-propyl[1,3]thiazolo[4,5-c]quinolin-4-amine, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2018-04-28 | Release date: | 2019-01-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands. Cell Rep, 25, 2018
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