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2NAV
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BU of 2nav by Molmil
NMR solution structure of Ex-4[1-16]/pl14a
Descriptor: Exendin-4, Alpha/kappa-conotoxin pl14a chimera
Authors:Schroeder, C.I, Swedberg, J.E, Craik, D.J.
Deposit date:2016-01-11
Release date:2016-05-04
Last modified:2016-08-17
Method:SOLUTION NMR
Cite:Truncated Glucagon-like Peptide-1 and Exendin-4 alpha-Conotoxin pl14a Peptide Chimeras Maintain Potency and alpha-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
J.Biol.Chem., 291, 2016
2NAW
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BU of 2naw by Molmil
NMR solution structure of Exendin-4/conotoxin chimera (Ex-4[1-27]/pl14a)
Descriptor: Exendin-4, Alpha/kappa-conotoxin pl14a chimera
Authors:Schroeder, C.I, Swedberg, J.E, Craik, D.J.
Deposit date:2016-01-12
Release date:2016-05-18
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Truncated Glucagon-like Peptide-1 and Exendin-4 alpha-Conotoxin pl14a Peptide Chimeras Maintain Potency and alpha-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
J.Biol.Chem., 291, 2016
4K1E
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BU of 4k1e by Molmil
Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Kallikrein-4, LITHIUM ION, ...
Authors:Ilyichova, O.V, Swedberg, J.E, de Veer, S.J, Sit, K.C, Harris, J.M, Buckle, A.M.
Deposit date:2013-04-04
Release date:2014-04-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics
Sci Rep, 6, 2016
4KGA
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BU of 4kga by Molmil
Crystal structure of kallikrein-related peptidase 4
Descriptor: 1,2-ETHANEDIOL, Kallikrein-4, NICKEL (II) ION
Authors:Ilyichova, O.V, Swedberg, J.E, de Veer, S.J, Sit, K.C, Harris, J.M, Buckle, A.M.
Deposit date:2013-04-29
Release date:2014-04-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics
Sci Rep, 6, 2016
7FBP
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BU of 7fbp by Molmil
FXIIa-cMCoFx1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XIIa light chain, cMCoFx1
Authors:Sengoku, T, Liu, W, de Veer, S.J, Huang, Y.H, Okada, C, Zdenek, C.N, Fry, B.G, Swedberg, J.E, Passioura, T, Craik, D.J, Suga, H, Ogata, K.
Deposit date:2021-07-12
Release date:2021-11-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human beta-Factor XIIa in a Cyclotide Scaffold.
J.Am.Chem.Soc., 143, 2021
4K8Y
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BU of 4k8y by Molmil
Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with Sunflower Trypsin Inhibitor (SFTI-1)
Descriptor: Kallikrein-4, Trypsin inhibitor 1
Authors:Ilyichova, O.V, Swedberg, J.E, de Veer, S.J, Sit, K.C, Harris, J.M, Buckle, A.M.
Deposit date:2013-04-19
Release date:2014-04-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1 Å)
Cite:Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics
Sci Rep, 6, 2016
4KEL
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BU of 4kel by Molmil
Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR(N)
Descriptor: Kallikrein-4, Trypsin inhibitor 1
Authors:Ilyichova, O.V, Swedberg, J.E, de Veer, S.J, Sit, K.C, Harris, J.M, Buckle, A.M.
Deposit date:2013-04-25
Release date:2014-04-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.148 Å)
Cite:KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors.
Biochemistry, 58, 2019
2NDM
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BU of 2ndm by Molmil
NMR solution structure of PawS Derived Peptide 21 (PDP-21)
Descriptor: PawS derived peptide 21
Authors:Franke, B, Jayasena, A.S, Fisher, M.F, Swedberg, J.E, Taylor, N.L, Mylne, J.S, Rosengren, K.
Deposit date:2016-07-17
Release date:2016-08-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana).
Biopolymers, 106, 2016
2NDN
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BU of 2ndn by Molmil
NMR solution structure of PawS Derived Peptide 20 (PDP-20)
Descriptor: PawS1a Derived Peptide 20
Authors:Franke, B, Jayasena, A.S, Fisher, M.F, Swedberg, J.E, Taylor, N.L, Mylne, J.S, Rosengren, K.
Deposit date:2016-07-26
Release date:2016-08-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana).
Biopolymers, 106, 2016
2NDL
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BU of 2ndl by Molmil
NMR solution structure of PawS Derived Peptide 22 (PDP-22)
Descriptor: PawS derived peptide
Authors:Franke, B, Jayasena, A.S, Fisher, M.F, Swedberg, J.E, Taylor, N.L, Mylne, J.S, Rosengren, K.
Deposit date:2016-07-17
Release date:2016-12-07
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Diverse cyclic seed peptides in the Mexican zinnia (Zinnia haageana).
Biopolymers, 106, 2016
6D3Z
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BU of 6d3z by Molmil
Protease SFTI complex
Descriptor: Plasminogen, Trypsin inhibitor 1
Authors:Law, R.H.P, Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
6D40
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BU of 6d40 by Molmil
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
Descriptor: Plasminogen, SULFATE ION, Trypsin inhibitor 1
Authors:Law, R.H.P, Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
6D3Y
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BU of 6d3y by Molmil
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
Descriptor: GLYCEROL, Plasminogen, SULFATE ION, ...
Authors:Law, R.H.P, Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
6D3X
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BU of 6d3x by Molmil
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
Descriptor: Plasminogen, Trypsin inhibitor 1
Authors:Law, R.H.P, Wu, G.
Deposit date:2018-04-17
Release date:2019-01-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
6Q1U
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BU of 6q1u by Molmil
Structure of plasmin and peptide complex
Descriptor: 1-methyl-1H-1,2,3-triazole, GLY-ARG-ALA-TYR-LYS-SER-LYS-PRO-PRO-ILE-ALA-PHE-PRO-ASP, Plasminogen
Authors:Wu, G, Law, R.H.P.
Deposit date:2019-08-06
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3467 Å)
Cite:Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides.
Angew.Chem.Int.Ed.Engl., 59, 2020
6VXY
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BU of 6vxy by Molmil
Triazole bridged SFTI1 inhibitor in complex with beta-trypsin
Descriptor: 1-methyl-1H-1,2,3-triazole, CALCIUM ION, Cationic trypsin, ...
Authors:White, A.M, King, G.J, Durek, T, Craik, D.J.
Deposit date:2020-02-25
Release date:2020-07-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.398 Å)
Cite:Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides.
Angew.Chem.Int.Ed.Engl., 2020
6NOX
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BU of 6nox by Molmil
Solution structure of SFTI-KLK5 inhibitor
Descriptor: SFTI-KLK5 Peptide
Authors:White, A.M.
Deposit date:2019-01-16
Release date:2019-04-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Amino Acid Scanning at P5' within the Bowman-Birk Inhibitory Loop Reveals Specificity Trends for Diverse Serine Proteases.
J. Med. Chem., 62, 2019
6O21
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BU of 6o21 by Molmil
Crystal Structure of Human KLK4 in Complex With Cleaved SFTI-FCQR(Asn14)[1,14] Inhibitor
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Kallikrein 4 (Prostase, enamel matrix, ...
Authors:Ilyichova, O.V, Buckle, A.M.
Deposit date:2019-02-22
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors.
Biochemistry, 58, 2019
4NE9
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BU of 4ne9 by Molmil
PCSK9 in complex with LDLR peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor, ...
Authors:Liu, S.
Deposit date:2013-10-28
Release date:2014-09-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.
Chem.Biol., 21, 2014
6BVH
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BU of 6bvh by Molmil
Trypsin complexed with a modified sunflower trypsin inhibitor, SFTI-TCTR(N12,N14)
Descriptor: CALCIUM ION, Cationic trypsin, GLYCEROL, ...
Authors:Riley, B.T, Chen, X.
Deposit date:2017-12-13
Release date:2018-12-19
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.927 Å)
Cite:Potent, multi-target serine protease inhibition achieved by a simplified beta-sheet motif.
PLoS ONE, 14, 2019
2MG9
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BU of 2mg9 by Molmil
Truncated EGF-A
Descriptor: CALCIUM ION, Low-density lipoprotein receptor
Authors:Schroeder, C.I, Rosengren, K.
Deposit date:2013-10-30
Release date:2014-04-02
Method:SOLUTION NMR
Cite:Design and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro.
Chem.Biol., 21, 2014
6U7Q
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BU of 6u7q by Molmil
NMR solution structure of SFTI-R10
Descriptor: GLY-ARG-CYS-THR-LYS-SER-ILE-PRO-PRO-ARG-CYS-PHE-PRO-ASP inhibitor
Authors:White, A.M, Harvey, P.J, Durek, T, Craik, D.J.
Deposit date:2019-09-03
Release date:2020-04-22
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides.
Angew.Chem.Int.Ed.Engl., 59, 2020
6U24
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BU of 6u24 by Molmil
NMR solution structure of triazole bridged SFTI-1
Descriptor: 1-methyl-1H-1,2,3-triazole, GLY-ARG-ALA-THR-LYS-SER-ILE-PRO-PRO-ILE-ALA-PHE-PRO-ASP
Authors:White, A.M, Harvey, P.J, Durek, T, Craik, D.J.
Deposit date:2019-08-19
Release date:2020-07-01
Last modified:2020-07-15
Method:SOLUTION NMR
Cite:Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides.
Angew.Chem.Int.Ed.Engl., 59, 2020
6U7U
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BU of 6u7u by Molmil
NMR solution structure of triazole bridged matriptase inhibitor
Descriptor: 1-methyl-1H-1,2,3-triazole, GLY-ARG-ALA-THR-LYS-SER-ILE-PRO-PRO-ARG-ALA-PHE-PRO-ASP
Authors:White, A.M, Harvey, P.J, Durek, T, Craik, D.J.
Deposit date:2019-09-03
Release date:2020-04-22
Last modified:2020-07-15
Method:SOLUTION NMR
Cite:Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides.
Angew.Chem.Int.Ed.Engl., 59, 2020
6U7S
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BU of 6u7s by Molmil
NMR solution structure of SFTI-1 based plasmin inhibitor
Descriptor: GLY-ARG-CYS-TYR-LYS-SER-LYS-PRO-PRO-ILE-CYS-PHE-PRO-ASP inhibitor
Authors:White, A.M, Harvey, P.J, Durek, T, Craik, D.J.
Deposit date:2019-09-03
Release date:2020-04-22
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides.
Angew.Chem.Int.Ed.Engl., 59, 2020

 

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