Author results

121D
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MOLECULAR STRUCTURE OF THE A-TRACT DNA DODECAMER D(CGCAAATTTGCG) COMPLEXED WITH THE MINOR GROOVE BINDING DRUG NETROPSIN
Descriptor:DNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3'), NETROPSIN
Authors:Tabernero, L., Verdaguer, N., Coll, M., Fita, I., Van Der Marel, G.A., Van Boom, J.H., Rich, A., Aymami, J.
Deposit date:1993-04-14
Release date:1994-01-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor groove binding drug netropsin.
Biochemistry, 32, 1993
1AHR
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CALMODULIN MUTANT WITH A TWO RESIDUE DELETION IN THE CENTRAL HELIX
Descriptor:CALMODULIN, CALCIUM ION
Authors:Tabernero, L., Sack, J.
Deposit date:1997-04-10
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding.
Structure, 5, 1997
1C0E
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ACTIVE SITE S19A MUTANT OF BOVINE HEART PHOSPHOTYROSYL PHOSPHATASE
Descriptor:PROTEIN (TYROSINE PHOSPHATASE (ORTHOPHOSPHORIC MONOESTER PHOSPHOHYDROLASE)), PHOSPHATE ION
Authors:Tabernero, L., Evans, B.N., Tishmack, P.A., Van Etten, R.L., Stauffacher, C.V.
Deposit date:1999-07-15
Release date:1999-09-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of the bovine protein tyrosine phosphatase dimer reveals a potential self-regulation mechanism.
Biochemistry, 38, 1999
1HDT
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STRUCTURE OF A RETRO-BINDING PEPTIDE INHIBITOR COMPLEXED WITH HUMAN ALPHA-THROMBIN
Descriptor:ALPHA-THROMBIN, HIRUGEN PEPTIDE, methyl N-(4-carbamimidamidobutanoyl)-L-phenylalanyl-L-allothreonyl-L-phenylalaninate
Authors:Tabernero, L., Sack, J.
Deposit date:1994-07-25
Release date:1995-10-15
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.
J.Mol.Biol., 246, 1995
1QAX
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TERNARY COMPLEX OF PSEUDOMONAS MEVALONII HMG-COA REDUCTASE WITH HMG-COA AND NAD+
Descriptor:PROTEIN (3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE), 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Tabernero, L., Bochar, D.A., Rodwell, V.W., Stauffacher, C.V.
Deposit date:1999-04-06
Release date:1999-06-18
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QAY
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TERNARY COMPLEX OF PSEUDOMONAS MEVALONII HMG-COA REDUCTASE WITH MEVALONATE AND NAD+
Descriptor:PROTEIN (3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE), (R)-MEVALONATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Tabernero, L., Bochar, D.A., Rodwell, V.W., Stauffacher, C.V.
Deposit date:1999-04-07
Release date:1999-06-18
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase.
Proc.Natl.Acad.Sci.USA, 96, 1999
1T02
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CRYSTAL STRUCTURE OF A STATIN BOUND TO CLASS II HMG-COA REDUCTASE
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, (3R,5R)-7-((1R,2R,6S,8R,8AS)-2,6-DIMETHYL-8-{[(2R)-2-METHYLBUTANOYL]OXY}-1,2,6,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID, SULFATE ION
Authors:Tabernero, L., Rodwell, V.W., Stauffacher, C.
Deposit date:2004-04-07
Release date:2004-08-03
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase.
J.Biol.Chem., 278, 2003
1D1P
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CRYSTAL STRUCTURE OF A YEAST LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LTP1)
Descriptor:TYROSINE PHOSPHATASE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Wang, S., Tabernero, L., Zhang, M., Harms, E., Van Etten, R.L., Stauffacher, C.V.
Deposit date:1999-09-20
Release date:2000-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of a low-molecular weight protein tyrosine phosphatase from Saccharomyces cerevisiae and its complex with the substrate p-nitrophenyl phosphate.
Biochemistry, 39, 2000
1D1Q
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CRYSTAL STRUCTURE OF A YEAST LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LTP1) COMPLEXED WITH THE SUBSTRATE PNPP
Descriptor:TYROSINE PHOSPHATASE (E.C.3.1.3.48), 4-NITROPHENYL PHOSPHATE, PHOSPHATE ION, ...
Authors:Wang, S., Tabernero, L., Zhang, M., Harms, E., Van Etten, R.L., Staufacher, C.V.
Deposit date:1999-09-20
Release date:2000-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of a low-molecular weight protein tyrosine phosphatase from Saccharomyces cerevisiae and its complex with the substrate p-nitrophenyl phosphate.
Biochemistry, 39, 2000
1R31
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HMG-COA REDUCTASE FROM PSEUDOMONAS MEVALONII COMPLEXED WITH HMG-COA
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION, COENZYME A, ...
Authors:Watson, J.M., Steussy, C.N., Burgner, J.W., Lawrence, C.M., Tabernero, L., Rodwell, V.W., Stauffacher, C.V.
Deposit date:2003-09-30
Release date:2003-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-CoA Reductase.
To be Published
1R7I
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HMG-COA REDUCTASE FROM P. MEVALONII, NATIVE STRUCTURE AT 2.2 ANGSTROMS RESOLUTION.
Descriptor:3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION, GLYCEROL
Authors:Watson, J.M., Steussy, C.N., Burgner, J.W., Lawrence, C.M., Tabernero, L., Rodwell, V.W., Stauffacher, C.V.
Deposit date:2003-10-21
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-COA Reductase.
To be Published
2UXS
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2.7A CRYSTAL STRUCTURE OF INORGANIC PYROPHOSPHATASE (RV3628) FROM MYCOBACTERIUM TUBERCULOSIS AT PH 7.5
Descriptor:INORGANIC PYROPHOSPHATASE, PHOSPHATE ION
Authors:Cole, R.E., Cianci, M., Hall, J.F., Matsuda, T., Kigawa, T., Yokoyama, S., Hasnain, S.S., Tabernero, L.
Deposit date:2007-03-29
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Rv3628: An Inorganic Pyrophosphatase from Mycobacterium Tuberculosis
To be Published
2ZMC
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CRYSTAL STRUCTURE OF HUMAN MITOTIC CHECKPOINT KINASE MPS1 CATALYTIC DOMAIN APO FORM
Descriptor:Dual specificity protein kinase TTK, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
Authors:Chu, M.L.H., Chavas, L.M.G., Douglas, K.T., Eyers, P.A., Tabernero, L.
Deposit date:2008-04-16
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125.
J.Biol.Chem., 283, 2008
2ZMD
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CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN T686A MUTANT IN COMPLEX WITH SP600125 INHIBITOR
Descriptor:Dual specificity protein kinase TTK, 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
Authors:Chu, M.L.H., Chavas, L.M.G., Douglas, K.T., Eyers, P.A., Tabernero, L.
Deposit date:2008-04-16
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125.
J.Biol.Chem., 283, 2008
3HMN
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CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH ATP
Descriptor:Dual specificity protein kinase TTK, ADENOSINE-5'-TRIPHOSPHATE, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL
Authors:Chu, M.L.H., Chavas, L.M.G., Williams, D.H., Tabernero, L., Eyers, P.A.
Deposit date:2009-05-29
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.
Biochemistry, 49, 2010
3HMO
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CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH THE INHIBITOR STAUROSPORINE
Descriptor:Dual specificity protein kinase TTK, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, STAUROSPORINE, ...
Authors:Chu, M.L.H., Chavas, L.M.G., Williams, D.H., Tabernero, L., Eyers, P.A.
Deposit date:2009-05-29
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.
Biochemistry, 49, 2010
3HMP
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CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH A QUINAZOLIN LIGAND COMPOUND 4
Descriptor:Dual specificity protein kinase TTK, 7-chloro-N-(cyclopropylmethyl)quinazolin-4-amine, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, ...
Authors:Chu, M.L.H., Chavas, L.M.G., Williams, D.H., Tabernero, L., Eyers, P.A.
Deposit date:2009-05-29
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.
Biochemistry, 49, 2010
5MJY
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO1 DOMAIN (SARA COMPLEX STRUCTURE)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, Zinc finger FYVE domain-containing protein 9
Authors:Levy, C., Gahloth, D.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5MJZ
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO1 DOMAIN (APO STRUCTURE)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23
Authors:Levy, C., Gahloth, D.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.867 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5MK0
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO1 DOMAIN (ENDOFIN PEPTIDE COMPLEX)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, Zinc finger FYVE domain-containing protein 16
Authors:Levy, C., Gahloth, D.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.765 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5MK1
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO1 DOMAIN (CHMP4A PEPTIDE COMPLEX STRUCTURE)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, Charged multivesicular body protein 4a
Authors:Levy, C., Gahloth, D.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5MK2
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO1 DOMAIN (CHMP4B PEPTIDE COMPLEX STRUCTURE)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, Charged multivesicular body protein 4b
Authors:Levy, C., Gahloth, D.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5MK3
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CRYSTAL STRUCTURE OF THE HIS DOMAIN PROTEIN TYROSINE PHOSPHATASE (HD-PTP/PTPN23) BRO 1 DOMAIN (CHMP4C PEPTIDE COMPLEX STRUCTURE)
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, Charged multivesicular body protein 4c
Authors:Levy, C.
Deposit date:2016-12-02
Release date:2017-08-16
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Specific Interaction of TGF beta Signaling Regulators SARA/Endofin with HD-PTP.
Structure, 25, 2017
5LM1
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CRYSTAL STRUCTURE OF HD-PTP PHOSPHATASE IN COMPLEX WITH UBAP1
Descriptor:Tyrosine-protein phosphatase non-receptor type 23, UBAP-1
Authors:Levy, C.
Deposit date:2016-07-28
Release date:2016-11-30
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.
Structure, 24, 2016
5LM2
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CRYSTAL STRUCTURE OF HD-PTP PHOSPHATASE
Descriptor:Tyrosine-protein phosphatase non-receptor type 23
Authors:Levy, C.
Deposit date:2016-07-28
Release date:2016-11-30
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1.
Structure, 24, 2016
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