Author results

1JHB
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HUMAN GLUTAREDOXIN IN FULLY REDUCED FORM, NMR, 20 STRUCTURES
分子名称:GLUTAREDOXIN
著者Sun, C., Bushweller, J.H.
登録日1998-02-17
公開日1998-08-26
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献The NMR solution structure of human glutaredoxin in the fully reduced form.
J.Mol.Biol., 280, 1998
1F9X
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AVERAGE NMR SOLUTION STRUCTURE OF THE BIR-3 DOMAIN OF XIAP
分子名称:INHIBITOR OF APOPTOSIS PROTEIN XIAP, ZINC ION
著者Sun, C., Cai, M., Meadows, R.P., Fesik, S.W.
登録日2000-07-11
公開日2001-07-11
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP.
J.Biol.Chem., 275, 2000
1XOX
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SOLUTION STRUCTURE OF HUMAN SURVIVIN
分子名称:Apoptosis inhibitor survivin, ZINC ION
著者Sun, C., Nettesheim, D., Liu, Z., Olejniczak, E.T.
登録日2004-10-07
公開日2005-01-18
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of human survivin and its binding interface with smac/diablo
Biochemistry, 44, 2005
6BTM
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STRUCTURE OF ALTERNATIVE COMPLEX III FROM FLAVOBACTERIUM JOHNSONIAE (WILD TYPE)
分子名称:Alternative Complex III subunit A, Alternative Complex III subunit B, Alternative Complex III subunit C, ...
著者Sun, C., Benlekbir, S., Venkatakrishnan, P., Yuhang, W., Tajkhorshid, E., Rubinstein, J.L., Gennis, R.B.
登録日2017-12-07
公開日2018-05-09
最終更新日2019-02-20
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure of the alternative complex III in a supercomplex with cytochrome oxidase.
Nature, 557, 2018
2JOD
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PAC1-RSHORT N-TERMINAL EC DOMAIN PACAP(6-38) COMPLEX
分子名称:Pituitary adenylate cyclase-activating polypeptide type I receptor, Pituitary adenylate cyclase-activating polypeptide
著者Olejniczak, E.T., Sun, C., Song, D., Davis-Taber, R.A., Barrett, L.W., Scott, V.E., Richardson, P.L., Pereda-lopez, A., Uchic, M.E., Solomon, L.R., Lake, M.R., Walter, K.A., Hajduk, P.J.
登録日2007-03-07
公開日2007-05-22
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3NEW
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P38-ALPHA COMPLEXED WITH COMPOUND 10
分子名称:Mitogen-activated protein kinase 14, 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one
著者Goedken, E.R., Comess, K.M., Sun, C., Argiriadi, M., Jia, Y., Quinn, C.M., Banach, D.L., Marcotte, D., Borhani, D.
登録日2010-06-09
公開日2010-12-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases.
Acs Chem.Biol., 6, 2011
4OQ5
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CRYSTAL STRUCTURE OF HUMAN MCL-1 BOUND TO INHIBITOR 4-(4-METHYLNAPHTHALEN-1-YL)-2-{[(4-PHENOXYPHENYL)SULFONYL]AMINO}BENZOIC ACID
分子名称:Induced myeloid leukemia cell differentiation protein Mcl-1, 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid
著者Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.
登録日2014-02-07
公開日2014-03-12
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.
Bioorg.Med.Chem.Lett., 24, 2014
4OQ6
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CRYSTAL STRUCTURE OF HUMAN MCL-1 BOUND TO INHIBITOR 4-HYDROXY-4'-PROPYLBIPHENYL-3-CARBOXYLIC ACID
分子名称:Induced myeloid leukemia cell differentiation protein Mcl-1, 4-hydroxy-4'-propylbiphenyl-3-carboxylic acid
著者Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.
登録日2014-02-07
公開日2014-03-12
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.
Bioorg.Med.Chem.Lett., 24, 2014
4WQN
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CRYSTAL STRUCTURE OF N6-METHYLADENOSINE RNA READER YTHDF2
分子名称:YTH domain-containing family protein 2, GLYCEROL, 1,2-ETHANEDIOL
著者Zhu, T., Roundtree, I.A., Wang, P., Wang, X., Wang, L., Sun, C., Tian, Y., Li, J., He, C., Xu, Y.
登録日2014-10-22
公開日2014-11-19
最終更新日2014-12-10
実験手法X-RAY DIFFRACTION (2.121 Å)
主引用文献Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine.
Cell Res., 24, 2014
5CPR
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THE NOVEL SUV4-20 INHIBITOR A-196 VERIFIES A ROLE FOR EPIGENETICS IN GENOMIC INTEGRITY
分子名称:Histone-lysine N-methyltransferase SUV420H1, ZINC ION, S-ADENOSYLMETHIONINE, ...
著者Jakob, C.G., Upadhyay, A.K., Sun, C.
登録日2015-07-21
公開日2017-01-25
最終更新日2017-02-22
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
Nat. Chem. Biol., 13, 2017
5KJ2
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THE NOVEL P300/CBP INHIBITOR A-485 UNCOVERS A UNIQUE MECHANISM OF ACTION TO TARGET AR IN CASTRATE RESISTANT PROSTATE CANCER
分子名称:Histone acetyltransferase p300, N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide, SODIUM ION
著者Jakob, C.G., Qiu, W., Edalji, R.P., Sun, C.
登録日2016-06-17
公開日2017-09-27
最終更新日2019-04-10
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Nature, 550, 2017
1G3F
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NMR STRUCTURE OF A 9 RESIDUE PEPTIDE FROM SMAC/DIABLO COMPLEXED TO THE BIR3 DOMAIN OF XIAP
分子名称:INHIBITOR OF APOPTOSIS PROTEIN 3, SMAC, ZINC ION
著者Liu, Z., Sun, C., Olejniczak, E.T., Meadows, R.P., Betz, S.F., Oost, T., Herrmann, J., Wu, J.C., Fesik, S.W.
登録日2000-10-24
公開日2001-01-10
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Nature, 408, 2000
1I3O
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CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3
分子名称:CASPASE 3, BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, ZINC ION
著者Riedl, S.J., Renatus, M., Schwarzenbacher, R., Zhou, Q., Sun, C., Fesik, S.W., Liddington, R.C., Salvesen, G.S.
登録日2001-02-15
公開日2001-03-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for the inhibition of caspase-3 by XIAP.
Cell(Cambridge,Mass.), 104, 2001
1TFQ
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NMR STRUCTURE OF AN ANTAGONISTS OF THE XIAP-CASPASE-9 INTERACTION COMPLEXED TO THE BIR3 DOMAIN OF XIAP
分子名称:Baculoviral IAP repeat-containing protein 4, ZINC ION, N-METHYLALANYL-3-METHYLVALYL-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
著者Oost, T.K., Sun, C., Armstrong, R.C., Al-Assaad, A.S., Betz, S.F., Deckwerth, T.L., Elmore, S.W., Meadows, R.P., Olejniczak, E.T., Oleksijew, A., Oltersdorf, T., Rosenberg, S.H., Shoemaker, A.R., Zou, H., Fesik, S.W.
登録日2004-05-27
公開日2004-09-07
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer.
J.Med.Chem., 47, 2004
1TFT
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NMR STRUCTURE OF AN ANTAGONISTS OF THE XIAP-CASPASE-9 INTERACTION COMPLEXED TO THE BIR3 DOMAIN OF XIAP
分子名称:Baculoviral IAP repeat-containing protein 4, ZINC ION, 1-[3,3-DIMETHYL-2-(2-METHYLAMINO-PROPIONYLAMINO)-BUTYRYL]-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMIDE
著者Oost, T.K., Sun, C., Armstrong, R.C., Al-Assaad, A.S., Betz, S.F., Deckwerth, T.L., Elmore, S.W., Meadows, R.P., Olejniczak, E.T., Oleksijew, A.K., Oltersdorf, T., Rosenberg, S.H., Shoemaker, A.R., Zou, H., Fesik, S.W.
登録日2004-05-27
公開日2005-05-03
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
J.Med.Chem., 47, 2004
2A9H
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NMR STRUCTURAL STUDIES OF A POTASSIUM CHANNEL / CHARYBDOTOXIN COMPLEX
分子名称:Voltage-gated potassium channel, charybdotoxin
著者Yu, L., Sun, C., Song, D., Shen, J., Xu, N., Gunasekera, A., Hajduk, P.J., Olejniczak, E.T.
登録日2005-07-11
公開日2006-01-10
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.
Biochemistry, 44, 2005
2E6W
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SOLUTION STRUCTURE AND CALCIUM BINDING PROPERTIES OF EF-HANDS 3 AND 4 OF CALSENILIN
分子名称:Calsenilin, CALCIUM ION
著者Yu, L., Sun, C., Mendoza, R., Hebert, E., Pereda-Lopez, A., Hajduk, P.J., Olejniczak, E.T.
登録日2007-01-05
公開日2007-11-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and calcium-binding properties of EF-hands 3 and 4 of calsenilin.
Protein Sci., 16, 2007
2NW4
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CRYSTAL STRUCTURE OF THE RAT ANDROGEN RECEPTOR LIGAND BINDING DOMAIN COMPLEX WITH BMS-564929
分子名称:Androgen receptor, 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE
著者Ostrowski, J., Kuhns, J.E., Lupisella, J.A., Manfredi, M.C., Beehler, B.C., Krystek, S.R., Bi, Y., Sun, C., Seethala, R., Golla, R., Sleph, P.G., Fura, A., An, Y., Kish, K.F., Sack, J.S., Mookhtiar, K.A., Grover, G.J., Hamann, L.G.
登録日2006-11-14
公開日2006-12-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats.
Endocrinology, 148, 2007
4MGJ
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CRYSTAL STRUCTURE OF CYTOCHROME P450 2B4 F429H IN COMPLEX WITH 4-CPI
分子名称:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 4-(4-CHLOROPHENYL)IMIDAZOLE
著者Yang, Y., Zhang, H., Usharani, D., Bu, W., Im, S., Tarasev, M., Rwere, F., Meagher, J., Sun, C., Stuckey, J., Shaik, S., Waskell, L.
登録日2013-08-28
公開日2014-08-13
最終更新日2014-09-24
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate-Histidine Hydrogen Bond.
Biochemistry, 53, 2014
4QG6
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CRYSTAL STRUCTURE OF PKM2-Y105E MUTANT
分子名称:Pyruvate kinase PKM, PROLINE
著者Wang, P., Sun, C., Zhu, T., Xu, Y.
登録日2014-05-22
公開日2015-02-25
最終更新日2015-03-25
実験手法X-RAY DIFFRACTION (3.207 Å)
主引用文献Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4QG8
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CRYSTAL STRUCTURE OF PKM2-K305Q MUTANT
分子名称:Pyruvate kinase PKM, MAGNESIUM ION, POTASSIUM ION, ...
著者Wang, P., Sun, C., Zhu, T., Xu, Y.
登録日2014-05-22
公開日2015-02-25
最終更新日2015-03-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4QG9
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CRYSTAL STRUCTURE OF PKM2-R399E MUTANT
分子名称:Pyruvate kinase PKM, MAGNESIUM ION, ACETATE ION
著者Wang, P., Sun, C., Zhu, T., Xu, Y.
登録日2014-05-22
公開日2015-02-25
最終更新日2015-03-25
実験手法X-RAY DIFFRACTION (2.381 Å)
主引用文献Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4QGC
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CRYSTAL STRUCTURE OF PKM2-K422R MUTANT
分子名称:Pyruvate kinase PKM, POTASSIUM ION, SULFATE ION, ...
著者Wang, P., Sun, C., Zhu, T., Xu, Y.
登録日2014-05-22
公開日2015-02-25
最終更新日2015-03-25
実験手法X-RAY DIFFRACTION (2.296 Å)
主引用文献Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
4RPP
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CRYSTAL STRUCTURE OF PKM2-K422R MUTANT BOUND WITH FBP
分子名称:Pyruvate kinase PKM, BETA-FRUCTOSE-1,6-DIPHOSPHATE
著者Wang, P., Sun, C., Zhu, T., Xu, Y.
登録日2014-10-31
公開日2015-02-25
最終更新日2015-03-25
実験手法X-RAY DIFFRACTION (2.585 Å)
主引用文献Structural insight into mechanisms for dynamic regulation of PKM2
Protein Cell, 2015
5C56
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CRYSTAL STRUCTURE OF USP7/HAUSP IN COMPLEX WITH ICP0
分子名称:Ubiquitin E3 ligase ICP0, Ubiquitin carboxyl-terminal hydrolase 7
著者Cheng, J., Li, Z., Gong, R., Fang, J., Yang, Y., Sun, C., Yang, H., Xu, Y.
登録日2015-06-19
公開日2015-07-08
最終更新日2015-11-11
実験手法X-RAY DIFFRACTION (2.685 Å)
主引用文献Molecular mechanism for the substrate recognition of USP7.
Protein Cell, 6, 2015