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1MNM
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BU of 1mnm by Molmil
YEAST MATALPHA2/MCM1/DNA TERNARY TRANSCRIPTION COMPLEX CRYSTAL STRUCTURE
Descriptor: DNA (STE6 OPERATOR DNA), PROTEIN (MAT ALPHA-2 TRANSCRIPTIONAL REPRESSOR), PROTEIN (MCM1 TRANSCRIPTIONAL REGULATOR)
Authors:Tan, S, Richmond, T.J.
Deposit date:1997-11-03
Release date:1998-03-18
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of the yeast MATalpha2/MCM1/DNA ternary complex.
Nature, 391, 1998
1YTF
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BU of 1ytf by Molmil
YEAST TFIIA/TBP/DNA COMPLEX
Descriptor: DNA (5'-D(*GP*TP*TP*TP*TP*AP*TP*AP*TP*AP*CP*AP*TP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*AP*TP*GP*TP*AP*TP*AP*TP*AP*AP*AP*AP*C)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)), ...
Authors:Tan, S, Hunziker, Y, Sargent, D.F, Richmond, T.J.
Deposit date:1996-04-05
Release date:1996-06-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a yeast TFIIA/TBP/DNA complex.
Nature, 381, 1996
5WT9
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BU of 5wt9 by Molmil
Complex structure of PD-1 and nivolumab-Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Nivolumab, Light Chain of Nivolumab, ...
Authors:Tan, S, Zhang, H, Chai, Y, Song, H, Tong, Z, Wang, Q, Qi, J, Wong, G, Zhu, X, Liu, W.J, Gao, S, Wang, Z, Shi, Y, Yang, F, Gao, G.F, Yan, J.
Deposit date:2016-12-10
Release date:2017-02-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:An unexpected N-terminal loop in PD-1 dominates binding by nivolumab.
Nat Commun, 8, 2017
5XJ4
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BU of 5xj4 by Molmil
Complex structure of durvalumab-scFv/PD-L1
Descriptor: Programmed cell death 1 ligand 1, durvalumab-VH, durvalumab-VL
Authors:Tan, S, Liu, K, Chai, Y, Gao, G.F, Qi, J.
Deposit date:2017-04-29
Release date:2018-04-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab
Protein Cell, 9, 2018
8HIT
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BU of 8hit by Molmil
Crystal structure of anti-CTLA-4 humanized IgG1 MAb--JS007 in complex with human CTLA-4
Descriptor: Cytotoxic T-lymphocyte protein 4, JS007-VH, JS007-VL
Authors:Tan, S, Shi, Y, Wang, Q, Gao, G.F, Guan, J, Chai, Y, Qi, J.
Deposit date:2022-11-21
Release date:2023-02-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer.
Mabs, 15, 2023
7XOG
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BU of 7xog by Molmil
Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Postfusion state)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide, ...
Authors:Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J.
Deposit date:2022-05-01
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants.
Sci Bull (Beijing), 68, 2023
7XOE
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BU of 7xoe by Molmil
Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Prefusion state)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide
Authors:Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J.
Deposit date:2022-05-01
Release date:2024-02-14
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants.
Sci Bull (Beijing), 68, 2023
1F3U
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BU of 1f3u by Molmil
CRYSTAL STRUCTURE OF THE RAP30/74 INTERACTION DOMAINS OF HUMAN TFIIF
Descriptor: TRANSCRIPTION INITIATION FACTOR IIF, ALPHA SUBUNIT, BETA SUBUNIT
Authors:Gaiser, F, Tan, S, Richmond, T.J.
Deposit date:2000-06-06
Release date:2000-10-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Novel dimerization fold of RAP30/RAP74 in human TFIIF at 1.7 A resolution.
J.Mol.Biol., 302, 2000
5GRJ
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BU of 5grj by Molmil
Crystal structure of human PD-L1 with monoclonal antibody avelumab
Descriptor: Programmed cell death 1 ligand 1, avelumab H chain, avelumab L chain
Authors:Liu, K, Tan, S, Chai, Y, Chen, D, Song, H, Zhang, C.W.-H, Shi, Y, Liu, J, Tan, W, Lyu, J, Gao, S, Yan, J, Qi, J, Gao, G.F.
Deposit date:2016-08-11
Release date:2016-11-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.206 Å)
Cite:Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy.
Cell Res., 27, 2017
1NH2
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BU of 1nh2 by Molmil
Crystal structure of a yeast TFIIA/TBP/DNA complex
Descriptor: 5'-D(*GP*TP*TP*TP*TP*AP*TP*AP*TP*AP*CP*AP*TP*AP*CP*A)-3', 5'-D(*TP*GP*TP*AP*(5IU)P*GP*TP*AP*TP*AP*(5IU)P*AP*AP*AP*AP*C)-3', Transcription initiation factor IIA large chain, ...
Authors:Bleichenbacher, M, Tan, S, Richmond, T.J.
Deposit date:2002-12-18
Release date:2003-10-21
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes.
J.Mol.Biol., 332, 2003
1NVP
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BU of 1nvp by Molmil
HUMAN TFIIA/TBP/DNA COMPLEX
Descriptor: 5'-D(*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*CP*CP*CP*CP*CP*C)-3', 5'-D(*GP*GP*GP*GP*GP*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*G)-3', TATA box binding protein, ...
Authors:Bleichenbacher, M, Tan, S, Richmond, T.J.
Deposit date:2003-02-04
Release date:2003-10-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes.
J.Mol.Biol., 332, 2003
1SRS
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BU of 1srs by Molmil
SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA
Descriptor: DNA (5'-D(*CP*CP*(5IU)P*TP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*CP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*CP*AP*TP*GP*GP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*A P*AP*G)-3'), PROTEIN (SERUM RESPONSE FACTOR (SRF))
Authors:Pellegrini, L, Tan, S, Richmond, T.J.
Deposit date:1995-07-28
Release date:1995-07-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of serum response factor core bound to DNA.
Nature, 376, 1995
6CW2
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BU of 6cw2 by Molmil
Crystal structure of a yeast SAGA transcriptional coactivator Ada2/Gcn5 HAT subcomplex, crystal form 1
Descriptor: Histone acetyltransferase GCN5, Transcriptional adapter 2, ZINC ION, ...
Authors:Sun, J, Paduch, M, Kim, S.A, Kramer, R.M, Barrios, A.F, Lu, V, Luke, J, Usatyuk, S, Kossiakoff, A.A, Tan, S.
Deposit date:2018-03-29
Release date:2018-09-19
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CW3
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BU of 6cw3 by Molmil
Crystal structure of a yeast SAGA transcriptional coactivator Ada2/Gcn5 HAT subcomplex, crystal form 2
Descriptor: Histone acetyltransferase GCN5, Transcriptional adapter 2, ZINC ION, ...
Authors:Sun, J, Paduch, M, Kim, S.A, Kramer, R.M, Barrios, A.F, Lu, V, Luke, J, Usatyuk, S, Kossiakoff, A.A, Tan, S.
Deposit date:2018-03-29
Release date:2018-09-19
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6ISC
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BU of 6isc by Molmil
complex structure of mCD226-ecto and hCD155-D1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CD226 antigen, Poliovirus receptor
Authors:Wang, H, Qi, J, Zhang, S, Li, Y, Tan, S, Gao, G.F.
Deposit date:2018-11-16
Release date:2018-12-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6ISA
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BU of 6isa by Molmil
mCD226
Descriptor: CD226 antigen
Authors:Wang, H, Qi, J, Zhang, S, Li, Y, Tan, S, Gao, G.F.
Deposit date:2018-11-16
Release date:2018-12-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6ISB
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BU of 6isb by Molmil
crystal structure of human CD226
Descriptor: CD226 antigen
Authors:Wang, H, Qi, J, Zhang, S, Li, Y, Tan, S, Gao, G.F.
Deposit date:2018-11-16
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6J14
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BU of 6j14 by Molmil
Complex structure of GY-14 and PD-1
Descriptor: GY-14 heavy chain V fragment, GY-14 light chain V fragment, Programmed cell death protein 1
Authors:Chen, D, Tan, S, Whang, H, Zhang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F.
Deposit date:2018-12-27
Release date:2019-11-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.
Iscience, 14, 2019
6J15
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BU of 6j15 by Molmil
Complex structure of GY-5 Fab and PD-1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GY-5 heavy chain Fab, ...
Authors:Chen, D, Tan, S, Zhang, H, Wang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F.
Deposit date:2018-12-27
Release date:2019-11-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.
Iscience, 14, 2019
6JBT
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BU of 6jbt by Molmil
Complex structure of toripalimab-Fab and PD-1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain, ...
Authors:Guo, L, Tan, S, Chai, Y, Qi, J, Gao, G.F, Yan, J.
Deposit date:2019-01-26
Release date:2019-06-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy.
Mabs, 11, 2019
7SSA
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BU of 7ssa by Molmil
Cryo-EM structure of pioneer factor Cbf1 bound to the nucleosome
Descriptor: Centromere-binding protein 1, DNA (137-MER), Histone H2A.1, ...
Authors:Eek, P, Tan, S.
Deposit date:2021-11-10
Release date:2023-04-05
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions.
Mol.Cell, 83, 2023
8G57
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BU of 8g57 by Molmil
Structure of nucleosome-bound Sirtuin 6 deacetylase
Descriptor: DNA strand 1, DNA strand 2, Histone H2A type 1-B/E, ...
Authors:Chio, U.S, Rechiche, O, Bryll, A.R, Zhu, J, Feldman, J.L, Peterson, C.L, Tan, S, Armache, J.-P.
Deposit date:2023-02-11
Release date:2023-04-26
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Cryo-EM structure of the human Sirtuin 6-nucleosome complex.
Sci Adv, 9, 2023
7XYQ
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BU of 7xyq by Molmil
Crystal strucutre of PD-L1 and the computationally designed DBL1_03 protein binder
Descriptor: ARGININE, CD274 molecule, DBL1_03
Authors:Liu, K, Xu, Z, Han, P, Pacesa, M, Gao, G.F, Chai, Y, Tan, S.
Deposit date:2022-06-02
Release date:2023-04-12
Last modified:2023-05-17
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:De novo design of protein interactions with learned surface fingerprints.
Nature, 617, 2023
5HQ2
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BU of 5hq2 by Molmil
Structural model of Set8 histone H4 Lys20 methyltransferase bound to nucleosome core particle
Descriptor: DNA (149-MER), Guanine nucleotide exchange factor SRM1, Histone H2A, ...
Authors:Tavarekere, G, McGinty, R.K, Tan, S.
Deposit date:2016-01-21
Release date:2016-03-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate.
J.Mol.Biol., 428, 2016
4R8P
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BU of 4r8p by Molmil
Crystal structure of the Ring1B/Bmi1/UbcH5c PRC1 ubiquitylation module bound to the nucleosome core particle
Descriptor: DNA (147-mer), E3 ubiquitin-protein ligase RING2, Ubiquitin-conjugating enzyme E2 D3, ...
Authors:McGinty, R.K, Henrici, R.C, Tan, S.
Deposit date:2014-09-02
Release date:2014-11-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2846 Å)
Cite:Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome.
Nature, 514, 2014

 

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