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7NFA
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BU of 7nfa by Molmil
The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer
Descriptor: A33 Fab heavy chain, A33 Fab light chain
Authors:Tang, J, Zhang, C, Dalby, P, Kozielski, F.
Deposit date:2021-02-05
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer
To Be Published
7NC0
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BU of 7nc0 by Molmil
The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer
Descriptor: A33 Fab heavy chain, A33 Fab light chain
Authors:Tang, J, Zhang, C, Dalby, P, Kozielski, F.
Deposit date:2021-01-28
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer
To Be Published
2ANW
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BU of 2anw by Molmil
Expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: Implications for structure-based design of protease inhibitors
Descriptor: BENZAMIDINE, plasma kallikrein, light chain
Authors:Tang, J, Yu, C.L, Williams, S.R, Springman, E, Jeffery, D, Sprengeler, P.A, Estevez, A, Sampang, J, Shrader, W, Spencer, J.R, Young, W.B, McGrath, M.E, Katz, B.A.
Deposit date:2005-08-11
Release date:2005-10-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.
J.Biol.Chem., 280, 2005
2ANY
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BU of 2any by Molmil
Expression, Crystallization and the Three-dimensional Structure of the Catalytic Domain of Human Plasma Kallikrein: Implications for Structure-Based Design of Protease Inhibitors
Descriptor: BENZAMIDINE, PHOSPHATE ION, plasma kallikrein, ...
Authors:Tang, J, Yu, C.L, Williams, S.R, Springman, E, Jeffery, D, Sprengeler, P.A, Estevez, A, Sampang, J, Shrader, W, Spencer, J.R, Young, W.B, McGrath, M.E, Katz, B.A.
Deposit date:2005-08-11
Release date:2005-10-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.
J.Biol.Chem., 280, 2005
7CBB
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BU of 7cbb by Molmil
Crystal structure of SbnC in the biosynthesis of staphyloferrin B
Descriptor: ADENOSINE MONOPHOSPHATE, IucA/IucC family siderophore biosynthesis protein
Authors:Tang, J, Ju, Y, Zhou, H.
Deposit date:2020-06-11
Release date:2020-09-23
Last modified:2020-10-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and Biochemical Characterization of SbnC as a Representative Type B Siderophore Synthetase.
Acs Chem.Biol., 15, 2020
3J0F
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BU of 3j0f by Molmil
Sindbis virion
Descriptor: Capsid protein, E1 envelope glycoprotein, E2 envelope glycoprotein
Authors:Tang, J, Jose, J, Zhang, W, Chipman, P, Kuhn, R.J, Baker, T.S.
Deposit date:2011-07-08
Release date:2011-10-12
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Molecular Links between the E2 Envelope Glycoprotein and Nucleocapsid Core in Sindbis Virus.
J.Mol.Biol., 414, 2011
3IYM
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BU of 3iym by Molmil
Backbone Trace of the Capsid Protein Dimer of a Fungal Partitivirus from Electron Cryomicroscopy and Homology Modeling
Descriptor: Capsid protein
Authors:Tang, J, Pan, J, Havens, W.F, Ochoa, W.F, Li, H, Sinkovits, R.S, Guu, T.S.Y, Ghabrial, S.A, Nibert, M.L, Tao, J.Y, Baker, T.S.
Deposit date:2010-02-05
Release date:2010-07-28
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Backbone Trace of Partitivirus Capsid Protein from Electron Cryomicroscopy and Homology Modeling
Biophys.J., 99, 2010
6M11
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BU of 6m11 by Molmil
Crystal structure of Rnase L in complex with Sunitinib
Descriptor: 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, PHOSPHATE ION, ...
Authors:Tang, J, Huang, H.
Deposit date:2020-02-24
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Biochem.J., 477, 2020
6M12
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BU of 6m12 by Molmil
Crystal Structure of Rnase L in complex with SU11652
Descriptor: 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE, PHOSPHATE ION, Ribonuclease L, ...
Authors:Tang, J, Huang, H.
Deposit date:2020-02-24
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Biochem.J., 477, 2020
6M13
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BU of 6m13 by Molmil
Crystal structure of Rnase L in complex with Toceranib
Descriptor: 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide, PHOSPHATE ION, Ribonuclease L, ...
Authors:Tang, J, Huang, H.
Deposit date:2020-02-24
Release date:2020-09-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Sunitinib inhibits RNase L by destabilizing its active dimer conformation.
Biochem.J., 477, 2020
6KNK
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BU of 6knk by Molmil
Crystal structure of SbnH in complex with citryl-diaminoethane
Descriptor: (2S)-2-{2-[(2-AMINOETHYL)AMINO]-2-OXOETHYL}-2-HYDROXYBUTANEDIOIC ACID, (2~{S})-2-[2-[2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]ethylamino]-2-oxidanylidene-ethyl]-2-oxidanyl-butanedioic acid, PHOSPHATE ION, ...
Authors:Tang, J, Ju, Y, Zhou, H.
Deposit date:2019-08-05
Release date:2019-11-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Insights into Substrate Recognition and Activity Regulation of the Key Decarboxylase SbnH in Staphyloferrin B Biosynthesis.
J.Mol.Biol., 431, 2019
6KNI
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BU of 6kni by Molmil
Crystal structure of SbnH in complex with the cofactor PLP, a PLP-dependent decarboxylase in Staphyloferrin B biothesynthesis
Descriptor: PYRIDOXAL-5'-PHOSPHATE, Probable diaminopimelate decarboxylase protein
Authors:Tang, J, Ju, Y, Zhou, H.
Deposit date:2019-08-05
Release date:2019-11-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural Insights into Substrate Recognition and Activity Regulation of the Key Decarboxylase SbnH in Staphyloferrin B Biosynthesis.
J.Mol.Biol., 431, 2019
6KNH
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BU of 6knh by Molmil
Crystal structure of SbnH in complex with citrate, a PLP-dependent decarboxylase in Staphyloferrin B biothesynthesis
Descriptor: CITRIC ACID, PHOSPHATE ION, Probable diaminopimelate decarboxylase protein
Authors:Tang, J, Ju, Y, Zhou, H.
Deposit date:2019-08-05
Release date:2019-11-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural Insights into Substrate Recognition and Activity Regulation of the Key Decarboxylase SbnH in Staphyloferrin B Biosynthesis.
J.Mol.Biol., 431, 2019
7YIC
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BU of 7yic by Molmil
Crystal structure of reductase LSADH
Descriptor: Short chain alcohol dehydrogenase
Authors:Tang, J, Liuqing, C.
Deposit date:2022-07-15
Release date:2022-11-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:crystal structure of reductase LSADH
To Be Published
7DSY
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BU of 7dsy by Molmil
Crystal Structure of RNase L in complex with KM05073
Descriptor: 1-chloranyl-3-methylsulfinyl-6,7-dihydro-5H-2-benzothiophen-4-one, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, PHOSPHATE ION, ...
Authors:Tang, J, Huang, H.
Deposit date:2021-01-03
Release date:2021-11-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery
J.Med.Chem., 65, 2022
7DTS
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BU of 7dts by Molmil
Crystal structure of RNase L in complex with AC40357
Descriptor: 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, PHOSPHATE ION, Ribonuclease L, ...
Authors:Tang, J, Huang, H.
Deposit date:2021-01-06
Release date:2021-11-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery
J.Med.Chem., 65, 2022
7ELW
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BU of 7elw by Molmil
Crystal structure of RNase L in complex with Myricetin
Descriptor: 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, PHOSPHATE ION, Ribonuclease L, ...
Authors:Tang, J, Huang, H.
Deposit date:2021-04-12
Release date:2021-11-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery
J.Med.Chem., 65, 2022
5GR8
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BU of 5gr8 by Molmil
Crystal structure of PEPR1-AtPEP1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Elicitor peptide 1, ...
Authors:Chai, J.J, Tang, J.
Deposit date:2016-08-08
Release date:2016-12-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.587 Å)
Cite:Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1
Cell Res., 25, 2015
7E3X
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BU of 7e3x by Molmil
Crystal structure of SDR family NAD(P)-dependent oxidoreductase from exiguobacterium
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase
Authors:Chen, L, Tang, J, Yuan, S, Zhang, F, Chen, S.
Deposit date:2021-02-09
Release date:2021-09-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters
Catalysis Science And Technology, 2021
7E28
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BU of 7e28 by Molmil
Crystal structure of SDR family NAD(P)-dependent oxidoreductase from Exiguobacterium
Descriptor: Oxidoreductase
Authors:Chen, L, Tang, J, Yuan, S.
Deposit date:2021-02-05
Release date:2021-09-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters
Catalysis Science And Technology, 2021
7E24
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BU of 7e24 by Molmil
Crystal structure of SDR family NAD(P)-dependent oxidoreductase from Exiguobacterium
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase
Authors:Chen, L, Tang, J, Yuan, S.
Deposit date:2021-02-04
Release date:2021-09-29
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7203 Å)
Cite:Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters
Catalysis Science And Technology, 2021
1AXA
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BU of 1axa by Molmil
ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT
Descriptor: HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:Hong, L, Hartsuck, J.A, Foundling, S, Ermolieff, J, Tang, J.
Deposit date:1997-10-13
Release date:1998-04-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant.
Protein Sci., 7, 1998
1A9M
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BU of 1a9m by Molmil
G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E
Descriptor: HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:Hong, L, Zhang, X.-J, Foundling, S, Hartsuck, J.A, Tang, J.
Deposit date:1998-04-08
Release date:1998-06-17
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs.
FEBS Lett., 420, 1997
1M1C
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BU of 1m1c by Molmil
Structure of the L-A virus
Descriptor: Major coat protein
Authors:Naitow, H, Tang, J, Canady, M, Wickner, R.B, Johnson, J.E.
Deposit date:2002-06-18
Release date:2002-10-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:L-A virus at 3.4 A resolution reveals particle architecture and mRNA decapping mechanism.
Nat.Struct.Biol., 9, 2002
2VKM
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BU of 2vkm by Molmil
Crystal structure of GRL-8234 bound to BACE (Beta-secretase)
Descriptor: BETA-SECRETASE 1, N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Authors:Hong, L, Tang, J, Ghosh, A.K.
Deposit date:2007-12-04
Release date:2008-12-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Potent Memapsin 2 (Beta-Secretase) Inhibitors: Design, Synthesis, Protein-Ligand X-Ray Structure, and in Vivo Evaluation.
Bioorg.Med.Chem.Lett., 18, 2008

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