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1EVY
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GLYCEROL-3-PHOSPHATE DEHYDROGENASE
Descriptor:GLYCEROL-3-PHOSPHATE DEHYDROGENASE, PENTADECANE
Authors:Suresh, S., Turley, S., Opperdoes, F.R., Michels, P.A.M., Hol, W.G.J.
Deposit date:2000-04-20
Release date:2001-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana.
Structure Fold.Des., 8, 2000
1EVZ
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GLYCEROL-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH NAD
Descriptor:GLYCEROL-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PENTADECANE
Authors:Suresh, S., Turley, S., Opperdoes, F.R., Michels, P.A.M., Hol, W.G.J.
Deposit date:2000-04-21
Release date:2001-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana.
Structure Fold.Des., 8, 2000
1I32
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LEISHMANIA MEXICANA GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH INHIBITORS
Descriptor:GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, N-NAPHTHALEN-1-YLMETHYL-2'-[3,5-DIMETHOXYBENZAMIDO]-2'-DEOXY-ADENOSINE
Authors:Suresh, S., Bressi, J.C., Kennedy, K.J., Verlinde, C.L.M.J., Gelb, M.H., Hol, W.G.J.
Deposit date:2001-02-12
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors.
J.Mol.Biol., 309, 2001
1I33
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LEISHMANIA MEXICANA GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH INHIBITORS
Descriptor:GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, N-1,2,3,4-TETRAHYDRONAPHTH-1-YL-2'-[3,5-DIMETHOXYBENZAMIDO]-2'-DEOXY-ADENOSINE
Authors:Suresh, S., Bressi, J.C., Kennedy, K.J., Verlinde, C.L.M.J., Gelb, M.H., Hol, W.G.J.
Deposit date:2001-02-12
Release date:2001-10-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors.
J.Mol.Biol., 309, 2001
1GYQ
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CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE FROM LEISHMANIA MEXICANA IN COMPLEX WITH N6-BENZYL-NAD
Descriptor:PROTEIN (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE), N6-BENZYL-NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Suresh, S., Hol, W.
Deposit date:1999-03-05
Release date:1999-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.
Proc.Natl.Acad.Sci.USA, 96, 1999
1JDJ
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GLYCEROL-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH 2-FLUORO-6-CHLOROPURINE
Descriptor:GLYCEROL-3-PHOSPHATE DEHYDROGENASE, 6-CHLORO-2-FLUOROPURINE, PENTADECANE
Authors:Suresh, S., Wisedchaisri, G., Kennedy, K.J., Verlinde, C.L.M.J., Gelb, M.H., Hol, W.G.J.
Deposit date:2001-06-14
Release date:2002-06-14
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase.
Chem.Biol., 9, 2002
1M66
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GPDH COMPLEXED WITH INHIBITOR 2-BROMO-6-CHLORO-PURINE
Descriptor:Glycerol-3-phosphate dehydrogenase, 2-BROMO-6-CHLORO-PURINE, PALMITIC ACID
Authors:Choe, J., Suresh, S., Wisedchaisri, G., Kennedy, K.J., Gelb, M.H., Hol, W.G.J.
Deposit date:2002-07-12
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase
Chem.Biol., 9, 2002
1M67
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GPDH COMPLEXED WITH INHIBITOR 2-BROMO-6-HYDROXY-PURINE
Descriptor:Glycerol-3-phosphate dehydrogenase, 2-BROMO-6-HYDROXY-PURINE, PALMITIC ACID
Authors:Choe, J., Suresh, S., Wisedchaisri, G., Kennedy, K.J., Gelb, M.H., Hol, W.G.J.
Deposit date:2002-07-12
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase
Chem.Biol., 9, 2002
3ZHX
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl(phenylcarbonyl)amino]propyl]phosphonic acid
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
3ZHY
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A DI- SUBSTITUTED FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl(phenylcarbonyl)amino]propyl]phosphonic acid, ...
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
3ZHZ
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, [(1S)-1-(3,4-dichlorophenyl)-3-[oxidanyl-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]carbonyl-amino]propyl]phosphonic acid
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
3ZI0
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STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS DXR IN COMPLEX WITH A FOSMIDOMYCIN ANALOGUE
Descriptor:1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, [(1S)-1-(3,4-dichlorophenyl)-3-{hydroxy[2-(1H-1,2,4-triazol-1-ylmethyl)benzoyl]amino}propyl]phosphonic acid, MANGANESE (II) ION
Authors:Bjorkelid, C., Jansson, A.M., Bergfors, T., Unge, T., Mowbray, S.L., Jones, T.A.
Deposit date:2012-12-30
Release date:2013-10-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
J.Med.Chem., 56, 2013
1N1G
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GLYCEROL-3-PHOSPHATE DEHYDROGENASE WITH INHIBITOR BCP
Descriptor:glycerol-3-phosphate dehydrogenase, 2-BROMO-6-CHLORO-PURINE, PALMITIC ACID
Authors:Choe, J., Hol, W.G.
Deposit date:2002-10-17
Release date:2003-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase.
Chem.Biol., 9, 2002