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1TIB
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BU of 1tib by Molmil
CONFORMATIONAL LABILITY OF LIPASES OBSERVED IN THE ABSENCE OF AN OIL-WATER INTERFACE: CRYSTALLOGRAPHIC STUDIES OF ENZYMES FROM THE FUNGI HUMICOLA LANUGINOSA AND RHIZOPUS DELEMAR
Descriptor: LIPASE
Authors:Derewenda, U, Swenson, L, Wei, Y, Derewenda, Z.S.
Deposit date:1993-12-06
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Conformational lability of lipases observed in the absence of an oil-water interface: crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar.
J.Lipid Res., 35, 1994
1TIC
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BU of 1tic by Molmil
CONFORMATIONAL LABILITY OF LIPASES OBSERVED IN THE ABSENCE OF AN OIL-WATER INTERFACE: CRYSTALLOGRAPHIC STUDIES OF ENZYMES FROM THE FUNGI HUMICOLA LANUGINOSA AND RHIZOPUS DELEMAR
Descriptor: LIPASE
Authors:Derewenda, U, Swenson, L, Green, R, Joerger, R, Haas, M.J, Derewenda, Z.S.
Deposit date:1993-12-06
Release date:1995-01-26
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Conformational lability of lipases observed in the absence of an oil-water interface: crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar.
J.Lipid Res., 35, 1994
1TIA
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BU of 1tia by Molmil
AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES
Descriptor: LIPASE
Authors:Derewenda, U, Swenson, L, Yamaguchi, S, Wei, Y, Derewenda, Z.S.
Deposit date:1993-12-06
Release date:1995-01-26
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An unusual buried polar cluster in a family of fungal lipases.
Nat.Struct.Biol., 1, 1994
1WAB
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BU of 1wab by Molmil
PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Descriptor: ACETATE ION, PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Authors:Ho, Y.S, Swenson, L, Derewenda, U, Serre, L, Wei, Y, Dauter, Z, Hattori, M, Aoki, J, Arai, H, Adachi, T, Inoue, K, Derewenda, Z.S.
Deposit date:1996-10-30
Release date:1997-11-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer.
Nature, 385, 1997
1ESC
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BU of 1esc by Molmil
THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
Descriptor: ESTERASE
Authors:Wei, Y, Schottel, J.L, Derewenda, U, Swenson, L, Patkar, S, Derewenda, Z.S.
Deposit date:1994-10-07
Release date:1995-10-15
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1MUO
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BU of 1muo by Molmil
CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE
Descriptor: ADENOSINE, Aurora-related kinase 1
Authors:Cheetham, G.M.T, Knegtel, R.M.A, Coll, J.T, Renwick, S.B, Swenson, L, Weber, P, Lippke, J.A, Austen, D.A.
Deposit date:2002-09-24
Release date:2003-04-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase
J.Biol.Chem., 277, 2002
1OOZ
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BU of 1ooz by Molmil
Deletion mutant of SUCCINYL-COA:3-KETOACID COA TRANSFERASE FROM PIG HEART
Descriptor: POTASSIUM ION, Succinyl-CoA:3-ketoacid-coenzyme A transferase
Authors:Coros, A.M, Swenson, L, Wolodko, W.T, Fraser, M.E.
Deposit date:2003-03-04
Release date:2004-04-27
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the CoA transferase from pig heart to 1.7 A resolution.
Acta Crystallogr.,Sect.D, 60, 2004
1OOY
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BU of 1ooy by Molmil
SUCCINYL-COA:3-KETOACID COA TRANSFERASE FROM PIG HEART
Descriptor: PHOSPHATE ION, POTASSIUM ION, Succinyl-CoA:3-ketoacid-coenzyme A transferase, ...
Authors:Coros, A.M, Swenson, L, Wolodko, W.T, Fraser, M.E.
Deposit date:2003-03-04
Release date:2004-04-27
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the CoA transferase from pig heart to 1.7 A resolution.
Acta Crystallogr.,Sect.D, 60, 2004
1OPE
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BU of 1ope by Molmil
Deletion mutant of SUCCINYL-COA:3-KETOACID COA TRANSFERASE FROM PIG HEART
Descriptor: MERCURY (II) ION, POTASSIUM ION, Succinyl-CoA:3-ketoacid-coenzyme A transferase
Authors:Coros, A.M, Swenson, L, Wolodko, W.T, Fraser, M.E.
Deposit date:2003-03-05
Release date:2004-04-27
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the CoA transferase from pig heart to 1.7 A resolution.
Acta Crystallogr.,Sect.D, 60, 2004
1RJB
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BU of 1rjb by Molmil
Crystal Structure of FLT3
Descriptor: FL cytokine receptor
Authors:Griffith, J, Black, J, Faerman, C, Swenson, L, Wynn, M, Lu, F, Lippke, J, Saxena, K.
Deposit date:2003-11-19
Release date:2004-02-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.
Mol.Cell, 13, 2004
1YI4
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BU of 1yi4 by Molmil
Structure of Pim-1 bound to adenosine
Descriptor: ADENOSINE, Proto-oncogene serine/threonine-protein kinase Pim-1
Authors:Jacobs, M.D, Black, J, Futer, O, Swenson, L, Hare, B, Fleming, M, Saxena, K.
Deposit date:2005-01-11
Release date:2005-01-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
J.Biol.Chem., 280, 2005
1YI3
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BU of 1yi3 by Molmil
Crystal Structure of Pim-1 bound to LY294002
Descriptor: 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE, Proto-oncogene serine/threonine-protein kinase Pim-1
Authors:Jacobs, M.D, Black, J, Futer, O, Swenson, L, Hare, B, Fleming, M, Saxena, K.
Deposit date:2005-01-11
Release date:2005-01-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
J.Biol.Chem., 280, 2005
1YHS
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BU of 1yhs by Molmil
Crystal structure of Pim-1 bound to staurosporine
Descriptor: Proto-oncogene serine/threonine-protein kinase Pim-1, STAUROSPORINE
Authors:Jacobs, M.D, Black, J, Futer, O, Swenson, L, Hare, B, Fleming, M, Saxena, K.
Deposit date:2005-01-10
Release date:2005-01-25
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
J.Biol.Chem., 280, 2005
1ESE
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BU of 1ese by Molmil
THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
Descriptor: DIETHYL PHOSPHONATE, ESTERASE
Authors:Wei, Y, Schottel, J.L, Derewenda, U, Swenson, L, Patkar, S, Derewenda, Z.S.
Deposit date:1994-10-07
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1ESD
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BU of 1esd by Molmil
THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
Descriptor: ESTERASE, METHYLPHOSPHONIC ACID ESTER GROUP
Authors:Wei, Y, Schottel, J.L, Derewenda, U, Swenson, L, Patkar, S, Derewenda, Z.S.
Deposit date:1994-10-07
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
4YTF
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BU of 4ytf by Molmil
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Diseases
Descriptor: N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-N-(2,2,2-trifluoroethyl)-L-alaninamide, Tyrosine-protein kinase JAK2
Authors:Farmer, L, Ledeboer, M.W, Zuccola, H.J.
Deposit date:2015-03-17
Release date:2015-08-12
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
J.Med.Chem., 58, 2015
4YTI
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BU of 4yti by Molmil
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Disease
Descriptor: (2R)-2-methyl-2-[[2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-N-[2,2,2-tris(fluoranyl)ethyl]butanamide, Tyrosine-protein kinase JAK2
Authors:Zuccola, H.J, Ledeboer, M.
Deposit date:2015-03-17
Release date:2015-08-12
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
J.Med.Chem., 58, 2015
4YTC
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BU of 4ytc by Molmil
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Disease
Descriptor: N~3~-phenyl-1-[6-(phenylamino)pyrimidin-4-yl]-1H-1,2,4-triazole-3,5-diamine, Tyrosine-protein kinase JAK2
Authors:Zuccola, H.J, Ledeboer, M.
Deposit date:2015-03-17
Release date:2015-08-12
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
J.Med.Chem., 58, 2015
4YTH
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BU of 4yth by Molmil
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus kinase (JAK) 3 Inhibitor for the Treatment of Autoimmune Diseases
Descriptor: N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-N-(2,2,2-trifluoroethyl)-D-alaninamide, Tyrosine-protein kinase JAK2
Authors:Ledeboer, M.W, Zuccola, H.J.
Deposit date:2015-03-17
Release date:2015-08-12
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
J.Med.Chem., 58, 2015
1JFR
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BU of 1jfr by Molmil
CRYSTAL STRUCTURE OF THE STREPTOMYCES EXFOLIATUS LIPASE AT 1.9A RESOLUTION: A MODEL FOR A FAMILY OF PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES
Descriptor: LIPASE
Authors:Wei, Y, Derewenda, Z.S.
Deposit date:1997-07-11
Release date:1998-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution.
Structure, 6, 1998
1BWQ
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BU of 1bwq by Molmil
PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Descriptor: PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Authors:Ho, Y.S, Sheffield, P.J, Masuyama, J, Arai, H, Li, J, Aoki, J, Inoue, K, Derewenda, U, Derewenda, Z.
Deposit date:1998-09-27
Release date:1999-05-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Probing the Substrate Specificity of the Intracellular Brain Platelet-Activating Factor Acetylhydrolase
Protein Eng., 12, 1999
1BWP
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BU of 1bwp by Molmil
PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Descriptor: PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Authors:Ho, Y.S, Sheffield, P.J, Masuyama, J, Arai, H, Li, J, Aoki, J, Inoue, K, Derewenda, U, Derewenda, Z.
Deposit date:1998-09-27
Release date:1999-05-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Probing the Substrate Specificity of the Intracellular Brain Platelet-Activating Factor Acetylhydrolase
Protein Eng., 12, 1999
1BWR
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BU of 1bwr by Molmil
PROBING THE SUBSTRATE SPECIFICITY OF THE INTRACELLULAR BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Descriptor: PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
Authors:Ho, Y.S, Sheffield, P.J, Masuyama, J, Arai, H, Li, J, Aoki, J, Inoue, K, Derewenda, U, Derewenda, Z.
Deposit date:1998-09-27
Release date:1999-05-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Probing the Substrate Specificity of the Intracellular Brain Platelet-Activating Factor Acetylhydrolase
Protein Eng., 12, 1999
2ESM
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BU of 2esm by Molmil
Crystal Structure of ROCK 1 bound to fasudil
Descriptor: 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, Rho-associated protein kinase 1
Authors:Jacobs, M.
Deposit date:2005-10-26
Release date:2005-11-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity.
J.Biol.Chem., 281, 2006
2ETK
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BU of 2etk by Molmil
Crystal Structure of ROCK 1 bound to hydroxyfasudil
Descriptor: 1-(1-HYDROXY-5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, Rho-associated protein kinase 1
Authors:Jacobs, M.
Deposit date:2005-10-27
Release date:2005-11-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity.
J.Biol.Chem., 281, 2006

 

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