Author results

1CS4
  • Download 1cs4
  • View 1cs4
Molmil generated image of 1cs4
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG
Descriptor:TYPE V ADENYLATE CYCLASE, TYPE II ADENYLATE CYCLASE, GUANINE NUCLEOTIDE-BINDING PROTEIN G(S), ...
Authors:Tesmer, J.J.G., Dessauer, C.A., Sunahara, R.K., Johnson, R.A., Gilman, A.G., Sprang, S.R.
Deposit date:1999-08-16
Release date:2001-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry, 39, 2000
1CUL
  • Download 1cul
  • View 1cul
Molmil generated image of 1cul
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2',5'-DIDEOXY-ADENOSINE 3'-TRIPHOSPHATE AND MG
Descriptor:TYPE V ADENYLYL CYCLASE, TYPE II ADENYLYL CYCLASE, GUANINE NUCLEOTIDE-BINDING PROTEIN G(S), ...
Authors:Tesmer, J.J.G., Dessauer, C.A., Sunahara, R.K., Johnson, R.A., Gilman, A.G., Sprang, S.R.
Deposit date:1999-08-20
Release date:2001-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry, 39, 2000
3P0G
  • Download 3p0g
  • View 3p0g
Molmil generated image of 3p0g
STRUCTURE OF A NANOBODY-STABILIZED ACTIVE STATE OF THE BETA2 ADRENOCEPTOR
Descriptor:Beta-2 adrenergic receptor, Lysozyme, Camelid Antibody Fragment, ...
Authors:Rasmussen, S.G.F., Choi, H.-J., Fung, J.J., Pardon, E., Casarosa, P., Chae, P.S., DeVree, B.T., Rosenbaum, D.M., Thian, F.S., Kobilka, T.S., Schnapp, A., Konetzki, I., Sunahara, R.K., Gellman, S.H., Pautsch, A., Steyaert, J., Weis, W.I., Kobilka, B.K.
Deposit date:2010-09-28
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of a nanobody-stabilized active state of the b2 adrenoceptor
Nature, 469, 2011
3PDS
  • Download 3pds
  • View 3pds
Molmil generated image of 3pds
IRREVERSIBLE AGONIST-BETA2 ADRENOCEPTOR COMPLEX
Descriptor:Fusion protein Beta-2 adrenergic receptor/Lysozyme, 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, ...
Authors:Rosenbaum, D.M., Zhang, C., Lyons, J.A., Holl, R., Aragao, D., Arlow, D.H., Rasmussen, S.G.F., Choi, H.-J., DeVree, B.T., Sunahara, R.K., Chae, P.S., Gellman, S.H., Dror, R.O., Shaw, D.E., Weis, W.I., Caffrey, M., Gmeiner, P., Kobilka, B.K.
Deposit date:2010-10-24
Release date:2011-01-12
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure and function of an irreversible agonist-beta(2) adrenoceptor complex
Nature, 469, 2011
3SN6
  • Download 3sn6
  • View 3sn6
Molmil generated image of 3sn6
CRYSTAL STRUCTURE OF THE BETA2 ADRENERGIC RECEPTOR-GS PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Rasmussen, S.G.F., DeVree, B.T., Zou, Y., Kruse, A.C., Chung, K.Y., Kobilka, T.S., Thian, F.S., Chae, P.S., Pardon, E., Calinski, D., Mathiesen, J.M., Shah, S.T.A., Lyons, J.A., Caffrey, M., Gellman, S.H., Steyaert, J., Skiniotis, G., Weis, W.I., Sunahara, R.K., Kobilka, B.K.
Deposit date:2011-06-28
Release date:2011-07-20
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Nature, 477, 2011
4DKL
  • Download 4dkl
  • View 4dkl
Molmil generated image of 4dkl
CRYSTAL STRUCTURE OF THE MU-OPIOID RECEPTOR BOUND TO A MORPHINAN ANTAGONIST
Descriptor:Mu-type opioid receptor, lysozyme chimera, methyl 4-{[(5beta,6alpha)-17-(cyclopropylmethyl)-3,14-dihydroxy-4,5-epoxymorphinan-6-yl]amino}-4-oxobutanoate, ...
Authors:Manglik, A., Kruse, A.C., Kobilka, T.S., Thian, F.S., Mathiesen, J.M., Sunahara, R.K., Pardo, L., Weis, W.I., Kobilka, B.K., Granier, S.
Deposit date:2012-02-03
Release date:2012-03-21
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the {mu}-opioid receptor bound to a morphinan antagonist.
Nature, 485, 2012
5ZHP
  • Download 5zhp
  • View 5zhp
Molmil generated image of 5zhp
M3 MUSCARINIC ACETYLCHOLINE RECEPTOR IN COMPLEX WITH A SELECTIVE ANTAGONIST
Descriptor:Muscarinic acetylcholine receptor M3,Endolysin,Endolysin,Muscarinic acetylcholine receptor M3, TETRAETHYLENE GLYCOL, MALTOSE, ...
Authors:Liu, H., Hofmann, J., Fish, I., Schaake, B., Eitel, K., Bartuschat, A., Kaindl, J., Rampp, H., Banerjee, A., Hubner, H., Clark, M.J., Vincent, S.G., Fisher, J., Heinrich, M., Hirata, K., Liu, X., Sunahara, R.K., Shoichet, B.K., Kobilka, B.K., Gmeiner, P.
Deposit date:2018-03-13
Release date:2018-11-28
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6MXT
  • Download 6mxt
  • View 6mxt
Molmil generated image of 6mxt
CRYSTAL STRUCTURE OF HUMAN BETA2 ADRENERGIC RECEPTOR BOUND TO SALMETEROL AND NB71
Descriptor:Endolysin, Beta-2 adrenergic receptor chimera, nanobody Nb71, ...
Authors:Masureel, M., Zou, Y., Picard, L.P., van der Westhuizen, E., Mahoney, J.P., Rodrigues, J.P.G.L.M., Mildorf, T.J., Dror, R.O., Shaw, D.E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R.K., Weis, W.I., Zhang, C., Kobilka, B.K.
Deposit date:2018-10-31
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.959342 Å)
Cite:Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
Nat. Chem. Biol., 14, 2018
1AZT
  • Download 1azt
  • View 1azt
Molmil generated image of 1azt
GS-ALPHA COMPLEXED WITH GTP-GAMMA-S
Descriptor:GS-ALPHA, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1997-11-20
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the adenylyl cyclase activator Gsalpha
Science, 278, 1997
1CJK
  • Download 1cjk
  • View 1cjk
Molmil generated image of 1cjk
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH ADENOSINE 5'-(ALPHA THIO)-TRIPHOSPHATE (RP), MG, AND MN
Descriptor:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1999-04-16
Release date:1999-08-31
Last modified:2011-09-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJT
  • Download 1cjt
  • View 1cjt
Molmil generated image of 1cjt
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MN, AND MG
Descriptor:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1999-04-16
Release date:1999-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJU
  • Download 1cju
  • View 1cju
Molmil generated image of 1cju
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP AND MG
Descriptor:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1999-04-16
Release date:1999-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJV
  • Download 1cjv
  • View 1cjv
Molmil generated image of 1cjv
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MG, AND ZN
Descriptor:ADENYLATE CYCLASE, TYPE V, TYPE II, ...
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1999-04-19
Release date:1999-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1AZS
  • Download 1azs
  • View 1azs
Molmil generated image of 1azs
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE
Descriptor:VC1, IIC2, GS-ALPHA, ...
Authors:Tesmer, J.J.G., Sprang, S.R.
Deposit date:1997-11-20
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.
Science, 278, 1997
3I2F
  • Download 3i2f
  • View 3i2f
Molmil generated image of 3i2f
COCAINE ESTERASE WITH MUTATIONS T172R / G173Q, BOUND TO DTT ADDUCT
Descriptor:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
Authors:Tesmer, J.J.G., Nance, M.R.
Deposit date:2009-06-29
Release date:2010-06-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3I2G
  • Download 3i2g
  • View 3i2g
Molmil generated image of 3i2g
COCAINE ESTERASE WITH MUTATION G173Q, BOUND TO DTT ADDUCT
Descriptor:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
Authors:Tesmer, J.J.G., Nance, M.R.
Deposit date:2009-06-29
Release date:2010-06-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3I2H
  • Download 3i2h
  • View 3i2h
Molmil generated image of 3i2h
COCAINE ESTERASE WITH MUTATION L169K, BOUND TO DTT ADDUCT
Descriptor:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
Authors:Tesmer, J.J.G., Nance, M.R.
Deposit date:2009-06-29
Release date:2010-06-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3I2I
  • Download 3i2i
  • View 3i2i
Molmil generated image of 3i2i
COCAINE ESTERASE WITH MUTATION T172R, BOUND TO DTT ADDUCT
Descriptor:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
Authors:Tesmer, J.J.G., Nance, M.R.
Deposit date:2009-06-29
Release date:2010-06-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3I2J
  • Download 3i2j
  • View 3i2j
Molmil generated image of 3i2j
COCAINE ESTERASE, WILD TYPE, WITHOUT A LIGAND
Descriptor:Cocaine esterase, CHLORIDE ION, GLYCEROL, ...
Authors:Tesmer, J.J.G., Nance, M.R.
Deposit date:2009-06-29
Release date:2010-06-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3I2K
  • Download 3i2k
  • View 3i2k
Molmil generated image of 3i2k
COCAINE ESTERASE, WILD TYPE, BOUND TO A DTT ADDUCT
Descriptor:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
Authors:Tesmer, J.J.G., Nance, M.R.
Deposit date:2009-06-29
Release date:2010-06-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structural analysis of thermostabilizing mutations of cocaine esterase.
Protein Eng.Des.Sel., 23, 2010
3IDA
  • Download 3ida
  • View 3ida
Molmil generated image of 3ida
THERMOSTABLE COCAINE ESTERASE WITH MUTATIONS L169K AND G173Q, BOUND TO DTT ADDUCT
Descriptor:Cocaine esterase, CHLORIDE ION, (4S,5S)-4,5-BIS(MERCAPTOMETHYL)-1,3-DIOXOLAN-2-OL, ...
Authors:Tesmer, J.J.G., Nance, M.R.
Deposit date:2009-07-20
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse.
Mol.Pharmacol., 77, 2010
3PUH
  • Download 3puh
  • View 3puh
Molmil generated image of 3puh
COCAINE ESTERASE, WILD-TYPE BIOLOGICALLY ACTIVE DIMER
Descriptor:Cocaine esterase, GLYCEROL, SULFATE ION
Authors:Nance, M.R., Tesmer, J.J.G.
Deposit date:2010-12-04
Release date:2011-09-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011
3PUI
  • Download 3pui
  • View 3pui
Molmil generated image of 3pui
COCAINE ESTERASE WITH MUTATIONS G4C, S10C
Descriptor:Cocaine esterase, CHLORIDE ION, SODIUM ION
Authors:Nance, M.R., Tesmer, J.J.G.
Deposit date:2010-12-04
Release date:2011-09-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011