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2JPH
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BU of 2jph by Molmil
NMR solution structure of the Rho GTPase binding domain of human plexin-b1
Descriptor: Plexin-B1
Authors:Tong, Y, Buck, M.
Deposit date:2007-05-11
Release date:2008-03-18
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:Insights into Oncogenic Mutations of Plexin-B1 Based on the Solution Structure of the Rho GTPase Binding Domain
Structure, 16, 2008
6D0S
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BU of 6d0s by Molmil
RabGAP domain of human TBC1D22B
Descriptor: SULFATE ION, TBC1 domain family member 22B, UNKNOWN ATOM OR ION
Authors:Tong, Y, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2018-04-10
Release date:2018-06-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:RabGAP domain of human TBC1D22B
To be Published
7VF6
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BU of 7vf6 by Molmil
The crystal structure of PurZ0
Descriptor: GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, ...
Authors:Tong, Y, Zhang, Y.
Deposit date:2021-09-10
Release date:2023-05-24
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:Alternative Z-genome biosynthesis pathway shows evolutionary progression from Archaea to phage.
Nat Microbiol, 8, 2023
1NI1
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BU of 1ni1 by Molmil
Imidazole and cyanophenyl farnesyl transferase inhibitors
Descriptor: 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE, ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID, Protein farnesyltransferase alpha subunit, ...
Authors:Tong, Y, Lin, N.H, Wang, L, Hasvold, L, Wang, W, Leonard, N, Li, T, Li, Q, Cohen, J, Gu, W.Z, Zhang, H, Stoll, V, Bauch, J, Marsh, K, Rosenberg, S.H, Sham, H.L.
Deposit date:2002-12-20
Release date:2004-04-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
Bioorg.Med.Chem.Lett., 13, 2003
3NF1
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BU of 3nf1 by Molmil
Crystal structure of the TPR domain of kinesin light chain 1
Descriptor: Kinesin light chain 1
Authors:Tong, Y, Tempel, W, Shen, L, Shen, Y, Nedyalkova, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2010-06-09
Release date:2011-05-25
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the TPR domain of kinesin light chain 1
to be published
3GBJ
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BU of 3gbj by Molmil
Crystal structure of the motor domain of kinesin KIF13B bound with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, KIF13B protein, MAGNESIUM ION, ...
Authors:Tong, Y, Shen, L, Shen, Y, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2009-02-19
Release date:2009-03-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Crystal structure of the motor domain of kinesin KIF13B bound with ADP
To be Published
2IQJ
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BU of 2iqj by Molmil
Crystal structure of the GAP domain of SMAP1L (LOC64744) stromal membrane-associated protein 1-like
Descriptor: BETA-MERCAPTOETHANOL, Stromal membrane-associated protein 1-like, UNKNOWN ATOM OR ION, ...
Authors:Tong, Y, Dimov, S, Shen, L, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2006-10-13
Release date:2006-10-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the GAP domain of SMAP1L (LOC64744) stromal membrane-associated protein 1-like
To be Published
4IQ6
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BU of 4iq6 by Molmil
Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine
Descriptor: 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine, Glycogen synthase kinase-3 beta
Authors:Tong, Y, Stewart, K.D, Florjancic, A.S, Harlan, J.E, Merta, P.J, Przytulinska, M, Soni, N, Swinger, K.S, Zhu, H, Johnson, E.F, Shoemaker, A.R, Penning, T.D.
Deposit date:2013-01-10
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195.
ACS Med Chem Lett, 4, 2013
2OLM
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BU of 2olm by Molmil
ArfGap domain of HIV-1 Rev binding protein
Descriptor: GLYCEROL, Nucleoporin-like protein RIP, SULFATE ION, ...
Authors:Tong, Y, Tempel, W, Shen, L, Dimov, S, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-01-19
Release date:2007-01-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:ArfGap domain of HIV-1 Rev binding protein
To be Published
2P57
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BU of 2p57 by Molmil
GAP domain of ZNF289, an ID1-regulated zinc finger protein
Descriptor: GTPase-activating protein ZNF289, UNKNOWN ATOM OR ION, ZINC ION
Authors:Tong, Y, Dimov, S, Shen, L, Zhu, H, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-03-14
Release date:2007-03-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:GAP domain of ZNF289, an ID1-regulated zinc finger protein
To be Published
2QFZ
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BU of 2qfz by Molmil
Crystal structure of human TBC1 domain family member 22A
Descriptor: TBC1 domain family member 22A, UNKNOWN ATOM OR ION
Authors:Tong, Y, Tempel, W, Dimov, S, Dong, A, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human TBC1 domain family member 22A.
To be Published
2R2O
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BU of 2r2o by Molmil
Crystal structure of the effector domain of human Plexin B1
Descriptor: Plexin-B1, UNKNOWN ATOM OR ION
Authors:Tong, Y, Tempel, W, Shen, L, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-08-27
Release date:2007-09-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.
J.Biol.Chem., 282, 2007
2QQ8
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BU of 2qq8 by Molmil
Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14
Descriptor: TBC1 domain family member 14, UNKNOWN ATOM OR ION
Authors:Tong, Y, Tempel, W, Dimov, S, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-07-26
Release date:2007-08-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the putative RabGAP domain of human TBC1 domain family member 14.
To be Published
2REX
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BU of 2rex by Molmil
Crystal structure of the effector domain of PLXNB1 bound with Rnd1 GTPase
Descriptor: CALCIUM ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Tong, Y, Tempel, W, Shen, L, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2007-09-27
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the effector domain of PLXNB1 bound with Rnd1 GTPase.
To be Published
3GFT
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BU of 3gft by Molmil
Human K-Ras (Q61H) in complex with a GTP analogue
Descriptor: CITRIC ACID, GTPase KRas, MAGNESIUM ION, ...
Authors:Tong, Y, Tempel, W, Shen, L, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2009-02-27
Release date:2009-03-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Human K-Ras in complex with a GTP analogue
To be Published
3H6N
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BU of 3h6n by Molmil
Crystal Structure of the ubiquitin-like domain of plexin D1
Descriptor: ARSENIC, Plexin-D1, UNKNOWN ATOM OR ION
Authors:Tong, Y, Nedyalkova, L, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Buck, M, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2009-04-23
Release date:2009-05-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Crystal Structure of the ubiquitin-like domain of plexin D1
To be Published
3HM6
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BU of 3hm6 by Molmil
Crystal structure of the cytoplasmic domain of human plexin B1
Descriptor: Plexin-B1, UNKNOWN ATOM OR ION, Unknown peptide
Authors:Tong, Y, He, H, Shen, L, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2009-05-28
Release date:2009-06-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
J.Biol.Chem., 284, 2009
3KFV
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BU of 3kfv by Molmil
Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form
Descriptor: Tight junction protein ZO-3, UNKNOWN ATOM OR ION
Authors:Tong, Y, Nedyalkova, L, Tempel, W, Zhong, N, Guan, X, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2009-10-28
Release date:2009-11-03
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form
to be published
7M2F
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BU of 7m2f by Molmil
CDK2 with compound 14 inhibitor with carboxylate
Descriptor: Cyclin-dependent kinase 2, [(1r,4r)-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexyl]acetic acid
Authors:Longenecker, K.L, Qiu, W, Korepanova, A, Tong, Y.
Deposit date:2021-03-16
Release date:2021-07-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.632 Å)
Cite:Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors.
Acs Med.Chem.Lett., 12, 2021
7WAT
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BU of 7wat by Molmil
The Crystal Structure of Bifunctional Miltiradiene Synthase from Selaginella moellendorffii
Descriptor: Bifunctional diterpene synthase
Authors:Ma, X, Tong, Y, Jiang, T.
Deposit date:2021-12-15
Release date:2022-10-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and mechanistic insights into the precise product synthesis by a bifunctional miltiradiene synthase.
Plant Biotechnol J, 21, 2023
3LJU
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BU of 3lju by Molmil
Crystal structure of full length centaurin alpha-1 bound with the head group of PIP3
Descriptor: (2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoate, Arf-GAP with dual PH domain-containing protein 1, ZINC ION
Authors:Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2010-01-26
Release date:2010-11-24
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3CPF
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BU of 3cpf by Molmil
Crystal structure of human eukaryotic translation initiation factor EIF5A
Descriptor: Eukaryotic translation initiation factor 5A-1, UNKNOWN ATOM OR ION
Authors:Nedyalkova, L, Tong, Y, Tempel, W, Hong, B, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2008-03-31
Release date:2008-04-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2.
Proteins, 75, 2009
3EO3
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BU of 3eo3 by Molmil
Crystal structure of the N-acetylmannosamine kinase domain of human GNE protein
Descriptor: Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, UNKNOWN ATOM OR ION, ZINC ION
Authors:Nedyalkova, L, Tong, Y, Rabeh, W.M, Hong, B, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2008-09-26
Release date:2008-10-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Crystal structure of the N-acetylmannosamine kinase domain of GNE.
Plos One, 4, 2009
3FEH
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BU of 3feh by Molmil
Crystal structure of full length centaurin alpha-1
Descriptor: Centaurin-alpha-1, UNKNOWN ATOM OR ION, ZINC ION
Authors:Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2008-11-29
Release date:2008-12-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin {alpha}1.
Proc.Natl.Acad.Sci.USA, 107, 2010
3FM8
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BU of 3fm8 by Molmil
Crystal structure of full length centaurin alpha-1 bound with the FHA domain of KIF13B (CAPRI target)
Descriptor: Centaurin-alpha-1, Kinesin-like protein KIF13B, SULFATE ION, ...
Authors:Shen, L, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
Deposit date:2008-12-19
Release date:2009-08-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc.Natl.Acad.Sci.USA, 107, 2010

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