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5CLM
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BU of 5clm by Molmil
1,4-Oxazine BACE1 inhibitors
Descriptor: Beta-secretase 1, CHLORIDE ION, IODIDE ION, ...
Authors:Rombouts, F, Tresadern, G, Delgado, O, Martinez Lamenca, C, Van Gool, M, Garcia-Molina, A, Alonso De Diego, S, Oehlrich, D, Prokopcova, H, Alonso, J.M, Austin, N, Borghys, H, Van Brandt, S, Surkyn, M, De Cleyn, M, Vos, A, Alexander, R, MacDonald, G, Moechars, D, Trabanco, A, Gijsen, H.
Deposit date:2015-07-16
Release date:2015-09-30
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:1,4-Oxazine beta-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads.
J.Med.Chem., 58, 2015
6OD6
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BU of 6od6 by Molmil
Structure of BACE-1 in complex with Ligand 13
Descriptor: Beta-secretase 1, GLYCEROL, N-{3-[(3R)-1-amino-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-3-yl]-4-fluorophenyl}-5-cyanopyridine-2-carboxamide
Authors:Shaffer, P.L.
Deposit date:2019-03-26
Release date:2019-09-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Evaluation of a Series of beta-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads.
Acs Med.Chem.Lett., 10, 2019
7N66
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BU of 7n66 by Molmil
BACE-1 in complex with ligand 12
Descriptor: Beta-secretase 1, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Shaffer, P.L.
Deposit date:2021-06-07
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.
J.Med.Chem., 64, 2021
7N4N
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BU of 7n4n by Molmil
BACE-2 in complex with ligand 36
Descriptor: 1,2-ETHANEDIOL, Beta-secretase 2, N-{3-[(2S,5R)-6-amino-2-(fluoromethyl)-5-(methanesulfonyl)-5-methyl-2,3,4,5-tetrahydropyridin-2-yl]-4-fluorophenyl}-6-methoxypyrimidine-4-carboxamide, ...
Authors:Shaffer, P.L.
Deposit date:2021-06-04
Release date:2021-10-06
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate.
J.Med.Chem., 64, 2021
8G3T
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BU of 8g3t by Molmil
MBP-Mcl1 in complex with ligand 12
Descriptor: (1'S,3aS,5R,16R,17S,19Z,21R,21aR)-6'-chloro-20-fluoro-21-methoxy-16,17-dimethyl-2,3,3',3a,4',16,17,18,21,21a-decahydro-2'H,6H,8H-15lambda~6~-spiro[10,12-etheno-15lambda~6~-furo[3,2-i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-7,1'-naphthalene]-13,15,15(4H,14H)-trione, 1,2-ETHANEDIOL, FORMIC ACID, ...
Authors:Miller, B.R, Shaffer, P.
Deposit date:2023-02-08
Release date:2023-05-17
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
J.Med.Chem., 66, 2023
8G3X
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BU of 8g3x by Molmil
MBP-Mcl1 in complex with ligand 32
Descriptor: 1,2-ETHANEDIOL, Maltodextrin-binding protein, Induced myeloid leukemia cell differentiation protein Mcl-1 chimera, ...
Authors:Miller, B.R, Shaffer, P.
Deposit date:2023-02-08
Release date:2023-05-17
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
J.Med.Chem., 66, 2023
8G3S
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BU of 8g3s by Molmil
MBP-Mcl1 in complex with ligand 11
Descriptor: (1'S,3aS,5R,16R,17S,19E,21S,21aR)-6'-chloro-21-methoxy-16,17-dimethyl-2,3,3',3a,4',16,17,18,21,21a-decahydro-2'H,6H,8H-15lambda~6~-spiro[10,12-etheno-15lambda~6~-furo[3,2-i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-7,1'-naphthalene]-13,15,15(4H,14H)-trione, FORMIC ACID, Maltodextrin-binding protein, ...
Authors:Miller, B.R, Shaffer, P.
Deposit date:2023-02-08
Release date:2023-05-17
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
J.Med.Chem., 66, 2023
8G3Y
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BU of 8g3y by Molmil
MBP-Mcl1 in complex with ligand 34
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Miller, B.R, Shaffer, P.
Deposit date:2023-02-08
Release date:2023-05-17
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
J.Med.Chem., 66, 2023
8G3U
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BU of 8g3u by Molmil
MBP-Mcl1 in complex with ligand 21
Descriptor: (1'S,3aS,5R,16R,17S,19Z,21R,21aR)-6'-chloro-20-fluoro-21-{[(5S,9aS)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]methyl}-21-methoxy-16,17-dimethyl-2,3,3',3a,4',16,17,18,21,21a-decahydro-2'H,6H,8H-15lambda~6~-spiro[10,12-(ethanediylidene)-15lambda~6~-furo[3,2-i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-7,1'-naphthalene]-13,15,15(4H,14H)-trione, 1,2-ETHANEDIOL, Maltodextrin-binding protein, ...
Authors:Miller, B.R, Shaffer, P.
Deposit date:2023-02-08
Release date:2023-05-17
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
J.Med.Chem., 66, 2023
8G3W
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BU of 8g3w by Molmil
MBP-Mcl1 in complex with ligand 28
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Maltodextrin-binding protein, ...
Authors:Miller, B.R, Shaffer, P.
Deposit date:2023-02-08
Release date:2023-05-17
Last modified:2023-05-24
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Discovery of an Oral, Beyond-Rule-of-Five Mcl-1 Protein-Protein Interaction Modulator with the Potential of Treating Hematological Malignancies.
J.Med.Chem., 66, 2023

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