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5HEL
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CRYSTAL STRUCTURE OF THE N-TERMINUS Y153H BROMODOMAIN MUTANT OF HUMAN BRD2
Descriptor:Bromodomain-containing protein 2, 1,2-ETHANEDIOL
Authors:Tallant, C., Lori, C., Pasquo, A., Chiaraluce, R., Consalvi, V., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2016-01-06
Release date:2016-01-20
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of the N-terminus Y153H bromodomain mutant of human BRD2
To Be Published
5HEM
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CRYSTAL STRUCTURE OF THE N-TERMINUS D161Y BROMODOMAIN MUTANT OF HUMAN BRD2
Descriptor:Bromodomain-containing protein 2, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Tallant, C., Lori, C., Pasquo, A., Chiaraluce, R., Consalvi, V., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2016-01-06
Release date:2016-01-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2
To Be Published
5HEN
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CRYSTAL STRUCTURE OF THE N-TERMINUS R100L BROMODOMAIN MUTANT OF HUMAN BRD2
Descriptor:Bromodomain-containing protein 2, 1,2-ETHANEDIOL
Authors:Tallant, C., Lori, C., Pasquo, A., Chiaraluce, R., Consalvi, V., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2016-01-06
Release date:2016-01-20
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal structure of the N-terminus R100L bromodomain mutant of human BRD2
To Be Published
5HFQ
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN Q443H MUTANT OF HUMAN BRD2
Descriptor:Bromodomain-containing protein 2
Authors:Tallant, C., Lori, C., Pasquo, A., Chiaraluce, R., Consalvi, V., Fonseca, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2016-01-07
Release date:2016-01-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the second bromodomain Q443H mutant of human BRD2
To Be Published
5HFR
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN H395R MUTANT OF HUMAN BRD3
Descriptor:Bromodomain-containing protein 3, NITRATE ION, 1,2-ETHANEDIOL
Authors:Tallant, C., Lori, C., Pasquo, A., Chiaraluce, R., Consalvi, V., Fonseca, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2016-01-07
Release date:2016-01-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the second bromodomain H395R mutant of human BRD3
To Be Published
5M9N
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CRYSTAL STRUCTURE OF HUMAN TDRD1 EXTENDED TUDOR DOMAIN IN COMPLEX WITH A SYMMETRICALLY DIMETHYLATED E2F PEPTIDE
Descriptor:Tudor domain-containing protein 1, E2F peptide, 1,2-ETHANEDIOL, ...
Authors:Tallant, C., Savitsky, P., Moehlenbrink, J., Chan, C., Nunez-Alonso, G., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Fedorov, O., La Thangue, N.B., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2016-11-01
Release date:2016-11-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human TDRD1 extended Tudor domain in complex with a symmetrically dimethylated E2F peptide
To Be Published
5M9O
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CRYSTAL STRUCTURE OF HUMAN SND1 EXTENDED TUDOR DOMAIN IN COMPLEX WITH A SYMMETRICALLY DIMETHYLATED E2F PEPTIDE
Descriptor:Staphylococcal nuclease domain-containing protein 1, E2F peptide
Authors:Tallant, C., Savitsky, P., Moehlenbrink, J., Chan, C., Nunez-Alonso, G., Siejka, P., Sorrell, F.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Fedorov, O., La Thangue, N.B., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2016-11-01
Release date:2016-12-07
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of human SND1 extended Tudor domain in complex with a symmetrically dimethylated E2F peptide
To Be Published
5N2L
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF HUMAN BRD2 IN COMPLEX WITH A TETRAHYDROQUINOLINE ANALOGUE
Descriptor:Bromodomain-containing protein 2, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Tallant, C., Slavish, P.J., Siejka, P., Bharatham, N., Shadrick, W.R., Chai, S., Young, B.M., Boyd, V.A., Heroven, C., Wiggers, H.J., Picaud, S., Fedorov, O., Krojer, T., Chen, T., Lee, R.E., Guy, R.K., Shelat, A.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2017-02-07
Release date:2018-02-28
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue
To Be Published
5N2M
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A TETRAHYDROQUINOLINE ANALOGUE
Descriptor:Bromodomain-containing protein 4, propan-2-yl ~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate, 1,2-ETHANEDIOL
Authors:Tallant, C., Slavish, P.J., Siejka, P., Bharatham, N., Shadrick, W.R., Chai, S., Young, B.M., Boyd, V.A., Heroven, C., Wiggers, H.J., Picaud, S., Fedorov, O., Krojer, T., Chen, T., Lee, R.E., Guy, R.K., Shelat, A.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2017-02-07
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue
To Be Published
4LC2
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1B
Descriptor:Peregrin, NITRATE ION, 1,2-ETHANEDIOL
Authors:Tallant, C., Nunez-Alonso, G., Savitsky, P., Picaud, S., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-06-21
Release date:2013-07-24
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of the bromodomain of human BRPF1B
TO BE PUBLISHED
4PTB
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CRYSTAL STRUCTURE OF HUMAN SP100 PHD-BROMODOMAIN IN THE FREE STATE
Descriptor:Nuclear autoantigen Sp-100, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Tallant, C., Nunez-Alonso, G., Savitsky, P., Newman, J., Krojer, T., Szykowska, A., Burgess-Brown, N., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2014-03-10
Release date:2014-04-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of human SP100 PHD-Bromodomain in the free state
To be Published
4QY4
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN SMARCA2
Descriptor:SMARCA2 protein, ZINC ION
Authors:Tallant, C., Savitsky, P., Nunez-Alonso, G., Fonseca, M., Krojer, T., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2014-07-23
Release date:2014-08-27
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal structure of the bromodomain of human SMARCA2
To be Published
5BT3
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CRYSTAL STRUCTURE OF EP300 BROMODOMAIN IN COMPLEX WITH SGC-CBP30 CHEMICAL PROBE
Descriptor:Histone acetyltransferase p300, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, ISOPROPYL ALCOHOL
Authors:Tallant, C., Hay, D., Krojer, T., Nunez-Alonso, G., Picaud, S., Newman, J.A., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2015-06-02
Release date:2015-07-01
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Crystal structure of EP300 bromodomain in complex with a 3,5-dimethylisoxazol ligand
To Be Published
5BT4
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CRYSTAL STRUCTURE OF BRD4 FIRST BROMODOMAIN IN COMPLEX WITH SGC-CBP30 CHEMICAL PROBE
Descriptor:Bromodomain-containing protein 4, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole, 1,2-ETHANEDIOL
Authors:Tallant, C., Hay, D., Krojer, T., Nunez-Alonso, G., Picaud, S., Newman, J.A., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2015-06-02
Release date:2015-07-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of BRD4 first bromodomain in complex with a 3,5-dimethylisoxazol ligand
To Be Published
5BT5
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CRYSTAL STRUCTURE OF BRD2 SECOND BROMODOMAIN IN COMPLEX WITH SGC-CBP30 CHEMICAL PROBE
Descriptor:Bromodomain-containing protein 2, 1,2-ETHANEDIOL, 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-benzimidazole
Authors:Tallant, C., Hay, D., Krojer, T., Nunez-Alonso, G., Picaud, S., Newman, J.A., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2015-06-02
Release date:2015-07-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of BRD2 second bromodomain in complex with a 3,5-dimethylisoxazol ligand
To Be Published
5DKC
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRM (SMARCA2) IN COMPLEX WITH PFI-3 CHEMICAL PROBE
Descriptor:Probable global transcription activator SNF2L2, ZINC ION, (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one
Authors:Tallant, C., Owen, D.R., Gerstenberger, B.S., Fedorov, O., Savitsky, P., Nunez-Alonso, G., Fonseca, M., Krojer, T., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S.
Deposit date:2015-09-03
Release date:2015-10-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe
To Be Published
5DKD
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRG1 (SMARCA4) IN COMPLEX WITH PFI-3 CHEMICAL PROBE
Descriptor:Transcription activator BRG1, ZINC ION, 1,2-ETHANEDIOL, ...
Authors:Tallant, C., Owen, D.R., Gerstenberger, B.S., Fedorov, O., Savitsky, P., Nunez-Alonso, G., Newman, J.A., Filippakopoulos, P., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S.
Deposit date:2015-09-03
Release date:2015-10-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the bromodomain of human BRG1 (SMARCA4) in complex with PFI-3 chemical probe
To Be Published
5DKH
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRM (SMARCA2) IN COMPLEX WITH A HYDROXYPHENYL PROPENONE INHIBITOR 17
Descriptor:Probable global transcription activator SNF2L2, ZINC ION, (2E)-3-[(6S,9R)-4-(cyclopropylamino)-6,7,8,9-tetrahydro-5H-6,9-epiminocyclohepta[d]pyrimidin-10-yl]-1-(2-hydroxyphenyl)prop-2-en-1-one, ...
Authors:Tallant, C., Owen, D.R., Taylor, A., Fedorov, O., Savitsky, P., Siejka, P., Srikannathasan, V., Nowak, R., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2015-09-03
Release date:2016-09-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with a hydroxyphenyl propenone inhibitor 17
To Be Published
5E9V
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CRYSTAL STRUCTURE OF BRD9 BROMODOMAIN IN COMPLEX WITH AN INDOLIZINE LIGAND
Descriptor:Bromodomain-containing protein 9, 1-[1-(imidazo[1,2-a]pyridin-5-yl)-7-(morpholin-4-yl)indolizin-3-yl]ethanone, 1,2-ETHANEDIOL
Authors:Tallant, C., Hay, D.A., Krojer, T., Nunez-Alonso, G., Picaud, S., Fedorov, O., Schofield, C.J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Brennan, P.E., Knapp, S.
Deposit date:2015-10-15
Release date:2015-10-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of BRD9 bromodomain in complex with an indolizine ligand
To Be Published
5FBX
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH PNZ5 ISOXAZOLE INHIBITOR
Descriptor:Bromodomain-containing protein 4, (3~{S})-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methyl-3-phenyl-3~{H}-isoindol-1-one
Authors:Tallant, C., Clark, P.G.K., Siejka, P., Fedorov, O., Nowak, R., Srikannathasan, V., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Brennan, P.E., Dixon, D., Knapp, S.
Deposit date:2015-12-14
Release date:2015-12-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
To Be Published
5FFV
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH H3K14AC HISTONE PEPTIDE
Descriptor:Peregrin, Histone H3, 1,2-ETHANEDIOL
Authors:Tallant, C., Nunez-Alonso, G., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2015-12-19
Release date:2015-12-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of the bromodomain of human BRPF1 in complex with H3K14ac histone peptide
To Be Published
5FFW
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH H4K5ACK8AC HISTONE PEPTIDE
Descriptor:Peregrin, Histone H4
Authors:Tallant, C., Nunez-Alonso, G., Savitsky, P., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2015-12-19
Release date:2015-12-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the bromodomain of human BRPF1 in complex with H4K5acK8ac histone peptide
To Be Published
5FFY
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH A BENZIMIDAZOLE LIGAND
Descriptor:Peregrin, 4-ethyl-~{N}-(6-methoxy-1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)benzenesulfonamide
Authors:Tallant, C., Savitsky, P., Nunez-Alonso, G., Kopec, J., Fedorov, O., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2015-12-19
Release date:2015-12-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of the bromodomain of human BRPF1 in complex with a benzimidazole ligand
To Be Published
5FG4
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH OF-1 CHEMICAL PROBE
Descriptor:Peregrin, 4-bromanyl-~{N}-(6-methoxy-1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)-2-methyl-benzenesulfonamide
Authors:Tallant, C., Owen, D.R., Gerstenberger, B.S., Savitsky, P., Chaikuad, A., Fedorov, O., Nunez-Alonso, G., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Knapp, S.
Deposit date:2015-12-20
Release date:2016-01-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of the bromodomain of human BRPF1 in complex with OF-1 chemical probe
To Be Published
5FG5
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BRPF1 IN COMPLEX WITH PFI-4 CHEMICAL PROBE
Descriptor:Peregrin, ~{N}-(1,3-dimethyl-2-oxidanylidene-6-pyrrolidin-1-yl-benzimidazol-5-yl)-2-methoxy-benzamide, NITRATE ION
Authors:Tallant, C., Owen, D.R., Gerstenberger, B.S., Savitsky, P., Chaikuad, A., Fedorov, O., Nunez-Alonso, G., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Muller, S., Brennan, P.E., Knapp, S.
Deposit date:2015-12-20
Release date:2015-12-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the bromodomain of human BRPF1 in complex with PFI-4 chemical probe
To Be Published