Author results

2KTZ
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INHIBITOR INDUCED STRUCTURAL CHANGE IN THE HCV IRES DOMAIN IIA RNA
分子名称:HCV IRES Domain IIa RNA, (7R)-7-[(dimethylamino)methyl]-1-[3-(dimethylamino)propyl]-7,8-dihydro-1H-furo[3,2-e]benzimidazol-2-amine
著者Paulsen, R.B., Seth, P.P., Swayze, E.E., Griffey, R.H., Skalicky, J.J., Cheatham III, T.E., Davis, D.R.
登録日2010-02-10
公開日2010-04-28
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Inhibitor-induced structural change in the HCV IRES domain IIa RNA.
Proc.Natl.Acad.Sci.USA, 107, 2010
2KU0
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INHIBITOR INDUCED STRUCTURAL CHANGE IN THE HCV IRES DOMAIN IIA RNA
分子名称:HCV IRES Domain IIa RNA, (7S)-7-[(dimethylamino)methyl]-1-[3-(dimethylamino)propyl]-7,8-dihydro-1H-furo[3,2-e]benzimidazol-2-amine
著者Paulsen, R.B., Seth, P.P., Swayze, E.E., Griffey, R.H., Skalicky, J.J., Cheatham III, T.E., Davis, D.R.
登録日2010-02-10
公開日2010-04-28
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Inhibitor-induced structural change in the HCV IRES domain IIa RNA.
Proc.Natl.Acad.Sci.USA, 107, 2010
3OZ3
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VINYL CARBOCYCLIC LNA
分子名称:DNA (5'-D(*GP*CP*GP*TP*AP*(UVX)P*AP*CP*GP*C)-3'), (4S)-2-METHYL-2,4-PENTANEDIOL
著者Seth, P.R., Allerson, C.A., Berdeja, A., Siwkowski, A., Pallan, P.S., Gaus, H., Prakash, T.P., Watt, A.T., Egli, M., Swayze, E.E.
登録日2010-09-24
公開日2010-11-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.
J.Am.Chem.Soc., 132, 2010
3OZ4
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R-METHYL CARBOCYCLIC LNA
分子名称:DNA (5'-D(*GP*CP*GP*TP*AP*(URX)P*AP*CP*GP*C)-3')
著者Seth, P.R., Allerson, C.A., Berdeja, A., Siwkowski, A., Pallan, P.S., Gaus, H., Prakash, T.P., Watt, A.T., Egli, M., Swayze, E.E.
登録日2010-09-24
公開日2010-11-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.
J.Am.Chem.Soc., 132, 2010
3OZ5
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S-METHYL CARBOCYCLIC LNA
分子名称:DNA (5'-D(*GP*CP*GP*TP*AP*(UMX)P*AP*CP*GP*C)-3'), SPERMINE
著者Seth, P.R., Allerson, C.A., Berdeja, A., Siwkowski, A., Pallan, P.S., Gaus, H., Prakash, T.P., Watt, A.T., Egli, M., Swayze, E.E.
登録日2010-09-24
公開日2010-11-24
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA.
J.Am.Chem.Soc., 132, 2010
3Q61
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3'-FLUORO HEXITOL NUCLEIC ACID DNA STRUCTURE
分子名称:DNA (5'-D(*GP*CP*GP*TP*AP*(F3H)P*AP*CP*GP*C)-3')
著者Seth, P.R., Allerson, C.R., Prakash, T.P., Siwkowski, A., Berdeja, A., Yu, J., Pallan, P.S., Watt, A.T., Gaus, H., Bhat, B., Egli, M., Swayze, E.E.
登録日2010-12-30
公開日2012-01-18
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides.
J.Am.Chem.Soc., 133, 2011
4HQH
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DECAMER FLUORO CARBOCYCLIC LNA (R-F-CLNA) CRYSTAL STRUCTURE
分子名称:DNA (5'-D(*GP*CP*GP*TP*AP*(ULF)P*AP*CP*GP*C)-3')
著者Seth, P.P., Pallan, P.S., Swayze, E.E., Egli, M.
登録日2012-10-25
公開日2013-11-20
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Properties of a Fluorinated Carbocyclic LNA Analog
To be Published
2BE0
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COMPLEX BETWEEN PAROMOMYCIN DERIVATIVE JS5-39 AND THE 16S-RRNA A-SITE.
分子名称:5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3R,4R,5S)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R,4R,5S,6R)-3-AMINO-4,5-DIHYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-2-(HYDROXYMETHYL)-4-(2-((R)-PIPERIDIN-3-YLMETHYLAMINO)ETHOXY)-TETRAHYDROFURAN-3-YLOXY)-TETRAHYDRO-2H-PYRAN-3,4-DIOL
著者Francois, B., Westhof, E.
登録日2005-10-21
公開日2005-12-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site
ANGEW.CHEM.INT.ED.ENGL., 43, 2004
2BEE
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COMPLEX BETWEEN PAROMOMYCIN DERIVATIVE JS4 AND THE 16S-RRNA A SITE
分子名称:5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3R,4R,5S)-4-(2-(3-AMINOPROPYLAMINO)ETHOXY)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R,4R,5S,6R)-3-AMINO-4,5-DIHYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-2-(HYDROXYMETHYL)-TETRAHYDROFURAN-3-YLOXY)-TETRAHYDRO-2H-PYRAN-3,4-DIOL
著者Francois, B., Westhof, E.
登録日2005-10-24
公開日2005-12-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site
ANGEW.CHEM.INT.ED.ENGL., 43, 2004
3SD8
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CRYSTAL STRUCTURE OF ARA-FHNA DECAMER DNA
分子名称:5'-D(*GP*CP*GP*TP*AP*(F4H)P*AP*CP*GP*C)-3', STRONTIUM ION
著者Egli, M., Pallan, P.S.
登録日2011-06-08
公開日2012-08-29
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Structural Origins of Opposite Effects on Stability by Axial and Equatorial 3'-Fluoro Modifications of Hexitol Nucleic Acid (HNA)
To be Published
3UKB
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(R)-CET-BNA DECAMER STRUCTURE
分子名称:DNA (5'-D(*GP*CP*GP*TP*AP*(RCE)P*AP*CP*GP*C)-3')
著者Pallan, P.S., Egli, M.
登録日2011-11-09
公開日2012-06-20
最終更新日2012-08-08
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chem.Commun.(Camb.), 48, 2012
3UKC
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(S)-CET-BNA DECAMER STRUCTURE
分子名称:DNA (5'-D(*GP*CP*GP*TP*AP*(1TL)P*AP*CP*GP*C)-3')
著者Pallan, P.S., Egli, M.
登録日2011-11-09
公開日2012-06-20
最終更新日2012-08-08
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chem.Commun.(Camb.), 48, 2012
3UKE
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(S)-CMOE-BNA DECAMER STRUCTURE
分子名称:DNA (5'-D(*GP*CP*GP*TP*AP*(CSM)P*AP*CP*GP*C)-3')
著者Pallan, P.S., Egli, M.
登録日2011-11-09
公開日2012-06-20
最終更新日2012-08-08
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chem.Commun.(Camb.), 48, 2012
3V06
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CRYSTAL STRUCTURE OF S-6'-ME-3'-FLUORO HEXITOL NUCLEIC ACID
分子名称:DNA (5'-D(*GP*CP*GP*TP*AP*(F5H)P*AP*CP*GP*C)-3'), STRONTIUM ION
著者Pallan, P.S., Egli, M.
登録日2011-12-07
公開日2012-02-08
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Insights from crystal structures into the opposite effects on RNA affinity caused by the s- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic Acid.
Biochemistry, 51, 2012
3V07
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CRYSTAL STRUCTURE OF R-6'-ME-3'-FLUORO HEXITOL NUCLEIC ACID
分子名称:DNA (5'-D(*GP*CP*GP*TP*AP*(F6H)P*AP*CP*GP*C)-3')
著者Pallan, P.S., Egli, M.
登録日2011-12-07
公開日2012-02-08
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献Insights from crystal structures into the opposite effects on RNA affinity caused by the s- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic Acid.
Biochemistry, 51, 2012
4F2X
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STRUCTURE OF 3'-FLUORO CYCLOHEXENYL NUCLEIC ACID HEPTAMER
分子名称:5'-D(*GP*CP*GP*(XTF)P*GP*CP*G)-3', 5'-D(*CP*GP*CP*AP*CP*GP*C)-3', COBALT HEXAMMINE(III), ...
著者Pallan, P.S., Egli, M.
登録日2012-05-08
公開日2012-05-30
最終更新日2012-06-13
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2'-Fluoro RNA.
J.Org.Chem., 77, 2012
4F2Y
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STRUCTURE OF 3'-FLUORO CYCLOHEXENYL NUCLEIC ACID DECAMER
分子名称:5'-D(*GP*CP*GP*TP*AP*(XTF)P*AP*CP*GP*C)-3', MAGNESIUM ION
著者Pallan, P.S., Egli, M.
登録日2012-05-08
公開日2012-05-30
最終更新日2012-06-13
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2'-Fluoro RNA.
J.Org.Chem., 77, 2012