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2ANW
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EXPRESSION, CRYSTALLIZATION AND THREE-DIMENSIONAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMA KALLIKREIN: IMPLICATIONS FOR STRUCTURE-BASED DESIGN OF PROTEASE INHIBITORS
分子名称:plasma kallikrein, light chain, BENZAMIDINE
著者Tang, J., Yu, C.L., Williams, S.R., Springman, E., Jeffery, D., Sprengeler, P.A., Estevez, A., Sampang, J., Shrader, W., Spencer, J.R., Young, W.B., McGrath, M.E., Katz, B.A.
登録日2005-08-11
公開日2005-10-11
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.
J.Biol.Chem., 280, 2005
2ANY
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EXPRESSION, CRYSTALLIZATION AND THE THREE-DIMENSIONAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLASMA KALLIKREIN: IMPLICATIONS FOR STRUCTURE-BASED DESIGN OF PROTEASE INHIBITORS
分子名称:plasma kallikrein, light chain, PHOSPHATE ION, ...
著者Tang, J., Yu, C.L., Williams, S.R., Springman, E., Jeffery, D., Sprengeler, P.A., Estevez, A., Sampang, J., Shrader, W., Spencer, J.R., Young, W.B., McGrath, M.E., Katz, B.A.
登録日2005-08-11
公開日2005-10-11
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.
J.Biol.Chem., 280, 2005
3IYM
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BACKBONE TRACE OF THE CAPSID PROTEIN DIMER OF A FUNGAL PARTITIVIRUS FROM ELECTRON CRYOMICROSCOPY AND HOMOLOGY MODELING
分子名称:Capsid protein
著者Tang, J., Pan, J., Havens, W.F., Ochoa, W.F., Li, H., Sinkovits, R.S., Guu, T.S.Y., Ghabrial, S.A., Nibert, M.L., Tao, J.Y., Baker, T.S.
登録日2010-02-05
公開日2010-07-28
最終更新日2018-08-22
実験手法ELECTRON MICROSCOPY (4.7 Å)
主引用文献Backbone Trace of Partitivirus Capsid Protein from Electron Cryomicroscopy and Homology Modeling
Biophys.J., 99, 2010
3J0F
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SINDBIS VIRION
分子名称:Capsid protein, E1 envelope glycoprotein, E2 envelope glycoprotein
著者Tang, J., Jose, J., Zhang, W., Chipman, P., Kuhn, R.J., Baker, T.S.
登録日2011-07-08
公開日2011-10-12
最終更新日2012-05-30
実験手法ELECTRON MICROSCOPY (7 Å)
主引用文献Molecular Links between the E2 Envelope Glycoprotein and Nucleocapsid Core in Sindbis Virus.
J.Mol.Biol., 414, 2011
5GR8
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CRYSTAL STRUCTURE OF PEPR1-ATPEP1
分子名称:Leucine-rich repeat receptor-like protein kinase PEPR1, Elicitor peptide 1, N-ACETYL-D-GLUCOSAMINE, ...
著者Chai, J.J., Tang, J.
登録日2016-08-08
公開日2016-12-14
実験手法X-RAY DIFFRACTION (2.587 Å)
主引用文献Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1
Cell Res., 25, 2015
1M1C
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STRUCTURE OF THE L-A VIRUS
分子名称:Major coat protein
著者Naitow, H., Tang, J., Canady, M., Wickner, R.B., Johnson, J.E.
登録日2002-06-18
公開日2002-10-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献L-A virus at 3.4 A resolution reveals particle architecture and mRNA decapping mechanism.
Nat.Struct.Biol., 9, 2002
1DDJ
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CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN
分子名称:PLASMINOGEN
著者Wang, X., Terzyan, S., Tang, J., Loy, J., Lin, X., Zhang, X.
登録日1999-11-10
公開日2000-02-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Human plasminogen catalytic domain undergoes an unusual conformational change upon activation.
J.Mol.Biol., 295, 2000
1R42
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NATIVE HUMAN ANGIOTENSIN CONVERTING ENZYME-RELATED CARBOXYPEPTIDASE (ACE2)
分子名称:angiotensin I converting enzyme 2, disordered segment of collectrin homology domain, N-ACETYL-D-GLUCOSAMINE, ...
著者Towler, P., Staker, B., Prasad, S.G., Menon, S., Ryan, D., Tang, J., Parsons, T., Fisher, M., Williams, D., Dales, N.A., Patane, M.A., Pantoliano, M.W.
登録日2003-10-07
公開日2004-02-03
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
J.Biol.Chem., 279, 2004
1R4L
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INHIBITOR BOUND HUMAN ANGIOTENSIN CONVERTING ENZYME-RELATED CARBOXYPEPTIDASE (ACE2)
分子名称:angiotensin I converting enzyme 2, disordered segment of collectrin homology domain, N-ACETYL-D-GLUCOSAMINE, ...
著者Towler, P., Staker, B., Prasad, S.G., Menon, S., Ryan, D., Tang, J., Parsons, T., Fisher, M., Williams, D., Dales, N.A., Patane, M.A., Pantoliano, M.W.
登録日2003-10-07
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
J.Biol.Chem., 279, 2004
3RE9
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CRYSTAL STRUCTURE OF SORTASEC1 FROM STREPTOCOCCUS SUIS
分子名称:Sortase-like protein
著者Lu, G., Qi, J., Gao, F., Yan, J., Tang, J., Gao, G.F.
登録日2011-04-04
公開日2011-06-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A novel "open-form" structure of sortaseC from Streptococcus suis
Proteins, 2011
1AXA
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ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT
分子名称:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
著者Hong, L., Hartsuck, J.A., Foundling, S., Ermolieff, J., Tang, J.
登録日1997-10-13
公開日1998-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant.
Protein Sci., 7, 1998
1CJY
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HUMAN CYTOSOLIC PHOSPHOLIPASE A2
分子名称:PROTEIN (CYTOSOLIC PHOSPHOLIPASE A2), CALCIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
著者Dessen, A., Tang, J., Schmidt, H., Stahl, M., Clark, J.D., Seehra, J., Somers, W.S.
登録日1999-04-20
公開日2000-04-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism.
Cell(Cambridge,Mass.), 97, 1999
1F42
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THE P40 DOMAIN OF HUMAN INTERLEUKIN-12
分子名称:INTERLEUKIN-12 BETA CHAIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
著者Yoon, C., Johnston, S.C., Tang, J., Tobin, J.F., Somers, W.S.
登録日2000-06-07
公開日2001-06-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12.
EMBO J., 19, 2000
1F45
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HUMAN INTERLEUKIN-12
分子名称:INTERLEUKIN-12 BETA CHAIN, INTERLEUKIN-12 ALPHA CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
著者Yoon, C., Johnston, S.C., Tang, J., Tobin, J.F., Somers, W.S.
登録日2000-06-07
公開日2001-06-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12.
EMBO J., 19, 2000
3QJZ
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CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH BENZOTHIAZOLE 1
分子名称:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N-{6-[2-(methylsulfanyl)pyrimidin-4-yl]-1,3-benzothiazol-2-yl}acetamide, SULFATE ION
著者Whittington, D.A., Tang, J., Yakowec, P.
登録日2011-01-31
公開日2011-03-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors.
J.Med.Chem., 54, 2011
3QK0
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CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH BENZOTHIAZOLE 82
分子名称:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-[6-(6-chloro-5-{[(4-fluorophenyl)sulfonyl]amino}pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide
著者Whittington, D.A., Tang, J., Yakowec, P.
登録日2011-01-31
公開日2011-03-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors.
J.Med.Chem., 54, 2011
1A9M
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G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E
分子名称:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
著者Hong, L., Zhang, X.-J., Foundling, S., Hartsuck, J.A., Tang, J.
登録日1998-04-08
公開日1998-06-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs.
FEBS Lett., 420, 1997
1FB7
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CRYSTAL STRUCTURE OF AN IN VIVO HIV-1 PROTEASE MUTANT IN COMPLEX WITH SAQUINAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE
分子名称:HIV-1 PROTEASE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide
著者Hong, L., Zhang, X.C., Hartsuck, J.A., Tang, J.
登録日2000-07-14
公開日2000-12-13
最終更新日2013-02-27
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance.
Protein Sci., 9, 2000
1FKN
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STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR
分子名称:MEMAPSIN 2, inhibitor
著者Hong, L., Koelsch, G., Lin, X., Wu, S., Terzyan, S., Ghosh, A., Zhang, X.C., Tang, J.
登録日2000-08-09
公開日2000-10-09
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.
Science, 290, 2000
1GNM
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HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR)
分子名称:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
著者Hong, L., Treharne, A., Hartsuck, J.A., Foundling, S., Tang, J.
登録日1996-05-04
公開日1996-11-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases.
Biochemistry, 35, 1996
1GNN
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HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASN (V82N) COMPLEXED WITH U89360E (INHIBITOR)
分子名称:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
著者Hong, L., Treharne, A., Hartsuck, J.A., Foundling, S., Tang, J.
登録日1996-05-04
公開日1996-11-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases.
Biochemistry, 35, 1996
1GNO
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HIV-1 PROTEASE (WILD TYPE) COMPLEXED WITH U89360E (INHIBITOR)
分子名称:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
著者Hong, L., Treharne, A., Hartsuck, J.A., Foundling, S., Tang, J.
登録日1996-05-04
公開日1996-11-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases.
Biochemistry, 35, 1996
1L4D
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CRYSTAL STRUCTURE OF MICROPLASMINOGEN-STREPTOKINASE ALPHA DOMAIN COMPLEX
分子名称:PLASMINOGEN, STREPTOKINASE, SULFATE ION
著者Wakeham, N., Terzyan, S., Zhai, P., Loy, J.A., Tang, J., Zhang, X.C.
登録日2002-03-04
公開日2002-12-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Effects of deletion of streptokinase residues 48-59 on plasminogen activation
PROTEIN ENG., 15, 2002
1L4Z
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X-RAY CRYSTAL STRUCTURE OF THE COMPLEX OF MICROPLASMINOGEN WITH ALPHA DOMAIN OF STREPTOKINASE IN THE PRESENCE CADMIUM IONS
分子名称:Plasminogen, Streptokinase, CADMIUM ION
著者Wakeham, N., Terzyan, S., Zhai, P., Loy, J.A., Tang, J., Zhang, X.C.
登録日2002-03-06
公開日2002-12-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Effects of deletion of streptokinase residues 48-59 on plasminogen activation.
PROTEIN ENG., 15, 2002
1M4H
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CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH INHIBITOR OM00-3
分子名称:beta-Secretase, Inhibitor OM00-3
著者Hong, L., Turner, R.T., Koelsch, G., Ghosh, A.K., Tang, J.
登録日2002-07-02
公開日2002-08-28
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of Memapsin 2 (beta-Secretase) in Complex with Inhibitor OM00-3
Biochemistry, 41, 2002