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3K4E
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BU of 3k4e by Molmil
Puf3 RNA binding domain bound to Cox17 RNA 3' UTR recognition sequence site A
Descriptor: RNA (5'-R(P*CP*UP*UP*GP*UP*AP*UP*AP*UP*A)-3'), mRNA-binding protein PUF3
Authors:Zhu, D, Stumpf, C.R, Krahn, J.M, Wickens, M, Hall, T.M.T.
Deposit date:2009-10-05
Release date:2009-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A 5' cytosine binding pocket in Puf3p specifies regulation of mitochondrial mRNAs.
Proc.Natl.Acad.Sci.USA, 106, 2009
3K49
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BU of 3k49 by Molmil
Puf3 RNA binding domain bound to Cox17 RNA 3' UTR recognition sequence site B
Descriptor: CITRIC ACID, RNA (5'-R(*CP*CP*UP*GP*UP*AP*AP*AP*UP*A)-3'), mRNA-binding protein PUF3
Authors:Zhu, D, Stumpf, C.R, Krahn, J.M, Wickens, M, Hall, T.M.T.
Deposit date:2009-10-05
Release date:2009-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A 5' cytosine binding pocket in Puf3p specifies regulation of mitochondrial mRNAs.
Proc.Natl.Acad.Sci.USA, 106, 2009
6CJ5
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BU of 6cj5 by Molmil
Crystal Structure of Mnk2-D228G in Complex With Inhibitor
Descriptor: 3-(pyridin-3-yl)imidazo[1,2-a]pyridine-8-carboxamide, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION
Authors:Han, Q.
Deposit date:2018-02-26
Release date:2018-05-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
J. Med. Chem., 61, 2018
6CK6
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BU of 6ck6 by Molmil
Crystal Structure of Mnk2-D228G in complex with Inhibitor
Descriptor: 6'-[(6-aminopyrimidin-4-yl)amino]-8'-methyl-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION
Authors:Han, Q.
Deposit date:2018-02-27
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
J. Med. Chem., 61, 2018
6CKI
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BU of 6cki by Molmil
Co-crystal structure of MNK2 in Complex With Inhibitor
Descriptor: 3,3-dimethyl-6-[(pyrimidin-4-yl)amino]-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION
Authors:Han, Q.
Deposit date:2018-02-28
Release date:2018-05-09
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
J. Med. Chem., 61, 2018
6CJH
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BU of 6cjh by Molmil
Co-crystal structure of MNK2 in complex with an inhibitor
Descriptor: 3-phenyl-5-(pyridin-4-yl)-1H-indazole, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION
Authors:Han, Q.
Deposit date:2018-02-26
Release date:2018-05-09
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
J. Med. Chem., 61, 2018
6CJE
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BU of 6cje by Molmil
Crystal Structure of Mnk2-D228G in complex with Inhibitor
Descriptor: 4-[(9H-purin-6-yl)amino]benzamide, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION
Authors:Han, Q.
Deposit date:2018-02-26
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.36 Å)
Cite:Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
J. Med. Chem., 61, 2018
6CJY
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BU of 6cjy by Molmil
Crystal Structure of Mnk2-D228G in complex with Inhibitor
Descriptor: 5-[(7H-purin-6-yl)amino]-1H-isoindol-1-one, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION
Authors:Han, Q.
Deposit date:2018-02-27
Release date:2018-05-09
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
J. Med. Chem., 61, 2018
6CK3
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BU of 6ck3 by Molmil
Co-crytsal Structure of MNK2 in Complex With an Inhibitor
Descriptor: (3R)-3-methyl-5-[(pyrimidin-4-yl)amino]-2,3-dihydro-1H-isoindol-1-one, CHLORIDE ION, MAP kinase-interacting serine/threonine-protein kinase 2, ...
Authors:Han, Q.
Deposit date:2018-02-27
Release date:2018-05-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
J. Med. Chem., 61, 2018
6CJW
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BU of 6cjw by Molmil
Crystal Structure of Mnk2-D228G in Complex With Inhibitor
Descriptor: 3-(pyridin-4-yl)imidazo[1,2-b]pyridazine, MAP kinase-interacting serine/threonine-protein kinase 2, ZINC ION
Authors:Han, Q.
Deposit date:2018-02-27
Release date:2018-05-09
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
J. Med. Chem., 61, 2018

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