Author results

1KOZ
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SOLUTION STRUCTURE OF OMEGA-GRAMMOTOXIN SIA
Descriptor:Voltage-dependent Channel Inhibitor
Authors:Takeuchi, K., Park, E.J., Lee, C.W., Kim, J.I., Takahashi, H., Swartz, K.J., Shimada, I.
Deposit date:2001-12-25
Release date:2002-08-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel.
J.Mol.Biol., 321, 2002
2JOG
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STRUCTURE OF THE CALCINEURIN-NFAT COMPLEX
Descriptor:Calmodulin-dependent calcineurin A subunit alpha isoform, NFAT
Authors:Takeuchi, K., Roehrl, M.H., Sun, Z.Y., Wagner, G.
Deposit date:2007-03-10
Release date:2007-05-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates.
Structure, 15, 2007
2JXB
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STRUCTURE OF CD3EPSILON-NCK2 FIRST SH3 DOMAIN COMPLEX
Descriptor:T-cell surface glycoprotein CD3 epsilon chain, Cytoplasmic protein NCK2
Authors:Takeuchi, K., Yang, H., Ng, E., Park, S., Sun, Z.J., Reinherz, E.L., Wagner, G.
Deposit date:2007-11-09
Release date:2008-09-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.
J.Mol.Biol., 380, 2008
3WZZ
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CRYSTAL STRUCTURE OF PIP4KIIBETA
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-08
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X01
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X02
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X03
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH AMPPNP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X04
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CRYSTAL STRUCTURE OF PIP4KIIBETA COMPLEX WITH GMPPNP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X05
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CRYSTAL STRUCTURE OF PIP4KIIBETA T201M COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X06
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CRYSTAL STRUCTURE OF PIP4KIIBETA T201M COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X07
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CRYSTAL STRUCTURE OF PIP4KIIBETA N203A COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X08
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CRYSTAL STRUCTURE OF PIP4KIIBETA N203A COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X09
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CRYSTAL STRUCTURE OF PIP4KIIBETA F205L COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X0A
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CRYSTAL STRUCTURE OF PIP4KIIBETA F205L COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X0B
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CRYSTAL STRUCTURE OF PIP4KIIBETA I368A COMPLEX WITH AMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, ADENOSINE MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
3X0C
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CRYSTAL STRUCTURE OF PIP4KIIBETA I368A COMPLEX WITH GMP
Descriptor:Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, GUANOSINE-5'-MONOPHOSPHATE
Authors:Takeuchi, K., Lo, Y.H., Sumita, K., Senda, M., Terakawa, J., Dimitoris, A., Locasale, J.W., Sasaki, M., Yoshino, H., Zhang, Y., Kahoud, E.R., Takano, T., Yokota, T., Emerling, B., Asara, J.A., Ishida, T., Shimada, I., Daikoku, T., Cantley, L.C., Senda, T., Sasaki, A.T.
Deposit date:2014-10-09
Release date:2015-10-14
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis
Mol.Cell, 61, 2016
2RSG
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SOLUTION STRUCTURE OF THE CERT PH DOMAIN
Descriptor:Collagen type IV alpha-3-binding protein
Authors:Sugiki, T., Takeuchi, K., Tokunaga, Y., Kumagai, K., Kawano, M., Nishijima, M., Hanada, K., Takahashi, H., Shimada, I.
Deposit date:2012-02-25
Release date:2012-08-15
Last modified:2013-10-16
Method:SOLUTION NMR
Cite:Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT)
J.Biol.Chem., 287, 2012
5TNO
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DISCOVERY OF NOVEL AMINOBENZISOXAZOLE DERIVATIVES AS ORALLY AVAILABLE FACTOR IXA INHIBITORS
Descriptor:Coagulation factor IX, UNKNOWN LIGAND, SODIUM ION, ...
Authors:Sakurada, I., Endo, T., Hikita, K., Hirabayashi, T., Hosaka, Y., Kato, Y., Maeda, Y., Matsumoto, S., Mizuno, T., Nagasue, H., Nishimura, T., Shimada, S., Shinozaki, M., Taguchi, K., Takeuchi, K., Yokoyama, T., Hruza, A., Reichert, P., Zhang, T., Wood, H.B., Nakao, K., Furusako, S.
Deposit date:2016-10-14
Release date:2017-04-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5TNT
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DISCOVERY OF NOVEL AMINOBENZISOXAZOLE DERIVATIVES AS ORALLY AVAILABLE FACTOR IXA INHIBITORS
Descriptor:Coagulation factor IX, N-[(1S,4S,7R)-2-(3-amino-4-chloro[1,2]oxazolo[5,4-c]pyridin-7-yl)-2-azabicyclo[2.2.1]heptan-7-yl]-2-chloro-4-(3-methyl-1H-1,2,4-triazol-1-yl)benzamide, SODIUM ION, ...
Authors:Sakurada, I., Endo, T., Hikita, K., Hirabayashi, T., Hosaka, Y., Kato, Y., Maeda, Y., Matsumoto, S., Mizuno, T., Nagasue, A., Nishimura, T., Shimada, S., Shinozaki, M., Taguchi, K., Takeuchi, K., Yokoyama, T., Hruza, A., Reichert, P., Zhang, T., Wood, H.B., Nakao, K., Furusako, S.
Deposit date:2016-10-14
Release date:2017-04-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
1IE6
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SOLUTION STRUCTURE OF IMPERATOXIN A
Descriptor:IMPERATOXIN A
Authors:Lee, C.W., Takeuchi, K., Takahashi, H., Sato, K., Shimada, I., Kim, D.H., Kim, J.I.
Deposit date:2001-04-07
Release date:2003-06-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Molecular basis of the high-affinity activation of type 1 ryanodine receptors by imperatoxin A.
Biochem.J., 377, 2004
3B0B
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-S/CENP-X COMPLEX
Descriptor:Centromere protein S, Centromere protein X
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-06-08
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold.
Cell(Cambridge,Mass.), 148, 2012
3B0C
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W COMPLEX, CRYSTAL FORM I
Descriptor:Centromere protein T, Centromere protein W, CITRIC ACID
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-06-08
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold.
Cell(Cambridge,Mass.), 148, 2012
3B0D
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W COMPLEX, CRYSTAL FORM II
Descriptor:Centromere protein T, Centromere protein W, CITRIC ACID
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-06-08
Release date:2012-03-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.197 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold.
Cell(Cambridge,Mass.), 148, 2012
3VH5
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W/CENP-S/CENP-X HETEROTETRAMERIC COMPLEX, CRYSTAL FORM I
Descriptor:CENP-S, CENP-X, CENP-T, ...
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-08-23
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold
Cell(Cambridge,Mass.), 148, 2012
3VH6
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W/CENP-S/CENP-X HETEROTETRAMERIC COMPLEX, CRYSTAL FORM II
Descriptor:CENP-S, CENP-X, CENP-T, ...
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-08-23
Release date:2012-03-07
Method:X-RAY DIFFRACTION (3.351 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold
Cell(Cambridge,Mass.), 148, 2012
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