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6E0I
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BU of 6e0i by Molmil
Crystal structure of Glucokinase in complex with compound 72
Descriptor: 1-{4-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-[(pyridin-2-yl)sulfanyl]pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]piperidin-1 -yl}ethan-1-one, DIMETHYL SULFOXIDE, Glucokinase, ...
Authors:Hinklin, R.J, Baer, B.R, Boyd, S.A, Chicarelli, M.D, Condroski, K.R, DeWolf, W.E, Fischer, J, Frank, M, Hingorani, G.P, Lee, P.A, Neitzel, N.A, Pratt, S.A, Singh, A, Sullivan, F.X, Turner, T, Voegtli, W.C, Wallace, E.M, Williams, L, Aicher, T.D.
Deposit date:2018-07-06
Release date:2019-07-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.
Bioorg.Med.Chem., 28, 2020
6E0E
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BU of 6e0e by Molmil
Crystal structure of Glucokinase in complex with compound 6
Descriptor: 2-({2-[(4-methyl-1,3-thiazol-2-yl)amino]pyridin-3-yl}oxy)benzonitrile, Glucokinase, alpha-D-glucopyranose
Authors:Hinklin, R.J, Baer, B.R, Boyd, S.A, Chicarelli, M.D, Condroski, K.R, DeWolf, W.E, Fischer, J, Frank, M, Hingorani, G.P, Lee, P.A, Neitzel, N.A, Pratt, S.A, Singh, A, Sullivan, F.X, Turner, T, Voegtli, W.C, Wallace, E.M, Williams, L, Aicher, T.D.
Deposit date:2018-07-06
Release date:2019-07-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.
Bioorg.Med.Chem., 28, 2020
1BSV
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BU of 1bsv by Molmil
GDP-FUCOSE SYNTHETASE FROM ESCHERICHIA COLI COMPLEX WITH NADPH
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTEIN (GDP-FUCOSE SYNTHETASE)
Authors:Somers, W.S, Stahl, M.L, Sullivan, F.X.
Deposit date:1998-08-31
Release date:1999-08-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site.
Structure, 6, 1998
1DB3
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BU of 1db3 by Molmil
E.COLI GDP-MANNOSE 4,6-DEHYDRATASE
Descriptor: GDP-MANNOSE 4,6-DEHYDRATASE
Authors:Somoza, J.R, Menon, S, Somers, W.S, Sullivan, F.X.
Deposit date:1999-11-02
Release date:1999-11-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose.
Structure Fold.Des., 8, 2000
1KAQ
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BU of 1kaq by Molmil
Structure of Bacillus subtilis Nicotinic Acid Mononucleotide Adenylyl Transferase
Descriptor: NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE, NICOTINIC ACID ADENINE DINUCLEOTIDE
Authors:Olland, A.M, Underwood, K.W, Czerwinski, R.M, Lo, M.C, Aulabaugh, A, Bard, J, Stahl, M.L, Somers, W.S, Sullivan, F.X, Chopra, R.
Deposit date:2001-11-02
Release date:2002-07-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
J.Biol.Chem., 277, 2002
1KAM
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BU of 1kam by Molmil
Structure of Bacillus subtilis Nicotinic Acid Mononucleotide Adenylyl Transferase
Descriptor: NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE
Authors:Olland, A.M, Underwood, K.W, Czerwinski, R.M, Lo, M.C, Aulabaugh, A, Bard, J, Stahl, M.L, Somers, W.S, Sullivan, F.X, Chopra, R.
Deposit date:2001-11-02
Release date:2002-07-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferase.
J.Biol.Chem., 277, 2002
1FXS
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BU of 1fxs by Molmil
GDP-FUCOSE SYNTHETASE FROM ESCHERICHIA COLI COMPLEX WITH NADP
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTEIN (GDP-FUCOSE SYNTHETASE)
Authors:Somers, W.S, Stahl, M.L, Sullivan, F.X.
Deposit date:1998-09-01
Release date:1999-08-26
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site.
Structure, 6, 1998
1GFS
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BU of 1gfs by Molmil
GDP-FUCOSE SYNTHETASE FROM E. COLI
Descriptor: GDP-FUCOSE SYNTHETASE
Authors:Somers, W.S, Stahl, M.L, Sullivan, F.X.
Deposit date:1998-08-17
Release date:1999-08-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site.
Structure, 6, 1998
6USZ
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BU of 6usz by Molmil
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vigers, G.P, Smith, D.J.
Deposit date:2019-10-28
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer.
J.Med.Chem., 63, 2020
6USX
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BU of 6usx by Molmil
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer
Descriptor: 1-{4-[2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl}propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Vigers, G.P, Smith, D.J.
Deposit date:2019-10-28
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer.
J.Med.Chem., 63, 2020
6UT0
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BU of 6ut0 by Molmil
Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Vigers, G.P, Smith, D.J.
Deposit date:2019-10-29
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Identification of the Clinical Development CandidateMRTX849, a Covalent KRASG12CInhibitor for the Treatment of Cancer.
J.Med.Chem., 63, 2020

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