Author results

1JHB
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HUMAN GLUTAREDOXIN IN FULLY REDUCED FORM, NMR, 20 STRUCTURES
Descriptor:GLUTAREDOXIN
Authors:Sun, C., Bushweller, J.H.
Deposit date:1998-02-17
Release date:1998-08-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The NMR solution structure of human glutaredoxin in the fully reduced form.
J.Mol.Biol., 280, 1998
1F9X
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AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-3 DOMAIN OF XIAP
Descriptor:INHIBITOR OF APOPTOSIS PROTEIN XIAP, ZINC ION
Authors:Sun, C., Cai, M., Meadows, R.P., Fesik, S.W.
Deposit date:2000-07-11
Release date:2001-07-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP.
J.Biol.Chem., 275, 2000
1XOX
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SOLUTION STRUCTURE OF HUMAN SURVIVIN
Descriptor:Apoptosis inhibitor survivin, ZINC ION
Authors:Sun, C., Nettesheim, D., Liu, Z., Olejniczak, E.T.
Deposit date:2004-10-07
Release date:2005-01-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of human survivin and its binding interface with smac/diablo
Biochemistry, 44, 2005
6BTM
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STRUCTURE OF ALTERNATIVE COMPLEX III FROM FLAVOBACTERIUM JOHNSONIAE (WILD TYPE)
Descriptor:Alternative Complex III subunit A, Alternative Complex III subunit B, Alternative Complex III subunit C, ...
Authors:Sun, C., Benlekbir, S., Venkatakrishnan, P., Yuhang, W., Tajkhorshid, E., Rubinstein, J.L., Gennis, R.B.
Deposit date:2017-12-07
Release date:2018-05-09
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the alternative complex III in a supercomplex with cytochrome oxidase.
Nature, 557, 2018
2JOD
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PAC1-RSHORT N-TERMINAL EC DOMAIN PACAP(6-38) COMPLEX
Descriptor:Pituitary adenylate cyclase-activating polypeptide type I receptor, Pituitary adenylate cyclase-activating polypeptide
Authors:Olejniczak, E.T., Sun, C., Song, D., Davis-Taber, R.A., Barrett, L.W., Scott, V.E., Richardson, P.L., Pereda-lopez, A., Uchic, M.E., Solomon, L.R., Lake, M.R., Walter, K.A., Hajduk, P.J.
Deposit date:2007-03-07
Release date:2007-05-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3NEW
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P38-ALPHA COMPLEXED WITH COMPOUND 10
Descriptor:Mitogen-activated protein kinase 14, 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one
Authors:Goedken, E.R., Comess, K.M., Sun, C., Argiriadi, M., Jia, Y., Quinn, C.M., Banach, D.L., Marcotte, D., Borhani, D.
Deposit date:2010-06-09
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases.
Acs Chem.Biol., 6, 2011
4OQ5
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CRYSTAL STRUCTURE OF HUMAN MCL-1 BOUND TO INHIBITOR 4-(4-METHYLNAPHTHALEN-1-YL)-2-{[(4-PHENOXYPHENYL)SULFONYL]AMINO}BENZOIC ACID
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid
Authors:Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.
Deposit date:2014-02-07
Release date:2014-03-12
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.
Bioorg.Med.Chem.Lett., 24, 2014
4OQ6
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CRYSTAL STRUCTURE OF HUMAN MCL-1 BOUND TO INHIBITOR 4-HYDROXY-4'-PROPYLBIPHENYL-3-CARBOXYLIC ACID
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid
Authors:Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.
Deposit date:2014-02-07
Release date:2014-03-12
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.
Bioorg.Med.Chem.Lett., 24, 2014
4WQN
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CRYSTAL STRUCTURE OF N6-METHYLADENOSINE RNA READER YTHDF2
Descriptor:YTH domain-containing family protein 2, GLYCEROL, 1,2-ETHANEDIOL
Authors:Zhu, T., Roundtree, I.A., Wang, P., Wang, X., Wang, L., Sun, C., Tian, Y., Li, J., He, C., Xu, Y.
Deposit date:2014-10-22
Release date:2014-11-19
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2.121 Å)
Cite:Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine.
Cell Res., 24, 2014
5CPR
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THE NOVEL SUV4-20 INHIBITOR A-196 VERIFIES A ROLE FOR EPIGENETICS IN GENOMIC INTEGRITY
Descriptor:Histone-lysine N-methyltransferase SUV420H1, ZINC ION, S-ADENOSYLMETHIONINE, ...
Authors:Jakob, C.G., Upadhyay, A.K., Sun, C.
Deposit date:2015-07-21
Release date:2017-01-25
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
Nat. Chem. Biol., 13, 2017
5KJ2
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THE NOVEL P300/CBP INHIBITOR A-485 UNCOVERS A UNIQUE MECHANISM OF ACTION TO TARGET AR IN CASTRATE RESISTANT PROSTATE CANCER
Descriptor:Histone acetyltransferase p300, N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide, SODIUM ION
Authors:Jakob, C.G., Qiu, W., Edalji, R.P., Sun, C.
Deposit date:2016-06-17
Release date:2017-09-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Nature, 550, 2017
1G3F
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NMR STRUCTURE OF A 9 RESIDUE PEPTIDE FROM SMAC/DIABLO COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Descriptor:INHIBITOR OF APOPTOSIS PROTEIN 3, SMAC, ZINC ION
Authors:Liu, Z., Sun, C., Olejniczak, E.T., Meadows, R.P., Betz, S.F., Oost, T., Herrmann, J., Wu, J.C., Fesik, S.W.
Deposit date:2000-10-24
Release date:2001-01-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Nature, 408, 2000
1I3O
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CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3
Descriptor:CASPASE 3, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, ZINC ION
Authors:Riedl, S.J., Renatus, M., Schwarzenbacher, R., Zhou, Q., Sun, C., Fesik, S.W., Liddington, R.C., Salvesen, G.S.
Deposit date:2001-02-15
Release date:2001-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the inhibition of caspase-3 by XIAP.
Cell(Cambridge,Mass.), 104, 2001
1TFQ
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NMR STRUCTURE OF AN ANTAGONISTS OF THE XIAP-CASPASE-9 INTERACTION COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Descriptor:Baculoviral IAP repeat-containing protein 4, ZINC ION, N-METHYLALANYL-3-METHYLVALYL-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
Authors:Oost, T.K., Sun, C., Armstrong, R.C., Al-Assaad, A.S., Betz, S.F., Deckwerth, T.L., Elmore, S.W., Meadows, R.P., Olejniczak, E.T., Oleksijew, A., Oltersdorf, T., Rosenberg, S.H., Shoemaker, A.R., Zou, H., Fesik, S.W.
Deposit date:2004-05-27
Release date:2004-09-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer.
J.Med.Chem., 47, 2004
1TFT
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NMR STRUCTURE OF AN ANTAGONISTS OF THE XIAP-CASPASE-9 INTERACTION COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Descriptor:Baculoviral IAP repeat-containing protein 4, ZINC ION, 1-[3,3-DIMETHYL-2-(2-METHYLAMINO-PROPIONYLAMINO)-BUTYRYL]-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMIDE
Authors:Oost, T.K., Sun, C., Armstrong, R.C., Al-Assaad, A.S., Betz, S.F., Deckwerth, T.L., Elmore, S.W., Meadows, R.P., Olejniczak, E.T., Oleksijew, A.K., Oltersdorf, T., Rosenberg, S.H., Shoemaker, A.R., Zou, H., Fesik, S.W.
Deposit date:2004-05-27
Release date:2005-05-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
J.Med.Chem., 47, 2004
2A9H
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NMR STRUCTURAL STUDIES OF A POTASSIUM CHANNEL / CHARYBDOTOXIN COMPLEX
Descriptor:Voltage-gated potassium channel, charybdotoxin
Authors:Yu, L., Sun, C., Song, D., Shen, J., Xu, N., Gunasekera, A., Hajduk, P.J., Olejniczak, E.T.
Deposit date:2005-07-11
Release date:2006-01-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.
Biochemistry, 44, 2005
2E6W
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SOLUTION STRUCTURE AND CALCIUM BINDING PROPERTIES OF EF-HANDS 3 AND 4 OF CALSENILIN
Descriptor:Calsenilin, CALCIUM ION
Authors:Yu, L., Sun, C., Mendoza, R., Hebert, E., Pereda-Lopez, A., Hajduk, P.J., Olejniczak, E.T.
Deposit date:2007-01-05
Release date:2007-11-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and calcium-binding properties of EF-hands 3 and 4 of calsenilin.
Protein Sci., 16, 2007
2NW4
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CRYSTAL STRUCTURE OF THE RAT ANDROGEN RECEPTOR LIGAND BINDING DOMAIN COMPLEX WITH BMS-564929
Descriptor:Androgen receptor, 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE
Authors:Ostrowski, J., Kuhns, J.E., Lupisella, J.A., Manfredi, M.C., Beehler, B.C., Krystek, S.R., Bi, Y., Sun, C., Seethala, R., Golla, R., Sleph, P.G., Fura, A., An, Y., Kish, K.F., Sack, J.S., Mookhtiar, K.A., Grover, G.J., Hamann, L.G.
Deposit date:2006-11-14
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.
Endocrinology, 148, 2007
4MGJ
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CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 F429H IN COMPLEX WITH 4-CPI
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE
Authors:Yang, Y., Zhang, H., Usharani, D., Bu, W., Im, S., Tarasev, M., Rwere, F., Meagher, J., Sun, C., Stuckey, J., Shaik, S., Waskell, L.
Deposit date:2013-08-28
Release date:2014-08-13
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate-Histidine Hydrogen Bond.
Biochemistry, 53, 2014
4QG6
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CRYSTAL STRUCTURE OF PKM2-Y105E MUTANT
Descriptor:Pyruvate kinase PKM, PROLINE
Authors:Wang, P., Sun, C., Zhu, T., Xu, Y.
Deposit date:2014-05-22
Release date:2015-02-25
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3.207 Å)
Cite:Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4QG8
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CRYSTAL STRUCTURE OF PKM2-K305Q MUTANT
Descriptor:Pyruvate kinase PKM, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Wang, P., Sun, C., Zhu, T., Xu, Y.
Deposit date:2014-05-22
Release date:2015-02-25
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4QG9
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CRYSTAL STRUCTURE OF PKM2-R399E MUTANT
Descriptor:Pyruvate kinase PKM, MAGNESIUM ION, ACETATE ION
Authors:Wang, P., Sun, C., Zhu, T., Xu, Y.
Deposit date:2014-05-22
Release date:2015-02-25
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.381 Å)
Cite:Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4QGC
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CRYSTAL STRUCTURE OF PKM2-K422R MUTANT
Descriptor:Pyruvate kinase PKM, POTASSIUM ION, SULFATE ION, ...
Authors:Wang, P., Sun, C., Zhu, T., Xu, Y.
Deposit date:2014-05-22
Release date:2015-02-25
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.296 Å)
Cite:Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4RPP
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CRYSTAL STRUCTURE OF PKM2-K422R MUTANT BOUND WITH FBP
Descriptor:Pyruvate kinase PKM, BETA-FRUCTOSE-1,6-DIPHOSPHATE
Authors:Wang, P., Sun, C., Zhu, T., Xu, Y.
Deposit date:2014-10-31
Release date:2015-02-25
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.585 Å)
Cite:Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
5C56
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CRYSTAL STRUCTURE OF USP7/HAUSP IN COMPLEX WITH ICP0
Descriptor:Ubiquitin E3 ligase ICP0, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Cheng, J., Li, Z., Gong, R., Fang, J., Yang, Y., Sun, C., Yang, H., Xu, Y.
Deposit date:2015-06-19
Release date:2015-07-08
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.685 Å)
Cite:Molecular mechanism for the substrate recognition of USP7.
Protein Cell, 6, 2015