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6L3G
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BU of 6l3g by Molmil
Structural Basis for DNA Unwinding at Forked dsDNA by two coordinating Pif1 helicases
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*TP*TP*TP*T)-3'), ...
Authors:Su, N, Bharath, S.R, Song, H.
Deposit date:2019-10-10
Release date:2019-12-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases.
Nat Commun, 10, 2019
7WKS
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BU of 7wks by Molmil
Apo state of AtPIN3
Descriptor: Auxin efflux carrier component 3
Authors:Su, N.
Deposit date:2022-01-11
Release date:2022-08-10
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structures and mechanisms of the Arabidopsis auxin transporter PIN3.
Nature, 609, 2022
7WKW
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BU of 7wkw by Molmil
NPA bound state of AtPIN3
Descriptor: 2-(naphthalen-1-ylcarbamoyl)benzoic acid, Auxin efflux carrier component 3
Authors:Su, N.
Deposit date:2022-01-11
Release date:2022-08-10
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (2.62 Å)
Cite:Structures and mechanisms of the Arabidopsis auxin transporter PIN3.
Nature, 609, 2022
7XXB
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BU of 7xxb by Molmil
IAA bound state of AtPIN3
Descriptor: 1H-INDOL-3-YLACETIC ACID, Auxin efflux carrier component 3
Authors:Su, N.
Deposit date:2022-05-29
Release date:2022-08-10
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Structures and mechanisms of the Arabidopsis auxin transporter PIN3.
Nature, 609, 2022
7XEV
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BU of 7xev by Molmil
Structure of mTRPV2_2-APB
Descriptor: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2
Authors:Su, N.
Deposit date:2022-03-31
Release date:2022-08-17
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7XEO
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BU of 7xeo by Molmil
MbetaCD treated state of mTRPV2
Descriptor: Transient receptor potential cation channel subfamily V member 2
Authors:Su, N.
Deposit date:2022-03-31
Release date:2022-08-17
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7XEW
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BU of 7xew by Molmil
Structure of mTRPV2_Q525F
Descriptor: Transient receptor potential cation channel subfamily V member 2
Authors:Su, N.
Deposit date:2022-03-31
Release date:2022-08-17
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.59 Å)
Cite:Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7XER
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BU of 7xer by Molmil
Structure of mTRPV2_Q525T
Descriptor: CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2
Authors:Su, N.
Deposit date:2022-03-31
Release date:2022-08-17
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.47 Å)
Cite:Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7XEU
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BU of 7xeu by Molmil
Structure of mTRPV2_E2
Descriptor: CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2
Authors:Su, N.
Deposit date:2022-03-31
Release date:2022-08-17
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.77 Å)
Cite:Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7XEM
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BU of 7xem by Molmil
Cholesterol bound state of mTRPV2
Descriptor: CHOLESTEROL, Transient receptor potential cation channel subfamily V member 2
Authors:Su, N.
Deposit date:2022-03-31
Release date:2022-08-17
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
7YEP
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BU of 7yep by Molmil
2-APB bound state of mTRPV2
Descriptor: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2
Authors:Su, N.
Deposit date:2022-07-06
Release date:2022-08-17
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands.
Nat.Chem.Biol., 19, 2023
1WP8
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BU of 1wp8 by Molmil
crystal structure of Hendra Virus fusion core
Descriptor: Fusion glycoprotein F0,Fusion glycoprotein F0
Authors:Xu, Y, Liu, Y, Lou, Z, Su, N, Bai, Z, Gao, G.F, Rao, Z.
Deposit date:2004-08-31
Release date:2005-11-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of Nipah and Hendra virus fusion core proteins
FEBS J., 273, 2006
1WP7
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BU of 1wp7 by Molmil
crystal structure of Nipah Virus fusion core
Descriptor: fusion protein
Authors:Xu, Y, Liu, Y, Lou, Z, Su, N, Bai, Z, Gao, G.F, Rao, Z.
Deposit date:2004-08-31
Release date:2005-11-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Nipah Virus fusion core
To be Published
4W6E
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BU of 4w6e by Molmil
Human Tankyrase 1 with small molecule inhibitor
Descriptor: 2-(4-{6-[(3S)-3,4-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl}phenyl)-8-(hydroxymethyl)quinazolin-4(3H)-one, Tankyrase-1, ZINC ION
Authors:Kazmirski, S.L, Johannes, J, Boriack-Sjodin, P.A, Howard, T.
Deposit date:2014-08-20
Release date:2015-05-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.
Acs Med.Chem.Lett., 6, 2015
4W5S
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BU of 4w5s by Molmil
Tankyrase in complex with compound
Descriptor: 8-(hydroxymethyl)-2-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]quinazolin-4(3H)-one, GLYCEROL, Tankyrase-1, ...
Authors:Johannes, J, Kazmirski, S.L, Boriack-Sjodin, P.A, Howard, T.
Deposit date:2014-08-18
Release date:2015-05-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.
Acs Med.Chem.Lett., 6, 2015
6JMD
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BU of 6jmd by Molmil
Crystal structure of human DHODH in complex with inhibitor 1223
Descriptor: 3-[3,5-bis(fluoranyl)-4-[3-(hydroxymethyl)phenyl]phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-03-08
Release date:2020-03-18
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.781 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6FS1
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BU of 6fs1 by Molmil
MCL1 in complex with an indole acid ligand
Descriptor: 1,2-ETHANEDIOL, 7-[3-[(1,5-dimethylpyrazol-3-yl)methylsulfanylmethyl]-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Kasmirski, S, Hargreaves, D.
Deposit date:2018-02-18
Release date:2018-12-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Nat Commun, 9, 2018
6JME
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BU of 6jme by Molmil
Crystal structure of human DHODH in complex with inhibitor 0946
Descriptor: 3-[3,5-bis(fluoranyl)-4-(2-fluorophenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Yu, Y, Chen, Q.
Deposit date:2019-03-08
Release date:2020-03-18
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
6FS2
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BU of 6fs2 by Molmil
MCL1 in complex with indole acid ligand
Descriptor: 7-(2-methylphenyl)-3-[3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propyl]-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Hargreaves, D.
Deposit date:2018-02-18
Release date:2018-12-26
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Nat Commun, 9, 2018
8WMQ
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BU of 8wmq by Molmil
trans-Zeatin bound state of Arabidopsis AZG1 at pH5.5
Descriptor: (2E)-2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Adenine/guanine permease AZG1
Authors:Xu, L, Guo, J.
Deposit date:2023-10-04
Release date:2024-01-17
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1.
Nat.Plants, 10, 2024
8WO7
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BU of 8wo7 by Molmil
Apo state of Arabidopsis AZG1 T440Y
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Adenine/guanine permease AZG1
Authors:Xu, L, Guo, J.
Deposit date:2023-10-06
Release date:2024-01-10
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structures and mechanisms of the Arabidopsis cytokinin transporter AZG1.
Nat.Plants, 10, 2024
8X82
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BU of 8x82 by Molmil
The cryo-EM structure of insect gustatory receptor Gr43a I418A from Drosophila melanogaster
Descriptor: Gustatory receptor for sugar taste 43a
Authors:Ma, D, Guo, J.
Deposit date:2023-11-27
Release date:2024-02-07
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for sugar perception by Drosophila gustatory receptors.
Science, 383, 2024
8X83
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BU of 8x83 by Molmil
The cryo-EM structure of insect gustatory receptor Gr43a I418A from Drosophila melanogaster in complex with fructose
Descriptor: Gustatory receptor for sugar taste 43a, SODIUM ION, beta-D-fructofuranose
Authors:Ma, D, Guo, J.
Deposit date:2023-11-27
Release date:2024-02-07
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for sugar perception by Drosophila gustatory receptors.
Science, 383, 2024
8X84
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BU of 8x84 by Molmil
The cryo-EM structure of insect gustatory receptor Gr43a I418A from Drosophila melanogaster in complex with fructose and calcium
Descriptor: CALCIUM ION, Gustatory receptor for sugar taste 43a, beta-D-fructofuranose
Authors:Ma, D, Guo, J.
Deposit date:2023-11-27
Release date:2024-02-07
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for sugar perception by Drosophila gustatory receptors.
Science, 383, 2024
8W4U
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BU of 8w4u by Molmil
human KCNQ2-CaM in complex with PIP2 and HN37
Descriptor: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ...
Authors:Ma, D, Li, X, Guo, J.
Deposit date:2023-08-25
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Ligand activation mechanisms of human KCNQ2 channel.
Nat Commun, 14, 2023

 

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