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5KZN
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METABOTROPIC GLUTAMATE RECEPTOR
分子名称:Metabotropic glutamate receptor 2, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION
著者Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.
登録日2016-07-25
公開日2016-12-28
最終更新日2017-01-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J. Med. Chem., 59, 2016
5KZQ
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METABOTROPIC GLUTAMATE RECEPTOR IN COMPLEX WITH ANTAGONIST (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-AZANYL-3-[[3,4-BIS(FLUORANYL)PHENYL]SULFANYLMETHYL]-4-OXIDANYL-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID
分子名称:Metabotropic glutamate receptor 2, (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, N-ACETYL-D-GLUCOSAMINE
著者Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.
登録日2016-07-25
公開日2016-12-28
最終更新日2017-01-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J. Med. Chem., 59, 2016
3NO9
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CRYSTAL STRUCTURE OF APO FUMARATE HYDRATASE FROM MYCOBACTERIUM TUBERCULOSIS
分子名称:Fumarate hydratase class II
著者Li, H., Swanson, S., Yu, M., Hung, L.-W., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
登録日2010-06-25
公開日2010-07-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Crystal Structure of apo fumarate hydratase from Mycobacterium tuberculosis
To be Published
4UAQ
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CRYSTAL STRUCTURE OF THE ACCESSORY TRANSLOCATION ATPASE, SECA2, FROM MYCOBACTERIUM TUBERCULOSIS
分子名称:Protein translocase subunit SecA 2
著者Swanson-Smith, S., Ioerger, T.R., Rigel, N.W., Miller, B.K., Braunstein, M., Sacchettini, J.C., TB Structural Genomics Consortium (TBSGC)
登録日2014-08-11
公開日2015-09-09
最終更新日2016-02-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.
J.Bacteriol., 198, 2015
5CNI
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MGLU2 WITH GLUTAMATE
分子名称:Metabotropic glutamate receptor 2, GAMMA-L-GLUTAMIC ACID, CHLORIDE ION, ...
著者Clawson, D.K., Atwell, S., Monn, J.A.
登録日2015-07-17
公開日2015-09-09
最終更新日2015-10-07
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
J.Med.Chem., 58, 2015
4XAQ
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MGLUR2 ECD AND MGLUR3 ECD WITH LIGANDS
分子名称:Metabotropic glutamate receptor 2, (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, SULFATE ION, ...
著者Clawson, D.K.
登録日2014-12-15
公開日2015-02-04
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures.
J.Med.Chem., 58, 2015
4XAR
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MGLUR2 ECD AND MGLUR3 ECD COMPLEX WITH LIGANDS
分子名称:Metabotropic glutamate receptor 3, (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, IODIDE ION
著者Clawson, D.K.
登録日2014-12-15
公開日2015-02-11
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures.
J.Med.Chem., 58, 2015
4XAS
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MGLUR2 ECD LIGAND COMPLEX
分子名称:Metabotropic glutamate receptor 2, (1R,4S,5S,6S)-4-aminospiro[bicyclo[3.1.0]hexane-2,1'-cyclopropane]-4,6-dicarboxylic acid
著者Clawson, D.K.
登録日2014-12-15
公開日2015-02-04
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures.
J.Med.Chem., 58, 2015
5CNJ
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MGLUR2 WITH GLUTAMATE ANALOG
分子名称:Metabotropic glutamate receptor 2, N-ACETYL-D-GLUCOSAMINE, (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
著者Monn, J.A., Clawson, D.K.
登録日2015-07-17
公開日2015-09-09
最終更新日2015-10-07
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
J.Med.Chem., 58, 2015
5CNK
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MGLUR3 WITH GLUTAMATE
分子名称:Metabotropic glutamate receptor 3, GAMMA-L-GLUTAMIC ACID, IODIDE ION
著者Monn, J.A., Clawson, D.K.
登録日2015-07-17
公開日2015-09-09
最終更新日2015-10-07
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
J.Med.Chem., 58, 2015
5CNM
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MGLUR3 COMPLEXED WITH GLUTAMATE ANALOG
分子名称:Metabotropic glutamate receptor 3, (1R,2S,4R,5R,6R)-2-amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, CHLORIDE ION, ...
著者Monn, J.A., Clawson, D.K., McKinzie, D.
登録日2015-07-17
公開日2015-09-09
最終更新日2015-10-07
実験手法X-RAY DIFFRACTION (2.84 Å)
主引用文献Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
J.Med.Chem., 58, 2015
6B7H
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STRUCTURE OF MGLUR3 WITH AN AGONIST
分子名称:Metabotropic glutamate receptor 3, N-ACETYL-D-GLUCOSAMINE, (1S,2S,4S,5R,6S)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, ...
著者Monn, J.A., Clawson, D.K.
登録日2017-10-04
公開日2018-04-25
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Synthesis and Pharmacological Characterization of C4beta-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3Receptor Agonist.
J. Med. Chem., 61, 2018
1XJT
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CRYSTAL STRUCTURE OF ACTIVE FORM OF P1 PHAGE ENDOLYSIN LYZ
分子名称:Lysozyme, CITRIC ACID
著者Arockiasamy, A., Sacchettini, J.C.
登録日2004-09-24
公開日2005-01-11
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme.
Science, 307, 2005
1XJU
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CRYSTAL STRUCTURE OF SECRETED INACTIVE FORM OF P1 PHAGE ENDOLYSIN LYZ
分子名称:Lysozyme, SULFATE ION
著者Arockiasamy, A., Sacchettini, J.C.
登録日2004-09-24
公開日2005-01-11
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme.
Science, 307, 2005