Author results

1A0I
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ATP-DEPENDENT DNA LIGASE FROM BACTERIOPHAGE T7 COMPLEX WITH ATP
Descriptor:DNA LIGASE, ADENOSINE-5'-TRIPHOSPHATE
Authors:Subramanya, H.S., Doherty, A.J., Ashford, S.R., Wigley, D.B.
Deposit date:1997-12-01
Release date:1998-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7.
Cell(Cambridge,Mass.), 85, 1996
1A0P
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SITE-SPECIFIC RECOMBINASE, XERD
Descriptor:SITE-SPECIFIC RECOMBINASE XERD
Authors:Subramanya, H.S., Arciszewska, L.K., Baker, R.A., Bird, L.E., Sherratt, D.J., Wigley, D.B.
Deposit date:1997-12-05
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the site-specific recombinase, XerD.
EMBO J., 16, 1997
1OTF
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4-OXALOCROTONATE TAUTOMERASE-TRICLINIC CRYSTAL FORM
Descriptor:4-OXALOCROTONATE TAUTOMERASE
Authors:Subramanya, H.S., Roper, D.I., Dauter, Z., Dodson, E.J., Davies, G.J., Wilson, K.S., Wigley, D.B.
Deposit date:1995-11-09
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases.
Biochemistry, 35, 1996
1OTG
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5-CARBOXYMETHYL-2-HYDROXYMUCONATE ISOMERASE
Descriptor:5-CARBOXYMETHYL-2-HYDROXYMUCONATE ISOMERASE, SULFATE ION
Authors:Subramanya, H.S., Roper, D.I., Dauter, Z., Dodson, E.J., Davies, G.J., Wilson, K.S., Wigley, D.B.
Deposit date:1995-11-09
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases.
Biochemistry, 35, 1996
1PJR
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STRUCTURE OF DNA HELICASE
Descriptor:PCRA
Authors:Subramanya, H.S., Bird, L.E., Brannigan, J.A., Wigley, D.B.
Deposit date:1996-10-11
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a DExx box DNA helicase.
Nature, 384, 1996
4JYT
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CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR
Descriptor:Suppressor of tumorigenicity 14 protein, 4,4'-[{3-[(naphthalen-2-ylsulfonyl)amino]pyridine-2,6-diyl}bis(oxy)]dibenzenecarboximidamide
Authors:Subramanya, H.S., Ravi, B.C., Ashok, K.N., Chakshusmathi, G., Ramesh, K.S.
Deposit date:2013-04-01
Release date:2014-03-19
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors
ACS MED.CHEM.LETT., 4, 2013
4JZ1
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CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR
Descriptor:Suppressor of tumorigenicity 14 protein, 4,4'-[(3-{[(4-fluorophenyl)sulfonyl]amino}pyridine-2,6-diyl)bis(oxy)]dibenzenecarboximidamide
Authors:Subramanya, H.S., Ravi, B.C., Ashok, K.N., Chakshusmathi, G., Ramesh, K.S.
Deposit date:2013-04-02
Release date:2014-02-26
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors
ACS MED.CHEM.LETT., 4, 2013
4JZI
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CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR".
Descriptor:Suppressor of tumorigenicity 14 protein, N-(trans-4-aminocyclohexyl)-2,6-bis(4-carbamimidoylphenoxy)pyridine-4-carboxamide
Authors:Subramanya, H.S., Chandra, R.B., Ashok, K.N., Chakshusmathi, G., Ramesh, K.S.
Deposit date:2013-04-03
Release date:2014-02-26
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors
ACS MED.CHEM.LETT., 4, 2013
1KKJ
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CRYSTAL STRUCTURE OF SERINE HYDROXYMETHYLTRANSFERASE FROM B.STEAROTHERMOPHILUS
Descriptor:Serine Hydroxymethyltransferase, PYRIDOXAL-5'-PHOSPHATE
Authors:Trivedi, V., Gupta, A., Jala, V.R., Saravanan, P., Rao, G.S.J., Rao, N.A., Savithri, H.S., Subramanya, H.S.
Deposit date:2001-12-09
Release date:2002-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.
J.Biol.Chem., 277, 2002
1KKP
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CRYSTAL STRUCTURE OF SERINE HYDROXYMETHYLTRANSFERASE COMPLEXED WITH SERINE
Descriptor:Serine Hydroxymethyltransferase, PYRIDOXAL-5'-PHOSPHATE, SERINE
Authors:Trivedi, V., Gupta, A., Jala, V.R., Saravanan, P., Rao, G.S.J., Rao, N.A., Savithri, H.S., Subramanya, H.S.
Deposit date:2001-12-10
Release date:2002-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.
J.Biol.Chem., 277, 2002
1KL1
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CRYSTAL STRUCTURE OF SERINE HYDROXYMETHYLTRANSFERASE COMPLEXED WITH GLYCINE
Descriptor:Serine Hydroxymethyltransferase, PYRIDOXAL-5'-PHOSPHATE, GLYCINE
Authors:Trivedi, V., Gupta, A., Jala, V.R., Saravanan, P., Rao, G.S.J., Rao, N.A., Savithri, H.S., Subramanya, H.S.
Deposit date:2001-12-11
Release date:2002-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.
J.Biol.Chem., 277, 2002
1KL2
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CRYSTAL STRUCTURE OF SERINE HYDROXYMETHYLTRANSFERASE COMPLEXED WITH GLYCINE AND 5-FORMYL TETRAHYDROFOLATE
Descriptor:Serine Hydroxymethyltransferase, PYRIDOXAL-5'-PHOSPHATE, GLYCINE, ...
Authors:Trivedi, V., Gupta, A., Jala, V.R., Saravanan, P., Rao, G.S.J., Rao, N.A., Savithri, H.S., Subramanya, H.S.
Deposit date:2001-12-11
Release date:2002-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.
J.Biol.Chem., 277, 2002
1YJS
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K226Q MUTANT OF SERINE HYDROXYMETHYLTRANSFERASE FROM B. STEAROTHERMOPHILUS, COMPLEX WITH GLYCINE
Descriptor:SERINE HYDROXYMETHYLTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, GLYCINE
Authors:Bhavani, S., Trivedi, V., Jala, V.R., Subramanya, H.S., Kaul, P., Purnima, K., Prakash, V., Appaji, R.N., Savithri, H.S.
Deposit date:2005-01-15
Release date:2005-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of Lys-226 in the Catalytic Mechanism of Bacillus Stearothermophilus Serine Hydroxymethyltransferase-Crystal Structure and Kinetic Studies
Biochemistry, 44, 2005
1YJY
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K226M MUTANT OF SERINE HYDROXYMETHYLTRANSFERASE FROM B. STEAROTHERMOPHILUS, COMPLEX WITH SERINE
Descriptor:SERINE HYDROXYMETHYLTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, SERINE
Authors:Bhavani, S., Trivedi, V., Jala, V.R., Subramanya, H.S., Kaul, P., Purnima, K., Prakash, V., Appaji, R.N., Savithri, H.S.
Deposit date:2005-01-16
Release date:2005-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Role of Lys-226 in the Catalytic Mechanism of Bacillus Stearothermophilus Serine Hydroxymethyltransferase-Crystal Structure and Kinetic Studies
Biochemistry, 44, 2005
1YJZ
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K226M MUTANT OF SERINE HYDROXYMETHYLTRANSFERASE FROM B. STEAROTHERMOPHILUS
Descriptor:SERINE HYDROXYMETHYLTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Bhavani, S., Trivedi, V., Jala, V.R., Subramanya, H.S., Kaul, P., Purnima, K., Prakash, V., Appaji, R.N., Savithri, H.S.
Deposit date:2005-01-16
Release date:2005-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Role of Lys-226 in the Catalytic Mechanism of Bacillus Stearothermophilus Serine Hydroxymethyltransferase-Crystal Structure and Kinetic Studies
Biochemistry, 44, 2005
1I9G
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CRYSTAL STRUCTURE OF AN ADOMET DEPENDENT METHYLTRANSFERASE
Descriptor:HYPOTHETICAL PROTEIN RV2118C, S-ADENOSYLMETHIONINE
Authors:Gupta, A., Kumar, P.H., Dineshkumar, T.K., Varshney, U., Subramanya, H.S., TB Structural Genomics Consortium (TBSGC)
Deposit date:2001-03-20
Release date:2001-09-26
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv.
J.Mol.Biol., 312, 2001
2PJR
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HELICASE PRODUCT COMPLEX
Descriptor:DNA (5'-D(*TP*TP*TP*TP*T)-3'), DNA (5'-D(*GP*C)-3'), DNA (5'-D(*AP*CP*TP*GP*C)-3'), ...
Authors:Velankar, S.S., Soultanas, P., Dillingham, M.S., Subramanya, H.S., Wigley, D.B.
Deposit date:1999-03-12
Release date:1999-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism.
Cell(Cambridge,Mass.), 97, 1999
3PJR
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HELICASE SUBSTRATE COMPLEX
Descriptor:5'-D(*GP*CP*AP*GP*TP*GP*CP*TP*CP*GP*TP*TP*TP*TP*T)-3', 5'-D(*CP*GP*AP*GP*CP*AP*CP*TP*GP*C)-3', HELICASE PCRA, ...
Authors:Velankar, S.S., Soultanas, P., Dillingham, M.S., Subramanya, H.S., Wigley, D.B.
Deposit date:1999-03-12
Release date:1999-04-08
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism
Cell(Cambridge,Mass.), 97, 1999
4O97
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CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR
Descriptor:Suppressor of tumorigenicity 14 protein, Peptide CGLR, N-(trans-4-aminocyclohexyl)-3,5-bis[(3-carbamimidoylbenzyl)oxy]benzamide
Authors:Rao, K.N., Chandra, B.R., Ashok, K.N., Chakshusmathi, G., Ramesh, K.S., Subramanya, H.S.
Deposit date:2014-01-02
Release date:2014-05-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.
Bioorg.Med.Chem., 22, 2014
4O9V
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CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR
Descriptor:Suppressor of tumorigenicity 14 protein, Peptide CGLR, N-(trans-4-aminocyclohexyl)-3,5-bis(4-carbamimidoylphenoxy)benzamide
Authors:Rao, K.N., Chandra, B.R., Ashok, K.N., Chakshusmathi, G., Ramesh, K.S., Subramanya, H.S.
Deposit date:2014-01-03
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.
Bioorg.Med.Chem., 22, 2014
4RLH
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CRYSTAL STRUCTURE OF ENOYL ACP REDUCTASE FROM BURKHOLDERIA PSEUDOMALLEI IN COMPLEX WITH AFN-1252
Descriptor:Enoyl-[acyl-carrier-protein] reductase [NADH], N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)propanamide
Authors:Rao, K.N., Sarah, J., Anirudha, L., Subramanya, H.S.
Deposit date:2014-10-17
Release date:2015-12-09
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of enoyl ACP reductase from Burkholderia pseudomallei in complex with AFN-1252
To be Published
1SMV
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PRIMARY STRUCTURE OF SESBANIA MOSAIC VIRUS COAT PROTEIN: ITS IMPLICATIONS TO THE ASSEMBLY AND ARCHITECTURE OF THE VIRUS
Descriptor:SESBANIA MOSAIC VIRUS COAT PROTEIN, CALCIUM ION
Authors:Bhuvaneshwari, M., Murthy, M.R.N.
Deposit date:1995-06-16
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of sesbania mosaic virus at 3 A resolution.
Structure, 3, 1995
4R0I
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CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH INHIBITOR
Descriptor:Suppressor of tumorigenicity 14 protein, SERINE PROTEASE, MATRIPTASE, ...
Authors:Rao, K.N., Ashok, K.N., Chakshusmathi, G., Rajeev, G., Subramanya, H.
Deposit date:2014-07-31
Release date:2015-02-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach
Bioorg.Med.Chem.Lett., 25, 2015
4QL8
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CRYSTAL STRUCTURE OF ANDROGEN RECEPTOR IN COMPLEX WITH THE LIGAND
Descriptor:Androgen receptor, 2-chloro-4-[(3S,3aS,4S)-4-hydroxy-3-methoxy-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl]-3-methylbenzonitrile
Authors:Krishnamurthy, N., Sangeetha, R., Ghadiyaram, C., Sasmal, S., Subramanya, H.S.
Deposit date:2014-06-11
Release date:2015-06-17
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:3-alkoxy-pyrrolo[1,2-b]pyrazolines as selective androgen receptor modulators with ideal physicochemical properties for transdermal administration
J.Med.Chem., 57, 2014