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1NBI
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BU of 1nbi by Molmil
Structure of R175K mutated glycine N-methyltransferase complexed with S-adenosylmethionine, R175K:SAM.
Descriptor: Glycine N-methyltransferase, S-ADENOSYLMETHIONINE
Authors:Takata, Y, Takusagawa, F.
Deposit date:2002-12-02
Release date:2003-03-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Catalytic mechanism of glycine N-methyltransferase
Biochemistry, 42, 2003
1NBH
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BU of 1nbh by Molmil
Structure of glycine N-methyltransferase complexed with S-adenosylmethionine and acetate, GNMT:SAM:Ace
Descriptor: ACETATE ION, Glycine N-methyltransferase, S-ADENOSYLMETHIONINE
Authors:Takata, Y, Takusagawa, F.
Deposit date:2002-12-02
Release date:2003-03-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic mechanism of glycine N-methyltransferase
Biochemistry, 42, 2003
1KY4
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BU of 1ky4 by Molmil
S-Adenosylhomocysteine hydrolase refined with noncrystallographic restraints
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, S-adenosylhomocysteine hydrolase
Authors:Takata, Y, Takusagawa, F.
Deposit date:2002-02-03
Release date:2002-09-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic Mechanism of S-adenosylhomocysteine Hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
J.Biol.Chem., 277, 2002
1KY5
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BU of 1ky5 by Molmil
D244E mutant S-Adenosylhomocysteine hydrolase refined with noncrystallographic restraints
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 3'-OXO-ADENOSINE, S-adenosylhomocysteine hydrolase
Authors:Takata, Y, Takusagawa, F.
Deposit date:2002-02-03
Release date:2002-09-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic Mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
J.Biol.Chem., 277, 2002
1B3R
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BU of 1b3r by Molmil
RAT LIVER S-ADENOSYLHOMOCYSTEIN HYDROLASE
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (S-ADENOSYLHOMOCYSTEINE HYDROLASE)
Authors:Hu, Y, Komoto, J, Huang, Y, Takusagawa, F, Gomi, T, Ogawa, H, Takata, Y, Fujioka, M.
Deposit date:1998-12-14
Release date:1998-12-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.
Biochemistry, 38, 1999
1D4F
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BU of 1d4f by Molmil
CRYSTAL STRUCTURE OF RECOMBINANT RAT-LIVER D244E MUTANT S-ADENOSYLHOMOCYSTEINE HYDROLASE
Descriptor: ADENOSINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, S-ADENOSYLHOMOCYSTEINE HYDROLASE
Authors:Komoto, J, Huang, Y, Takusagawa, F, Gomi, T, Ogawa, H, Takata, Y, Fujioka, M.
Deposit date:2000-06-22
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Effects of site-directed mutagenesis on structure and function of recombinant rat liver S-adenosylhomocysteine hydrolase. Crystal structure of D244E mutant enzyme.
J.Biol.Chem., 275, 2000
1D2G
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BU of 1d2g by Molmil
CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE FROM RAT LIVER
Descriptor: GLYCINE N-METHYLTRANSFERASE
Authors:Huang, Y, Komoto, J, Takusagawa, F, Konishi, K, Takata, Y.
Deposit date:1999-10-08
Release date:1999-10-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
1D2H
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BU of 1d2h by Molmil
CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLHOMOCYSTEINE
Descriptor: GLYCINE N-METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Huang, Y, Komoto, J, Takusagawa, F, Konishi, K, Takata, Y.
Deposit date:1999-10-11
Release date:1999-10-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
1XWF
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BU of 1xwf by Molmil
K185N mutated S-adenosylhomocysteine hydrolase
Descriptor: ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Yamada, T, Takata, Y, Komoto, J, Gomi, T, Ogawa, H, Fujioka, M, Takusagawa, F.
Deposit date:2004-11-01
Release date:2005-09-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic mechanism of S-adenosylhomocysteine hydrolase: Roles of His 54, Asp130, Glu155, Lys185, and Aspl89.
Int.J.Biochem.Cell Biol., 37, 2005
1XVA
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BU of 1xva by Molmil
METHYLTRANSFERASE
Descriptor: ACETATE ION, GLYCINE N-METHYLTRANSFERASE, S-ADENOSYLMETHIONINE
Authors:Fu, Z, Hu, Y, Konishi, K, Takata, Y, Ogawa, H, Gomi, T, Fujioka, M, Takusagawa, F.
Deposit date:1996-07-20
Release date:1997-01-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of glycine N-methyltransferase from rat liver.
Biochemistry, 35, 1996
1PWH
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BU of 1pwh by Molmil
Rat Liver L-Serine Dehydratase- Complex with PYRIDOXYL-(O-METHYL-SERINE)-5-MONOPHOSPHATE
Descriptor: L-serine dehydratase, N-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-O-METHYL-L-SERINE, POTASSIUM ION
Authors:Yamada, T, Komoto, J, Takata, Y, Ogawa, H, Takusagawa, F.
Deposit date:2003-07-01
Release date:2003-12-02
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of serine dehydratase from rat liver.
Biochemistry, 42, 2003
1PWE
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BU of 1pwe by Molmil
Rat Liver L-Serine Dehydratase Apo Enzyme
Descriptor: L-serine dehydratase
Authors:Yamada, T, Komoto, J, Takata, Y, Ogawa, H, Takusagawa, F.
Deposit date:2003-07-01
Release date:2003-12-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of serine dehydratase from rat liver.
Biochemistry, 42, 2003
1XCJ
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BU of 1xcj by Molmil
Guanidinoacetate methyltransferase containing S-adenosylhomocysteine and guanidinoacetate
Descriptor: GUANIDINO ACETATE, Guanidinoacetate N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Komoto, J, Yamada, T, Takata, Y, Takusagawa, F.
Deposit date:2004-09-02
Release date:2004-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes.
Biochemistry, 43, 2004
1XCL
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BU of 1xcl by Molmil
Guanidinoacetate methyltransferase containing S-adenosylhomocysteine and guanidine
Descriptor: GUANIDINE, Guanidinoacetate N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Komoto, J, Yamada, T, Takata, Y, Takusagawa, F.
Deposit date:2004-09-02
Release date:2004-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes.
Biochemistry, 43, 2004
1RG9
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BU of 1rg9 by Molmil
S-Adenosylmethionine synthetase complexed with SAM and PPNP
Descriptor: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Komoto, J, Yamada, T, Takata, Y, Markham, G.D, Takusagawa, F.
Deposit date:2003-11-11
Release date:2004-03-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET.
Biochemistry, 43, 2004
1K0U
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BU of 1k0u by Molmil
Inhibition of S-adenosylhomocysteine Hydrolase by "acyclic sugar" Adenosine Analogue D-eritadenine
Descriptor: D-ERITADENINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE
Authors:Takusagawa, F, Huang, Y, Komoto, J, Takata, Y, Gomi, T, Ogawa, H, Fujioka, M, Powell, D.
Deposit date:2001-09-20
Release date:2001-10-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine.
J.Biol.Chem., 277, 2002
8IG0
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BU of 8ig0 by Molmil
Crystal structure of menin in complex with DS-1594b
Descriptor: (1R,2S,4R)-4-[[4-(5,6-dimethoxypyridazin-3-yl)phenyl]methylamino]-2-[methyl-[6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]cyclopentan-1-ol, DIMETHYL SULFOXIDE, Menin, ...
Authors:Suzuki, M, Yoneyama, T, Imai, E.
Deposit date:2023-02-20
Release date:2023-03-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1.
Cancer Cell Int, 23, 2023
2H5L
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BU of 2h5l by Molmil
S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine
Descriptor: (2R,3R)-4-(4-AMINO-1H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-2,3-DIHYDROXYBUTANOIC ACID, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Yamada, T, Komoto, J, Takusagawa, F.
Deposit date:2006-05-26
Release date:2007-04-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and function of eritadenine and its 3-deaza analogues: Potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents.
Biochem.Pharm., 73, 2007
1D2C
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BU of 1d2c by Molmil
METHYLTRANSFERASE
Descriptor: PROTEIN (GLYCINE N-METHYLTRANSFERASE)
Authors:Huang, Y, Takusagawa, F.
Deposit date:1999-09-23
Release date:1999-10-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
2RKB
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BU of 2rkb by Molmil
Serine dehydratase like-1 from human cancer cells
Descriptor: POTASSIUM ION, PYRIDOXAL-5'-PHOSPHATE, Serine dehydratase-like
Authors:Yamada, T, Komoto, J, Kasuya, T, Mori, H, Ogawa, H, Takusagawa, F.
Deposit date:2007-10-16
Release date:2008-04-01
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: Crystal structure and site-directed mutagenesis studies.
Biochim.Biophys.Acta, 1780, 2008
3ONE
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BU of 3one by Molmil
Crystal structure of Lupinus luteus S-adenosyl-L-homocysteine hydrolase in complex with adenine
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENINE, Adenosylhomocysteinase, ...
Authors:Brzezinski, K, Jaskolski, M.
Deposit date:2010-08-28
Release date:2011-08-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus).
Acta Crystallogr.,Sect.D, 68, 2012
3ONF
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BU of 3onf by Molmil
Crystal structure of Lupinus luteus S-adenosyl-L-homocysteine hydrolase in complex with cordycepin
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3'-DEOXYADENOSINE, Adenosylhomocysteinase, ...
Authors:Brzezinski, K, Jaskolski, M.
Deposit date:2010-08-28
Release date:2011-08-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus).
Acta Crystallogr.,Sect.D, 68, 2012
3OND
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BU of 3ond by Molmil
Crystal structure of Lupinus luteus S-adenosyl-L-homocysteine hydrolase in complex with adenosine
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE, Adenosylhomocysteinase, ...
Authors:Brzezinski, K, Jaskolski, M.
Deposit date:2010-08-28
Release date:2011-08-31
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus).
Acta Crystallogr.,Sect.D, 68, 2012
6KG2
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BU of 6kg2 by Molmil
Human MTHFD2 in complex with Compound 18
Descriptor: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, N-[2-chloranyl-4-[[7-methyl-8-(4-methylpiperazin-1-yl)-5-oxidanylidene-2,4-dihydro-1H-chromeno[3,4-c]pyridin-3-yl]carbonyl]phenyl]methanesulfonamide, ...
Authors:Suzuki, M, Matsui, Y, Ota, M, Kawai, J.
Deposit date:2019-07-10
Release date:2019-11-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity.
J.Med.Chem., 62, 2019
1P1C
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BU of 1p1c by Molmil
Guanidinoacetate Methyltransferase with Gd ion
Descriptor: GADOLINIUM ION, Guanidinoacetate N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Komoto, J, Takusagawa, F.
Deposit date:2003-04-12
Release date:2003-04-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Monoclinic guanidinoacetate methyltransferase and gadolinium ion-binding characteristics.
Acta Crystallogr.,Sect.D, 59, 2003

 

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