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1RGS
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REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE
Descriptor:CAMP DEPENDENT PROTEIN KINASE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Authors:Su, Y., Dostmann, W.R.G., Herberg, F.W., Durick, K., Xuong, N.-H., Ten Eyck, L., Taylor, S.S., Varughese, K.I.
Deposit date:1995-06-21
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains.
Science, 269, 1995
2GAR
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A PH-DEPENDENT STABLIZATION OF AN ACTIVE SITE LOOP OBSERVED FROM LOW AND HIGH PH CRYSTAL STRUCTURES OF MUTANT MONOMERIC GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE
Descriptor:GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, PHOSPHATE ION
Authors:Su, Y., Yamashita, M.M., Greasley, S.E., Mullen, C.A., Shim, J.H., Jennings, P.A., Benkovic, S.J., Wilson, I.A.
Deposit date:1998-05-13
Release date:1998-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A.
J.Mol.Biol., 281, 1998
3GAR
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A PH-DEPENDENT STABLIZATION OF AN ACTIVE SITE LOOP OBSERVED FROM LOW AND HIGH PH CRYSTAL STRUCTURES OF MUTANT MONOMERIC GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE
Descriptor:GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, PHOSPHATE ION
Authors:Su, Y., Yamashita, M.M., Greasley, S.E., Mullen, C.A., Shim, J.H., Jennings, P.A., Benkovic, S.J., Wilson, I.A.
Deposit date:1998-05-13
Release date:1998-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A.
J.Mol.Biol., 281, 1998
4YP3
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MUTANT HUMAN DNA POLYMERASE ETA Q38A/R61A INSERTING DCTP OPPOSITE AN 8-OXOGUANINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Deposit date:2015-03-12
Release date:2015-05-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YQW
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MUTANT HUMAN DNA POLYMERASE ETA Q38A/R61A INSERTING DCTP OPPOSITE TEMPLATE G
Descriptor:DNA polymerase eta, DNA (5'-D(*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Deposit date:2015-03-13
Release date:2015-05-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.064 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YR0
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MUTANT HUMAN DNA POLYMERASE ETA R61M INSERTING DCTP OPPOSITE AN 8-OXOGUANINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(P*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Deposit date:2015-03-13
Release date:2015-05-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YR2
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MUTANT HUMAN DNA POLYMERASE ETA R61M INSERTING DATP OPPOSITE AN 8-OXOGUANINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Deposit date:2015-03-14
Release date:2015-05-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YR3
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MUTANT HUMAN DNA POLYMERASE ETA R61M INSERTING DCTP OPPOSITE TEMPLATE G
Descriptor:DNA polymerase eta, DNA (5'-D(P*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Deposit date:2015-03-14
Release date:2015-05-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
5EWE
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TERNARY COMPLEX OF HUMAN DNA POLYMERASE ETA INSERTING RCTP OPPOSITE TEMPLATE G
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Egli, M., Guengerich, F.P.
Deposit date:2015-11-20
Release date:2016-01-13
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5EWF
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TERNARY COMPLEX OF HUMAN DNA POLYMERASE ETA INSERTING RCTP OPPOSITE AN 8-OXODEOXYGUANOSINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Egli, M., Guengerich, F.P.
Deposit date:2015-11-20
Release date:2016-01-13
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.782 Å)
Cite:Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
5EWG
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TERNARY COMPLEX OF HUMAN DNA POLYMERASE ETA INSERTING RATP OPPOSITE AN 8-OXODEOXYGUANOSINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Egli, M., Guengerich, F.P.
Deposit date:2015-11-20
Release date:2016-01-13
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta.
J.Biol.Chem., 291, 2016
1DIR
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CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER
Descriptor:DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I., Su, Y., Skinner, M.M., Matthews, D.A., Whitely, J.M., Xuong, N.H.
Deposit date:1994-04-18
Release date:1994-07-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver.
Acta Crystallogr.,Sect.D, 50, 1994
1HDR
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THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINE REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLI BY A CDNA CONSTRUCTED FROM ITS RAT HOMOLOGUE
Descriptor:DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Varughese, K.I., Su, Y., Xuong, N.H., Whiteley, J.M.
Deposit date:1993-08-18
Release date:1994-08-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue.
J.Biol.Chem., 268, 1993
2LAS
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MOLECULAR DETERMINANTS OF PARALOGUE-SPECIFIC SUMO-SIM RECOGNITION
Descriptor:Small ubiquitin-related modifier 1, M-IR2_peptide
Authors:Namanja, A., Li, Y., Su, Y., Wong, S., Lu, J., Colson, L., Wu, C., Li, S., Chen, Y.
Deposit date:2011-03-20
Release date:2011-12-14
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:Insights into High Affinity Small Ubiquitin-like Modifier (SUMO) Recognition by SUMO-interacting Motifs (SIMs) Revealed by a Combination of NMR and Peptide Array Analysis.
J.Biol.Chem., 287, 2012
5TBP
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CRYSTAL STRUCTURE OF RXR-ALPHA LIGAND BINDING DOMAIN COMPLEXED WITH SYNTHETIC MODULATOR K8003
Descriptor:Retinoic acid receptor RXR-alpha, [(1Z)-5-fluoro-2-methyl-1-{[4-(propan-2-yl)phenyl]methylidene}-1H-inden-3-yl]acetic acid, ACETATE ION, ...
Authors:Aleshin, A.E., Liddington, R.C., Su, Y., Zhang, X.
Deposit date:2016-09-12
Release date:2017-08-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha.
Nat Commun, 8, 2017
4N5G
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CRYSTAL STRUCTURE OF RXRA LBD COMPLEXED WITH A SYNTHETIC MODULATOR K8012
Descriptor:Retinoic acid receptor RXR-alpha, 5-(2-{(1Z)-5-fluoro-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole
Authors:Aleshin, A.E., Su, Y., Zhang, X., Liddington, R.C.
Deposit date:2013-10-09
Release date:2014-05-14
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site.
Chem.Biol., 21, 2014
4N8R
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CRYSTAL STRUCTURE OF RXRA LBD COMPLEXED WITH A SYNTHETIC MODULATOR K-8008
Descriptor:Retinoic acid receptor RXR-alpha, 5-(2-{(1Z)-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole
Authors:Aleshin, A.E., Su, Y., Zhang, X., Liddington, R.C.
Deposit date:2013-10-17
Release date:2014-05-14
Last modified:2014-06-11
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site.
Chem.Biol., 21, 2014
1ZXT
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CRYSTAL STRUCTURE OF A VIRAL CHEMOKINE
Descriptor:functional macrophage inflammatory protein 1-alpha homolog
Authors:Luz, J.G., Yu, M., Su, Y., Wu, Z., Zhou, Z., Sun, R., Wilson, I.A.
Deposit date:2005-06-08
Release date:2005-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A.
J.Mol.Biol., 352, 2005
3IL3
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STRUCTURE OF HAEMOPHILUS INFLUENZAE FABH
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3
Authors:Gajiwala, K.S., Margosiak, S., Lu, J., Cortez, J., Su, Y., Nie, Z., Appelt, K.
Deposit date:2009-08-06
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme.
Febs Lett., 583, 2009
3IL4
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STRUCTURE OF E. FAECALIS FABH IN COMPLEX WITH ACETYL COA
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3, ACETYL COENZYME *A
Authors:Gajiwala, K.S., Margosiak, S., Lu, J., Cortez, J., Su, Y., Nie, Z., Appelt, K.
Deposit date:2009-08-06
Release date:2009-08-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme.
Febs Lett., 583, 2009
3IL5
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STRUCTURE OF E. FAECALIS FABH IN COMPLEX WITH 2-({4-BROMO-3-[(DIETHYLAMINO)SULFONYL]BENZOYL}AMINO)BENZOIC ACID
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3, 2-({[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl}amino)benzoic acid
Authors:Gajiwala, K.S., Margosiak, S., Lu, J., Cortez, J., Su, Y., Nie, Z., Appelt, K.
Deposit date:2009-08-06
Release date:2009-08-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme.
Febs Lett., 583, 2009
3IL6
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STRUCTURE OF E. FAECALIS FABH IN COMPLEX WITH 2-({4-[(3R,5S)-3,5-DIMETHYLPIPERIDIN-1-YL]-3-PHENOXYBENZOYL}AMINO)BENZOIC ACID
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3, 2-[({4-[(3R,5S)-3,5-dimethylpiperidin-1-yl]-3-phenoxyphenyl}carbonyl)amino]benzoic acid, SULFATE ION
Authors:Gajiwala, K.S., Margosiak, S., Lu, J., Cortez, J., Su, Y., Nie, Z., Appelt, K.
Deposit date:2009-08-06
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme.
Febs Lett., 583, 2009
3IL7
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CRYSTAL STRUCTURE OF S. AUREUS FABH
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3
Authors:Gajiwala, K.S., Margosiak, S., Lu, J., Cortez, J., Su, Y., Nie, Z., Appelt, K.
Deposit date:2009-08-06
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme.
Febs Lett., 583, 2009
3IL9
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STRUCTURE OF E. COLI FABH
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 3
Authors:Gajiwala, K.S., Margosiak, S., Lu, J., Cortez, J., Su, Y., Nie, Z., Appelt, K.
Deposit date:2009-08-06
Release date:2009-08-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme.
Febs Lett., 583, 2009
4OSX
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STRUCTURE OF UNCLEAVED GLYCINE-BOUND HUMAN L-ASPARAGINASE PROTEIN
Descriptor:Isoaspartyl peptidase/L-asparaginase, SODIUM ION, GLYCINE
Authors:Nomme, J., Lavie, A.
Deposit date:2014-02-13
Release date:2014-03-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Free Glycine Accelerates the Autoproteolytic Activation of Human Asparaginase.
Chem.Biol., 20, 2013