Author results

3JBN
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CRYO-ELECTRON MICROSCOPY RECONSTRUCTION OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO P-TRNA
Descriptor:18S ribosomal RNA, P-tRNA, 40S ribosomal protein uS3, ...
Authors:Sun, M., Li, W., Blomqvist, K., Das, S., Hashem, Y., Dvorin, J.D., Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
3JBO
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CRYO-ELECTRON MICROSCOPY RECONSTRUCTION OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO P/E-TRNA
Descriptor:18S ribosomal RNA, P/E-tRNA, 40S ribosomal protein uS12, ...
Authors:Sun, M., Li, W., Blomqvist, K., Das, S., Hashem, Y., Dvorin, J.D., Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
3JBP
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CRYO-ELECTRON MICROSCOPY RECONSTRUCTION OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO E-TRNA
Descriptor:18S ribosomal RNA, E-tRNA, 40S ribosomal protein uS3, ...
Authors:Sun, M., Li, W., Blomqvist, K., Das, S., Hashem, Y., Dvorin, J.D., Frank, J.
Deposit date:2015-09-16
Release date:2015-10-14
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Dynamical features of the Plasmodium falciparum ribosome during translation.
Nucleic Acids Res., 43, 2015
3PJP
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A TANDEM SH2 DOMAIN IN TRANSCRIPTION ELONGATION FACTOR SPT6 BINDS THE PHOSPHORYLATED RNA POLYMERASE II C-TERMINAL REPEAT DOMAIN(CTD)
Descriptor:Transcription elongation factor SPT6, ACETATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Sun, M., Lariviere, L., Dengl, S., Mayer, A., Cramer, P.
Deposit date:2010-11-10
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A tandem SH2 domain in transcription elongation factor Spt6 binds the phosphorylated RNA polymerase II C-terminal repeat domain (CTD).
J.Biol.Chem., 285, 2010
4O2C
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AN NT-ACETYLATED PEPTIDE COMPLEXED WITH HLA-B*3901
Descriptor:HLA class I histocompatibility antigen, B-39 alpha chain, Beta-2-microglobulin, ...
Authors:Sun, M., Liu, J., Qi, J., Tefsen, B., Shi, Y., Yan, J., Gao, G.F.
Deposit date:2013-12-17
Release date:2014-07-23
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:N alpha-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted n alpha-acetylpeptide presentation
J.Immunol., 192, 2014
4O2E
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A PEPTIDE COMPLEXED WITH HLA-B*3901
Descriptor:HLA class I histocompatibility antigen, B-39 alpha chain, Beta-2-microglobulin, ...
Authors:Sun, M., Liu, J., Qi, J., Tefsen, B., Shi, Y., Yan, J., Gao, G.F.
Deposit date:2013-12-17
Release date:2014-07-23
Method:X-RAY DIFFRACTION (1.981 Å)
Cite:N alpha-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted n alpha-acetylpeptide presentation
J.Immunol., 192, 2014
4O2F
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A PEPTIDE COMPLEXED WITH HLA-B*3901
Descriptor:HLA class I histocompatibility antigen, B-39 alpha chain, Beta-2-microglobulin, ...
Authors:Sun, M., Liu, J., Qi, J., Tefsen, B., Shi, Y., Yan, J., Gao, G.F.
Deposit date:2013-12-17
Release date:2014-07-23
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:N alpha-terminal acetylation for T cell recognition: molecular basis of MHC class I-restricted n alpha-acetylpeptide presentation
J.Immunol., 192, 2014
3U1R
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STRUCTURE ANALYSIS OF A NEW PSYCHROPHILIC MARINE PROTEASE
Descriptor:Alkaline metalloprotease, ZINC ION, CALCIUM ION
Authors:Zhang, S.-C., Sun, M., Tang, L., Wang, Q.-H., Hao, J.-H., Han, Y., Hu, X.-J., Zhou, M., Lin, S.-X.
Deposit date:2011-09-30
Release date:2012-10-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure analysis of a new psychrophilic marine protease.
Plos One, 6, 2011
5CE7
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STRUCTURE OF A NON-CANONICAL CID OF CTK3
Descriptor:CTD kinase subunit gamma, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Muehlbacher, W., Mayer, A., Sun, M., Remmert, M., Cheung, A.C., Niesser, J., Soeding, J., Cramer, P.
Deposit date:2015-07-06
Release date:2015-08-05
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold.
Proteins, 83, 2015
5T5H
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STRUCTURE AND ASSEMBLY MODEL FOR THE TRYPANOSOMA CRUZI 60S RIBOSOMAL SUBUNIT
Descriptor:RNA LARGE SUBUNIT ALPHA, RNA LARGE SUBUNIT BETA, 5.8S rRNA, ...
Authors:Liu, Z., Gutierrez-Vargas, C., Wei, J., Grassucci, R.A., Ramesh, M., Espina, N., Sun, M., Tutuncuoglu, B., Madison-Antenucci, S., Woolford Jr., J.L., Tong, L., Frank, J.
Deposit date:2016-08-31
Release date:2016-10-12
Last modified:2018-03-28
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit.
Proc.Natl.Acad.Sci.USA, 113, 2016
1YT9
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HIV PROTEASE WITH OXIMINOARYLSULFONAMIDE BOUND
Descriptor:Pol polyprotein, (S)-N-((2S,3R)-3-HYDROXY-4-(4-((E)-(HYDROXYIMINO)METHYL)-N-ISOBUTYLPHENYLSULFONAMIDO)-1-PHENYLBUTAN-2-YL)-3-METHYL-2-(3-((2-METHYLTHIAZOL-4-YL)METHYL)-2-OXOIMIDAZOLIDIN-1-YL)BUTANAMIDE
Authors:Yeung, C.M., Klein, L.L., Flentge, C.A., Randolph, J.T., Zhao, C., Sun, M., Dekhtyar, T., Stoll, V.S., Kempf, D.J.
Deposit date:2005-02-10
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Oximinoarylsulfonamides as potent HIV protease inhibitors.
Bioorg.Med.Chem.Lett., 15, 2005
2A4F
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SYNTHESIS AND ACTIVITY OF N-AXYL AZACYCLIC UREA HIV-1 PROTEASE INHIBITORS WITH HIGH POTENCY AGAINST MULTIPLE DRUG RESISTANT VIRAL STRAINS.
Descriptor:Pol polyprotein, (5R,6R)-5-BENZYL-6-HYDROXY-2,4-BIS(4-HYDROXY-3-METHOXYBENZYL)-1-[3-(4-HYDROXYPHENYL)PROPANOYL]-1,2,4-TRIAZEPAN-3-ONE
Authors:Zhao, C., Sham, H., Sun, M., Lin, S., Stoll, V., Stewart, K.D., Mo, H., Vasavanonda, S., Saldivar, A., McDonald, E.
Deposit date:2005-06-28
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains
Bioorg.Med.Chem.Lett., 15, 2005
2EX0
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CRYSTAL STRUCTURE OF MULTIFUNCTIONAL SIALYLTRANSFERASE FROM PASTEURELLA MULTOCIDA
Descriptor:a2,3-sialyltransferase, a2,6-sialyltransferase
Authors:Ni, L., Sun, M., Chen, X., Fisher, A.J.
Deposit date:2005-11-07
Release date:2006-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Cytidine 5'-Monophosphate (CMP)-Induced Structural Changes in a Multifunctional Sialyltransferase from Pasteurella multocida
Biochemistry, 45, 2006
2EX1
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CRYSTAL STRUCTURE OF MUTIFUNCTIONAL SIALYLTRANSFERASE FROM PASTEURELLA MULTOCIDA WITH CMP BOUND
Descriptor:a2,3-sialyltransferase, a2,a6-sialyltransferase, CYTIDINE-5'-MONOPHOSPHATE
Authors:Ni, L., Sun, M., Chen, X., Fisher, A.J.
Deposit date:2005-11-07
Release date:2006-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Cytidine 5'-Monophosphate (CMP)-Induced Structural Changes in a Multifunctional Sialyltransferase from Pasteurella multocida
Biochemistry, 45, 2006
2VUJ
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ENVIRONMENTALLY ISOLATED GH11 XYLANASE
Descriptor:GH11 XYLANASE, GLYCEROL
Authors:Dumon, C., Varvak, A., Wall, M.A., Flint, J.E., Lewis, R.J., Lakey, J.H., Luginbuhl, P., Healey, S., Todaro, T., DeSantis, G., Sun, M., Parra-Gessert, L., Tan, X., Weiner, D.P., Gilbert, H.J.
Deposit date:2008-05-26
Release date:2008-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Engineering Hyperthermostability Into a Gh11 Xylanase is Mediated by Subtle Changes to Protein Structure.
J.Biol.Chem., 283, 2008
2VUL
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THERMOSTABLE MUTANT OF ENVIRONMENTALLY ISOLATED GH11 XYLANASE
Descriptor:GH11 XYLANASE, SULFATE ION, DODECAETHYLENE GLYCOL
Authors:Dumon, C., Varvak, A., Wall, M.A., Flint, J.E., Lewis, R.J., Lakey, J.H., Luginbuhl, P., Healey, S., Todaro, T., Desantis, G., Sun, M., Parra-Gessert, L., Tan, X., Weiner, D.P., Gilbert, H.J.
Deposit date:2008-05-27
Release date:2008-06-17
Last modified:2014-06-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Engineering Hyperthermostability Into a Gh11 Xylanase is Mediated by Subtle Changes to Protein Structure.
J.Biol.Chem., 283, 2008
3GXW
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STRUCTURE OF THE SH2 DOMAIN OF THE CANDIDA GLABRATA TRANSCRIPTION ELONGATION FACTOR SPT6, CRYSTAL FORM A
Descriptor:Transcription elongation factor SPT6, SUCCINIC ACID, SODIUM ION
Authors:Dengl, S., Mayer, A., Sun, M., Cramer, P.
Deposit date:2009-04-03
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and in vivo requirement of the yeast Spt6 SH2 domain
J.Mol.Biol., 389, 2009
3GXX
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STRUCTURE OF THE SH2 DOMAIN OF THE CANDIDA GLABRATA TRANSCRIPTION ELONGATION FACTOR SPT6, CRYSTAL FORM B
Descriptor:Transcription elongation factor SPT6
Authors:Dengl, S., Mayer, A., Sun, M., Cramer, P.
Deposit date:2009-04-03
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and in vivo requirement of the yeast Spt6 SH2 domain
J.Mol.Biol., 389, 2009
4D2H
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CRYSTAL STRUCTURE OF THE TETRAMERISATION DOMAIN OF HUMAN CTIP
Descriptor:RBBP8, SULFATE ION
Authors:Davies, O.R., Sun, M., Pellegrini, L.
Deposit date:2014-05-09
Release date:2015-01-14
Last modified:2015-02-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ctip Tetramer Assembly is Required for DNA-End Resection and Repair.
Nat.Struct.Mol.Biol., 22, 2015
4PKM
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CRYSTAL STRUCTURE OF BACILLUS THURINGIENSIS CRY51AA1 PROTOXIN AT 1.65 ANGSTROMS RESOLUTION
Descriptor:Cry51Aa1, GLYCEROL, SULFATE ION, ...
Authors:Xu, C., Chinte, U., Chen, L., Yao, Q., Zhou, D., Meng, Y., Li, L., Rose, J., Bi, L.J., Yu, Z., Sun, M., Wang, B.C.
Deposit date:2014-05-15
Release date:2015-06-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of Cry51Aa1: A potential novel insecticidal aerolysin-type beta-pore-forming toxin from Bacillus thuringiensis.
Biochem.Biophys.Res.Commun., 462, 2015
5GHE
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CRYSTAL STRUCTURE OF BACILLUS THURINGIENSIS CRY6AA2 PROTOXIN
Descriptor:Pesticidal crystal protein Cry6Aa
Authors:Huang, J., Guan, Z., Zou, T., Sun, M., Yin, P.
Deposit date:2016-06-19
Release date:2016-08-03
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Crystal structure of Cry6Aa: A novel nematicidal ClyA-type alpha-pore-forming toxin from Bacillus thuringiensis
Biochem.Biophys.Res.Commun., 478, 2016
4IT7
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CRYSTAL STRUCTURE OF AL-CPI
Descriptor:CPI
Authors:Mei, G.Q., Liu, S.L., Sun, M.Z., Liu, J.
Deposit date:2013-01-17
Release date:2014-01-29
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for the Immunomodulatory Function of Cysteine Protease Inhibitor from Human Roundworm Ascaris lumbricoides.
Plos One, 9, 2014
3QI1
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DESIGN AND SYNTHESIS OF HYDROXYETHYLAMINE (HEA) BACE-1 INHIBITORS: PRIME SIDE CHROMANE-CONTAINING INHIBITORS
Descriptor:Beta-secretase 1, N-[(2S,3R)-4-{[(2R,4S)-2-cyclopropyl-6-(2,2-dimethylpropyl)-3,4-dihydro-2H-chromen-4-yl]amino}-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Authors:Yao, N.
Deposit date:2011-01-26
Release date:2012-03-28
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
6NO9
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PIM1 IN COMPLEX WITH CPD16 (5-AMINO-N-(5-((4R,5R)-4-AMINO-5-FLUOROAZEPAN-1-YL)-1-METHYL-1H-PYRAZOL-4-YL)-2-(2,6-DIFLUOROPHENYL)THIAZOLE-4-CARBOXAMIDE)
Descriptor:Serine/threonine-protein kinase pim-1, GLYCEROL, PHOSPHATE ION, ...
Authors:Murray, J.M., Noland, C.
Deposit date:2019-01-15
Release date:2019-02-27
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.712 Å)
Cite:Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma.
J. Med. Chem., 62, 2019
2II6
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CRYSTAL STRUCTURE OF PASTEURELLA MULTOCIDA SIALYLTRANSFERASE D141N MUTANT IN OPEN CONFORMATION WITH CMP BOUND
Descriptor:Alpha-2,3/2,6-sialyltransferase/sialidase, CYTIDINE-5'-MONOPHOSPHATE
Authors:Fisher, A.J., Ni, L.
Deposit date:2006-09-27
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural analysis of multifunctional sialyltransferase from Pasteurella multocida.
To be Published
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