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Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor
Descriptor:	N-[5-(4-{[(3-chlorophenyl)sulfonyl]amino}phenyl)-1H-indazol-3-yl]furan-2-carboxamide, Non-receptor tyrosine-protein kinase TYK2
Authors:	Argiriadi, M.A, Talanian, R.V, Borhani, D.W.
Deposit date:	2012-03-07
Release date:	2012-10-03
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor. Bmc Struct.Biol., 12, 2012

Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor
Descriptor:	N-[4-(3-amino-1H-indazol-5-yl)phenyl]-3-chlorobenzenesulfonamide, Non-receptor tyrosine-protein kinase TYK2
Authors:	Argiriadi, M.A, Talanian, R.V, Borhani, D.W.
Deposit date:	2012-03-07
Release date:	2012-10-03
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor. Bmc Struct.Biol., 12, 2012

MK2 complex with inhibitor 6-(5-(2-aminopyrimidin-4-ylamino)-2-hydroxyphenyl)-N-methylbenzo[b]thiophene-2-carboxamide
Descriptor:	6-{5-[(2-aminopyrimidin-4-yl)amino]-2-hydroxyphenyl}-N-methylidene-1-benzothiophene-2-carboxamide, MAP kinase-activated protein kinase 2
Authors:	Argiriadi, M.A, Talanian, R.V, Borhani, D.W.
Deposit date:	2009-10-16
Release date:	2010-01-12
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode. Bioorg.Med.Chem.Lett., 20, 2010

MK2 complexed to inhibitor N4-(7-(benzofuran-2-yl)-1H-indazol-5-yl)pyrimidine-2,4-diamine
Descriptor:	MAP kinase-activated protein kinase 2, N~4~-[7-(1-benzofuran-2-yl)-1H-indazol-5-yl]pyrimidine-2,4-diamine
Authors:	Argiriadi, M.A, Talanian, R.V, Borhani, D.W.
Deposit date:	2009-10-20
Release date:	2010-01-12
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode. Bioorg.Med.Chem.Lett., 20, 2010