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4UIS
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BU of 4uis by Molmil
The cryoEM structure of human gamma-Secretase complex
Descriptor: GAMMA-SECRETASE, LYSOZYME
Authors:Sun, L, Zhao, L, Yang, G, Yan, C, Zhou, R, Zhou, X, Xie, T, Zhao, Y, Wu, S, Li, X, Shi, Y.
Deposit date:2015-04-03
Release date:2015-06-10
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structural Basis of Human Gamma-Secretase Assembly.
Proc.Natl.Acad.Sci.USA, 112, 2015
5T5S
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BU of 5t5s by Molmil
A fragment of a human tRNA synthetase
Descriptor: Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L, Schimmel, P.
Deposit date:2016-08-31
Release date:2016-11-30
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5T76
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BU of 5t76 by Molmil
A fragment of a human tRNA synthetase
Descriptor: Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L, Schimmel, P.
Deposit date:2016-09-02
Release date:2016-11-30
Last modified:2017-01-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5KNN
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BU of 5knn by Molmil
Evolutionary gain of alanine mischarging to non-cognate tRNAs with a G4:U69 base pair
Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, Alanine--tRNA ligase, cytoplasmic
Authors:Sun, L, He, W, Yang, X.-L.
Deposit date:2016-06-28
Release date:2016-09-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair.
J.Am.Chem.Soc., 138, 2016
3UA3
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BU of 3ua3 by Molmil
Crystal Structure of Protein Arginine Methyltransferase PRMT5 in complex with SAH
Descriptor: Protein arginine N-methyltransferase 5, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Sun, L, Wang, M, Lv, Z, Yang, N, Liu, Y, Bao, S, Gong, W, Xu, R.M.
Deposit date:2011-10-20
Release date:2011-12-14
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into protein arginine symmetric dimethylation by PRMT5
Proc.Natl.Acad.Sci.USA, 108, 2011
3UA4
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BU of 3ua4 by Molmil
Crystal Structure of Protein Arginine Methyltransferase PRMT5
Descriptor: GLYCEROL, Protein arginine N-methyltransferase 5
Authors:Sun, L, Wang, M, Lv, Z, Yang, N, Liu, Y, Bao, S, Gong, W, Xu, R.M.
Deposit date:2011-10-21
Release date:2011-12-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Structural insights into protein arginine symmetric dimethylation by PRMT5
Proc.Natl.Acad.Sci.USA, 108, 2011
3V0U
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BU of 3v0u by Molmil
Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding
Descriptor: Perakine reductase
Authors:Sun, L, Chen, Y, Rajendran, C, Panjikar, S, Mueller, U, Wang, M, Rosenthal, C, Mindnich, R, Penning, T.M, Stoeckigt, J.
Deposit date:2011-12-08
Release date:2012-02-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
J.Biol.Chem., 287, 2012
3V0S
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BU of 3v0s by Molmil
Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding
Descriptor: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, Perakine reductase
Authors:Sun, L, Chen, Y, Rajendran, C, Panjikar, S, Mueller, U, Wang, M, Rosenthal, C, Mindnich, R, Penning, T.M, Stoeckigt, J.
Deposit date:2011-12-08
Release date:2012-02-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.773 Å)
Cite:Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
J.Biol.Chem., 287, 2012
3UYI
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BU of 3uyi by Molmil
Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding
Descriptor: Perakine reductase
Authors:Sun, L, Chen, Y, Rajendran, C, Panjikar, S, Mueller, U, Wang, M, Rosenthal, C, Mindnich, R, Penning, T.M, Stoeckigt, J.
Deposit date:2011-12-06
Release date:2012-02-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.313 Å)
Cite:Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
J.Biol.Chem., 287, 2012
3V0T
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BU of 3v0t by Molmil
Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding
Descriptor: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, Perakine Reductase
Authors:Sun, L, Chen, Y, Rajendran, C, Panjikar, S, Mueller, U, Wang, M, Rosenthal, C, Mindnich, R, Penning, T.M, Stoeckigt, J.
Deposit date:2011-12-08
Release date:2012-02-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.333 Å)
Cite:Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding.
J.Biol.Chem., 287, 2012
2LJ4
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BU of 2lj4 by Molmil
Solution structure of the TbPIN1
Descriptor: Peptidyl-prolyl cis-trans isomerase/rotamase, putative
Authors:Sun, L, Lin, D, Zhao, Y.
Deposit date:2011-09-06
Release date:2012-08-22
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structural analysis of the single-domain parvulin TbPin1.
Plos One, 7, 2012
3JA7
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BU of 3ja7 by Molmil
Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution
Descriptor: Portal protein gp20
Authors:Sun, L, Zhang, X, Gao, S, Rao, P.A, Padilla-Sanchez, V, Chen, Z, Sun, S, Xiang, Y, Subramaniam, S, Rao, V.B, Rossmann, M.G.
Deposit date:2015-04-21
Release date:2015-07-22
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution.
Nat Commun, 6, 2015
1P5J
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BU of 1p5j by Molmil
Crystal Structure Analysis of Human Serine Dehydratase
Descriptor: L-serine dehydratase, PYRIDOXAL-5'-PHOSPHATE
Authors:Sun, L, Liu, Y, Rao, Z.
Deposit date:2003-04-27
Release date:2004-06-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystallization and preliminary crystallographic analysis of human serine dehydratase.
Acta Crystallogr.,Sect.D, 59, 2003
7SA0
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BU of 7sa0 by Molmil
Crystal structure of CDK2 liganded with compound EF4195
Descriptor: 1,2-ETHANEDIOL, 2-{[(3R)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amino}-5-(trifluoromethyl)benzoic acid, Cyclin-dependent kinase 2
Authors:Sun, L, Schonbrunn, E.
Deposit date:2021-09-21
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Development of selective allosteric inhibitors of cyclin-dependent kinase 2 (CDK2)
To Be Published
7S7A
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BU of 7s7a by Molmil
Crystal structure of CDK2 liganded with compound EF3019
Descriptor: 1,2-ETHANEDIOL, 2-{[2-(2H-indazol-3-yl)ethyl]amino}-5-(trifluoromethyl)benzoic acid, Cyclin-dependent kinase 2
Authors:Sun, L, Schonbrunn, E.
Deposit date:2021-09-15
Release date:2022-09-28
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Allosteric inhibitors of cyclin-dependent kinase 2(CDK2) are negatively cooperative with cyclin binding as potential anticancer and non-hormonal contraceptive agents
To Be Published
7S9X
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BU of 7s9x by Molmil
Crystal structure of CDK2 liganded with compound WN378
Descriptor: 2-[(9H-carbazol-3-yl)amino]-5-(trifluoromethyl)benzoic acid, Cyclin-dependent kinase 2
Authors:Sun, L, Schonbrunn, E.
Deposit date:2021-09-21
Release date:2022-10-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Development of selective allosteric inhibitors of cyclin-dependent kinase 2 (CDK2)
To Be Published
6DIZ
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BU of 6diz by Molmil
EV-A71 strain 11316 complexed with tryptophan dendrimer MADAL_0385
Descriptor: SPHINGOSINE, VP1, VP2, ...
Authors:Sun, L, Lee, H, Thibaut, H.J, Rivero-Buceta, E, Martinez-Gualda, B, Delang, L, Leyssen, P, Gago, F, San-Felix, A, Hafenstein, S, Mirabelli, C, Neyts, J.
Deposit date:2018-05-24
Release date:2019-04-24
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Viral engagement with host (co-)receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid.
Plos Pathog., 15, 2019
4XOI
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BU of 4xoi by Molmil
Structure of hsAnillin bound with RhoA(Q63L) at 2.1 Angstroms resolution
Descriptor: Actin-binding protein anillin, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Sun, L, Guan, R, Lee, I.-J, Liu, Y, Chen, M, Wang, J, Wu, J, Chen, Z.
Deposit date:2015-01-16
Release date:2015-07-15
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (2.092 Å)
Cite:Mechanistic insights into the anchorage of the contractile ring by anillin and mid1
Dev.Cell, 33, 2015
8GQ6
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BU of 8gq6 by Molmil
Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex
Descriptor: Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ...
Authors:Sun, L, Chen, Z, Hu, Y, Mao, Q.
Deposit date:2022-08-29
Release date:2023-09-06
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex
To Be Published
4JPN
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BU of 4jpn by Molmil
Bacteriophage phiX174 H protein residues 143-221
Descriptor: Minor spike protein H
Authors:Sun, L, Young, L.N, Boudko, S.B, Fokine, A, Zhang, X, Rossmann, M.G, Fane, B.A.
Deposit date:2013-03-19
Release date:2013-12-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Icosahedral bacteriophage Phi X174 forms a tail for DNA transport during infection.
Nature, 505, 2014
4JPP
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BU of 4jpp by Molmil
Bacteriophage phiX174 H protein residues 143-282
Descriptor: Minor spike protein H
Authors:Sun, L, Young, L.N, Boudko, S.B, Fokine, A, Zhang, X, Rossmann, M.G, Fane, B.A.
Deposit date:2013-03-19
Release date:2013-12-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Icosahedral bacteriophage Phi X174 forms a tail for DNA transport during infection.
Nature, 505, 2014
4XOH
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BU of 4xoh by Molmil
Mechanistic insights into anchorage of the contractile ring from yeast to humans
Descriptor: Division mal foutue 1 protein
Authors:Chen, Z, Wu, J.-Q, Wang, J, Guan, R, Sun, L, Lee, I.-J, Liu, Y, Chen, M.
Deposit date:2015-01-16
Release date:2015-07-15
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Mechanistic insights into the anchorage of the contractile ring by anillin and mid1
Dev.Cell, 33, 2015
7RWE
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BU of 7rwe by Molmil
Crystal structure of CDK2 liganded with compound GPHR787
Descriptor: 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid, Cyclin-dependent kinase 2
Authors:Sun, L, Schonbrunn, E.
Deposit date:2021-08-19
Release date:2022-08-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.
J.Med.Chem., 66, 2023
7RXO
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BU of 7rxo by Molmil
Crystal structure of CDK2 liganded with compound WN333
Descriptor: 1,2-ETHANEDIOL, 2-{[2-(1H-indol-3-yl)ethyl]amino}-5-(methoxycarbonyl)benzoic acid, Cyclin-dependent kinase 2
Authors:Sun, L, Schonbrunn, E.
Deposit date:2021-08-23
Release date:2022-08-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.
J.Med.Chem., 66, 2023
7S4T
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BU of 7s4t by Molmil
Crystal structure of CDK2 liganded with compound EF2252
Descriptor: 1,2-ETHANEDIOL, 2-{[2-(6-chloro-1H-indol-3-yl)ethyl]amino}-5-nitrobenzoic acid, Cyclin-dependent kinase 2
Authors:Sun, L, Schonbrunn, E.
Deposit date:2021-09-09
Release date:2022-09-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.
J.Med.Chem., 66, 2023

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PDB entries from 2024-03-13

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