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6C6D
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BU of 6c6d by Molmil
20mer crystal structure of CC chemokine 5 (CCL5)
Descriptor: C-C motif chemokine 5
Authors:Liang, W.G, Tang, W.J.
Deposit date:2018-01-18
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:20mer crystal structure of CC chemokine 5 (CCL5)
To Be Published
2WC0
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BU of 2wc0 by Molmil
crystal structure of human insulin degrading enzyme in complex with iodinated insulin
Descriptor: 1,4-DIETHYLENE DIOXIDE, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J.
Deposit date:2009-03-06
Release date:2009-03-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
2WBY
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BU of 2wby by Molmil
Crystal structure of human insulin-degrading enzyme in complex with insulin
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, INSULIN-DEGRADING ENZYME, ...
Authors:Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J.
Deposit date:2009-03-06
Release date:2009-03-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284, 2009
2WK3
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BU of 2wk3 by Molmil
Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42)
Descriptor: BETA-AMYLOID PROTEIN 42, INSULIN DEGRADING ENZYME, ZINC ION
Authors:Guo, Q, Tang, W.J.
Deposit date:2009-06-05
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Molecular Basis for the Recognition and Cleavages of Igf-II, Tgf-Alpha, and Amylin by Human Insulin Degrading Enzyme.
J.Mol.Biol., 395, 2010
1YRU
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BU of 1yru by Molmil
Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin and 1mM calcium chloride
Descriptor: Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin
Authors:Guo, Q, Shen, Y, Tang, W.J.
Deposit date:2005-02-04
Release date:2005-09-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin
Embo J., 24, 2005
1YRT
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BU of 1yrt by Molmil
Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin
Descriptor: Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin
Authors:Guo, Q, Shen, Y, Lee, Y.S, Gibbs, C.S, Mrksich, M, Tang, W.J.
Deposit date:2005-02-04
Release date:2006-01-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Embo J., 24, 2005
1ZOT
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BU of 1zot by Molmil
crystal structure analysis of the CyaA/C-Cam with PMEAPP
Descriptor: (ADENIN-9-YL-ETHOXYMETHYL)-HYDROXYPHOSPHINYL-DIPHOSPHATE, CALCIUM ION, Calmodulin, ...
Authors:Guo, Q, Tang, W.J.
Deposit date:2005-05-13
Release date:2005-08-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Embo J., 24, 2005
2COL
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BU of 2col by Molmil
Crystal structure analysis of CyaA/C-Cam with Pyrophosphate
Descriptor: Bifunctional hemolysin-adenylate cyclase, CALCIUM ION, Calmodulin, ...
Authors:Guo, Q, Tang, W.J, Shen, Y.
Deposit date:2005-05-18
Release date:2006-01-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin
Embo J., 24, 2005
7RZI
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BU of 7rzi by Molmil
Insulin Degrading Enzyme pC/pC
Descriptor: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
Authors:Mancl, J.M, Liang, W.G, Tang, W.J.
Deposit date:2021-08-27
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZG
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BU of 7rzg by Molmil
Insulin Degrading Enzyme O/pO
Descriptor: Cysteine-free Insulin-degrading enzyme
Authors:Mancl, J.M, Liang, W.G, Tang, W.J.
Deposit date:2021-08-27
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZH
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BU of 7rzh by Molmil
Insulin Degrading Enzyme O/O
Descriptor: Cysteine-free Insulin-degrading enzyme
Authors:Mancl, J.M, Liang, W.G, Tang, W.J.
Deposit date:2021-08-27
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZF
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BU of 7rzf by Molmil
Insulin Degrading Enzyme O/pC
Descriptor: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
Authors:Mancl, J.M, Liang, W.G, Tang, W.J.
Deposit date:2021-08-27
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
7RZE
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BU of 7rze by Molmil
Insulin Degrading Enzyme pO/pC
Descriptor: Cysteine-free Insulin-degrading enzyme, Insulin A chain, Insulin B chain
Authors:Mancl, J.M, Liang, W.G, Tang, W.J.
Deposit date:2021-08-27
Release date:2022-08-31
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Ensemble cryoEM reveals a substrate-induced shift in the conformational dynamics of human insulin degrading enzyme
To be published
3H44
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BU of 3h44 by Molmil
Crystal Structure of Insulin Degrading Enzyme in Complex with macrophage inflammatory protein 1 alpha
Descriptor: 1,4-DIETHYLENE DIOXIDE, C-C motif chemokine 3, Insulin-degrading enzyme, ...
Authors:Ren, M, Guo, Q, Tang, W.J.
Deposit date:2009-04-17
Release date:2010-04-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Macrophage Inflammatory Protein-1 Is A Novel High Affinity Substrate For Human Insulin Degrading Enzyme
To be Published
3HGZ
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BU of 3hgz by Molmil
Crystal structure of human insulin-degrading enzyme in complex with amylin
Descriptor: Insulin-degrading enzyme, Islet amyloid polypeptide, ZINC ION
Authors:Guo, Q, Bian, Y, Tang, W.J.
Deposit date:2009-05-14
Release date:2009-12-08
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
5UOE
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BU of 5uoe by Molmil
Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)
Descriptor: FAB Heavy chain with engineered elbow, FAB light chain, Insulin-degrading enzyme
Authors:Liang, W.G, Bailey, L, Kossiakoff, T, Tang, W.J.
Deposit date:2017-01-31
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)
To Be Published
3CQF
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BU of 3cqf by Molmil
Crystal structure of anthrolysin O (ALO)
Descriptor: Thiol-activated cytolysin
Authors:Bourdeau, R.W, Malito, E, Tang, W.J.
Deposit date:2008-04-02
Release date:2009-03-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted by Bacillus anthracis
J.Biol.Chem., 284, 2009
3CWW
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BU of 3cww by Molmil
Crystal Structure of IDE-bradykinin complex
Descriptor: 1,4-DIETHYLENE DIOXIDE, ACETATE ION, Insulin-degrading enzyme, ...
Authors:Malito, E, Tang, W.J.
Deposit date:2008-04-23
Release date:2008-11-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme
Biochemistry, 47, 2008
3E4A
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BU of 3e4a by Molmil
Human IDE-inhibitor complex at 2.6 angstrom resolution
Descriptor: 1,4-DIETHYLENE DIOXIDE, ACETIC ACID, HYDROXAMATE PEPTIDE II1, ...
Authors:Malito, E, Leissring, M.A, Choi, S, Cuny, G.D, Tang, W.J.
Deposit date:2008-08-11
Release date:2009-05-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Plos One, 5, 2010
1PK0
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BU of 1pk0 by Molmil
Crystal Structure of the EF3-CaM complexed with PMEApp
Descriptor: (ADENIN-9-YL-ETHOXYMETHYL)-HYDROXYPHOSPHINYL-DIPHOSPHATE, CALCIUM ION, Calmodulin, ...
Authors:Shen, Y, Tang, W.J.
Deposit date:2003-06-04
Release date:2004-02-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Proc.Natl.Acad.Sci.USA, 101, 2004
1XFX
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BU of 1xfx by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride
Descriptor: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFZ
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BU of 1xfz by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride
Descriptor: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFU
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BU of 1xfu by Molmil
Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin
Descriptor: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFY
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BU of 1xfy by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin
Descriptor: CALCIUM ION, Calmodulin 2, Calmodulin-sensitive adenylate cyclase, ...
Authors:Shen, Y, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005
1XFV
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BU of 1xfv by Molmil
Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
Descriptor: 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin 2, ...
Authors:Shen, Q, Zhukovskaya, N.L, Guo, Q, Florian, J, Tang, W.J.
Deposit date:2004-09-15
Release date:2005-05-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
EMBO J., 24, 2005

 

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